04.12.2019 bis 04.12.2019

BEMC Talk, 04.12.2019: Causal Decision Analysis of Benefits, Harms and Cost-effectiveness – Estimands, Outcomes, Models and More

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Uwe Siebert, Hall in Tirol, Österreich


Das Berlin Epidemiologic Methods Colloquium (BEMC) bietet Epidemiologinnen und Epidemiologen eine lokale Plattform, auf der wir uns vernetzen, neue Methoden erlernen und aktuelle Themen in diesem Bereich diskutieren können. BEMC bietet interaktive monatliche BEMC Talks und BEMC JClub in englischer Sprache.

Decision analysis (or decision-analytic modeling) is a systematic approach to decision making under uncertainty that involves combining evidence for different estimands and outcomes from different study types and different sources in order to derive causal conclusions for future clinical, policy or research actions.
This talk provides an overview on the concepts and methods of causal decision-analytic modeling as a tool for (1) benefit-harm analysis informing clinical guidelines and personalized medical decision making, (2) cost-effectiveness analysis informing reimbursement decision making and (3) value-of-information analysis for future research prioritization.
Case examples of published decision analyses will be used to illustrate the fields of application, different model types, the importance of using causal model input parameters (particularly from real-world data), the choice of different estimands (e.g., from the ICH E9 framework) and their causal interpretations, approaches to integrate intercurrent events, as well as guidelines for best modeling practices, possible pitfalls in causal modeling, and future developments.




Uwe Siebert, Hall in Tirol, Österreich
Prof. Dr. Uwe Siebert, MPH, MSc, is Professor of Public Health, Medical Decision Making and Health Technology Assessment (UMIT), Adj. Professor of Health Policy and Management (Harvard Univ.) and the Cahir of the Department of Public Health, Health Services Research, and Health Technology Assessment


Berlin Epidemiologic Methods Colloquium




Hertwig–Hörsaal (Oscar Hertwig-Haus, Anatomie), Charité Campus Mitte, 10117 Berlin
Look for our signs! If you are standing at the front of the Anatomy building in the park, the entrance is off to your left. It’s the same entrance as the CCM Medical Library, 1st floor.


Please register: BEMC Website



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