Ausgewählte Publikationen der Charité
Die Wissenschaftlerinnen und Wissenschaftler der Charité veröffentlichen mehr als 4.000 Fachpublikationen im Jahr.
Hier stellen wir Ihnen pro Monat zehn ausgewählte Publikationen vor.
Sie befinden sich hier:
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Open Data markiert Publikationen mit offen geteilten Daten. Voraussetzungen für Open Data sind die freie Verfügbarkeit der Originaldaten, maschinenlesbares Format und ein eindeutiger Verweis auf Open Data im Volltext nach den Kriterien des BIH Quest Centers.
Publikationen 2022
März 2022
Autoren:DISCHARGE Trial Group et al.
Titel:CT or Invasive Coronary Angiography in Stable Chest Pain.
Zeitschrift (Journal):N Engl J Med. 2022 Mar 4. doi: 10.1056/NEJMoa2200963. :Seiten (Pages):
Aus der Charité: Bosserdt M, Rieckmann N, Zimmermann E, Müller-Nordhorn J, Laule M, Neskovic AN, Haase R, Feger S, Neumann K, Dreger H, Rief M, Wieske V, Estrella M, Dewey M.Autoren:Ferreira JP et al.
Titel:Mineralocorticoid Receptor Antagonists and Empagliflozin in Patients With Heart Failure and Preserved Ejection Fraction.
Zeitschrift (Journal):J Am Coll Cardiol. 2022 Mar 29;79(12):1129-1137. :Seiten (Pages):
Aus der Charité: Anker SD.
Autoren:Arumahandi de Silva AN et al.
Titel:Pausing methotrexate improves immunogenicity of COVID-19 vaccination in elderly patients with rheumatic diseases.
Zeitschrift (Journal):Ann Rheum Dis. 2022 Mar 14:annrheumdis-2021-221876. :Seiten (Pages):
Aus der Charité: Arumahandi de Silva AN, Frommert LM, Albach FN, Scholz V, Jeworowski LM, Schwarz T, Ten Hagen A, Zernicke J, Corman VM, Drosten C, Burmester GR, Biesen R.Autoren:Yu JSL et al.
Titel:Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance.
Zeitschrift (Journal):Nat Microbiol. 2022 Apr;7(4):542-555. :Seiten (Pages):
Aus der Charité: Herrera-Dominguez L, Hartl J, Freiwald A, Mülleder M, Ralser M.
Autoren:Anker SD et al.
Titel:Responder analysis for improvement in six-minute walk test with ferric carboxymaltose in patients with heart failure with reduced ejection fraction and iron deficiency.
Zeitschrift (Journal):Eur J Heart Fail. 2022 Mar 25. doi: 10.1002/ejhf.2491. :Seiten (Pages):
Aus der Charité: Anker SD.Autoren:Filippatos G et al.
Titel:Finerenone in patients with CKD and T2D with and without heart failure: A prespecified subgroup analysis of the FIDELIO-DKD trial.
Zeitschrift (Journal):Eur J Heart Fail. 2022 Mar 3. doi: 10.1002/ejhf.2469. :Seiten (Pages):
Aus der Charité: Anker SD.Autoren:Kapalczynska M et al.
Titel:BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.
Zeitschrift (Journal):Nat Commun. 2022 Mar 24;13(1):1577. :Seiten (Pages):
Aus der Charité: Kapalczynska M, Lin M, Heuberger J, Muellerke S, Fischer AS, Berger H, Kidess E, Tacke F, Sigal M.
Autoren:Kačarević ŽP et al.
Titel:Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration.
Zeitschrift (Journal):Bioact Mater. 2021 Dec 2;14:15-30. :Seiten (Pages):
Aus der Charité: Kačarević ŽP, Rider P, Witte F.Autoren:Rider P et al.
Titel:Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery.
Zeitschrift (Journal):Bioact Mater. 2021 Nov 29;14:152-168. :Seiten (Pages):
Aus der Charité: Rider P, Kačarević ŽP, Witte F.Autoren:Hertzberg J et al.
Titel:TADA-a machine learning tool for functional annotation-based prioritisation of pathogenic CNVs.
Zeitschrift (Journal):Genome Biol. 2022 Mar 1;23(1):67. :Seiten (Pages):
Aus der Charité: Hertzberg J, Mundlos S.
Februar 2022
Autoren:Brandt L et al.
Titel:Adverse events after antipsychotic discontinuation: an individual participant data meta-analysis.
Zeitschrift (Journal):Lancet Psychiatry. 2022 Mar;9(3):232-242. :Seiten (Pages):
Aus der Charité: Brandt L, Bermpohl F, Loncar L, Neumann K, Heinz A, Gutwinski S.Autoren:Turc G et al.
Titel:Comparison of Mobile Stroke Unit With Usual Care for Acute Ischemic Stroke Management: A Systematic Review and Meta-analysis.
Zeitschrift (Journal):JAMA Neurol. 2022 Feb 7:e215321. :Seiten (Pages):
Aus der Charité: Weber JE, Nolte CH, Ebinger M, Audebert HJ.Autoren:Ng YLD et al.
Titel:Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Zeitschrift (Journal):Nat Commun. 2022 Feb 23;13(1):1009. :Seiten (Pages):
Aus der Charité: Ng YLD, Ramberger E, Dolnik A, Müller S, Walther W, Keller U, Bullinger L, Krönke J.Autoren:Doehner W et al.
Titel:Iron deficiency is related to low functional outcome in patients at early rehabilitation after acute stroke.
Zeitschrift (Journal):J Cachexia Sarcopenia Muscle. 2022 Feb 14. doi: 10.1002/jcsm.12927. :Seiten (Pages):
Aus der Charité: Doehner W, Scherbakov N, Schellenberg T, Scheitz JF.Autoren:Demircan K et al.
Titel:Humoral immune response to COVID-19 mRNA vaccination in relation to selenium status.
Zeitschrift (Journal):Redox Biol. 2022 Apr;50:102242. :Seiten (Pages):
Aus der Charité: Demircan K, Chillon TS, Sun Q, Heller RA, Klingenberg GJ, Seemann P, Schomburg L.Autoren:Doffo J et al.
Titel:NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.
Zeitschrift (Journal):Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2105691119. :Seiten (Pages):
Aus der Charité: Doffo J, Bamopoulos SA, Köse H, Zang C, Habringer S, Schick M, Keller U, Wirth M.Autoren:Neudorfer C et al.
Titel:Personalizing deep brain stimulation using advanced imaging sequences.
Zeitschrift (Journal):Ann Neurol. 2022 Feb 14. doi: 10.1002/ana.26326. :Seiten (Pages):
Aus der Charité: Neudorfer C, Kroneberg D, Al-Fatly B, Goede L, Kübler D, Faust K, Tietze A, Picht T, Kühn A, Schneider GH, Horn A.Autoren:Markó L et al.
Titel:Effect of Sunitinib Treatment on Skin Sodium Accumulation in Patients With Renal Cancer: a Pilot Study.
Zeitschrift (Journal):Hypertension. 2022 Feb 22:HYPERTENSIONAHA12219079. :Seiten (Pages):
Aus der Charité: Markó L, Dörr A, Kuehne T, Dechend R, Flörcken A, Müller DN.Autoren:Graw JA et al.
Titel:The role of cell-free hemoglobin and haptoglobin in acute kidney injury in critically ill adults with ARDS and therapy with VV ECMO.
Zeitschrift (Journal):Crit Care. 2022 Feb 22;26(1):50. :Seiten (Pages):
Aus der Charité: Graw JA, Hildebrandt P, Krannich A, Balzer F, Spies C, Francis RC, Kuebler WM, Weber-Carstens S, Menk M, Hunsicker O.Autoren:Kleinert P & Kircher M.
Titel:A framework to score the effects of structural variants in health and disease.
Zeitschrift (Journal):Genome Res. 2022 Feb 23:gr.275995.121. :Seiten (Pages):
Aus der Charité: Kleinert P, Kircher M.
Januar 2022
Autoren:Gruell H et al.
Titel:mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant.
Zeitschrift (Journal):Nat Med. 2022 Jan 19:1–4. :Seiten (Pages):
Aus der Charité: Tober-Lau P, Hillus D, Kurth F, Sander LE.Autoren:Reincke SM et al.
Titel:SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies.
Zeitschrift (Journal):Science. 2022 Jan 25:eabm5835. :Seiten (Pages):
Aus der Charité: Reincke SM, Kornau HC, Corman VM, van Hoof S, Sánchez-Sendin E, Schmidt ML, Schwarz T, Jeworowski LM, Brandl SE, Rasmussen HF, Homeyer MA, Stöffler L, Kunkel D, Huo S, Horler J, von Wardenburg N, Schmitz D, Drosten C, Prüss H, Kreye J.Autoren:Georg P et al.
Titel:Complement activation induces excessive T cell cytotoxicity in severe COVID-19.
Zeitschrift (Journal):Cell. 2021 Dec 28:S0092-8674(21)01562-2. :Seiten (Pages):
Aus der Charité: Georg P, Astaburuaga-García R, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Thiel A, Hippenstiel S, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Obermayer B, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Kuebler WM, Meisel C, Ralser M, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B.Autoren:Steinfeldt J et al.
Titel:Neural network-based integration of polygenic and clinical information: development and validation of a prediction model for 10-year risk of major adverse cardiac events in the UK Biobank cohort.
Zeitschrift (Journal):Lancet Digit Health. 2022 Feb;4(2):e84-e94. :Seiten (Pages):
Aus der Charité: Steinfeldt J, Buergel T, Loock L, Kittner P, Ruyoga G, Zu Belzen JU, Sasse S, Strangalies H, Christmann L, Hollmann N, Wolf B, Landmesser U, Eils R.Autoren:Schick M et al.
Titel:Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.
Zeitschrift (Journal):Nat Commun. 2022 Jan 12;13(1):281. :Seiten (Pages):
Aus der Charité: Schick M, Zhang L, Isaakaidis K, Rohleder E, Habringer S, Chapuy B, Wirth M, Keller U.Autoren:Baranowsky A et al.
Titel:Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment.
Zeitschrift (Journal):Bone Res. 2022 Jan 27;10(1):9. :Seiten (Pages):
Aus der Charité: Jahn D, Appelt J, Albrecht KK, Otto E, Köhli P, Fuchs M, Tsitsilonis S, Keller J.Autoren:Ganos C et al.
Titel:A neural network for tics: insights from causal brain lesions and deep brain stimulation.
Zeitschrift (Journal):Brain. 2022 Jan 13:awac009. :Seiten (Pages):
Aus der Charité: Ganos C, Al-Fatly B, Fischer JF, Neudorfer C, Kühn AA, Horn A.Autoren:Carbon NM et al.
Titel:Impact of protocol-based physiotherapy on insulin sensitivity and peripheral glucose metabolism in critically ill patients.
Zeitschrift (Journal):J Cachexia Sarcopenia Muscle. 2022 Jan 24. doi: 10.1002/jcsm.12920. :Seiten (Pages):
Aus der Charité: Carbon NM, Engelhardt LJ, Wollersheim T, Grunow JJ, Spies CD, Märdian S, Mai K, Spranger J, Weber-Carstens S.Autoren:Maleitzke T et al.
Titel:Intramuscular and intratendinous placenta-derived mesenchymal stromal-like cell treatment of a chronic quadriceps tendon rupture.
Zeitschrift (Journal):J Cachexia Sarcopenia Muscle. 2022 Jan 5. doi: 10.1002/jcsm.12894. :Seiten (Pages):
Aus der Charité: Maleitzke T, Reinke P, Agres AN, Alves SA, Akyüz L, Fleckenstein FN, Bichmann A, Perka C, Duda GN, Winkler T.Autoren:Breiderhoff T et al.
Titel:Claudin-10a Deficiency Shifts Proximal Tubular Cl- Permeability to Cation Selectivity via Claudin-2 Redistribution.
Zeitschrift (Journal):J Am Soc Nephrol. 2022 Jan 14:ASN.2021030286. :Seiten (Pages):
Aus der Charité: Breiderhoff T, Meoli L, Fromm A, Kriuchkova N, Nagel O, Ladilov Y, Krug S, Mueller D, Mutig K, Günzel D.
Publikationen 2021
Dezember 2021
Autoren:Forslund SK et al.
Titel:Combinatorial, additive and dose-dependent drug-microbiome associations.
Zeitschrift (Journal):Nature. 2021 Dec;600(7889):500-505. :Seiten (Pages):
Aus der Charité: Forslund SK, Markó L, Birkner T, Bork P.
Autoren:Wendisch D et al.
Titel:SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Zeitschrift (Journal):Cell. 2021 Dec 22;184(26):6243-6261.e27. :Seiten (Pages):
Aus der Charité: Wendisch D, Mittermaier M, Chua RL, Timm S, Brumhard S, Hiller AL, Pascual-Reguant A, Mothes R, Pott F, Kazmierski J, Radke J, Pergantis P, Conrad C, Sawitzki B, Horst D, Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Elezkurtaj S, Thibeault C, Witzenrath M, Suttorp N, Drosten C, Goffinet C, Kurth F, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Conrad C, Selbach M, Sander LE.Autoren:Fleseriu M et al.
Titel:Maintenance of response to oral octreotide compared with injectable somatostatin receptor ligands in patients with acromegaly: a phase 3, multicentre, randomised controlled trial.
Zeitschrift (Journal):Lancet Diabetes Endocrinol. 2021 Dec 22:S2213-8587(21)00296-5. :Seiten (Pages):
Aus der Charité: Strasburger CJ.Autoren:Sutharsan S et al.
Titel:Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial.
Zeitschrift (Journal):Lancet Respir Med. 2021 Dec 20:S2213-2600(21)00454-9. :Seiten (Pages):
Aus der Charité: Mall MA.Autoren:Butler J et al.
Titel:Effect of empagliflozin in patients with heart failure across the spectrum of left ventricular ejection fraction.
Zeitschrift (Journal):Eur Heart J. 2021 Dec 8:ehab798. :Seiten (Pages):
Aus der Charité: Anker SD.Autoren:Demir M et al.
Titel:The fecal mycobiome in non-alcoholic fatty liver disease.
Zeitschrift (Journal):J Hepatol. 2021 Dec 10:S0168-8278(21)02238-8. :Seiten (Pages):
Aus der Charité: Demir M, Roderburg C, Tacke F.Autoren:Arends CM et al.
Titel:Clonal hematopoiesis associates with improved survival in metastatic colorectal cancer patients from the FIRE-3 trial.
Zeitschrift (Journal):Blood. 2021 Dec 21:blood.2021014108. :Seiten (Pages):
Aus der Charité: Arends CM, Stahler A, Hablesreiter R, Strzelecka PM, Stein CM, Tilgner M, Bullinger L, Modest DP, Stintzing S, Damm F.Autoren:Graeber SY et al.
Titel:Effects of Elexacaftor/Tezacaftor/Ivacaftor Therapy on CFTR Function in Patients with Cystic Fibrosis and One or Two F508del Alleles.
Zeitschrift (Journal):Am J Respir Crit Care Med. 2021 Dec 22. doi: 10.1164/rccm.202110-2249OC. :Seiten (Pages):
Aus der Charité: Graeber SY, Vitzthum C, Stahl M, Rohrbach A, Drescher M, Mall MA.Autoren:Radke MH et al.
Titel:Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.
Zeitschrift (Journal):Sci Transl Med. 2021 Dec;13(622):eabe8952. :Seiten (Pages):
Aus der Charité: Parakkat P, Carballo JL, Gotthardt M.
Autoren:Altrichter S et al.
Titel:An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria.
Zeitschrift (Journal):J Allergy Clin Immunol. 2021 Dec 23:S0091-6749(21)02682-8. :Seiten (Pages):
Aus der Charité: Altrichter S, Siebenhaar F, Maurer M.
November 2021
Autoren:Pieske B et al.
Titel:Effect of Sacubitril/Valsartan vs Standard Medical Therapies on Plasma NT-proBNP Concentration and Submaximal Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction: The PARALLAX Randomized Clinical Trial.
Zeitschrift (Journal):JAMA. 2021 Nov 16;326(19):1919-1929. :Seiten (Pages):
Aus der Charité: Pieske B.Autoren:Lam BYH et al.
Titel:MC3R links nutritional state to childhood growth and the timing of puberty.
Zeitschrift (Journal):Nature. 2021 Nov;599(7885):436-441. :Seiten (Pages):
Aus der Charité: Langenberg C.Autoren:Metz M et al.
Titel:Fenebrutinib in H1 antihistamine-refractory chronic spontaneous urticaria: a randomized phase 2 trial.
Zeitschrift (Journal):Nat Med. 2021 Nov;27(11):1961-1969. :Seiten (Pages):
Aus der Charité: Metz M, Maurer M.Autoren:Fischer M et al.
Titel:Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study.
Zeitschrift (Journal):Lancet Oncol. 2021 Dec;22(12):1764-1776. :Seiten (Pages):
Aus der Charité: Schulte JH.Autoren:Butler J et al.
Titel:Empagliflozin, Health Status, and Quality of Life in Patients with Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial.
Zeitschrift (Journal):Circulation. 2021 Nov 15. doi: 10.1161/CIRCULATIONAHA.121.057812. :Seiten (Pages):
Aus der Charité: Anker SD.Autoren:Berndt N et al.
Titel:CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases.
Zeitschrift (Journal):Circulation. 2021 Nov 11. doi: 10.1161/CIRCULATIONAHA.121.055646. :Seiten (Pages):
Aus der Charité: Berndt N, Eckstein J, Wallach I, Nordmeyer S, Kelm M, Goubergrits L, Schafstedde M, Hennemuth A, Kuehne T, Holzhütter HG.Autoren:Triana S et al.
Titel:Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.
Zeitschrift (Journal):Nat Immunol. 2021 Dec;22(12):1577-1589. :Seiten (Pages):
Aus der Charité: Jopp-Saile L, Haas S.Autoren:Pietzner M et al.
Titel:Synergistic insights into human health from aptamer- and antibody-based proteomic profiling.
Zeitschrift (Journal):Nat Commun. 2021 Nov 24;12(1):6822. :Seiten (Pages):
Aus der Charité: Pietzner M, Langenberg C.Autoren:Schmelz K et al.
Titel:Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Zeitschrift (Journal):Nat Commun. 2021 Nov 23;12(1):6804. :Seiten (Pages):
Aus der Charité: Schmelz K, Toedling J, Cwikla MC, Kruetzfeldt LM, Proba J, Boral S, Lodrini M, Chen CY, Szymansky A, Astrahantseff K, Kuenkele A, Haase K, Deubzer HE, Hertwig F, Hundsdoerfer P, Henssen AG, Schulte JH, Eggert A.Autoren:Hey J et al.
Titel:Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease.
Zeitschrift (Journal):Nat Commun. 2021 Nov 11;12(1):6520. :Seiten (Pages):
Aus der Charité: Mall MA.Autoren:Nabi D et al.
Titel:CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes.
Zeitschrift (Journal):Nat Commun. 2021 Nov 11;12(1):6547. :Seiten (Pages):
Aus der Charité: Nabi D.
Oktober 2021
Autoren:Witkowski M et al.
Titel:Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.
Zeitschrift (Journal):Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. :Seiten (Pages):
Aus der Charité: Witkowski M, Tizian C, Niemeyer D, Jones TC, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, Mc Ewen S, Zocche S, Viviano E, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Diefenbach A.Autoren:Pietzner M et al.
Titel:Mapping the proteo-genomic convergence of human diseases.
Zeitschrift (Journal):Science. 2021 Oct 14:eabj1541. :Seiten (Pages):
Aus der Charité: Pietzner M, Langenberg C.
Autoren:Tober-Lau P et al.
Titel:Long-term immunogenicity of BNT162b2 vaccination in older people and younger health-care workers.
Zeitschrift (Journal):Lancet Respir Med. 2021 Nov;9(11):e104-e105. :Seiten (Pages):
Aus der Charité: Tober-Lau P, Schwarz T, Hillus D, Suttorp N, Kappert K, Seybold J, Drosten C, Kurth F, Sander LE, Corman VM.Autoren:Haghikia A et al.
Titel:Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
Zeitschrift (Journal):Eur Heart J. 2021 Oct 1:ehab644. :Seiten (Pages):
Aus der Charité: Haghikia A, Zimmermann F, Schumann P, Jasina A, Roessler J, Schmidt D, Heinze P, Nageswaran V, Aigner A, Cineus R, Hegazy AN, Kränkel N, Leistner DM, Heimesaat MM, Bereswill S, Rauch G, Seeland U, Müller DN, Landmesser U.Autoren:Dahlmann M et al.
Titel:Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models.
Zeitschrift (Journal):Mol Cancer. 2021 Oct 21;20(1):129. :Seiten (Pages):
Aus der Charité: Dahlmann M, Gambara G, Pachmayr E, Mokritzkij M, Gül-Klein S, Brandl A, Schweiger-Eisbacher C, Keilholz U, Walther W, Rau B, Stein U.Autoren:Schmid S et al.
Titel:Genetic and epigenetic characterization of posterior pituitary tumors.
Zeitschrift (Journal):Acta Neuropathol. 2021 Dec;142(6):1025-1043. :Seiten (Pages):
Aus der Charité: Schmid S, Perez E, Thieme A, Dittmayer C, Koch A, Capper D.Autoren:Krieger TG et al.
Titel:Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy.
Zeitschrift (Journal):Nat Commun. 2021 Oct 5;12(1):5826. :Seiten (Pages):
Aus der Charité: Krieger TG, Ten FW, Ishaque N, Jechow K, Debnath O, Eils R, Conrad C.Autoren:Budde K et al.
Titel:Conversion from Calcineurin Inhibitor to Belatacept-based Maintenance Immunosuppression in Renal Transplant Recipients: a Randomized Phase 3b Trial.
Zeitschrift (Journal):J Am Soc Nephrol. 2021 Oct 27:ASN.2021050628. :Seiten (Pages):
Aus der Charité: Budde K.Autoren:Schrezenmeier E et al.
Titel:B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients.
Zeitschrift (Journal):J Am Soc Nephrol. 2021 Oct 19:ASN.2021070966. :Seiten (Pages):
Aus der Charité: Schrezenmeier E, Rincon-Arevalo H, Stefanski AL, Staub-Hohenbleicher H, Choi M, Bachmann F, Pross V, Hammett C, Eckardt KU, Kotsch K, Döerner T, Budde K, Sattler A, Halleck F.Autoren:Heine J et al.
Titel:Long-Term Cognitive Outcome in Anti-N-Methyl-D-Aspartate Receptor Encephalitis.
Zeitschrift (Journal):Ann Neurol. 2021 Sep 30. doi: 10.1002/ana.26241. :Seiten (Pages):
Aus der Charité: Heine J, Kopp UA, Klag J, Ploner CJ, Prüss H, Finke C.
September 2021
Autoren:Lee S et al.
Titel:Virus-induced senescence is driver and therapeutic target in COVID-19.
Zeitschrift (Journal):Nature. 2021 Sep 13. doi: 10.1038/s41586-021-03995-1. :Seiten (Pages):
Aus der Charité: Lee S, Richter-Pechanska P, Belenki D, Kausche L, Niemeyer D, Mülleder M, Michaelis EG, Lau A, Schönlein M, Drosten C, Ralser M, Eils R, Reimann M, Fan DNY, Schmitt CA.Autoren:Loyal L et al.
Titel:Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.
Zeitschrift (Journal):Science. 2021 Aug 31:eabh1823. :Seiten (Pages):
Aus der Charité: Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C.Autoren:Modest DP et al.
Titel:Panitumumab Plus Fluorouracil and Folinic Acid Versus Fluorouracil and Folinic Acid Alone as Maintenance Therapy in RAS Wild-Type Metastatic Colorectal Cancer: The Randomized PANAMA Trial (AIO KRK 0212).
Zeitschrift (Journal):J Clin Oncol. 2021 Sep 17:JCO2101332. :Seiten (Pages):
Aus der Charité: Modest DP, Kurreck A, Stahler A, Held S, Jarosch A, Horst D, Stintzing S.Autoren:Katsoulis M et al.
Titel:Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health records.
Zeitschrift (Journal):Lancet Diabetes Endocrinol. 2021 Oct;9(10):681-694. :Seiten (Pages):
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August 2021
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Titel:EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction.
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Titel:Association Between Neuronal Autoantibodies and Cognitive Impairment in Patients With Lung Cancer.
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Juni 2021
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Titel:Caloric restriction disrupts the microbiota and colonization resistance.
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Titel:Dose-intensified Versus Conventional-dose Salvage Radiotherapy for Biochemically Recurrent Prostate Cancer After Prostatectomy: The SAKK 09/10 Randomized Phase 3 Trial.
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Titel:Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died.
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Mai 2021
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Titel:Estimating infectiousness throughout SARS-CoV-2 infection course.
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Titel:Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study.
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Titel:Choose wisely: imaging for diagnosis of axial spondyloarthritis.
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Titel:Association of a Marker of N-Acetylglucosamine With Progressive Multiple Sclerosis and Neurodegeneration.
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Titel:Safety and Efficacy of Vadadustat for Anemia in Patients Undergoing Dialysis.
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Titel:Vadadustat in Patients with Anemia and Non-Dialysis-Dependent CKD.
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März 2021
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Titel:Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
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Titel:Cetuximab, docetaxel, and cisplatin versus platinum, fluorouracil, and cetuximab as first-line treatment in patients with recurrent or metastatic head and neck squamous-cell carcinoma (GORTEC 2014-01 TPExtreme): a multicentre, open-label, randomised, phase 2 trial.
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Titel:TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma.
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Zeitschrift (Journal):Mol Cell. 2021 Feb 23:S1097-2765(21)00092-7. :Seiten (Pages):
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Titel:Chronic Rhinosinusitis with Nasal Polyps is Associated with Impaired TMEM16A-mediated Epithelial Chloride Secretion.
Zeitschrift (Journal):J Allergy Clin Immunol. 2021 Feb 17:S0091-6749(21)00224-4. :Seiten (Pages):
Aus der Charité: Graeber SY, Mall MA.Autoren:Agostini F et al.
Titel:Multiomics Analysis Provides Insight into the Laboratory Evolution of Escherichia coli toward the Metabolic Usage of Fluorinated Indoles.
Zeitschrift (Journal):ACS Cent Sci. 2021 Jan 27;7(1):81-92. :Seiten (Pages):
Aus der Charité: Agostini F.Autoren:Mencacci NE et al.
Titel:Bi-allelic variants in TSPOAP1, encoding the active zone protein RIMBP1, cause autosomal recessive dystonia.
Zeitschrift (Journal):J Clin Invest. 2021 Feb 4:140625. :Seiten (Pages):
Aus der Charité: Brockmann MM, Rosenmund C.Autoren:Dong P et al.
Titel:A Dual Fluorescence-Spin Label Probe for Visualization and Quantification of Target Molecules in Tissue by Multiplexed FLIM - EPR Spectroscopy.
Zeitschrift (Journal):Angew Chem Int Ed Engl. 2021 Feb 5. doi: 10.1002/anie.202012852. :Seiten (Pages):
Aus der Charité: Dong P, Lohan SB, Patzelt A, Meinke MC.Autoren:Iftekhar A et al.
Titel:Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.
Zeitschrift (Journal):Nat Commun. 2021 Feb 12;12(1):1003. :Seiten (Pages):
Aus der Charité: Berger H, Heuberger J, Sigal M.Autoren:Niehus S et al.
Titel:PopDel identifies medium-size deletions simultaneously in tens of thousands of genomes.
Zeitschrift (Journal):Nat Commun. 2021 Feb 1;12(1):730. :Seiten (Pages):
Aus der Charité: Niehus S, Sulem P, Kehr B.
Januar 2021
Autoren:Lotta LA et al.
Titel:A cross-platform approach identifies genetic regulators of human metabolism and health.
Zeitschrift (Journal):Nat Genet. 2021 Jan;53(1):54-64. :Seiten (Pages):
Aus der Charité: Langenberg C.Autoren:Vollmer T et al.
Titel:The intratumoral CXCR3 chemokine system is predictive of chemotherapy response in human bladder cancer.
Zeitschrift (Journal):Sci Transl Med. 2021 Jan 13;13(576):eabb3735. :Seiten (Pages):
Aus der Charité: Vollmer T, Schlickeiser S, Amini L, Schulenberg S, Wendering DJ, Jurisch A, Noster R, Kunkel D, Brindle NR, Savidis I, Akyüz L, Roch T, Babel N, Reinke P, Volk HD, Schmueck-Henneresse M.Autoren:Westhovens R et al.
Titel:Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial.
Zeitschrift (Journal):Ann Rheum Dis. 2021 Jan 15:annrheumdis-2020-219213. :Seiten (Pages):
Aus der Charité: Burmester GR .Autoren:Deshpande D et al.
Titel:Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.
Zeitschrift (Journal):Nat Commun. 2021 Jan 18;12(1):426. :Seiten (Pages):
Aus der Charité: Deshpande D, Klose CSN.Autoren:Rodríguez de Los Santos M et al.
Titel:A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions.
Zeitschrift (Journal):Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2014481118. :Seiten (Pages):
Aus der Charité: Rodríguez de Los Santos M, Rivalan M, Stumpf A, Velasquez LM, Voigt A, Long M, Vogt G, Fischer-Zirnsak B, Horn D, Mundlos S, Kornak U, Schmitz D, Winter Y.Autoren:Horn D et al.
Titel:Biallelic truncating variants in MAPKAPK5 cause a new developmental disorder involving neurological, cardiac, and facial anomalies combined with synpolydactyly.
Zeitschrift (Journal):Genet Med. 2021 Jan 13. doi: 10.1038/s41436-020-01052-2. :Seiten (Pages):
Aus der Charité: Horn D, Schwartzmann S, Ehmke N, Boschann F.Autoren:Cheret C et al.
Titel:Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels.
Zeitschrift (Journal):Cell Rep. 2021 Jan 12;34(2):108623. :Seiten (Pages):
Aus der Charité: Cheret C, Ahnert-Hilger G.Autoren:Lipp T et al.
Titel:Heterogeneity of Pollen Food Allergy Syndrome in Seven Southern European Countries: the @IT.2020 Multicenter Study.
Zeitschrift (Journal):Allergy. 2021 Jan 25. doi: 10.1111/all.14742. :Seiten (Pages):
Aus der Charité: Lipp T, Hoffmann TM, Potapova E, Matricardi PM, Dramburg S.Autoren:Simsek C et al.
Titel:At Least Seven Distinct Rotavirus Genotype Constellations in Bats with Evidence of Reassortment and Zoonotic Transmissions.
Zeitschrift (Journal):mBio. 2021 Jan 19;12(1):e02755-20. :Seiten (Pages):
Aus der Charité: Corman VM, Rasche A, Drosten C, Drexler JF, Matthijnssens J.Autoren:Wolk K et al.
Titel:Activity and components of the G-CSF pathway in hidradenitis suppurativa.
Zeitschrift (Journal):Br J Dermatol. 2021 Jan 5. doi: 10.1111/bjd.19795. :Seiten (Pages):
Aus der Charité: Wolk K, Brembach TC, Cucinotta S, Pokrywka A, Irmer ML, Triebus J, Witte-Händel E, Volk HD, Ghoreschi K, Sabat R.
Publikationen 2020
Dezember 2020
Autoren:Veenvliet JV et al.
Titel:Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites.
Zeitschrift (Journal):Science. 2020 Dec 11;370(6522):eaba4937. :Seiten (Pages):
Aus der Charité: Herrmann BG.Autoren:Trump S et al.
Titel:Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.
Zeitschrift (Journal):Nat Biotechnol. 2020 Dec 24. doi: 10.1038/s41587-020-00796-1. :Seiten (Pages):
Aus der Charité: Trump S, Lukassen S, Anker MS, Chua RL, Liebig J, Thürmann L, Corman VM, Loske J, Krieger T, Hennig BP, Messingschlager M, Pott F, Kazmierski J, Twardziok S, Albrecht JP, Eils J, Hadzibegovic S, Lena A, Heidecker B, Bürgel T, Steinfeldt J, Goffinet C, Kurth F, Witzenrath M, Ishaque N, Sander LE, Drosten C, Eils R, Conrad C, Landmesser U, Lehmann I.Autoren:Abraham WT et al.
Titel:Effect of empagliflozin on exercise ability and symptoms in heart failure patients with reduced and preserved ejection fraction, with and without type 2 diabetes.
Zeitschrift (Journal):Eur Heart J. 2020 Dec 22:ehaa943. :Seiten (Pages):
Aus der Charité: Anker SD.Autoren:Meinhardt J et al.
Titel:Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.
Zeitschrift (Journal):Nat Neurosci. 2020 Nov 30. doi: 10.1038/s41593-020-00758-5. :Seiten (Pages):
Aus der Charité: Meinhardt J, Radke J, Dittmayer C, Mothes R, Schneider J, Brünink S, Greuel S, Lehmann M, Hassan O, Aschman T, Schumann E, Chua RL, Conrad C, Eils R, Stenzel W, Windgassen M, Rößler L, Goebel HH, Martin H, Scheibe F, Körtvélyessy P, Siegmund B, Kühl AA, Elezkurtaj S, Horst D, Oesterhelweg L, Tsokos M, Drosten C, Corman VM, Radbruch H, Heppner FL.Autoren:Kraushar ML et al.
Titel:Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit.
Zeitschrift (Journal):Mol Cell. 2020 Dec 17:S1097-2765(20)30837-6. :Seiten (Pages):
Aus der Charité: Kraushar ML, Krupp F, Turko P, Ambrozkiewicz MC, Sprink T, Schaub T, Münster-Wandowski A, Bürger J, Yamamoto H, Tarabykin V, Vida I, Spahn CMT.Autoren:Piepoli MF et al.
Titel:OUTSTEP-HF: randomised controlled trial comparing short-term effects of sacubitril/valsartan versus enalapril on daily physical activity in patients with chronic heart failure with reduced ejection fraction.
Zeitschrift (Journal):Eur J Heart Fail. 2020 Dec 13. doi: 10.1002/ejhf.2076. :Seiten (Pages):
Aus der Charité: Edelmann F.Autoren:Anker SD et al.
Titel:Baseline Characteristics of Patients with Heart Failure with Preserved Ejection Fraction in the EMPEROR-Preserved Trial.
Zeitschrift (Journal):Eur J Heart Fail. 2020 Nov 29. doi: 10.1002/ejhf.2064. :Seiten (Pages):
Aus der Charité: Anker SD.Autoren:Grinat J et al.
Titel:The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.
Zeitschrift (Journal):Nat Commun. 2020 Dec 21;11(1):6422. :Seiten (Pages):
Aus der Charité: Heuberger J.Autoren:Pietzner M et al.
Titel:Genetic architecture of host proteins involved in SARS-CoV-2 infection.
Zeitschrift (Journal):Nat Commun. 2020 Dec 16;11(1):6397. :Seiten (Pages):
Aus der Charité: Ralser M, Langenberg C.Autoren:Loyal L et al.
Titel:SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8+ T cells.
Zeitschrift (Journal):Nat Commun. 2020 Dec 11;11(1):6357. :Seiten (Pages):
Aus der Charité: Loyal L, Warth S, Jürchott K, Nikolaou C, Nienen M, Durlanik S, Kruse B, Frentsch M, Sabat R, Wolk K, Thiel A.
November 2020
Autoren:Clément K et al.
Titel:Setmelanotide POMC and LEPR Phase 3 Trial Investigators. Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials.
Zeitschrift (Journal):Lancet Diabetes Endocrinol. 2020 Dec;8(12):960-970. :Seiten (Pages):
Aus der Charité: Puder L, Kühnen P.Autoren:Anker SD et al.
Titel:EMPEROR-Reduced Trial Committees and Investigators. Effect of Empagliflozin on Cardiovascular and Renal Outcomes in Patients With Heart Failure by Baseline Diabetes Status - Results from the EMPEROR-Reduced Trial.
Zeitschrift (Journal):Circulation. 2020 Nov 11. doi: 10.1161/CIRCULATIONAHA.120.051824. :Seiten (Pages):
Aus der Charité: Anker SD.Autoren:Guendel F et al.
Titel:Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues.
Zeitschrift (Journal):Immunity. 2020 Nov 17;53(5):1015-1032.e8. :Seiten (Pages):
Aus der Charité: Guendel F, Kofoed-Branzk M, Gronke K, Tizian C, Witkowski M, Brachs S, Mashreghi MF, Diefenbach A.Autoren:Tosti L et al.
Titel:Single nucleus and in situ RNA sequencing reveals cell topographies in the human pancreas.
Zeitschrift (Journal):Gastroenterology. 2020 Nov 16:S0016-5085(20)35399-3. :Seiten (Pages):
Aus der Charité: Tosti L, Debnath O, Tiesmeyer S, Trefzer T, Ten FW, Lukassen S, Kühl AA, Spieckermann S, Ishaque N, Eils R, Conrad C.Autoren:McVey MJ et al.
Titel:Platelet Extracellular Vesicles mediate Transfusion-related Acute Lung Injury by imbalancing the Sphingolipid Rheostat.
Zeitschrift (Journal):Blood. 2020 Nov 24:blood.2020005985. :Seiten (Pages):
Aus der Charité: Weidenfeld S, Tabuchi A, Simmons S, Kuebler W.Autoren:Reimann M et al.
Titel:Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas.
Zeitschrift (Journal):Blood. 2020 Nov 24:blood.2020005244. :Seiten (Pages):
Aus der Charité: Reimann M, Schrezenmeier JF, Richter-Pechanska P, Dolnik A, Hick TP, Schleich K, Cai X, Fan DNY, Masswig S, Denker S, Busse A, Gätjens-Sanchez AM, Bullinger L.Autoren:Dejaco C et al.
Titel:Influence of COVID-19 pandemic on decisions for the management of people with inflammatory rheumatic and musculoskeletal diseases: a survey among EULAR countries.
Zeitschrift (Journal):Ann Rheum Dis. 2020 Nov 6:annrheumdis-2020-218697. :Seiten (Pages):
Aus der Charité: Buttgereit F.Autoren:Holstein J et al.
Titel:Immunophenotyping in pemphigus reveals a Th17/Tfh17-dominated immune response promoting desmoglein1/3-specific autoantibody production.
Zeitschrift (Journal):J Allergy Clin Immunol. 2020 Nov 19:S0091-6749(20)31624-9. :Seiten (Pages):
Aus der Charité: Solimani F, Meier K, Ghoreschi K.Autoren:Anker MS et al.
Titel:Ventricular tachycardia, premature ventricular contractions, and mortality in unselected patients with lung, colon, or pancreatic cancer: a prospective study.
Zeitschrift (Journal):Eur J Heart Fail. 2020 Nov 22. doi: 10.1002/ejhf.2059. :Seiten (Pages):
Aus der Charité: Anker MS, Riess H, Eucker J, Haverkamp W, Landmesser U, Anker SD.Autoren:Lebenheim L et al.
Titel:A novel giant non-cholinergic striatal interneuron restricted to the ventrolateral striatum coexpresses Kv3.3 potassium channel, parvalbumin, and the vesicular GABA transporter.
Zeitschrift (Journal):Mol Psychiatry. 2020 Nov 14. doi: 10.1038/s41380-020-00948-4. :Seiten (Pages):
Aus der Charité: Lebenheim L, Booker SA, Derst C, Weiss T, Wagner F, Gruber C, Vida I, Veh RW.
Oktober 2020
Autoren:M Real F et al.
Titel:The mole genome reveals regulatory rearrangements associated with adaptive intersexuality.
Zeitschrift (Journal):Science. 2020 Oct 9;370(6513):208-214. :Seiten (Pages):
Aus der Charité: M Real F, Schöpflin R, Schindler M, Mundlos S, Lupiáñez DG.Autoren:Kreye J et al.
Titel:A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model.
Zeitschrift (Journal):Cell. 2020 Sep 23:S0092-8674(20)31246-0. :Seiten (Pages):
Aus der Charité: Kreye J, Reincke SM, Kornau HC, Sánchez-Sendin E, Corman VM, Höltje M, Stöffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Müller MA, Drosten C, Wendisch D, Sander LE, Prüss H.Autoren:Roemhild A et al.
Titel:Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial.
Zeitschrift (Journal):BMJ. 2020 Oct 21;371:m3734. :Seiten (Pages):
Aus der Charité: Roemhild A, Otto NM, Moll G, Abou-El-Enein M, Kaiser D, Bold G, Schachtner T, Choi M, Oellinger R, Landwehr-Kenzel S, Juerchott K, Sawitzki B, Giesler C, Sefrin A, Beier C, Wagner DL, Schlickeiser S, Streitz M, Schmueck-Henneresse M, Amini L, Babel N, Volk HD, Reinke P.Autoren:Leistner DM et al.
Titel:Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study.
Zeitschrift (Journal):Eur Heart J. 2020 Oct 1;41(37):3549-3560. :Seiten (Pages):
Aus der Charité: Leistner DM, Kränkel N, Meteva D, Abdelwahed YS, Seppelt C, Stähli BE, Skurk C, Lauten A, Mochmann HC, Fröhlich G, Rauch-Kröhnert U, Flores E, Riedel M, Sieronski L, Kia S, Strässler E, Haghikia A, Dirks F, Steiner JK, Mueller DN, Volk HD, Klotsche J, Landmesser U.Autoren:Fujikura K et al.
Titel:Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions.
Zeitschrift (Journal):Gut. 2020 Oct 7:gutjnl-2020-321217. :Seiten (Pages):
Aus der Charité: Felsenstein M.Autoren:Schoon J et al.
Titel:Metal-Specific Biomaterial Accumulation in Human Peri-Implant Bone and Bone Marrow.
Zeitschrift (Journal):Adv Sci (Weinh). 2020 Aug 3;7(20):2000412. :Seiten (Pages):
Aus der Charité: Schoon J, Rakow A, Ort MJ, Jacobi D, Reinke S, Perka C, Duda GN, Geissler S.Autoren:Cohen SB et al.
Titel:Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme.
Zeitschrift (Journal):Ann Rheum Dis. 2020 Oct 28:annrheumdis-2020-218510. :Seiten (Pages):
Aus der Charité: Burmester GR.Autoren:Zuraw B et al.
Titel:Oral once-daily berotralstat for the prevention of hereditary angioedema attacks: a randomized, double-blind, placebo-controlled phase 3 trial.
Zeitschrift (Journal):J Allergy Clin Immunol. 2020 Oct 21:S0091-6749(20)31484-6. :Seiten (Pages):
Aus der Charité: Maurer M.Autoren:Koehler J et al.
Titel:Telemonitoring in patients with chronic heart failure and moderate depressed symptoms: results of the Telemedical Interventional Monitoring in Heart Failure (TIM-HF) study.
Zeitschrift (Journal):Eur J Heart Fail. 2020 Oct 15. doi: 10.1002/ejhf.2025. :Seiten (Pages):
Aus der Charité: Koehler J, Stengel A, Hofmann T, Koehler K, Rose M, Deckwart O, Anker SD, Koehler F.Autoren:Ballhausen A et al.
Titel:Phase I study of everolimus, letrozole, and trastuzumab in patients with hormone receptor-positive metastatic breast cancer or other solid tumors.
Zeitschrift (Journal):Clin Cancer Res. 2020 Oct 28:clincanres.2878.2020. :Seiten (Pages):
Aus der Charité: Ballhausen A.
September 2020
Autoren:Ostendorf L et al.
Titel:Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus.
Zeitschrift (Journal):N Engl J Med. 2020 Sep 17;383(12):1149-1155. :Seiten (Pages):
Aus der Charité: Ostendorf L, Burns M, Durek P, Heinz GA, Heinrich F, Garantziotis P, Enghard P, Richter U, Biesen R, Schneider U, Knebel F, Burmester G, Radbruch A, Mei HE, Mashreghi MF, Hiepe F, Alexander T.Autoren:Schweizer L et al.
Titel:Molecular characterization of CNS paragangliomas identifies cauda equina paragangliomas as a distinct tumor entity.
Zeitschrift (Journal):Acta Neuropathol. 2020 Sep 14. doi: 10.1007/s00401-020-02218-7. :Seiten (Pages):
Aus der Charité: Schweizer L, Thierfelder F, Wessels L, Misch M, Kim HY, Jödicke R, Teichmann D, Kaul D, Kahn J, Bockmayr M, Vajkoczy P, Heppner FL, Capper D, Schöler A, Koch A.Autoren:Verner G et al.
Titel:Maternal Psychological Resilience During Pregnancy and Newborn Telomere Length: A Prospective Study.
Zeitschrift (Journal):Am J Psychiatry. 2020 Sep 11:appiajp202019101003. :Seiten (Pages):
Aus der Charité: Verner G, Buss C, Entringer S.Autoren:Bogdanow B et al.
Titel:Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.
Zeitschrift (Journal):Nat Commun. 2020 Sep 24;11(1):4845. :Seiten (Pages):
Aus der Charité: Schmidt M, Weisbach H, Gruska I, Vetter B, Selbach M, Hagemeier C, Wiebusch L.Autoren:Amini L et al.
Titel:CRISPR-Cas9-Edited Tacrolimus-Resistant Antiviral T Cells for Advanced Adoptive Immunotherapy in Transplant Recipients.
Zeitschrift (Journal):Mol Ther. 2020 Sep 8:S1525-0016(20)30468-8. :Seiten (Pages):
Aus der Charité: Amini L, Wagner DL, Rössler U, Zarrinrad G, Wagner LF, Vollmer T, Wendering DJ, Kornak U, Volk HD, Reinke P, Schmueck-Henneresse M.Autoren:Klotz-Noack K et al.
Titel:SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells.
Zeitschrift (Journal):Cell Rep. 2020 Sep 22;32(12):108184. :Seiten (Pages):
Aus der Charité:Klotz-Noack K, Klinger B, Bublitz N, Uhlitz F, Riemer P, Lüthen M, Sell T, Kasack K, Gastl B, Ispasanie SSS, Simon T, Horst D, Blüthgen N, Schäfer R, Morkel M, Sers C.Autoren:Wang Y et al.
Titel:Selenium deficiency is linearly associated with hypoglycemia in healthy adults.
Zeitschrift (Journal):Redox Biol. 2020 Sep 1;37:101709. :Seiten (Pages):
Aus der Charité: Rijntjes E, Schomburg L.Autoren:Knaak C et al.
Titel:Treatment and Mortality of Hemophagocytic Lymphohistiocytosis in Adult Critically Ill Patients: A Systematic Review With Pooled Analysis.
Zeitschrift (Journal):Crit Care Med. 2020 Nov;48(11):e1137-e1146. :Seiten (Pages):
Aus der Charité: Knaak C, Schuster FS, Nyvlt P, Spies C, Keh D, Lachmann G.Autoren:Puthucheary ZA et al.
Titel:Implications for post critical illness trial design: sub-phenotyping trajectories of functional recovery among sepsis survivors.
Zeitschrift (Journal):Crit Care. 2020 Sep 25;24(1):577. :Seiten (Pages):
Aus der Charité: Heintze C, Neumann K, Wollersheim T, Schmidt KFR.Autoren:Scholz J et al.
Titel:Vitamin A controls the allergic response through T follicular helper cell as well as plasmablast differentiation.
Zeitschrift (Journal):Allergy. 2020 Sep 7. doi: 10.1111/all.14581. :Seiten (Pages):
Aus der Charité: Scholz J, Worm M, Heine G.
August 2020
Autoren:Sadik A et al.
Titel:IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.
Zeitschrift (Journal):Cell. 2020 Sep 3;182(5):1252-1270.e34. :Seiten (Pages):
Aus der Charité: Ishaque N, Trump S.Autoren:Schulte-Schrepping J et al.
Titel:Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Zeitschrift (Journal):Cell. 2020 Aug 5:S0092-8674(20)30992-2. :Seiten (Pages):
Aus der Charité: Paclik D, Schlickeiser S, Brumhard S, Wendisch D, Conrad C, Kunkel D, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Meisel C, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Sawitzki B, Sander LE.Autoren:Grünwald V et al.
Titel:Randomized Comparison of Pazopanib and Doxorubicin as First-Line Treatment in Patients With Metastatic Soft Tissue Sarcoma Age 60 Years or Older: Results of a German Intergroup Study.
Zeitschrift (Journal):J Clin Oncol. 2020 Aug 24:JCO2000714. :Seiten (Pages):
Aus der Charité: Kunitz A.Autoren:Kresoja KP et al.
Titel:Transcatheter tricuspid valve repair in the setting of heart failure with preserved or reduced left ventricular ejection fraction.
Zeitschrift (Journal):Eur J Heart Fail. 2020 Aug 2. doi: 10.1002/ejhf.1975. :Seiten (Pages):
Aus der Charité: Lauten A, Alushi B, Stangl K, Landmesser U.Autoren:Correll CU et al.
Titel:Effects of Olanzapine Combined With Samidorphan on Weight Gain in Schizophrenia: A 24-Week Phase 3 Study.
Zeitschrift (Journal):Am J Psychiatry. 2020 Aug 14:appiajp202019121279. :Seiten (Pages):
Aus der Charité: Correll CU.Autoren:Sattler A et al.
Titel:SARS-CoV-2 specific T-cell responses and correlations with COVID-19 patient predisposition.
Zeitschrift (Journal):J Clin Invest. 2020 Aug 24:140965. :Seiten (Pages):
Aus der Charité: Sattler A, Angermair S, Stockmann H, Heim KM, Khadzhynov D, Treskatsch S, Halleck F, Kreis ME, Kotsch K.Autoren:Erfinanda L et al.
Titel:Estrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation.
Zeitschrift (Journal):Eur Respir J. 2020 Aug 6:2000921. :Seiten (Pages):
Aus der Charité: Erfinanda L, Kohse F, Gallo K, Preissner R, Kuebler WM.Autoren:von Haehling S et al.
Titel:Muscle wasting as an independent predictor of survival in patients with chronic heart failure.
Zeitschrift (Journal):J Cachexia Sarcopenia Muscle. 2020 Aug 6. doi: 10.1002/jcsm.12603. :Seiten (Pages):
Aus der Charité: Anker MS, Doehner W, Anker SD.Autoren:Daneshgar A et al.
Titel:The human liver matrisome - Proteomic analysis of native and fibrotic human liver extracellular matrices for organ engineering approaches.
Zeitschrift (Journal):Biomaterials. 2020 Oct;257:120247. :Seiten (Pages):
Aus der Charité: Daneshgar A, Tang P, Arnold A, Pohl J, Moosburner S, Raschzok N, Bahra M, Pratschke J, Sauer IM, Hillebrandt KH.Autoren:Krenzien F et al.
Titel:The ILLS Laparoscopic Liver Surgery Fellow Skills Curriculum.
Zeitschrift (Journal):Ann Surg. 2020 Aug 21. doi: 10.1097/SLA.0000000000004175. :Seiten (Pages):
Aus der Charité: Krenzien F, Schöning W, Brunnbauer P, Benzing C, Öllinger R, Biebl M, Bahra M, Raschzok N, Schmelzle M, Pratschke J.
Juli 2020
Autoren:Burmester GR et al.
Titel:Continuing versus tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA): a double-blind, multicentre, randomised controlled trial.
Zeitschrift (Journal):Lancet. 2020 Jul 25;396(10246):267-276. :Seiten (Pages):
Aus der Charité: Burmester GR, Buttgereit F.Autoren:Braun J et al.
Titel:SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19.
Zeitschrift (Journal):Nature. 2020 Jul 29. doi: 10.1038/s41586-020-2598-9. :Seiten (Pages):
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Titel:Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age.
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Titel:Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease.
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Titel:TWIST1 Drives Smooth Muscle Cell Proliferation in Pulmonary Hypertension via Loss of GATA-6 and BMPR2.
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Titel:Comparison of Organoid Swelling and in vivo Biomarkers of CFTR Function to Determine Effects of Lumacaftor-ivacaftor in Patients with Cystic Fibrosis Homozygous for the F508del Mutation.
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Titel:Dynamic conjugate F-SHARP microscopy.
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Juni 2020
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Titel:Association of Migraine With Aura and Other Risk Factors With Incident Cardiovascular Disease in Women.
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Titel:Phosphodiesterase 3A and Arterial Hypertension.
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Titel:Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production.
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Titel:Phenotype and risk factors of venom-induced anaphylaxis: a case-control study of the European Anaphylaxis Registry.
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Titel:Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4+ T lymphocytes.
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Titel:Clozapine modulates retinoid homeostasis in human brain and normalizes serum retinoic acid deficit in patients with schizophrenia.
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Titel:Epilepsy-causing STX1B mutations translate altered protein functions into distinct phenotypes in mouse neurons.
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Titel:GFR in Healthy Aging: an Individual Participant Data Meta-Analysis of Iohexol Clearance in European Population-Based Cohorts.
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Titel:Neutrophil Gelatinase-Associated Lipocalin Protects from ANCA-Induced GN by Inhibiting TH17 Immunity.
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Mai 2020
Autoren:Sawitzki B et al.
Titel:Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.
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Titel:Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells.
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Titel:Safety of 80 antidepressants, antipsychotics, anti-attention-deficit/hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta-review of 78 adverse effects.
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Titel:Use of all cause mortality to quantify the consequences of covid-19 in Nembro, Lombardy: descriptive study.
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Titel:Investigation of a COVID-19 outbreak in Germany resulting from a single travel-associated primary case: a case series.
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Titel:Obesity and weight loss are inversely related to mortality and cardiovascular outcome in prediabetes and type 2 diabetes: data from the ORIGIN trial.
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Titel:Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages.
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Titel:Canakinumab for Treatment of Adult-Onset Still's Disease to Achieve Reduction of Arthritic Manifestation (CONSIDER): phase II, randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial.
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Titel:PGE₂ deficiency predisposes to anaphylaxis by causing mast cell hyper-responsiveness.
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Titel:Rationale and Study Design of OUTSTEP-HF: A Randomized Controlled Study to Assess the Effect of Sacubitril/Valsartan and Enalapril on Physical Activity measured by Accelerometry in Patients with Heart Failure with Reduced Ejection Fraction.
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Aus der Charité: Edelmann F.
April 2020
Autoren:Wölfel R et al.
Titel:Virological assessment of hospitalized patients with COVID-2019.
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Titel:A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection.
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Titel:Functional consequences of metabolic zonation in murine livers: New insights for an old story.
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Titel:Minimal clinically important difference in quality of life scores for patients with heart failure and reduced ejection fraction.
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Titel:RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.
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Titel:The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.
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Titel:Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.
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Titel:Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway.
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Titel:Performance of immune-based and microbiological tests in children with TB meningitis in Europe - a multi-center Paediatric Tuberculosis Network European Trials Group (ptbnet) study.
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Titel:SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.
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März 2020
Autoren:Bockstahler M et al.
Titel:Heart-Specific Immune Responses in an Animal Model of AutoimmuneRelated Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation.
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Titel:Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity.
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Titel:Complement deposition at the neuromuscular junction in seronegative myasthenia gravis.
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Titel:Association of Magnetoencephalographically Measured High-Frequency Oscillations in Visual Cortex With Circuit Dysfunctions in Local and Large-scale Networks During Emerging Psychosis.
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Titel:Adult Tissue Extracellular Matrix Determines Tissue Specification of Human iPSC-Derived Embryonic Stage Mesodermal Precursor Cells.
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Titel:Evaluation of high-sensitivity C-reactive protein and uric acid in vericiguat-treated patients with heart failure with reduced ejection fraction.
Zeitschrift (Journal):Eur J Heart Fail. 2020 Mar 25. doi: 10.1002/ejhf.1787. :Seiten (Pages):
Aus der Charité: Pieske B.Autoren:Anker MS et al.
Titel:Increased resting heart rate and prognosis in treatment-naïve unselected cancer patients: results from a prospective observational study.
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Titel:Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming.
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Titel:New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.
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Titel:SuperCYPsPred-a web server for the prediction of cytochrome activity.
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Februar 2020
Autoren:Maechler F et al.
Titel:Contact isolation versus standard precautions to decrease acquisition of extended-spectrum β-lactamase-producing Enterobacterales in non-critical care wards: a cluster-randomised crossover trial.
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Titel:SUMO pathway inhibition targets an aggressive pancreatic cancer subtype.
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Titel:MT-102 prevents tissue wasting and improves survival in a rat model of severe cancer cachexia.
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Titel:Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice.
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Titel:Plasma carotenoids, tocopherols and retinol - Association with age in the Berlin Aging Study II.
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Titel:Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network.
Zeitschrift (Journal):Elife. 2020 Feb 19;9:e51156. :Seiten (Pages):
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Titel:c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells.
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Aus der Charité: Tizian C, Hölsken O, Cosovanu C, Kofoed-Branzk M, Diefenbach A, Neumann C.Autoren:Hotter B et al.
Titel:Inflammatory and stress markers predicting pneumonia, outcome, and etiology in patients with stroke: Biomarkers for predicting pneumonia, functional outcome, and death after stroke.
Zeitschrift (Journal):Neurol Neuroimmunol Neuroinflamm. 2020 Feb 25;7(3):e692. :Seiten (Pages):
Aus der Charité: Hotter B, Hoffmann S, Ulm L, Meisel C, Meisel A.Autoren:Weilnhammer V et al.
Titel:Psychotic Experiences in Schizophrenia and Sensitivity to Sensory Evidence.
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Titel:Orally applied bacterial lysate in infants at risk for atopy does not prevent atopic dermatitis, allergic rhinitis, asthma or allergic sensitization at school age: follow-up of a randomized trial.
Zeitschrift (Journal):Allergy. 2020 Feb 22. doi: 10.1111/all.14247. :Seiten (Pages):
Aus der Charité: Roßberg S, Keller T, Icke K, Keil T, Lau S.
Januar 2020
Autoren:Gidon A et al.
Titel:Dendritic action potentials and computation in human layer 2/3 cortical neurons.
Zeitschrift (Journal):Science. 2020 Jan 3;367(6473):83-87. :Seiten (Pages):
Aus der Charité: Fidzinski P, Bolduan F, Holtkamp M, Vida I, Larkum ME.Autoren:Correll CU et al.
Titel:Metformin add-on vs. antipsychotic switch vs. continued antipsychotic treatment plus healthy lifestyle education in overweight or obese youth with severe mental illness: results from the IMPACT trial.
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Aus der Charité: Correll CU, Kapoor S.Autoren:Barz MJ et al.
Titel:Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia.
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Aus der Charité: Barz MJ, Hof J, Groeneveld-Krentz S, Astrahantseff K, von Stackelberg A.Autoren:Correll CU et al.
Titel:Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial.
Zeitschrift (Journal):Blood. 2020 Jan 22. doi: 10.1182/blood.2019002499. :Seiten (Pages):
Aus der Charité: Correll CU.Autoren:Ratziu V et al.
Titel:Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study.
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Aus der Charité: Tacke F.Autoren:Schürmann D et al.
Titel:Safety, pharmacokinetics, and antiretroviral activity of islatravir (ISL, MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor, following single-dose administration to treatment-naive adults infected with HIV-1: an open-label, phase 1b, consecutive-panel trial.
Zeitschrift (Journal):Lancet HIV. 2020;S2352-3018(19)30372-8. :Seiten (Pages):
Aus der Charité: Schürmann D, Keicher C, Huser A, Hofmann J.Autoren:Bartels F et al.
Titel:Neuronal autoantibodies associated with cognitive impairment in melanoma patients.
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Aus der Charité: Bartels F, Stronisch T, Farmer K, Kiecker F, Finke C.Autoren:Stintzing S et al.
Titel:Consensus molecular subgroups (CMS) of colorectal cancer (CRC) and first-line efficacy of FOLFIRI plus cetuximab or bevacizumab in the FIRE3 (AIO KRK-0306) trial.
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Aus der Charité: Stintzing S.Autoren:Petutschnigg J et al.
Titel:Body fat phenotypes and treatment response to spironolactone in ambulatory patients with heart failure and preserved ejection fraction: a post-hoc analysis of the Aldo-DHF trial.
Zeitschrift (Journal):Eur J Heart Fail. 2020 Jan 7:10.1002/ejhf.1723. :Seiten (Pages):
Aus der Charité: Petutschnigg J, Trippel TD, Hashemi D, Pieske B, Edelmann F.Autoren:Scheffel J et al.
Titel:Cold-induced urticarial autoinflammatory syndrome related to factor XII activation.
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Aus der Charité: Scheffel J, Mahnke NA, Wu J, Bonnekoh H, Church MK, Maurer M, Krause K.
Publikationen 2019
Dezember 2019
Autoren:Stahn AC et al.
Titel:Brain Changes in Response to Long Antarctic Expeditions.
Zeitschrift (Journal):N Engl J Med. 2019 Dec 5;381(23):2273-2275. :Seiten (Pages):
Aus der Charité: Stahn AC, Gunga HC.Autoren:Deodhar A et al.
Titel:Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial.
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Aus der Charité: Poddubnyy D, Sieper J.Autoren:Koche RP et al.
Titel:Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.
Zeitschrift (Journal):Nat Genet. 2019 Dec 16;10.1038/s41588-019-0547-z. :Seiten (Pages):
Aus der Charité: Helmsauer K, MacArthur IC, Chamorro R, Munoz-Perez N, Dorado Garcia H, Bei Y, Röefzaad C, Bardinet V, Szymansky A, Winkler A, Thole T, Timme N, Fuchs S, Klironomos F, Schmelz K, Künkele A, Hundsdörfer P, Deubzer H, Toedling J, Hertwig F, Eggert A, Schulte JH, Henssen AG.Autoren:Solmi M et al.
Titel:Disparities in cancer screening in people with mental illness across the world versus the general population: prevalence and comparative meta-analysis including 4,717,839 people.
Zeitschrift (Journal):Lancet Psychiatry. 2020 Jan;7(1):52-63. :Seiten (Pages):
Aus der Charité: Correll CU.Autoren:Stintzing S et al.
Titel:Consensus molecular subgroups (CMS) of colorectal cancer (CRC) and first-line efficacy of FOLFIRI plus cetuximab or bevacizumab in the FIRE3 (AIO KRK-0306) trial.
Zeitschrift (Journal):Ann Oncol. 2019 Nov 1;30(11):1796-1803. :Seiten (Pages):
Aus der Charité: Stintzing S.Autoren:Möckel M et al.
Titel:Improve Management of acute heart failure with ProcAlCiTonin in EUrope: results of the randomized clinical trial IMPACT EU Biomarkers in Cardiology (BIC) 18.
Zeitschrift (Journal):Eur J Heart Fail. 2019 Dec 12. doi: 10.1002/ejhf.1667. :Seiten (Pages):
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Titel:Baseline features of the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial.
Zeitschrift (Journal):Eur J Heart Fail. 2019 Dec;21(12):1596-1604. :Seiten (Pages):
Aus der Charité: Pieske B et al..Autoren:Marg A et al.
Titel:Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.
Zeitschrift (Journal):Nat Commun. 2019 Dec 18;10(1):5776. :Seiten (Pages):
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Titel:Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.
Zeitschrift (Journal):Nat Commun. 2019 Dec 10;10(1):5629. :Seiten (Pages):
Aus der Charité: Ziegler JF, Böttcher C, Letizia M, Yerinde C, Wu H, Freise I, Rodriguez-Sillke Y, Stoyanova AK, Kreis ME, Asbach P, Kunkel D, Priller J, Anagnostopoulos I, Kühl AA, Bojarski C, Glauben R, Siegmund B, Weidinger C.Autoren:Gusic M et al.
Titel:Bi-Allelic UQCRFS1 Variants Are Associated with Mitochondrial Complex III Deficiency, Cardiomyopathy, and Alopecia Totalis.
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November 2019
Autoren:Middleton PG et al.
Titel:Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele.
Zeitschrift (Journal):N Engl J Med. 2019 Nov 7;381(19):1809-1819. :Seiten (Pages):
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Titel:Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis (SELECT-AXIS 1): a multicentre, randomised, double-blind, placebo-controlled, phase 2/3 trial.
Zeitschrift (Journal):Lancet. 2019 Dec 7;394(10214):2108-2117. :Seiten (Pages):
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Titel:A support programme for secondary prevention in patients with transient ischaemic attack and minor stroke (INSPiRE-TMS): an open-label, randomised controlled trial.
Zeitschrift (Journal):Lancet Neurol. 2019 Nov 7. doi: 10.1016/S1474-4422(19)30369-2. :Seiten (Pages):
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Zeitschrift (Journal):Nat Methods. 2019 Nov 25. doi: 10.1038/s41592-019-0638-x. :Seiten (Pages):
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Titel:Mapping microglia states in the human brain through the integration of high-dimensional techniques.
Zeitschrift (Journal):Nat Neurosci. 2019 Dec;22(12):2098-2110. :Seiten (Pages):
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Titel:Long-term effects of Na+ /Ca2+ exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction.
Zeitschrift (Journal):Eur J Heart Fail. 2019 Nov 24. doi: 10.1002/ejhf.1619. :Seiten (Pages):
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Titel:Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation.
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Titel:Niche-mimicking interactions in peptide-functionalized 3D hydrogels amplify mesenchymal stromal cell paracrine effects.
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Titel:Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington's disease.
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Titel:The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches.
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Oktober 2019
Autoren:Maurer M et al.
Titel:Ligelizumab for Chronic Spontaneous Urticaria.
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Titel:Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.
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Titel:Improving Stratification for Children With Late Bone Marrow B-Cell Acute Lymphoblastic Leukemia Relapses With Refined Response Classification and Integration of Genetics.
Zeitschrift (Journal):J Clin Oncol. 2019 Oct 23:JCO1901694. doi: 10.1200/JCO.19.01694. :Seiten (Pages):
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Titel:Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages.
Zeitschrift (Journal):EMBO Mol Med. 2019 Nov 7;11(11):e10698. :Seiten (Pages):
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Titel:Reduction of Postoperative Wound Infections by Antiseptica (RECIPE)?: A Randomized Controlled Trial.
Zeitschrift (Journal):Ann Surg. 2019 Oct 9. doi: 10.1097/SLA.0000000000003645. :Seiten (Pages):
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Titel:Network-Specific Synchronization of Electrical Slow-Wave Oscillations Regulates Sleep Drive in Drosophila.
Zeitschrift (Journal):Curr Biol. 2019 Nov 4;29(21):3611-3621.e3. :Seiten (Pages):
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Titel:CMKLR1-targeting peptide tracers for PET/MR imaging of breast cancer.
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Titel:Decision-Analytic Modeling for Time-Effectiveness of the Sequence of Induction Treatments for Moderate to Severe Plaque Psoriasis.
Zeitschrift (Journal):JAMA Dermatol. 2019 Oct 16. doi: 10.1001/jamadermatol.2019.2941. :Seiten (Pages):
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Titel:Association of uric acid levels before start of conditioning with mortality after alloSCT: a prospective, non-interventional study of the EBMT Transplant Complication Working Party.
Zeitschrift (Journal):Haematologica. 2019 Oct 10. doi: 10.3324/haematol.2019.228668. :Seiten (Pages):
Aus der Charité: Penack O, Blau IW.Autoren:Arends CM et al.
Titel:Clonal hematopoiesis in patients with ANCA-associated vasculitis.
Zeitschrift (Journal):Haematologica. 2019 Oct 3. doi: 10.3324/haematol.2019.223305. :Seiten (Pages):
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September 2019
Autoren:Nave AH et al.
Titel:Physical Fitness Training in Patients with Subacute Stroke (PHYS-STROKE): multicentre, randomised controlled, endpoint blinded trial.
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Titel:How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).
Zeitschrift (Journal):Eur Heart J. 2019 Oct 21;40(40):3297-3317. :Seiten (Pages):
Aus der Charité: Pieske B, Tschöpe C, Anker SD, Edelmann F, Morris DA, Pieske-Kraigher E.Autoren:Wefers AK, et al.
Titel:Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.
Zeitschrift (Journal):Acta Neuropathol. 2019 Sep 28. doi: 10.1007/s00401-019-02078-w. :Seiten (Pages):
Aus der Charité: Capper D.Autoren:Jurmeister P et al.
Titel:Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases.
Zeitschrift (Journal):Sci Transl Med. 2019 Sep 11;11(509). :Seiten (Pages):
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Titel:Immunosuppression in inflammatory cardiomyopathy and parvovirus B19 persistence.
Zeitschrift (Journal):Eur J Heart Fail. 2019 Sep 2. doi: 10.1002/ejhf.1560. :Seiten (Pages):
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Titel:R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.
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Titel:Association of Cortical Glutamate and Working Memory Activation in Patients With Schizophrenia: A Multimodal Proton Magnetic Resonance Spectroscopy and Functional Magnetic Resonance Imaging Study. Biol Psychiatry. 2019 Jul 26. doi: 10.1016/j.biopsych.2019.07.011.
Zeitschrift (Journal):Biol Psychiatry. 2019 Jul 26. doi: 10.1016/j.biopsych.2019.07.011. :Seiten (Pages):
Aus der Charité: Kaminski J, Gleich T, Fukuda Y, Katthagen T, Heinz A, Schlagenhauf F.Autoren:Zimmermann C et al.
Titel:Mast cells are critical for controlling the bacterial burden and the healing of infected wounds.
Zeitschrift (Journal):Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20500-20504. :Seiten (Pages):
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Titel:Intrathecal IgM production is a strong risk factor for early conversion to multiple sclerosis.
Zeitschrift (Journal):Neurology. 2019 Oct 8;93(15):e1439-e1451. :Seiten (Pages):
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Titel:Tomoelastography distinguishes non-invasively between benign and malignant liver lesions.
Zeitschrift (Journal):Cancer Res. 2019 Sep 24. doi: 10.1158/0008-5472.CAN-19-2150. :Seiten (Pages):
Aus der Charité: Shahryari M, Tzschätzsch H, Guo J, Marticorena Garcia SR, Böning G, Fehrenbach U, Stencel L, Asbach P, Hamm B, Braun J, Sack I.
August 2019
Autoren:Olin-Sandoval V et al.
Titel:Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism.
Zeitschrift (Journal):Nature. 2019 Aug;572(7768):249-253. :Seiten (Pages):
Aus der Charité: Mülleder M, Ralser M.Autoren:Brandt L et al.
Titel:Risk of Psychosis Among Refugees: A Systematic Review and Meta-analysis.
Zeitschrift (Journal):JAMA Psychiatry. 2019 Aug 14. doi: 10.1001/jamapsychiatry.2019.1937. :Seiten (Pages):
Aus der Charité: Brandt L, Henssler J, Wall S, Gabel D, Heinz A.Autoren:Masuda T et al.
Titel:Association With Hospitalization and All-Cause Discontinuation Among Patients With Schizophrenia on Clozapine vs Other Oral Second-Generation Antipsychotics: A Systematic Review and Meta-analysis of Cohort Studies.
Zeitschrift (Journal):JAMA Psychiatry. 2019 Jul 31. doi: 10.1001/jamapsychiatry.2019.1702. :Seiten (Pages):
Aus der Charité: Correll CU.Autoren:Dölle-Bierke S et al.
Titel:Detection of KIT D816V mutation in patients with severe anaphylaxis and normal basal tryptase-first data from the Anaphylaxis Registry (NORA).
Zeitschrift (Journal):J Allergy Clin Immunol. 2019 Aug 12. doi: 10.1016/j.jaci.2019.07.037. :Seiten (Pages):
Aus der Charité: Dölle-Bierke S, Siebenhaar F, Burmeister T, Worm M.Autoren:Kuhlmann SL et al.
Titel:Prevalence, 12-Month Prognosis, and Clinical Management Need of Depression in Coronary Heart Disease Patients: A Prospective Cohort Study.
Zeitschrift (Journal):Psychother Psychosom. 2019 Aug 26:1-12. doi: 10.1159/000501502. :Seiten (Pages):
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Titel:Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators.
Zeitschrift (Journal):Nat Commun. 2019 Aug 14;10(1):3664. :Seiten (Pages):
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Titel:Deep brain stimulation induced normalization of the human functional connectome in Parkinson's disease.
Zeitschrift (Journal):Brain. 2019 Aug 14. doi: 10.1093/brain/awz239. :Seiten (Pages):
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Titel:Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor.
Zeitschrift (Journal):Brain. 2019 Aug 3. doi: 10.1093/brain/awz236. :Seiten (Pages):
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Titel:Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
Zeitschrift (Journal):J Cachexia Sarcopenia Muscle. 2019 Aug 23. doi: 10.1002/jcsm.12491. :Seiten (Pages):
Aus der Charité: Hahn A, Kny M, Pablo-Tortola C, Schmidt S, Nowak M, Weber-Carstens S, Luft FC, Fielitz J.Autoren:Rasche A et al.
Titel:Highly diversified shrew hepatitis B viruses corroborate ancient origins and divergent infection patterns of mammalian hepadnaviruses.
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Juli 2019
Autoren:Despang A et al.
Titel:Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture.
Zeitschrift (Journal):Nat Genet. 2019 Aug;51(8):1263-1271. :Seiten (Pages):
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Titel:The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis.
Zeitschrift (Journal):Nat Immunol. 2019 Aug;20(8):1012-1022. :Seiten (Pages):
Aus der Charité: Mattiola I.Autoren:Brandt R et al.
Titel:Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium.
Zeitschrift (Journal):Nat Commun. 2019 Jul 2;10(1):2919. :Seiten (Pages):
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Titel:Enzymatically-degradable alginate hydrogels promote cell spreading and in vivo tissue infiltration.
Zeitschrift (Journal):Biomaterials. 2019 Oct;217:119294. :Seiten (Pages):
Aus der Charité: Lueckgen A, Garske DS, Ellinghaus A, Duda GN, Cipitria A.Autoren:Fischer-Zirnsak B et al.
Titel:Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders.
Zeitschrift (Journal):Am J Hum Genet. 2019 Jul 19. doi: 10.1016/j.ajhg.2019.07.002 :Seiten (Pages):
Aus der Charité: Fischer-Zirnsak B, Segebrecht L, Schubach M, Hildebrand G, Horn D, Kornak U, Ehmke N.Autoren:Hotter B et al.
Titel:High-resolution diffusion-weighted imaging identifies ischemic lesions in a majority of transient ischemic attack patients.
Zeitschrift (Journal):Ann Neurol. 2019 Jul 12. doi: 10.1002/ana.25551. :Seiten (Pages):
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Titel:Immunologic Profiling of Mutational and Transcriptional Subgroups in Pediatric and Adult High-Grade Gliomas.
Zeitschrift (Journal):Cancer Immunol Res. 2019 Jul 2. doi: 10.1158/2326-6066.CIR-18-0939. :Seiten (Pages):
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Titel:US Time-Harmonic Elastography for the Early Detection of Glomerulonephritis.
Zeitschrift (Journal):Radiology. 2019 Jul 9:182574. :Seiten (Pages):
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Titel:Kidney Injury after Intravenous versus Intra-arterial Contrast Agent in Patients Suspected of Having Coronary Artery Disease: A Randomized Trial.
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Aus der Charité: Schönenberger E, Bosserdt M, Zimmermann E, Tauber R, Laule M, Dewey M.Autoren:Schumacher H et al.
Titel:IgA autoantibodies against native myelin basic protein in a patient with MS.
Zeitschrift (Journal):Neurol Neuroimmunol Neuroinflamm. 2019 May 1;6(4):e569. :Seiten (Pages):
Aus der Charité: Höltje M, Prüss H.
Juni 2019
Autoren:Haase R et al.
Titel:Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data.
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Titel:R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
Zeitschrift (Journal):Nat Cell Biol. 2019 Jul;21(7):812-823. :Seiten (Pages):
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Titel:Dipeptidyl Peptidase-4 Inhibitors and the Risk of Bullous Pemphigoid Among Patients With Type 2 Diabetes.
Zeitschrift (Journal):Diabetes Care. 2019 Jun 10. doi: 10.2337/dc19-0409. :Seiten (Pages):
Aus der Charité: Douros A.Autoren:Abraham WT et al.
Titel:Rationale and design of the EMPERIAL-Preserved and EMPERIAL-Reduced trials of empagliflozin in patients with chronic heart failure.
Zeitschrift (Journal):Eur J Heart Fail. 2019 Jun 19. doi: 10.1002/ejhf.1486. :Seiten (Pages):
Aus der Charité: Anker SD.Autoren:de Almeida Marcelino AL et al.
Titel:Subthalamic neuromodulation improves short-term motor learning in Parkinson's disease.
Zeitschrift (Journal):Brain. 2019 Jun 6. doi: 10.1093/brain/awz152. :Seiten (Pages):
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Titel:VEGF - Supplemented extracellular matrix is sufficient to induce endothelial differentiation of human iPSC.
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Titel:Outcome heterogeneity and bias in acute experimental spinal cord injury: A meta-analysis.
Zeitschrift (Journal):Neurology. 2019 Jul 2;93(1):e40-e51. :Seiten (Pages):
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Titel:PEDIA: prioritization of exome data by image analysis.
Zeitschrift (Journal):Genet Med. 2019 Jun 5. doi: 10.1038/s41436-019-0566-2. :Seiten (Pages):
Aus der Charité: Hsieh, Mensah, Pantel, Coutelier, Danyel, Ehmke, Fischer-Zirnsak, Graul-Neumann, Haddad, Hajjir, Hertzberg, Kaindl, Köhler, Kornak, Leitheiser, Ott, Rosnev, Spielmann, Winter, Zhao, Zhu, Mundlos, Horn.Autoren:Stacy M et al.
Titel:Abnormal involuntary movement scale in tardive dyskinesia: Minimal clinically important difference.
Zeitschrift (Journal):Mov Disord. 2019 Jun 24. doi: 10.1002/mds.27769. :Seiten (Pages):
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Titel:Image-guided Irreversible Electroporation of Localized Prostate Cancer: Functional and Oncologic Outcomes.
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Aus der Charité: Collettini F, Enders J, Stephan C, Fischer T, Baur ADJ, Penzkofer T, Busch J, Hamm B, Gebauer B.
Mai 2019
Autoren:Spahn DR et al.
Titel:Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial.
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Titel:Long-term effectiveness of oral second-generation antipsychotics in patients with schizophrenia and related disorders: a systematic review and meta-analysis of direct head-to-head comparisons.
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Titel:Early discharge and home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban: an international multicenter single-arm clinical trial.
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Titel:Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany.
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Titel:Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis.
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Titel:Collagen Fibrils Mechanically Contribute to Tissue Contraction in an In Vitro Wound Healing Scenario.
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Titel:Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis.
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Titel:RegulationSpotter: annotation and interpretation of extratranscriptic DNA variants.
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Titel:MutationDistiller: user-driven identification of pathogenic DNA variants.
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April 2019
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Titel:Acute and midterm outcomes of the post-approval MELODY Registry: a multicentre registry of transcatheter pulmonary valve implantation.
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Titel:Medical Graphic Narratives to Improve Patient Comprehension and Periprocedural Anxiety Before Coronary Angiography and Percutaneous Coronary Intervention: A Randomized Trial.
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Titel:Therapeutic Targeting of High Mobility Group Box-1 in Pulmonary Arterial Hypertension.
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Titel:Mutational Diversity and Therapy Response in Breast Cancer: A Sequencing Analysis in the Neoadjuvant GeparSepto Trial.
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Titel:Non-HLA agonistic anti-angiotensin II type 1 receptor antibodies induce a distinctive phenotype of antibody-mediated rejection in kidney transplant recipients.
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Titel:Confirmation of the prognostic value of pretherapeutic tumor SUR and MTV in patients with esophageal squamous cell carcinoma.
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Titel:Damage of the lateral geniculate nucleus in MS: Assessing the missing node of the visual pathway.
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März 2019
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Titel:Mode-of-action of the PROPELLA concept in fulminant myocarditis.
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Titel:Neuronal Autoantibodies Associated with Cognitive Impairment in Melanoma Patients.
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Titel:Orphan disease status of cancer cachexia in the USA and in the European Union: a systematic re-view.
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Titel:2018 EULAR recommendations for a core data set to support observational research and clinical care in giant cell arteritis.
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Titel:Treatment of primary Sjögren's syndrome with ianalumab (VAY736) targeting B cells by BAFF re-ceptor blockade coupled with enhanced, antibody-dependent cellular cytotoxicity.
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Titel:Exercise training in patients with a left ventricular assist device (Ex-VAD): rationale and design of a multicentre, prospective, assessor-blinded, randomized, controlled trial.
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Titel:PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia.
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Titel:Enhanced PD-1 and diminished PD-L1 upregulation capacity mark post-activated lupus B cells.
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Titel:Treatments of Cold Urticaria: A Systematic Review.
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Januar 2019
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Titel:Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients.
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Titel:Avelumab in patients with previously treated metastatic melanoma: phase 1b results from the JAVELIN Solid Tumor trial.
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