Expert public only
Inferring cancer evolution
We would likt to cordially invite you to the Keynote Lecture of Prof. Florian Markowetz.
Cancer has long been understood as a somatic evolutionary process, but many details of tumor progression remain elusive. Florian Markowetz will talk about computational methods to infer evolutionary pathways leading to tumour heterogeneity. He will start by discussing how to quantify intra-patient heterogeneity by rigorous analysis of copy-number profiles from multiple patient samples. Using a study in ovarian cancer he will describe how summary statistics of phylogenetic quantification of genetic heterogeneity can predict patient survival. Then, he will present a probabilistic framework to reconstruct intra-tumor evolution from data obtained by bulk bisulfite sequencing of mixed tumor samples or single cell genomes. The approach jointly estimates the number and composition of clones in the sample as well as the most likely tree connecting them. He will finish with an outlook how to put cancer genomics in a tissue context.
The keynote lecture is mainly directed at researchers, physician scientists and students, who are working in the fields of basic research and/or clinical translational research. Attendance of this public lecture is free of charge. Please register at: DKTK-Berlin(at)charite.de.
Prof. Reinhold Schäfer Prof. Ulrich Keilholz
Deputy Director Acting Director
Charité Comprehensive Cancer Center Charité Comprehensive Cancer Center
Organizational and administrative matters
Professor Florian Markowetz
Universtity of Cambridge
Cancer Research UK Cambridge Institute
R. Schäfer; Institute of Pathology and German Cancer Cosortium (DKTK)
U. Keilholz; Charité Comprehensive Cancer Center (CCCC)
May 11, 2016
4 -5 pm
Charité – Universitätsmedizin | Campus Charité Mitte
Institute of Pathology
Lecture Hall Pathology
Virchowweg 15 | D-10117 Berlin
Please Register b May 9th, 2016: DKTK-Berlin(at)charite.de