Our research group is located at the Institute of Biochemistry of the Charité - Universitätsmedizin Berlin. The main goal of our research is the development of mathematical models enabling computer simulations of the dynamical behaviour of complex molecular reaction systems operating at cellular level as, for example, metabolic pathways, proteolysis and antigen presentation or self-organization of cellular organelles. Cell types under current investigation comprise hepatocytes, parasites (Toxoplasma gondii, Plasmodium falciparum), neurons and cancer cells.
We use either kinetic models based on deterministic or stochastic equations of motion or flux-balance methods (constrained optimization) depending on the complexity of the reaction network studied and on the availability of experimental data on kinetic properties of the underlying enzymes and transporters and the levels of transcripts, proteins, and metabolites.
From 2004 to 2009, our group was part of the national research initiative for systems biology HepatoSys sponsered by the German Federal Ministry of Education and Research (BMBF), where Prof. Holzhütter was the coordinator of the interdisciplinary Platform Modeling. From 2010, we also participate in the following project Virtual Liver. A larger part of our projects is integrated into this research program.
Funding is also received from the the Collaborative Research Centre "Theoretical Biology: Robustness, Modularity and Evolutionary Design of Living Systems" (SFB 618), the Research Training Group (DFG-Graduiertenkolleg 1772) "Computational Systems Biology" (CSB) and the e:Bio - Innovationswettbewerb Systembiologie with the joint research project HepatomaSys sponsered by the German Federal Ministry of Education and Research (BMBF).