Hermann-Georg Holzhütter

Charité - Universitätsmedizin Berlin
Institut für Biochemie
Computational Systems Biochemistry Group
Charitéplatz 1 (Virchowweg 6)
10117 Berlin

phone +49 30 450 528 166
fax +49 30 450 528 937
pc-fax +49 30 450 7528 446

Research Interests

Recent Publications

Drasdo D, Bode J, Dahmen U, Dirsch O, Dooley S, Gebhardt R, Ghallab A, Godoy P, Häussinger D, Hammad S, Hoehme S, Holzhütter HG, Klingmüller U, Kuepfer L, Timmer J, Zerial M, Hengstler JG. (2014) The virtual liver: state of the art and future perspectives. Arch Toxicol. 2014 Oct 21. [Epub ahead of print] [doi, PubMed]

Liepe J, Holzhütter HG, Kloetzel PM, Stumpf MP, Mishto M. (2014) Modelling proteasome and proteasome regulator activities. Biomolecules. 2014 Jun 20;4(2):585-99. [doi, PubMed]

Ricken T, Werner D, Holzhütter HG, König M, Dahmen U, Dirsch O. (2014) Modeling function-perfusion behavior in liver lobules including tissue, blood, glucose, lactate and glycogen by use of a coupled two-scale PDE-ODE approach. Biomech Model Mechanobiol. 2014 Sep 19. [Epub ahead of print] [doi, PubMed]

Schleicher J, Guthke R, Dahmen U, Dirsch O, Holzhuetter HG, Schuster S. (2014) A theoretical study of lipid accumulation in the liver-implications for nonalcoholic fatty liver disease. Biochim Biophys Acta. 2014 Jan;1841(1):62-9. [doi, PubMed]

Berndt N, Holzhütter HG. (2013) The High Energy Demand of Neuronal Cells Caused by Passive Leak Currents is Not a Waste of Energy. Cell Biochem Biophys. 2013 Nov;67(2):527-35. [doi, PubMed]

Berndt N, Holzhütter HG, Bulik S. (2013) Implications of enzyme deficiencies on mitochondrial energy metabolism and reactive oxygen species formation of neurons involved in rotenone-induced Parkinson's disease: a model-based analysis. FEBS J. 2013 Oct;280(20):5080-93. Epub 2013 Sep 12. [doi, PubMed]

Holzhütter HG, Lock JF, Taheri P, Bulik S, Goede A, Stockmann M. (2013) Assessment of hepatic detoxification activity: proposal of an improved variant of the (13)c-methacetin breath test. PLoS One. 2013;8(8):e70780. [doi, PubMed]

Hovestädt M, Kuckelkorn U, Niewienda A, Keller C, Goede A, Ay B, Günther S, Janek K, Volkmer R, Holzhütter HG. (2013) Rapid degradation of solid-phase bound peptides by the 20S proteasome. J Pept Sci. 2013 Sep;19(9):588-97. Epub 2013 Jul 28. [doi, PubMed]

Huchzermeyer C, Berndt N, Holzhütter HG, Kann O. (2013) Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network. J Cereb Blood Flow Metab. 2013 Feb;33(2):263-71. [doi, PubMed]

Jacobasch G, Holzhütter HG, M. Kruschewski M, Pforte H, Dongowski G. (2013) Dickdarmentzündungen hemmen die Butyratresorption im Kolonepithel – Schutzeffekte durch resistente Stärke Typ 3 (RS3) und RS3/Rutin. Ernährung/Nutrition, 37, 365-382 [abstract, pdf]

Knüppel S, Rohde K, Meidtner K, Drogan D, Holzhütter HG, Boeing H, Fisher E. (2013) Evaluation of 41 Candidate Gene Variants for Obesity in the EPIC-Potsdam Cohort by Multi-Locus Stepwise Regression. PLoS One. 2013 Jul 12;8(7):e68941. [doi, PubMed]

König M., Holzhütter HG., Berndt N. (2013) Metabolic Gradients as Key Regulators in Zonation of Tumor Energy Metabolism: A Tissue-scale Model Based Study.
Biotechnol J. 2013 Sep;8(9):1058-69. [doi, PubMed]

Bazzani S, Hoppe A, Holzhütter HG. (2012) Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism. BMC Syst Biol. 6(1):118. Epub Aug 2012. [PubMed]

Berndt N, Bulik S, Holzhütter HG. (2012) Kinetic Modeling of the Mitochondrial Energy Metabolism of Neuronal Cells: The Impact of Reduced Α-Ketoglutarate Dehydrogenase Activities on ATP Production and Generation of Reactive Oxygen Species. Int J Cell Biol., 2012:757594. Epub 2012 Jun 10. [doi, PubMed]

Binder B, Holzhütter HG. (2012) A Hypothetical Model of Cargo-Selective Rab Recruitment During Organelle Maturation. Cell Biochem Biophys. 2012 May;63(1):59-71. [doi, PubMed]

Bölling C, Dumontier M, Weidlich M, Holzhütter HG. (2012) Role-based representation and inference of biochemical processes ICBO 2012: 3rd International Conference on Biomedical Ontology [ICBO2012]

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, Lecluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol. 2013 Aug;87(8):1315-530. Epub 2013 Aug 23. [doi, PubMed]

Holzhütter HG, Drasdo D, Preusser T, Lippert J, Henney AM. (2012) The virtual liver: a multidisciplinary, multilevel challenge for systems biology. Wiley Interdiscip Rev Syst Biol Med. 2012 May-Jun;4(3):221-35. [PubMed]

Hoppe A, Holzhütter HG. (2012) ModeScore: A method to infer changed activity of metabolic function from transcript profiles. OpenAccess Series in Informatics (OASIcs) 26:1-11. [pdf, doi]

Hoppe A, Ilkavets I, Dooley S, Holzhütter HG. (2012) Metabolic Consequences of TGFb Stimulation in Cultured Primary Mouse Hepatocytes Screened from Transcript Data with ModeScore. Metabolites 2012, 2(4), 983-1003. [doi]

Karlstaedt A, Fliegner D, Kararigas G, Ruderisch HS, Regitz-Zagrosek V, Holzhütter HG. (2012) CardioNet: A human metabolic network suited for the study of cardiomyocyte metabolism. BMC Syst Biol. 2012 Aug 29;6(1):114. [PubMed]

König M., Bulik S. and Holzhütter HG. (2012) Quantifying the Contribution of the Liver to the Homeostasis of Plasma Glucose: A Detailed Kinetic Model of Hepatic Glucose Metabolism Integrated with the Hormonal Control by Insulin, Glucagon and Epinephrine. PLoS Comput Biol. 2012 Jun;8(6):e1002577. Epub 2012 Jun 21. [PubMed]

König M., Dräger A. and Holzhütter HG. (2012) CySBML: a Cytoscape plugin for SBML Bioinformatics. 2012 Jul 5. [PubMed]

König M. and Holzhütter HG. (2012) Kinetic Modeling of Human Hepatic Glucose Metabolism in T2DM Predicts Higher Risk of Hypoglycemic Events in Rigorous Insulin Therapy
J Biol Chem. 2012 Oct 26;287(44):36978-89. [doi, PubMed]