Studienbeschreibung

Endothelial dysfunction and CArdiovascular Risk after PreEclampsia (CARPE)

CARPE

Epidemiological studies have shown that preeclamptic pregnancy increases cardiovascular risk up to fourfold. In this study we want to investigate vascular function at different sites (myocardium, upper arm, fingertips, retina) and identify possible biomarkers for early detection of increased long-term risk 5 to 15 years after a preeclamptic pregnancy.

Endothelial dysfunction and cardiovascular longterm risk will be investigated after early and late preeclamptic pregnancy and controls.

• https://www.mdc-berlin.de/cru

• https://www.mdc-berlin.de/cru#t-studies

ClinicalTrials.gov-Nr (NCT)

NCT05277233

04.04.2022

Untersuchte Krankheit, Gesundheitsproblem

• O14 - Präeklampsie

Einschlusskriterien

18 - 60

Weiblich

• 5 to 15 years after first preeclamptic pregnancy
• 5 to 15 years after first healthy pregnancy (controls)

Ausschlusskriterien

• Refusal to participate in the study
• Incapacity or other circumstances that do not allow subjects to fully understand the nature, significance, and scope of this study
• MRI contraindications: Metal implants in the body, intolerance to contrast media, wearing pacemakers or defibrillators, claustrophobia, renal or hepatic dysfunction
• Hypertension before first pregnancy
• AV block, COPD, bronchial asthma
• Pregnancy and/or active breastfeeding
• Glaucoma disease, epilepsy

Charakteristika

Nicht-interventionell

Nicht zutreffend

myocardial perfusion | measured by adenosine MRI

-

Interventionsgruppen, Beobachtungsgruppen

• Arm 1

  women after early preeclampsia

• Arm 2

  women after late preeclampsia

• Arm 3

  women after healthy pregnancy

Kontakt

Frau Heike Schenck

030 450540 565

heike.schenck(at)charite.de

Frau Dr.rer.nat. Kristin Kräker

030 450540328

kristin.kraeker(at)charite.de