Selected Publications by Charité authors

Every year, Charité researchers publish more than 4,000 scientific journal articles. Every month, we select ten of these articles for you to enjoy.

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The term open access refers to worldwide, barrier-free access to research results. Open access publications are accessible online, free of charge and have no permission restrictions. This means anyone can read, copy, print, distribute and search for and within the information available (Please consult the Medical Library for further information).

The open code badge denotes publications which are based on analyses made using freely available software. To qualify for this badge, publications must comply with the BIH Quest Center criteria: the publication must be based on newly developed or specifically adapted code. This must be referred to in the publication and be made freely available.

The term open data denotes publications whose data are freely available to everyone. To fulfil open data requirements, original data must be freely accessible to others and published in a machine-readable format. Publications must also carry a clear reference to the BIH Quest Center’s ‘open data criteria’ in their full version.

Publications 2022

December 2022

Authors:Anker SD et al.
Title:Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved.

Journal:Nat Med. 2022 Dec;28(12):2512-2520. :Pages:
Charité-based author(s): Anker SD.
Authors:Brevini T et al.
Title:FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.

Journal:Nature. 2022 Dec 5. doi: 10.1038/s41586-022-05594-0. :Pages:
Charité-based author(s): Vallier L.
Authors:Roediger J et al.
Title:Automated deep brain stimulation programming based on electrode location: a randomised, crossover trial using a data-driven algorithm.

Journal:Lancet Digit Health. 2022 Dec 15:S2589-7500(22)00214-X. :Pages:
Charité-based author(s): Roediger J, Achtzehn J, Busch JL, Krämer AP, Faust K, Schneider GH, Krause P, Horn A, Kühn AA.
Authors:Felten M et al.
Title:Ventilator-induced Lung Injury Is Modulated by the Circadian Clock.

Journal:Am J Respir Crit Care Med. 2022 Dec 8. doi: 10.1164/rccm.202202-0320OC. :Pages:
Charité-based author(s): Felten M, Ferencik S, Teixeira Alves LG, Lienau J, Müller-Redetzky HC, Michalick L, Kuebler WM, Ananthasubramaniam B, Maier B, Kramer A, Witzenrath M.
Authors:Erfinanda L et al.
Title:Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation.

Journal:Sci Transl Med. 2022 Dec 7;14(674):eabg8577. :Pages:
Charité-based author(s): Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Hocke A, Hippenstiel S, Suttorp N, Mall MA, Witzenrath M, Kuebler WM.
Authors:Harnett D et al.
Title:A critical period of translational control during brain development at codon resolution.

Journal:Nat Struct Mol Biol. 2022 Dec;29(12):1277-1290. :Pages:
Charité-based author(s): Ambrozkiewicz MC, Dannenberg R, Münster-Wandowski A, Spahn CMT, Tarabykin V.
Authors:Bonczarowska JH et al.
Title:Pathogen genomics study of an early medieval community in Germany reveals extensive co-infections.

Journal:Genome Biol. 2022 Dec 13;23(1):250. :Pages:
Charité-based author(s): Mühlemann B, Jones TC.
Authors:Sauer K et al.
Title:Primary radiation damage in bone evolves via collagen destruction by photoelectrons and secondary emission self-absorption.

Journal:Nat Commun. 2022 Dec 20;13(1):7829. :Pages:
Charité-based author(s): Sauer K, Zaslansky P.
Authors:Ríos AS et al.
Title:Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease.

Journal:Nat Commun. 2022 Dec 14;13(1):7707. :Pages:
Charité-based author(s): Ríos AS, Oxenford S, Neudorfer C, Butenko K, Li N, Rajamani N, Horn A.
Authors:Bader JM et al.
Title:Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status.

Journal:Cell Rep Med. 2023 Jan 17;4(1):100877. :Pages:
Charité-based author(s): Misch M, Koch A.

November 2022

Authors:Carrasco-Zanini J et al.
Title:Proteomic signatures for identification of impaired glucose tolerance.

Journal:Nat Med. 2022 Nov;28(11):2293-2300. :Pages:
Charité-based author(s): Pietzner M, Langenberg C.
Authors:Surendran P et al.
Title:Rare and common genetic determinants of metabolic individuality and their effects on human health.

Journal:Nat Med. 2022 Nov;28(11):2321-2332. :Pages:
Charité-based author(s): Pietzner M, Langenberg C.
Authors:Jarick KJ et al.
Title:Non-redundant functions of group 2 innate lymphoid cells.

Journal:Nature. 2022 Nov;611(7937):794-800. :Pages:
Charité-based author(s): Jarick KJ, Topczewska PM, Jakob MO, Gao X, Boulekou S, Stokic-Trtica V, Leclère PS, Preußer A, Rompe ZA, Stamm A, Ivanov A, Beule D, Helfrich S, Duerr CU, Kühl AA, Stehle C, Romagnani C, Diefenbach A, Klose CSN.
Authors:Arends CM et al.
Title:Associations of clonal haematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke.

Journal:Blood. 2022 Nov 28. doi: 10.1182/blood.2022017661. :Pages:
Charité-based author(s): Arends CM, Strzelecka PM, Kufner A, Löwe P, Huo S, Stein CM, Piper SK, Tilgner M, Sperber PS, Dimitriou S, Hablesreiter R, Harms C, Bullinger L, Weber JE, Endres M, Damm F.
Authors:Gallo K et al.
Title:SuperNatural 3.0-a database of natural products and natural product-based derivatives.

Journal:Nucleic Acids Res. 2022 Nov 18. doi: 10.1093/nar/gkac1008. :Pages:
Charité-based author(s): Gallo K, Kemmler E, Goede A, Becker F, Dunkel M, Preissner R, Banerjee P.
Authors:Anker SD et al.
Title:Weight change and clinical outcomes in heart failure with reduced ejection fraction: insights from EMPEROR-Reduced.

Journal:Eur J Heart Fail. 2022 Nov 2. doi: 10.1002/ejhf.2728. :Pages:
Charité-based author(s): Anker SD, Doehner W.
Authors:Jurmeister P et al.
Title:DNA methylation-based classification of sinonasal tumors.

Journal:Nat Commun. 2022 Nov 28;13(1):7148 :Pages:
Charité-based author(s): Jurmeister P, Glöß S, Roller R, Leitheiser M, Schmid S, Fritz R, Dittmayer C, Friedrich C, Thieme A, Keyl P, Jarosch A, Schallenberg S, Hoffmann I, Vollbrecht C, Lehmann A, Hummel M, Heim D, Bockmayr M, Koch A, Heppner F, Capper D.
Authors:Fernández Zapata C et al.
Title:Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease.

Journal:Nat Commun. 2022 Nov 23;13(1):7210. :Pages:
Charité-based author(s): Fernández Zapata C, Spruth EJ, Gallaccio G, Dehlinger A, Dames C, Leman JKH, Meisel A, Schlickeiser S, Kunkel D, Paul F, Priller J, Böttcher C.
Authors:Vierock J et al.
Title:WiChR, a highly potassium-selective channelrhodopsin for low-light one- and two-photon inhibition of excitable cells.

Journal:Sci Adv. 2022 Dec 9;8(49):eadd7729. :Pages:
Charité-based author(s): Vierock J, Tillert L.
Authors:Terhorst-Molawi D et al.
Title:Anti-KIT antibody, barzolvolimab, reduces skin mast cells and disease activity in chronic inducible urticaria.

Journal:Allergy. 2022 Nov 16. doi: 10.1111/all.15585. :Pages:
Charité-based author(s): Terhorst-Molawi D, Grekowitz E, Kiefer L, Metz M, Maurer M.

October 2022

Authors:Ringel AR et al.
Title:Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes.

Journal:Cell. 2022 Sep 29;185(20):3689-3704.e21. :Pages:
Charité-based author(s): Ringel AR, Schöpflin R, Phan MHQ, Ibrahim DM, Mundlos S, Robson MI.
Authors:Ercu M et al.
Title:Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage.

Journal:Circulation. 2022 Oct 19. doi: 10.1161/CIRCULATIONAHA.122.060210. :Pages:
Charité-based author(s): Mücke MB, Markó L, Sholokh A, Esmati Y, Gong M, Batolomaeus TUP, Forslund SK, Müller DN, Bähring S, Hübner N, Bader M.
Authors:Rückert T et al.
Title:Clonal expansion and epigenetic inheritance of long-lasting NK cell memory.

Journal:Nat Immunol. 2022 Nov;23(11):1551-1563. :Pages:
Charité-based author(s): Ludwig LS, Romagnani C.
Authors:Schöpflin R et al.
Title:Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline rearranged genomes.

Journal:Nat Commun. 2022 Oct 29;13(1):6470. :Pages:
Charité-based author(s): Schöpflin R, Melo US, Hertzberg J, Holtgrewe M, Klever MK, Jungnitsch J, Türkmen S, Horn D, Mundlos S.
Authors:Immisch L et al.
Title:H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma.

Journal:J Immunother Cancer. 2022 Oct;10(10):e005535. :Pages:
Charité-based author(s): Immisch L, Papafotiou G, Willimsky G.
Authors:Schweizer U et al.
Title:Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice.

Journal:Redox Biol. 2022 Sep 24;57:102490. :Pages:
Charité-based author(s): Wirth EK, Köhrle J, Schomburg L.
Authors:Haber AC et al.
Title:Open tools for quantitative anonymization of tabular phenotype data: literature review.

Journal:Brief Bioinform. 2022 Oct 10:bbac440. :Pages:
Charité-based author(s): Haber AC, Prasser F.
Authors:Rohmann JL et al.
Title:Effect of mobile stroke unit dispatch in all patients with acute stroke or TIA.

Journal:Ann Neurol. 2022 Oct 30. doi: 10.1002/ana.26541. Epub ahead of print. :Pages:
Charité-based author(s): Rohmann JL, Piccininni M, Ebinger M, Weber JE, Geisler F, Freitag E, Harmel P, Lorenz-Meyer I, Rohrpasser-Napierkowski I, Nolte CH, Endres M, Audebert HJ.
Authors:Kleefeld F et al.
Title:Morphologic and Molecular Patterns of Polymyositis With Mitochondrial Pathology and Inclusion Body Myositis.

Journal:Neurology. 2022 Nov 15;99(20):e2212-e2222. :Pages:
Charité-based author(s): Kleefeld F, Schneider U, Goebel HH, Schuelke M, Hahn K, Preusse C, Stenzel W.
Authors:Correll CU et al.
Title:Reduction in Multiple Cardiometabolic Risk Factors With Combined Olanzapine/Samidorphan Compared With Olanzapine: Post Hoc Analyses From a 24-Week Phase 3 Study.

Journal:Schizophr Bull. 2022 Oct 28:sbac144. :Pages:
Charité-based author(s): Correll CU.

September 2022

Authors:Buergel T et al.
Title:Metabolomic profiles predict individual multidisease outcomes.

Journal:Nat Med. 2022 Sep 22. doi: 10.1038/s41591-022-01980-3. :Pages:
Charité-based author(s): -Buergel T, Steinfeldt J, Ruyoga G, Pietzner M, Upmeier Zu Belzen J, Loock L, Kittner P, Christmann L, Hollmann N, Strangalies H, Braunger JM, Wild B, Spranger J, Klostermann F, Langenberg C, Eils R, Landmesser U.
Authors:Ostendorf BN et al.
Title:Common human genetic variants of APOE impact murine COVID-19 mortality.

Journal:Nature. 2022 Sep 21. doi: 10.1038/s41586-022-05344-2. :Pages:
Charité-based author(s): Ostendorf BN.
Authors:Lange JT et al.
Title:The evolutionary dynamics of extrachromosomal DNA in human cancers.

Journal:Nat Genet. 2022 Oct;54(10):1527-1533. :Pages:
Charité-based author(s): Chen CY, Henssen AG.
Authors:Butler J et al.
Title:Effects of Empagliflozin in Women and Men With Heart Failure and Preserved Ejection Fraction.

Journal:Circulation. 2022 Oct 4;146(14):1046-1055. :Pages:
Charité-based author(s): Rauch-Kröhnert U, Anker SD.
Authors:Haber PK et al.
Title:Molecular Markers of Response to Anti-PD1 Therapy in Advanced Hepatocellular Carcinoma.

Journal:Gastroenterology. 2022 Sep 12:S0016-5085(22)01039-3. :Pages:
Charité-based author(s): Haber PK, Özdirik B, Müller T, Schmelzle M, Llovet JM.
Authors:Knorr J et al.
Title:Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis.

Journal:Hepatology. 2022 Sep 4. doi: 10.1002/hep.32776. :Pages:
Charité-based author(s): Knorr J, Holtmann TM, Geisler L, Hundertmark J, Kohlhepp MS, Demir M, Tacke F, Wree A.
Authors:Böhm M et al.
Title:Heart failure outcomes according to heart rate and effects of empagliflozin in patients of the EMPEROR-Preserved trial.

Journal:Eur J Heart Fail. 2022 Sep 10. doi: 10.1002/ejhf.2677. :Pages:
Charité-based author(s): Anker SD.
Authors:Sibille J et al.
Title:High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons.

Journal:Nat Commun. 2022 Sep 5;13(1):5218. :Pages:
Charité-based author(s): Sibille J, Gehr C, Balasubramanian H, Teh KL, Lupashina T, Kremkow J.
Authors:Ebert MJ et al.
Title:Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation.

Journal:J Clin Invest. 2022 Sep 20:e160089. :Pages:
Charité-based author(s): Ebert MJ, Jerke U, Eulenberg-Gustavus C, Kling L, Kirchner M, Mertins P, Eckardt KU, Schreiber A, Kettritz R.
Authors:Fischer AS et al.
Title:R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.

Journal:J Clin Invest. 2022 Sep 13:e151363. :Pages:
Charité-based author(s): Fischer AS, Müllerke S, Arnold A, Heuberger J, Berger H, Lin M, Wizenty J, Horst D, Tacke F, Sigal M.

August 2022

Authors:Broto M et al.
Title:Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs.

Journal:Nat Nanotechnol. 2022 Aug 4. doi: 10.1038/s41565-022-01179-0. :Pages:
Charité-based author(s): Kaminski MM, Greensmith R, Schubert AJ.
Authors:Zhai Y et al.
Title:Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia.

Journal:Mol Cancer. 2022 Aug 19;21(1):166. doi: 10.1186/s12943-022-01635-4. :Pages:
Charité-based author(s): Dolnik A, Bullinger L.
Authors:Proft F et al.
Title:Early identification of axial psoriatic arthritis among patients with psoriasis: a prospective multicentre study.

Journal:Ann Rheum Dis. 2022 Aug 3:annrheumdis-2022-222562. :Pages:
Charité-based author(s): Proft F, Lüders S, Rios Rodriguez V, Protopopov M, Poddubnyy D.
Authors:Solmi M et al.
Title:Efficacy and acceptability of psychosocial interventions in schizophrenia: systematic overview and quality appraisal of the meta-analytic evidence.

Journal:Mol Psychiatry. 2022 Aug 23. doi: 10.1038/s41380-022-01727-z. :Pages:
Charité-based author(s): Solmi M, Correll CU.
Authors:Pietzner M et al.
Title:ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.

Journal:Nat Commun. 2022 Aug 15;13(1):4484. :Pages:
Charité-based author(s): Pietzner M, Chua RL, Jechow K, Radbruch H, Trump S, Heidecker B, Heppner FL, Eils R, Mall MA, Sander LE, Lehmann I, Lukassen S, Conrad C, Langenberg C.
Authors:Wang Z et al.
Title:Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens.

Journal:J Exp Med. 2022 Oct 3;219(10):e20220826. :Pages:
Charité-based author(s): Muenn F, Tober-Lau P, Hillus D, Kurth F, Sander LE, Gaebler C.
Authors:Letizia M et al.
Title:Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.

Journal:EMBO Mol Med. 2022 Sep 7;14(9):e15687. :Pages:
Charité-based author(s): Letizia M, Gerbeth L, Sand A, Brunkhorst M, Weidner P, Ziegler JF, Böttcher C, Schlickeiser S, Fernández C, Kunkel D, Sanders A, Siegmund B, Weidinger C.
Authors:Kazmierski J et al.
Title:Nonproductive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immune responses.

Journal:Mol Syst Biol. 2022 Aug;18(8):e10961. :Pages:
Charité-based author(s): Kazmierski J, Friedmann K, Postmus D, Emanuel J, Jansen J, Richter A, Bosquillon de Jarcy L, Schüler C, Drosten C, Sander LE, Müller MA, Niemeyer D, Goffinet C.
Authors:Lebedin M.
Title:Different classes of genomic inserts contribute to human antibody diversity.

Journal:Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2205470119. :Pages:
Charité-based author(s): Lebedin M, Vázquez García C, de la Rosa K.
Authors:Bressem KK et al.
Title:Deep Learning Detects Changes Indicative of Axial Spondyloarthritis at MRI of Sacroiliac Joints.

Journal:Radiology. 2022 Aug 9:212526. :Pages:
Charité-based author(s): Bressem KK, Adams LC, Proft F, Hermann KGA, Diekhoff T, Spiller L, Niehues SM, Hamm B, Protopopov M, Rios Rodriguez V, Haibel H, Rademacher J, Torgutalp M, Vahldiek JL, Poddubnyy D.

July 2022

Authors:Derks J et al.
Title:Increasing the throughput of sensitive proteomics by plexDIA.

Journal:Nat Biotechnol. 2022 Jul 14. doi: 10.1038/s41587-022-01389-w. :Pages:
Charité-based author(s): Ralser M, Demichev V.
Authors:Noviello CM et al.
Title:Structural mechanisms of GABAA receptor autoimmune encephalitis.

Journal:Cell. 2022 Jul 7;185(14):2469-2477.e13. :Pages:
Charité-based author(s): Kreye J, Prüss H.
Authors:Butler J et al.
Title:Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial.

Journal:Eur Heart J. 2022 Jul 28:ehac401. doi: 10.1093/eurheartj/ehac401. :Pages:
Charité-based author(s): Anker SD.
Authors:Doehner W et al.
Title:Uric acid and sodium-glucose cotransporter-2 inhibition with empagliflozin in heart failure with reduced ejection fraction: the EMPEROR-reduced trial.

Journal:Eur Heart J. 2022 Jul 5:ehac320. :Pages:
Charité-based author(s): Doehner W, Anker SD.
Authors:Böhm M et al.
Title:Empagliflozin Improves Outcomes in Patients With Heart Failure and Preserved Ejection Fraction Irrespective of Age.

Journal:J Am Coll Cardiol. 2022 Jul 5;80(1):1-18. :Pages:
Charité-based author(s): Anker SD.
Authors:Mall MA et al.
Title:Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function Mutation: A Phase 3B, Randomized, Placebo-Controlled Study.

Journal:Am J Respir Crit Care Med. 2022 Jul 11. doi: 10.1164/rccm.202202-0392OC. :Pages:
Charité-based author(s): Mall MA.
Authors:Imoto Y et al.
Title:Dynamin is primed at endocytic sites for ultrafast endocytosis.

Journal:Neuron. 2022 Jul 1:S0896-6273(22)00548-7. doi: 10.1016/j.neuron.2022.06.010. Epub ahead of print. :Pages:
Charité-based author(s): Fenske P, Mamer L, Zarebidaki F, Söhl-Kielczynski B, Trimbuch T, Rosenmund C.
Authors:Linde C et al.
Title:Cardiac contractility modulation therapy improves health status in patients with heart failure with preserved ejection fraction: a pilot study (CCM-HFpEF).

Journal:Eur J Heart Fail. 2022 Jul 20. doi: 10.1002/ejhf.2619. :Pages:
Charité-based author(s): Tschöpe C.
Authors:Pocock SJ et al.
Title:Biomarker-driven prognostic models in chronic heart failure with preserved ejection fraction: the EMPEROR-Preserved trial.

Journal:Eur J Heart Fail. 2022 Jul 7. doi: 10.1002/ejhf.2607. :Pages:
Charité-based author(s): Anker SD.
Authors:Dorado García H et al.
Title:Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.

Journal:Nat Commun. 2022 Jul 25;13(1):4297. :Pages:
Charité-based author(s): Dorado García H, Pusch F, Bei Y, von Stebut J, Helmsauer K, Meyer-Liesener S, Timme N, Bardinet V, Chamorro González R, MacArthur IC, Chen CY, Schulz J, Furth C, Lala B, Eggert A, Seifert G, Hundsoerfer P, Lissat A, Dubois F, Horst D, Schulte JH, Spuler S, Haase K, Scheer M, Henssen AG.
Authors:Demichev V et al.
Title:dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts.

Journal:Nat Commun. 2022 Jul 8;13(1):3944. :Pages:
Charité-based author(s): Demichev V, Szyrwiel L, Niewienda A, Ludwig D, Mülleder M, Ralser M.

June 2022

Authors:Hilal T et al.
Title:Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.

Journal:Science. 2022 Jun 17;376(6599):1338-1343. :Pages:
Charité-based author(s): Hilal T, Loerke J, Bürger J, Spahn CMT.
Authors:Filippatos G et al.
Title:Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes.

Journal:Circulation. 2022 Jun 28. doi: 10.1161/CIRCULATIONAHA.122.059785. :Pages:
Charité-based author(s): Anker SD.
Authors:Berlak M et al.
Title:Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.

Journal:Mol Cancer. 2022 Jun 10;21(1):126. :Pages:
Charité-based author(s): Berlak M, Dorel M, Winkler A, McGearey A, Rodriguez-Fos E, Dorado-Garcia H, Lang P, Deubzer HE, Künkele A, Eggert A, Henssen AG, Hertwig F, Blüthgen N, Schulte JH.
Authors:Ostuzzi G et al.
Title:Continuing, reducing, switching, or stopping antipsychotics in individuals with schizophrenia-spectrum disorders who are clinically stable: a systematic review and network meta-analysis.

Journal:Lancet Psychiatry. 2022 Aug;9(8):614-624. :Pages:
Charité-based author(s): Correll CU.
Authors:Torgutalp M et al.
Title:Treatment with tumour necrosis factor inhibitors is associated with a time-shifted retardation of radiographic spinal progression in patients with axial spondyloarthritis.

Journal:Ann Rheum Dis. 2022 Jun 13. doi: 10.1136/annrheumdis-2022-222324. :Pages:
Charité-based author(s): Torgutalp M, Rios Rodriguez V, Proft F, Protopopov M, Verba M, Rademacher J, Haibel H, Sieper J, Poddubnyy D.
Authors:Wiebe E et al.
Title:Optimising both disease control and glucocorticoid dosing is essential for bone protection in patients with rheumatic disease.

Journal:Ann Rheum Dis. 2022 Jun 9. doi: 10.1136/annrheumdis-2022-222339. :Pages:
Charité-based author(s): Wiebe E, Huscher D, Schaumburg D, Palmowski A, Hermann S, Buttgereit T, Biesen R, Burmester GR, Palmowski Y, Buttgereit F.
Authors:Steinhaus R et al.
Title:FABIAN-variant: predicting the effects of DNA variants on transcription factor binding.

Journal:Nucleic Acids Res. 2022 May 26;50(W1):W322–9. :Pages:
Charité-based author(s): Steinhaus R, Seelow D.
Authors:Hönzke K et al.
Title:Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.

Journal:Eur Respir J. 2022 Jun 21:2102725. :Pages:
Charité-based author(s): Hönzke K, Obermayer B, Fathykova D, Kessler M, Baumgardt M, Löwa A, Hoffmann K, Graff P, Mieth M, Hellwig K, Demir Z, Dohmen M, Hinze C, Elezkurtaj S, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Suttorp N, Witzenrath M, Drosten C, Sander LE, Hippenstiel S, Hocke AC.
Authors:Sorg AL et al.
Title:Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021.

Journal:Nat Commun. 2022 Jun 6;13(1):3128. :Pages:
Charité-based author(s): Bergfeld L, Corman V, Semmler I, Von Bernuth H, Drosten C.
Authors:Ong YT et al.
Title:A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth.

Journal:Nat Metab. 2022 Jun;4(6):672-682. :Pages:
Charité-based author(s): Andrade J, Castro M, Lim J, Gerhardt H, Potente M.

May 2022

Authors:Correll CU et al.
Title:Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors.

Journal:World Psychiatry. 2022 Jun;21(2):248-271. :Pages:
Charité-based author(s): Correll CU.
Authors:Ostuzzi G et al.
Title:Oral and long-acting antipsychotics for relapse prevention in schizophrenia-spectrum disorders: a network meta-analysis of 92 randomized trials including 22,645 participants.

Journal:World Psychiatry. 2022 Jun;21(2):295-307. :Pages:
Charité-based author(s): Correll CU.
Authors:Blohmer JU et al.
Title:Effect of Denosumab Added to 2 Different nab-Paclitaxel Regimens as Neoadjuvant Therapy in Patients With Primary Breast Cancer: The GeparX 2 × 2 Randomized Clinical Trial.

Journal:JAMA Oncol. 2022 May 19:e221059. :Pages:
Charité-based author(s): Blohmer JU.
Authors:Triebkorn P et al.
Title:Brain simulation augments machine-learning-based classification of dementia.

Journal:Alzheimers Dement (N Y). 2022 May 15;8(1):e12303. :Pages:
Charité-based author(s): Triebkorn P, Stefanovski L, Dhindsa K, Diaz-Cortes MA, Bey P, Bülau K, Pai R, Spiegler A, Ritter P.
Authors:Graeber SY et al.
Title:Effects of Elexacaftor/Tezacaftor/Ivacaftor Therapy on Lung Clearance Index and Magnetic Resonance Imaging in Patients with Cystic Fibrosis and One or Two F508del Alleles.

Journal:Am J Respir Crit Care Med. 2022 May 10. doi: 10.1164/rccm.202201-0219OC. :Pages:
Charité-based author(s): Graeber SY, Stahl M, Doellinger F, Vitzthum C, Röhmel J, Allomba C, Mall MA.
Authors:Dörner T et al.
Title:Mechanism of action of baricitinib and identification of biomarkers and key immune pathways in patients with active systemic lupus erythematosus.

Journal:Ann Rheum Dis. 2022 May 24:annrheumdis-2022-222335. :Pages:
Charité-based author(s): Dörner T.
Authors:Preuße C et al.
Title:Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis.

Journal:Acta Neuropathol. 2022 May 25. doi: 10.1007/s00401-022-02438-z. :Pages:
Charité-based author(s): Preuße C, Paesler B, Cengiz D, Uruha A, Dittmayer C, Hoffmann S, Timm S, Dengler NF, Schneider U, Feist E, Goebel HH, Stenzel W.
Authors:Mantei A et al.
Title:Mycobacterium tuberculosis-specific CD4 T-cell scoring discriminates tuberculosis infection from disease.

Journal:Eur Respir J. 2022 May 26:2101780. :Pages:
Charité-based author(s): Mantei A, Meyer T, Schürmann M, Beßler C, Bias H, Helmuth J, Volk HD, Schürmann D, Meisel C.
Authors:Anker SD et al.
Title:Outcomes with empagliflozin in heart failure with preserved ejection fraction using DELIVER-like endpoint definitions.

Journal:Eur J Heart Fail. 2022 May 23. doi: 10.1002/ejhf.2558. :Pages:
Charité-based author(s): Anker SD.
Authors:Kaufmann JO et al.
Title:ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries.

Journal:Nat Commun. 2022 May 23;13(1):2867. :Pages:
Charité-based author(s): Kaufmann JO, Brangsch J, Kader A, Mangarova DB, Adams LC, Möckel J, Taupitz M, Hamm B, Makowski MR.
Authors:Radke J et al.
Title:The genomic and transcriptional landscape of primary central nervous system lymphoma.

Journal:Nat Commun. 2022 May 10;13(1):2558. :Pages:
Charité-based author(s): Radke J, Ishaque N, Koll R, Schumann E, Pritsch F, Sahay S, Pehl D, Radbruch H, Osterloh A, Korfel A, Misch M, Onken J, Faust K, Vajkoczy P, Anagnostopoulos I, Lenze D, Hummel M, Schmitt CA, Eils R, Heppner FL.

April 2022

Authors:Trubetskoy V et al.
Title:Mapping genomic loci implicates genes and synaptic biology in schizophrenia.

Journal:Nature. 2022 Apr;604(7906):502-508. :Pages:
Charité-based author(s): Trubetskoy V, Panagiotaropoulou G, Awasthi S, Braun A, Hahn E, Kraft J, Skarabis N, Ta TMT, Walter W, Ripke S.
Authors:Aust S et al.
Title:Efficacy of Augmentation of Cognitive Behavioral Therapy With Transcranial Direct Current Stimulation for Depression: A Randomized Clinical Trial.

Journal:JAMA Psychiatry. 2022 Apr 20:e220696. :Pages:
Charité-based author(s): Aust S, Spies J, Herrera-Melendez AL, Bajbouj M.
Authors:Deodhar AA et al.
Title:Safety of ixekizumab in patients with psoriatic arthritis: data from four clinical trials with over 2000 patient-years of exposure.

Journal:Ann Rheum Dis. 2022 Apr 7:annrheumdis-2021-222027. :Pages:
Charité-based author(s): Burmester GR.
Authors:Jiang T et al.
Title:Stimulation of the EP₃ receptor causes lung edema by activation of TRPC6 in pulmonary endothelial cells.

Journal:Eur Respir J. 2022 Apr 21:2102635. :Pages:
Charité-based author(s): Jiang T, Samapati R, Lei D, Erfinanda L, Simmons S, Kuebler WM.
Authors:Abu-Akel A et al.
Title:Psychosocial functioning in the balance between autism and psychosis: evidence from three populations.

Journal:Mol Psychiatry. 2022 Apr 14. doi: 10.1038/s41380-022-01543-5. :Pages:
Charité-based author(s): Montag C.
Authors:Sbierski-Kind J et al.
Title:Effects of caloric restriction on the gut microbiome are linked with immune senescence.

Journal:Microbiome. 2022 Apr 4;10(1):57. :Pages:
Charité-based author(s): Sbierski-Kind J, Grenkowitz S, Schlickeiser S, Sandforth A, Friedrich M, Kunkel D, Brachs S, Mai K, Volk HD, Spranger J, von Schwartzenberg RJ.
Authors:Dreier JP et al.
Title:Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study.

Journal:Brain. 2022 Apr 12:awab457. :Pages:
Charité-based author(s): Dreier JP, Winkler MKL, Major S, Horst V, Kola V, Lemale CL, Kang EJ, Lückl J, Jorks D, Oliveira-Ferreira AI, Schoknecht K, Reiffurth C, Milakara D, Wiesenthal D, Hecht N, Dengler NF, Liotta A, Wolf S, Bohner G, Scheel M, Vajkoczy P, Woitzik J.
Authors:Potapova E et al.
Title:Molecular reactivity profiling upon immunotherapy with a 300 IR sublingual house dust mite tablet reveals marked humoral changes towards major allergens.

Journal:Allergy. 2022 Apr 26. doi: 10.1111/all.15327. :Pages:
Charité-based author(s): Potapova E, Matricardi PM.
Authors:Buttgereit T et al.
Title:Idiopathic mast cell activation syndrome is more often suspected than diagnosed-A prospective real-life study.

Journal:Allergy. 2022 Apr 1. doi: 10.1111/all.15304. :Pages:
Charité-based author(s): Buttgereit T, Gu S, Gutsche A, Maurer M, Siebenhaar F.
Authors:Lemoine M et al.
Title:Screening HIV patients at risk for NAFLD using MRI-PDFF and transient elastography: a European multicenter prospective study.

Journal:Clin Gastroenterol Hepatol. 2022 Apr 15:S1542-3565(22)00390-1. :Pages:
Charité-based author(s): Post G, Ingiliz P.

March 2022

Authors:DISCHARGE Trial Group et al.
Title:CT or Invasive Coronary Angiography in Stable Chest Pain.

Journal:N Engl J Med. 2022 Mar 4. doi: 10.1056/NEJMoa2200963. :Pages:
Charité-based author(s): Bosserdt M, Rieckmann N, Zimmermann E, Müller-Nordhorn J, Laule M, Neskovic AN, Haase R, Feger S, Neumann K, Dreger H, Rief M, Wieske V, Estrella M, Dewey M.
Authors:Ferreira JP et al.
Title:Mineralocorticoid Receptor Antagonists and Empagliflozin in Patients With Heart Failure and Preserved Ejection Fraction.

Journal:J Am Coll Cardiol. 2022 Mar 29;79(12):1129-1137. :Pages:
Charité-based author(s): Anker SD.
Authors:Arumahandi de Silva AN et al.
Title:Pausing methotrexate improves immunogenicity of COVID-19 vaccination in elderly patients with rheumatic diseases.

Journal:Ann Rheum Dis. 2022 Mar 14:annrheumdis-2021-221876. :Pages:
Charité-based author(s): Arumahandi de Silva AN, Frommert LM, Albach FN, Scholz V, Jeworowski LM, Schwarz T, Ten Hagen A, Zernicke J, Corman VM, Drosten C, Burmester GR, Biesen R.
Authors:Yu JSL et al.
Title:Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance.

Journal:Nat Microbiol. 2022 Apr;7(4):542-555. :Pages:
Charité-based author(s): Herrera-Dominguez L, Hartl J, Freiwald A, Mülleder M, Ralser M.
Authors:Anker SD et al.
Title:Responder analysis for improvement in six-minute walk test with ferric carboxymaltose in patients with heart failure with reduced ejection fraction and iron deficiency.

Journal:Eur J Heart Fail. 2022 Mar 25. doi: 10.1002/ejhf.2491. :Pages:
Charité-based author(s): Anker SD.
Authors:Filippatos G et al.
Title:Finerenone in patients with CKD and T2D with and without heart failure: A prespecified subgroup analysis of the FIDELIO-DKD trial.

Journal:Eur J Heart Fail. 2022 Mar 3. doi: 10.1002/ejhf.2469. :Pages:
Charité-based author(s): Anker SD.
Authors:Kapalczynska M et al.
Title:BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.

Journal:Nat Commun. 2022 Mar 24;13(1):1577. :Pages:
Charité-based author(s): Kapalczynska M, Lin M, Heuberger J, Muellerke S, Fischer AS, Berger H, Kidess E, Tacke F, Sigal M.
Authors:Kačarević ŽP et al.
Title:Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration.

Journal:Bioact Mater. 2021 Dec 2;14:15-30. :Pages:
Charité-based author(s): Kačarević ŽP, Rider P, Witte F.
Authors:Rider P et al.
Title:Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery.

Journal:Bioact Mater. 2021 Nov 29;14:152-168. :Pages:
Charité-based author(s): Rider P, Kačarević ŽP, Witte F.
Authors:Hertzberg J et al.
Title:TADA-a machine learning tool for functional annotation-based prioritisation of pathogenic CNVs.

Journal:Genome Biol. 2022 Mar 1;23(1):67. :Pages:
Charité-based author(s): Hertzberg J, Mundlos S.

February 2022

Authors:Brandt L et al.
Title:Adverse events after antipsychotic discontinuation: an individual participant data meta-analysis.

Journal:Lancet Psychiatry. 2022 Mar;9(3):232-242. :Pages:
Charité-based author(s): Brandt L, Bermpohl F, Loncar L, Neumann K, Heinz A, Gutwinski S.
Authors:Turc G et al.
Title:Comparison of Mobile Stroke Unit With Usual Care for Acute Ischemic Stroke Management: A Systematic Review and Meta-analysis.

Journal:JAMA Neurol. 2022 Feb 7:e215321. :Pages:
Charité-based author(s): Weber JE, Nolte CH, Ebinger M, Audebert HJ.
Authors:Ng YLD et al.
Title:Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.

Journal:Nat Commun. 2022 Feb 23;13(1):1009. :Pages:
Charité-based author(s): Ng YLD, Ramberger E, Dolnik A, Müller S, Walther W, Keller U, Bullinger L, Krönke J.
Authors:Doehner W et al.
Title:Iron deficiency is related to low functional outcome in patients at early rehabilitation after acute stroke.

Journal:J Cachexia Sarcopenia Muscle. 2022 Feb 14. doi: 10.1002/jcsm.12927. :Pages:
Charité-based author(s): Doehner W, Scherbakov N, Schellenberg T, Scheitz JF.
Authors:Demircan K et al.
Title:Humoral immune response to COVID-19 mRNA vaccination in relation to selenium status.

Journal:Redox Biol. 2022 Apr;50:102242. :Pages:
Charité-based author(s): Demircan K, Chillon TS, Sun Q, Heller RA, Klingenberg GJ, Seemann P, Schomburg L.
Authors:Doffo J et al.
Title:NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.

Journal:Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2105691119. :Pages:
Charité-based author(s): Doffo J, Bamopoulos SA, Köse H, Zang C, Habringer S, Schick M, Keller U, Wirth M.
Authors:Neudorfer C et al.
Title:Personalizing deep brain stimulation using advanced imaging sequences.

Journal:Ann Neurol. 2022 Feb 14. doi: 10.1002/ana.26326. :Pages:
Charité-based author(s): Neudorfer C, Kroneberg D, Al-Fatly B, Goede L, Kübler D, Faust K, Tietze A, Picht T, Kühn A, Schneider GH, Horn A.
Authors:Markó L et al.
Title:Effect of Sunitinib Treatment on Skin Sodium Accumulation in Patients With Renal Cancer: a Pilot Study.

Journal:Hypertension. 2022 Feb 22:HYPERTENSIONAHA12219079. :Pages:
Charité-based author(s): Markó L, Dörr A, Kuehne T, Dechend R, Flörcken A, Müller DN.
Authors:Graw JA et al.
Title:The role of cell-free hemoglobin and haptoglobin in acute kidney injury in critically ill adults with ARDS and therapy with VV ECMO.

Journal:Crit Care. 2022 Feb 22;26(1):50. :Pages:
Charité-based author(s): Graw JA, Hildebrandt P, Krannich A, Balzer F, Spies C, Francis RC, Kuebler WM, Weber-Carstens S, Menk M, Hunsicker O.
Authors:Kleinert P & Kircher M.
Title:A framework to score the effects of structural variants in health and disease.

Journal:Genome Res. 2022 Feb 23:gr.275995.121. :Pages:
Charité-based author(s): Kleinert P, Kircher M.

January 2022

Authors:Gruell H et al.
Title:mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant.

Journal:Nat Med. 2022 Jan 19:1–4. :Pages:
Charité-based author(s): Tober-Lau P, Hillus D, Kurth F, Sander LE.
Authors:Reincke SM et al.
Title:SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies.

Journal:Science. 2022 Jan 25:eabm5835. :Pages:
Charité-based author(s): Reincke SM, Kornau HC, Corman VM, van Hoof S, Sánchez-Sendin E, Schmidt ML, Schwarz T, Jeworowski LM, Brandl SE, Rasmussen HF, Homeyer MA, Stöffler L, Kunkel D, Huo S, Horler J, von Wardenburg N, Schmitz D, Drosten C, Prüss H, Kreye J.
Authors:Georg P et al.
Title:Complement activation induces excessive T cell cytotoxicity in severe COVID-19.

Journal:Cell. 2021 Dec 28:S0092-8674(21)01562-2. :Pages:
Charité-based author(s): Georg P, Astaburuaga-García R, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Thiel A, Hippenstiel S, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Obermayer B, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Kuebler WM, Meisel C, Ralser M, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B.
Authors:Steinfeldt J et al.
Title:Neural network-based integration of polygenic and clinical information: development and validation of a prediction model for 10-year risk of major adverse cardiac events in the UK Biobank cohort.

Journal:Lancet Digit Health. 2022 Feb;4(2):e84-e94. :Pages:
Charité-based author(s): Steinfeldt J, Buergel T, Loock L, Kittner P, Ruyoga G, Zu Belzen JU, Sasse S, Strangalies H, Christmann L, Hollmann N, Wolf B, Landmesser U, Eils R.
Authors:Schick M et al.
Title:Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.

Journal:Nat Commun. 2022 Jan 12;13(1):281. :Pages:
Charité-based author(s): Schick M, Zhang L, Isaakaidis K, Rohleder E, Habringer S, Chapuy B, Wirth M, Keller U.
Authors:Baranowsky A et al.
Title:Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment.

Journal:Bone Res. 2022 Jan 27;10(1):9. :Pages:
Charité-based author(s): Jahn D, Appelt J, Albrecht KK, Otto E, Köhli P, Fuchs M, Tsitsilonis S, Keller J.
Authors:Ganos C et al.
Title:A neural network for tics: insights from causal brain lesions and deep brain stimulation.

Journal:Brain. 2022 Jan 13:awac009. :Pages:
Charité-based author(s): Ganos C, Al-Fatly B, Fischer JF, Neudorfer C, Kühn AA, Horn A.
Authors:Carbon NM et al.
Title:Impact of protocol-based physiotherapy on insulin sensitivity and peripheral glucose metabolism in critically ill patients.

Journal:J Cachexia Sarcopenia Muscle. 2022 Jan 24. doi: 10.1002/jcsm.12920. :Pages:
Charité-based author(s): Carbon NM, Engelhardt LJ, Wollersheim T, Grunow JJ, Spies CD, Märdian S, Mai K, Spranger J, Weber-Carstens S.
Authors:Maleitzke T et al.
Title:Intramuscular and intratendinous placenta-derived mesenchymal stromal-like cell treatment of a chronic quadriceps tendon rupture.

Journal:J Cachexia Sarcopenia Muscle. 2022 Jan 5. doi: 10.1002/jcsm.12894. :Pages:
Charité-based author(s): Maleitzke T, Reinke P, Agres AN, Alves SA, Akyüz L, Fleckenstein FN, Bichmann A, Perka C, Duda GN, Winkler T.
Authors:Breiderhoff T et al.
Title:Claudin-10a Deficiency Shifts Proximal Tubular Cl- Permeability to Cation Selectivity via Claudin-2 Redistribution.

Journal:J Am Soc Nephrol. 2022 Jan 14:ASN.2021030286. :Pages:
Charité-based author(s): Breiderhoff T, Meoli L, Fromm A, Kriuchkova N, Nagel O, Ladilov Y, Krug S, Mueller D, Mutig K, Günzel D.

Publications 2021

December 2021

Authors:Forslund SK et al.
Title:Combinatorial, additive and dose-dependent drug-microbiome associations.

Journal:Nature. 2021 Dec;600(7889):500-505. :Pages:
Charité-based author(s): Forslund SK, Markó L, Birkner T, Bork P.
Authors:Wendisch D et al.
Title:SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.

Journal:Cell. 2021 Dec 22;184(26):6243-6261.e27. :Pages:
Charité-based author(s): Wendisch D, Mittermaier M, Chua RL, Timm S, Brumhard S, Hiller AL, Pascual-Reguant A, Mothes R, Pott F, Kazmierski J, Radke J, Pergantis P, Conrad C, Sawitzki B, Horst D, Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Elezkurtaj S, Thibeault C, Witzenrath M, Suttorp N, Drosten C, Goffinet C, Kurth F, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Conrad C, Selbach M, Sander LE.
Authors:Fleseriu M et al.
Title:Maintenance of response to oral octreotide compared with injectable somatostatin receptor ligands in patients with acromegaly: a phase 3, multicentre, randomised controlled trial.

Journal:Lancet Diabetes Endocrinol. 2021 Dec 22:S2213-8587(21)00296-5. :Pages:
Charité-based author(s): Strasburger CJ.
Authors:Sutharsan S et al.
Title:Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial.

Journal:Lancet Respir Med. 2021 Dec 20:S2213-2600(21)00454-9. :Pages:
Charité-based author(s): Mall MA.
Authors:Butler J et al.
Title:Effect of empagliflozin in patients with heart failure across the spectrum of left ventricular ejection fraction.

Journal:Eur Heart J. 2021 Dec 8:ehab798. :Pages:
Charité-based author(s): Anker SD.
Authors:Demir M et al.
Title:The fecal mycobiome in non-alcoholic fatty liver disease.

Journal:J Hepatol. 2021 Dec 10:S0168-8278(21)02238-8. :Pages:
Charité-based author(s): Demir M, Roderburg C, Tacke F.
Authors:Arends CM et al.
Title:Clonal hematopoiesis associates with improved survival in metastatic colorectal cancer patients from the FIRE-3 trial.

Journal:Blood. 2021 Dec 21:blood.2021014108. :Pages:
Charité-based author(s): Arends CM, Stahler A, Hablesreiter R, Strzelecka PM, Stein CM, Tilgner M, Bullinger L, Modest DP, Stintzing S, Damm F.
Authors:Graeber SY et al.
Title:Effects of Elexacaftor/Tezacaftor/Ivacaftor Therapy on CFTR Function in Patients with Cystic Fibrosis and One or Two F508del Alleles.

Journal:Am J Respir Crit Care Med. 2021 Dec 22. doi: 10.1164/rccm.202110-2249OC. :Pages:
Charité-based author(s): Graeber SY, Vitzthum C, Stahl M, Rohrbach A, Drescher M, Mall MA.
Authors:Radke MH et al.
Title:Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.

Journal:Sci Transl Med. 2021 Dec;13(622):eabe8952. :Pages:
Charité-based author(s): Parakkat P, Carballo JL, Gotthardt M.
Authors:Altrichter S et al.
Title:An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria.

Journal:J Allergy Clin Immunol. 2021 Dec 23:S0091-6749(21)02682-8. :Pages:
Charité-based author(s): Altrichter S, Siebenhaar F, Maurer M.

November 2021

Authors:Pieske B et al.
Title:Effect of Sacubitril/Valsartan vs Standard Medical Therapies on Plasma NT-proBNP Concentration and Submaximal Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction: The PARALLAX Randomized Clinical Trial.

Journal:JAMA. 2021 Nov 16;326(19):1919-1929. :Pages:
Charité-based author(s): Pieske B.
Authors:Lam BYH et al.
Title:MC3R links nutritional state to childhood growth and the timing of puberty.

Journal:Nature. 2021 Nov;599(7885):436-441. :Pages:
Charité-based author(s): Langenberg C.
Authors:Metz M et al.
Title:Fenebrutinib in H₁ antihistamine-refractory chronic spontaneous urticaria: a randomized phase 2 trial.

Journal:Nat Med. 2021 Nov;27(11):1961-1969. :Pages:
Charité-based author(s): Metz M, Maurer M.
Authors:Fischer M et al.
Title:Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study.

Journal:Lancet Oncol. 2021 Dec;22(12):1764-1776. :Pages:
Charité-based author(s): Schulte JH.
Authors:Butler J et al.
Title:Empagliflozin, Health Status, and Quality of Life in Patients with Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial.

Journal:Circulation. 2021 Nov 15. doi: 10.1161/CIRCULATIONAHA.121.057812. :Pages:
Charité-based author(s): Anker SD.
Authors:Berndt N et al.
Title:CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases.

Journal:Circulation. 2021 Nov 11. doi: 10.1161/CIRCULATIONAHA.121.055646. :Pages:
Charité-based author(s): Berndt N, Eckstein J, Wallach I, Nordmeyer S, Kelm M, Goubergrits L, Schafstedde M, Hennemuth A, Kuehne T, Holzhütter HG.
Authors:Triana S et al.
Title:Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states.

Journal:Nat Immunol. 2021 Dec;22(12):1577-1589. :Pages:
Charité-based author(s): Jopp-Saile L, Haas S.
Authors:Pietzner M et al.
Title:Synergistic insights into human health from aptamer- and antibody-based proteomic profiling.

Journal:Nat Commun. 2021 Nov 24;12(1):6822. :Pages:
Charité-based author(s): Pietzner M, Langenberg C.
Authors:Schmelz K et al.
Title:Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.

Journal:Nat Commun. 2021 Nov 23;12(1):6804. :Pages:
Charité-based author(s): Schmelz K, Toedling J, Cwikla MC, Kruetzfeldt LM, Proba J, Boral S, Lodrini M, Chen CY, Szymansky A, Astrahantseff K, Kuenkele A, Haase K, Deubzer HE, Hertwig F, Hundsdoerfer P, Henssen AG, Schulte JH, Eggert A.
Authors:Hey J et al.
Title:Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease.

Journal:Nat Commun. 2021 Nov 11;12(1):6520. :Pages:
Charité-based author(s): Mall MA.
Authors:Nabi D et al.
Title:CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes.

Journal:Nat Commun. 2021 Nov 11;12(1):6547. :Pages:
Charité-based author(s): Nabi D.

October 2021

Authors:Witkowski M et al.
Title:Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.

Journal:Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. :Pages:
Charité-based author(s): Witkowski M, Tizian C, Niemeyer D, Jones TC, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, Mc Ewen S, Zocche S, Viviano E, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Diefenbach A.
Authors:Pietzner M et al.
Title:Mapping the proteo-genomic convergence of human diseases.

Journal:Science. 2021 Oct 14:eabj1541. :Pages:
Charité-based author(s): Pietzner M, Langenberg C.
Authors:Tober-Lau P et al.
Title:Long-term immunogenicity of BNT162b2 vaccination in older people and younger health-care workers.

Journal:Lancet Respir Med. 2021 Nov;9(11):e104-e105. :Pages:
Charité-based author(s): Tober-Lau P, Schwarz T, Hillus D, Suttorp N, Kappert K, Seybold J, Drosten C, Kurth F, Sander LE, Corman VM.
Authors:Haghikia A et al.
Title:Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.

Journal:Eur Heart J. 2021 Oct 1:ehab644. :Pages:
Charité-based author(s): Haghikia A, Zimmermann F, Schumann P, Jasina A, Roessler J, Schmidt D, Heinze P, Nageswaran V, Aigner A, Cineus R, Hegazy AN, Kränkel N, Leistner DM, Heimesaat MM, Bereswill S, Rauch G, Seeland U, Müller DN, Landmesser U.
Authors:Dahlmann M et al.
Title:Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models.

Journal:Mol Cancer. 2021 Oct 21;20(1):129. :Pages:
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Title:Genetic and epigenetic characterization of posterior pituitary tumors.

Journal:Acta Neuropathol. 2021 Dec;142(6):1025-1043. :Pages:
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Title:Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy.

Journal:Nat Commun. 2021 Oct 5;12(1):5826. :Pages:
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Title:Conversion from Calcineurin Inhibitor to Belatacept-based Maintenance Immunosuppression in Renal Transplant Recipients: a Randomized Phase 3b Trial.

Journal:J Am Soc Nephrol. 2021 Oct 27:ASN.2021050628. :Pages:
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Title:B and T Cell Responses after a Third Dose of SARS-CoV-2 Vaccine in Kidney Transplant Recipients.

Journal:J Am Soc Nephrol. 2021 Oct 19:ASN.2021070966. :Pages:
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Title:Long-Term Cognitive Outcome in Anti-N-Methyl-D-Aspartate Receptor Encephalitis.

Journal:Ann Neurol. 2021 Sep 30. doi: 10.1002/ana.26241. :Pages:
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September 2021

Authors:Lee S et al.
Title:Virus-induced senescence is driver and therapeutic target in COVID-19.

Journal:Nature. 2021 Sep 13. doi: 10.1038/s41586-021-03995-1. :Pages:
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Title:Cross-reactive CD4⁺ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.

Journal:Science. 2021 Aug 31:eabh1823. :Pages:
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Title:Panitumumab Plus Fluorouracil and Folinic Acid Versus Fluorouracil and Folinic Acid Alone as Maintenance Therapy in RAS Wild-Type Metastatic Colorectal Cancer: The Randomized PANAMA Trial (AIO KRK 0212).

Journal:J Clin Oncol. 2021 Sep 17:JCO2101332. :Pages:
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Title:Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health records.

Journal:Lancet Diabetes Endocrinol. 2021 Oct;9(10):681-694. :Pages:
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Title:Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide.

Journal:Cell Res. 2021 Sep 24. doi: 10.1038/s41422-021-00569-8. :Pages:
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Title:Prospective, double-blind diagnostic multicentre study of confocal laser endomicroscopy for wheat sensitivity in patients with irritable bowel syndrome.

Journal:Gut. 2021 Sep 20:gutjnl-2021-325181. :Pages:
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Title:Time-resolved in vivo ubiquitinome profiling by DIA-MS reveals USP7 targets on a proteome-wide scale.

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Title:Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5.

Journal:Nat Commun. 2021 Sep 7;12(1):5324. :Pages:
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Title:Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures.

Journal:J Exp Med. 2021 Nov 1;218(11):e20210012. :Pages:
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Title:Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study.

Journal:Redox Biol. 2021 Sep 21;47:102145. :Pages:
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August 2021

Authors:Anker SD et al.
Title:EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction.

Journal:N Engl J Med. 2021 Aug 27. doi: 10.1056/NEJMoa2107038 :Pages:
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Title:Triple Therapy for Cystic Fibrosis Phe508del-Gating and -Residual Function Genotypes.

Journal:N Engl J Med. 2021 Aug 26;385(9):815-825 :Pages:
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Title:Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children.

Journal:Nat Biotechnol. 2021 Aug 18. doi: 10.1038/s41587-021-01037-9 :Pages:
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Title:The pediatric precision oncology INFORM registry: clinical outcome and benefit for patients with very high-evidence targets.

Journal:Cancer Discov. 2021 Aug 9:candisc.0094.2021 :Pages:
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Title:Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study.

Journal:Lancet Respir Med. 2021 Aug 12:S2213-2600(21)00357-X :Pages:
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Title:Effect of Empagliflozin on Worsening Heart Failure Events in Patients with Heart Failure and a Preserved Ejection Fraction: The EMPEROR-Preserved Trial.

Journal:Circulation. 2021 Aug 29. doi: 10.1161/CIRCULATIONAHA.121.056824 :Pages:
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Title:An in vitro platform supports generation of human innate lymphoid cells from CD34+ hematopoietic progenitors that recapitulate ex vivo identity.

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Title:Granulocyte-Colony Stimulating Factor (G-CSF) to treat acute-on-chronic liver failure, a multicenter randomized trial (GRAFT study).

Journal:J Hepatol. 2021 Aug 5:S0168-8278(21)01963-2 :Pages:
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Title:Efficacy and safety of inhaled ENaC inhibitor BI 1265162 in patients with cystic fibrosis: BALANCE-CF™ 1 - a randomised, Phase II study.

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Title:Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19.

Journal:Nat Commun. 2021 Aug 11;12(1):4869 :Pages:
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July 2021

Authors:Bartels F et al.
Title:Association Between Neuronal Autoantibodies and Cognitive Impairment in Patients With Lung Cancer.

Journal:JAMA Oncol. 2021 Jul 1:e212049. :Pages:
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Title:Magnetic Resonance Imaging Detects Progression of Lung Disease and Impact of Newborn Screening in Preschool Children with Cystic Fibrosis.

Journal:Am J Respir Crit Care Med. 2021 Jul 20. doi: 10.1164/rccm.202102-0278OC. :Pages:
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Title:High In-Hospital Mortality in COVID Patients Receiving ECMO in Germany - A Critical Analysis.

Journal:Am J Respir Crit Care Med. 2021 Jul 20. doi: 10.1164/rccm.202105-1145LE. :Pages:
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Title:Treatment of isolated REM-sleep behavior disorder using melatonin as a chronobiotic.

Journal:J Pineal Res. 2021 Jul 26:e12759. :Pages:
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Title:Disparities in Screening and Treatment of Cardiovascular Diseases in Patients With Mental Disorders Across the World: Systematic Review and Meta-Analysis of 47 Observational Studies.

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Title:Intercellular coupling between peripheral circadian oscillators by TGF-β signaling.

Journal:Sci Adv. 2021 Jul 23;7(30):eabg5174. :Pages:
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Title:Adhesion dynamics in the neocortex determine the start of migration and the post-migratory orientation of neurons.

Journal:Sci Adv. 2021 Jul 2;7(27):eabf1973. :Pages:
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Title:GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma.

Journal:J Immunother Cancer. 2021 Jul;9(7):e002923. :Pages:
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Title:Tolerance development in cow's milk-allergic infants receiving amino acid-based formula: A randomized controlled trial.

Journal:J Allergy Clin Immunol. 2021 Jul 2:S0091-6749(21)01053-8. :Pages:
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June 2021

Authors:von Schwartzenberg RJ et al.
Title:Caloric restriction disrupts the microbiota and colonization resistance.

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Title:Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells.

Journal:Nat Biotechnol. 2021 Jun 3. doi: 10.1038/s41587-021-00927-2. :Pages:
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Title:Dose-intensified Versus Conventional-dose Salvage Radiotherapy for Biochemically Recurrent Prostate Cancer After Prostatectomy: The SAKK 09/10 Randomized Phase 3 Trial.

Journal:Eur Urol. 2021 Jun 14:S0302-2838(21)01802-9. :Pages:
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Title:Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died.

Journal:JAMA Neurol. 2021 Jun 11. doi: 10.1001/jamaneurol.2021.2004. :Pages:
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Title:Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients.

Journal:Sci Immunol. 2021 Jun 15;6(60):eabj1031. :Pages:
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Title:SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.

Journal:Nat Commun. 2021 Jun 21;12(1):3818. :Pages:
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Authors:Gabriel CH et al.
Title:Live-cell imaging of circadian clock protein dynamics in CRISPR-generated knock-in cells.

Journal:Nat Commun. 2021 Jun 18;12(1):3796. :Pages:
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Title:Comprehensive micro-scaled proteome and phosphoproteome characterization of archived retrospective cancer repositories.

Journal:Nat Commun. 2021 Jun 11;12(1):3576. :Pages:
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May 2021

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Title:Estimating infectiousness throughout SARS-CoV-2 infection course.

Journal:Science. 2021 May 25:eabi5273. :Pages:
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Title:Efficacy and acceptability of pharmacological, psychosocial, and brain stimulation interventions in children and adolescents with mental disorders: an umbrella review.

Journal:World Psychiatry. 2021 Jun;20(2):244-275. :Pages:
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Authors:Haeusler KG et al.
Title:Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study.

Journal:Lancet Neurol. 2021 Jun;20(6):426-436. :Pages:
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Title:Finerenone Reduces Onset of Atrial Fibrillation in Patients with Chronic Kidney Disease and Type 2 Diabetes.

Journal:J Am Coll Cardiol. 2021 May 4:S0735-1097(21)04966-4. :Pages:
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Title:Standard versus reduced dose of antipsychotics for relapse prevention in multi-episode schizophrenia: a systematic review and meta-analysis of randomised controlled trials.

Journal:Lancet Psychiatry. 2021 Jun;8(6):471-486. :Pages:
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Title:Choose wisely: imaging for diagnosis of axial spondyloarthritis.

Journal:Ann Rheum Dis. 2021 May 28:annrheumdis-2021-220136. :Pages:
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Title:Fetal meconium does not have a detectable microbiota before birth.

Journal:Nat Microbiol. 2021 May 10. doi: 10.1038/s41564-021-00904-0. :Pages:
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Title:Association of a Marker of N-Acetylglucosamine With Progressive Multiple Sclerosis and Neurodegeneration.

Journal:JAMA Neurol. 2021 May 10:e211116. :Pages:
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Title:Cannabinoid receptor activation acutely increases synaptic vesicle numbers by activating synapsins in human synapses.

Journal:Mol Psychiatry. 2021 Apr 30. doi: 10.1038/s41380-021-01095-0. :Pages:
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Title:Role of angiopoietin-2 in venous thrombus resolution and chronic thromboembolic disease.

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April 2021

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Title:Safety and Efficacy of Vadadustat for Anemia in Patients Undergoing Dialysis.

Journal:N Engl J Med. 2021 Apr 29;384(17):1601-1612. :Pages:
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Title:Vadadustat in Patients with Anemia and Non-Dialysis-Dependent CKD.

Journal:N Engl J Med. 2021 Apr 29;384(17):1589-1600. :Pages:
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Journal:Nat Cell Biol. 2021 Apr;23(4):413-423. :Pages:
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Title:Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre-post studies.

Journal:Lancet Psychiatry. 2021 May;8(5):387-404. :Pages:
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Title:Systemic sclerosis-associated myositis features minimal inflammation and characteristic capillary pathology.

Journal:Acta Neuropathol. 2021 Apr 17. doi: 10.1007/s00401-021-02305-3. :Pages:
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Title:SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself.

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Title:Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients.

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Title:Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker.

Journal:Biol Psychiatry. 2021 Jan 30:S0006-3223(21)00078-0. :Pages:
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Title:VirtualTaste: a web server for the prediction of organoleptic properties of chemical compounds.

Journal:Nucleic Acids Res. 2021 Apr 27:gkab292. :Pages:
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Title:MutationTaster2021.

Journal:Nucleic Acids Res. 2021 Apr 24:gkab266. :Pages:
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March 2021

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Title:Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.

Journal:JAMA. 2021 Mar 2;325(9):843-854. :Pages:
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Title:Ultra-fast proteomics with Scanning SWATH.

Journal:Nat Biotechnol. 2021 Mar 25. doi: 10.1038/s41587-021-00860-4. :Pages:
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Title:Cetuximab, docetaxel, and cisplatin versus platinum, fluorouracil, and cetuximab as first-line treatment in patients with recurrent or metastatic head and neck squamous-cell carcinoma (GORTEC 2014-01 TPExtreme): a multicentre, open-label, randomised, phase 2 trial.

Journal:Lancet Oncol. 2021 Apr;22(4):463-475. :Pages:
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Title:Association Between Cardiovascular Risk Factors and Cognitive Impairment in People With Schizophrenia: A Systematic Review and Meta-analysis.

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Title:TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma.

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Title:Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.

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Title:Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking.

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Authors:Brisson NM et al.
Title:Association of machine learning based predictions of medial knee contact force with cartilage loss over 2.5 years in knee osteoarthritis.

Journal:Arthritis Rheumatol. 2021 Mar 24. doi: 10.1002/art.41735. :Pages:
Charité-based author(s): Brisson NM, Damm P, Duda GN.
Authors:Rasche A et al.
Title:A hepatitis B virus causes chronic infections in equids worldwide.

Journal:Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2013982118. :Pages:
Charité-based author(s): Rasche A, Goldmann N, Moreira-Soto A, de Oliveira Carneiro I, Drexler JF.
Authors:Waterstraat G et al.
Title:Noninvasive neuromagnetic single-trial analysis of human neocortical population spikes.

Journal:Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2017401118. :Pages:
Charité-based author(s): Waterstraat G, Curio G.

Febuary 2021

Authors:Ebinger M et al.
Title:Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin.

Journal:JAMA. 2021 Feb 2;325(5):454-466. :Pages:
Charité-based author(s):Ebinger M, Siegerink B, Kunz A, Weber JE, Geisler F, Freitag E, Lange J, Behrens J, Erdur H, Ganeshan R, Liman T, Scheitz JF, Schlemm L, Harmel P, Lorenz-Meyer I, Napierkowski I, Waldschmidt C, Nolte CH, Grittner U, Wiener E, Bohner G, Rohmann JL, Endres M, Audebert HJ.
Authors:Allou L et al.
Title:Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator.

Journal:Nature. 2021 Feb 10. doi: 10.1038/s41586-021-03208-9. :Pages:
Charité-based author(s): Allou L, Magg A, Schöpflin R, Chan WL, Spielmann M, Cova G, Mundlos S.
Authors:Schmalbrock LK et al.
Title:Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.

Journal:Blood. 2021 Feb 17:blood.2020007626. :Pages:
Charité-based author(s): Dolnik A, Sträng E, Bullinger L.
Authors:Nikolay R et al.
Title:Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization.

Journal:Mol Cell. 2021 Feb 23:S1097-2765(21)00092-7. :Pages:
Charité-based author(s): Nikolay R, Hilal T, Qin B, Schwefel D, Bürger J, Loerke J, Flügel T, Selbach M, Spahn CMT.
Authors:Salomon JJ et al.
Title:Chronic Rhinosinusitis with Nasal Polyps is Associated with Impaired TMEM16A-mediated Epithelial Chloride Secretion.

Journal:J Allergy Clin Immunol. 2021 Feb 17:S0091-6749(21)00224-4. :Pages:
Charité-based author(s): Graeber SY, Mall MA.
Authors:Agostini F et al.
Title:Multiomics Analysis Provides Insight into the Laboratory Evolution of Escherichia coli toward the Metabolic Usage of Fluorinated Indoles.

Journal:ACS Cent Sci. 2021 Jan 27;7(1):81-92. :Pages:
Charité-based author(s): Agostini F.
Authors:Mencacci NE et al.
Title:Bi-allelic variants in TSPOAP1, encoding the active zone protein RIMBP1, cause autosomal recessive dystonia.

Journal:J Clin Invest. 2021 Feb 4:140625. :Pages:
Charité-based author(s): Brockmann MM, Rosenmund C.
Authors:Dong P et al.
Title:A Dual Fluorescence-Spin Label Probe for Visualization and Quantification of Target Molecules in Tissue by Multiplexed FLIM - EPR Spectroscopy.

Journal:Angew Chem Int Ed Engl. 2021 Feb 5. doi: 10.1002/anie.202012852. :Pages:
Charité-based author(s): Dong P, Lohan SB, Patzelt A, Meinke MC.
Authors:Iftekhar A et al.
Title:Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells.

Journal:Nat Commun. 2021 Feb 12;12(1):1003. :Pages:
Charité-based author(s): Berger H, Heuberger J, Sigal M.
Authors:Niehus S et al.
Title:PopDel identifies medium-size deletions simultaneously in tens of thousands of genomes.

Journal:Nat Commun. 2021 Feb 1;12(1):730. :Pages:
Charité-based author(s): Niehus S, Sulem P, Kehr B.

January 2021

Authors:Lotta LA et al.
Title:A cross-platform approach identifies genetic regulators of human metabolism and health.

Journal:Nat Genet. 2021 Jan;53(1):54-64. :Pages:
Charité-based author(s): Langenberg C.
Authors:Vollmer T et al.
Title:The intratumoral CXCR3 chemokine system is predictive of chemotherapy response in human bladder cancer.

Journal:Sci Transl Med. 2021 Jan 13;13(576):eabb3735. :Pages:
Charité-based author(s): Vollmer T, Schlickeiser S, Amini L, Schulenberg S, Wendering DJ, Jurisch A, Noster R, Kunkel D, Brindle NR, Savidis I, Akyüz L, Roch T, Babel N, Reinke P, Volk HD, Schmueck-Henneresse M.
Authors:Westhovens R et al.
Title:Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial.

Journal:Ann Rheum Dis. 2021 Jan 15:annrheumdis-2020-219213. :Pages:
Charité-based author(s): Burmester GR .
Authors:Deshpande D et al.
Title:Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.

Journal:Nat Commun. 2021 Jan 18;12(1):426. :Pages:
Charité-based author(s): Deshpande D, Klose CSN.
Authors:Rodríguez de Los Santos M et al.
Title:A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions.

Journal:Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2014481118. :Pages:
Charité-based author(s): Rodríguez de Los Santos M, Rivalan M, Stumpf A, Velasquez LM, Voigt A, Long M, Vogt G, Fischer-Zirnsak B, Horn D, Mundlos S, Kornak U, Schmitz D, Winter Y.
Authors:Horn D et al.
Title:Biallelic truncating variants in MAPKAPK5 cause a new developmental disorder involving neurological, cardiac, and facial anomalies combined with synpolydactyly.

Journal:Genet Med. 2021 Jan 13. doi: 10.1038/s41436-020-01052-2. :Pages:
Charité-based author(s): Horn D, Schwartzmann S, Ehmke N, Boschann F.
Authors:Cheret C et al.
Title:Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels.

Journal:Cell Rep. 2021 Jan 12;34(2):108623. :Pages:
Charité-based author(s): Cheret C, Ahnert-Hilger G.
Authors:Lipp T et al.
Title:Heterogeneity of Pollen Food Allergy Syndrome in Seven Southern European Countries: the @IT.2020 Multicenter Study.

Journal:Allergy. 2021 Jan 25. doi: 10.1111/all.14742. :Pages:
Charité-based author(s): Lipp T, Hoffmann TM, Potapova E, Matricardi PM, Dramburg S.
Authors:Simsek C et al.
Title:At Least Seven Distinct Rotavirus Genotype Constellations in Bats with Evidence of Reassortment and Zoonotic Transmissions.

Journal:mBio. 2021 Jan 19;12(1):e02755-20. :Pages:
Charité-based author(s): Corman VM, Rasche A, Drosten C, Drexler JF, Matthijnssens J.
Authors:Wolk K et al.
Title:Activity and components of the G-CSF pathway in hidradenitis suppurativa.

Journal:Br J Dermatol. 2021 Jan 5. doi: 10.1111/bjd.19795. :Pages:
Charité-based author(s): Wolk K, Brembach TC, Cucinotta S, Pokrywka A, Irmer ML, Triebus J, Witte-Händel E, Volk HD, Ghoreschi K, Sabat R.

Publications 2020

December 2020

Authors:Veenvliet JV et al.
Title:Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites.

Journal:Science. 2020 Dec 11;370(6522):eaba4937. :Pages:
Charité-based author(s): Herrmann BG.
Authors:Trump S et al.
Title:Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.

Journal:Nat Biotechnol. 2020 Dec 24. doi: 10.1038/s41587-020-00796-1. :Pages:
Charité-based author(s): Trump S, Lukassen S, Anker MS, Chua RL, Liebig J, Thürmann L, Corman VM, Loske J, Krieger T, Hennig BP, Messingschlager M, Pott F, Kazmierski J, Twardziok S, Albrecht JP, Eils J, Hadzibegovic S, Lena A, Heidecker B, Bürgel T, Steinfeldt J, Goffinet C, Kurth F, Witzenrath M, Ishaque N, Sander LE, Drosten C, Eils R, Conrad C, Landmesser U, Lehmann I.
Authors:Abraham WT et al.
Title:Effect of empagliflozin on exercise ability and symptoms in heart failure patients with reduced and preserved ejection fraction, with and without type 2 diabetes.

Journal:Eur Heart J. 2020 Dec 22:ehaa943. :Pages:
Charité-based author(s): Anker SD.
Authors:Meinhardt J et al.
Title:Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.

Journal:Nat Neurosci. 2020 Nov 30. doi: 10.1038/s41593-020-00758-5. :Pages:
Charité-based author(s): Meinhardt J, Radke J, Dittmayer C, Mothes R, Schneider J, Brünink S, Greuel S, Lehmann M, Hassan O, Aschman T, Schumann E, Chua RL, Conrad C, Eils R, Stenzel W, Windgassen M, Rößler L, Goebel HH, Martin H, Scheibe F, Körtvélyessy P, Siegmund B, Kühl AA, Elezkurtaj S, Horst D, Oesterhelweg L, Tsokos M, Drosten C, Corman VM, Radbruch H, Heppner FL.
Authors:Kraushar ML et al.
Title:Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit.

Journal:Mol Cell. 2020 Dec 17:S1097-2765(20)30837-6. :Pages:
Charité-based author(s): Kraushar ML, Krupp F, Turko P, Ambrozkiewicz MC, Sprink T, Schaub T, Münster-Wandowski A, Bürger J, Yamamoto H, Tarabykin V, Vida I, Spahn CMT.
Authors:Piepoli MF et al.
Title:OUTSTEP-HF: randomised controlled trial comparing short-term effects of sacubitril/valsartan versus enalapril on daily physical activity in patients with chronic heart failure with reduced ejection fraction.

Journal:Eur J Heart Fail. 2020 Dec 13. doi: 10.1002/ejhf.2076. :Pages:
Charité-based author(s): Edelmann F.
Authors:Anker SD et al.
Title:Baseline Characteristics of Patients with Heart Failure with Preserved Ejection Fraction in the EMPEROR-Preserved Trial.

Journal:Eur J Heart Fail. 2020 Nov 29. doi: 10.1002/ejhf.2064. :Pages:
Charité-based author(s): Anker SD.
Authors:Grinat J et al.
Title:The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness.

Journal:Nat Commun. 2020 Dec 21;11(1):6422. :Pages:
Charité-based author(s): Heuberger J.
Authors:Pietzner M et al.
Title:Genetic architecture of host proteins involved in SARS-CoV-2 infection.

Journal:Nat Commun. 2020 Dec 16;11(1):6397. :Pages:
Charité-based author(s): Ralser M, Langenberg C.
Authors:Loyal L et al.
Title:SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8+ T cells.

Journal:Nat Commun. 2020 Dec 11;11(1):6357. :Pages:
Charité-based author(s): Loyal L, Warth S, Jürchott K, Nikolaou C, Nienen M, Durlanik S, Kruse B, Frentsch M, Sabat R, Wolk K, Thiel A.

November 2020

Authors:Clément K et al.
Title:Setmelanotide POMC and LEPR Phase 3 Trial Investigators. Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials.

Journal:Lancet Diabetes Endocrinol. 2020 Dec;8(12):960-970. :Pages:
Charité-based author(s): Puder L, Kühnen P.
Authors:Anker SD et al.
Title:EMPEROR-Reduced Trial Committees and Investigators. Effect of Empagliflozin on Cardiovascular and Renal Outcomes in Patients With Heart Failure by Baseline Diabetes Status - Results from the EMPEROR-Reduced Trial.

Journal:Circulation. 2020 Nov 11. doi: 10.1161/CIRCULATIONAHA.120.051824. :Pages:
Charité-based author(s): Anker SD.
Authors:Guendel F et al.
Title:Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues.

Journal:Immunity. 2020 Nov 17;53(5):1015-1032.e8. :Pages:
Charité-based author(s): Guendel F, Kofoed-Branzk M, Gronke K, Tizian C, Witkowski M, Brachs S, Mashreghi MF, Diefenbach A.
Authors:Tosti L et al.
Title:Single nucleus and in situ RNA sequencing reveals cell topographies in the human pancreas.

Journal:Gastroenterology. 2020 Nov 16:S0016-5085(20)35399-3. :Pages:
Charité-based author(s): Tosti L, Debnath O, Tiesmeyer S, Trefzer T, Ten FW, Lukassen S, Kühl AA, Spieckermann S, Ishaque N, Eils R, Conrad C.
Authors:McVey MJ et al.
Title:Platelet Extracellular Vesicles mediate Transfusion-related Acute Lung Injury by imbalancing the Sphingolipid Rheostat.

Journal:Blood. 2020 Nov 24:blood.2020005985. :Pages:
Charité-based author(s): Weidenfeld S, Tabuchi A, Simmons S, Kuebler W.
Authors:Reimann M et al.
Title:Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas.

Journal:Blood. 2020 Nov 24:blood.2020005244. :Pages:
Charité-based author(s): Reimann M, Schrezenmeier JF, Richter-Pechanska P, Dolnik A, Hick TP, Schleich K, Cai X, Fan DNY, Masswig S, Denker S, Busse A, Gätjens-Sanchez AM, Bullinger L.
Authors:Dejaco C et al.
Title:Influence of COVID-19 pandemic on decisions for the management of people with inflammatory rheumatic and musculoskeletal diseases: a survey among EULAR countries.

Journal:Ann Rheum Dis. 2020 Nov 6:annrheumdis-2020-218697. :Pages:
Charité-based author(s): Buttgereit F.
Authors:Holstein J et al.
Title:Immunophenotyping in pemphigus reveals a Th17/Tfh17-dominated immune response promoting desmoglein1/3-specific autoantibody production.

Journal:J Allergy Clin Immunol. 2020 Nov 19:S0091-6749(20)31624-9. :Pages:
Charité-based author(s): Solimani F, Meier K, Ghoreschi K.
Authors:Anker MS et al.
Title:Ventricular tachycardia, premature ventricular contractions, and mortality in unselected patients with lung, colon, or pancreatic cancer: a prospective study.

Journal:Eur J Heart Fail. 2020 Nov 22. doi: 10.1002/ejhf.2059. :Pages:
Charité-based author(s): Anker MS, Riess H, Eucker J, Haverkamp W, Landmesser U, Anker SD.
Authors:Lebenheim L et al.
Title:A novel giant non-cholinergic striatal interneuron restricted to the ventrolateral striatum coexpresses Kv3.3 potassium channel, parvalbumin, and the vesicular GABA transporter.

Journal:Mol Psychiatry. 2020 Nov 14. doi: 10.1038/s41380-020-00948-4. :Pages:
Charité-based author(s): Lebenheim L, Booker SA, Derst C, Weiss T, Wagner F, Gruber C, Vida I, Veh RW.

October 2020

Authors:M Real F et al.
Title:The mole genome reveals regulatory rearrangements associated with adaptive intersexuality.

Journal:Science. 2020 Oct 9;370(6513):208-214. :Pages:
Charité-based author(s): M Real F, Schöpflin R, Schindler M, Mundlos S, Lupiáñez DG.
Authors:Kreye J et al.
Title:A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model.

Journal:Cell. 2020 Sep 23:S0092-8674(20)31246-0. :Pages:
Charité-based author(s): Kreye J, Reincke SM, Kornau HC, Sánchez-Sendin E, Corman VM, Höltje M, Stöffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Müller MA, Drosten C, Wendisch D, Sander LE, Prüss H.
Authors:Roemhild A et al.
Title:Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial.

Journal:BMJ. 2020 Oct 21;371:m3734. :Pages:
Charité-based author(s): Roemhild A, Otto NM, Moll G, Abou-El-Enein M, Kaiser D, Bold G, Schachtner T, Choi M, Oellinger R, Landwehr-Kenzel S, Juerchott K, Sawitzki B, Giesler C, Sefrin A, Beier C, Wagner DL, Schlickeiser S, Streitz M, Schmueck-Henneresse M, Amini L, Babel N, Volk HD, Reinke P.
Authors:Leistner DM et al.
Title:Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study.

Journal:Eur Heart J. 2020 Oct 1;41(37):3549-3560. :Pages:
Charité-based author(s): Leistner DM, Kränkel N, Meteva D, Abdelwahed YS, Seppelt C, Stähli BE, Skurk C, Lauten A, Mochmann HC, Fröhlich G, Rauch-Kröhnert U, Flores E, Riedel M, Sieronski L, Kia S, Strässler E, Haghikia A, Dirks F, Steiner JK, Mueller DN, Volk HD, Klotsche J, Landmesser U.
Authors:Fujikura K et al.
Title:Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions.

Journal:Gut. 2020 Oct 7:gutjnl-2020-321217. :Pages:
Charité-based author(s): Felsenstein M.
Authors:Schoon J et al.
Title:Metal-Specific Biomaterial Accumulation in Human Peri-Implant Bone and Bone Marrow.

Journal:Adv Sci (Weinh). 2020 Aug 3;7(20):2000412. :Pages:
Charité-based author(s): Schoon J, Rakow A, Ort MJ, Jacobi D, Reinke S, Perka C, Duda GN, Geissler S.
Authors:Cohen SB et al.
Title:Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme.

Journal:Ann Rheum Dis. 2020 Oct 28:annrheumdis-2020-218510. :Pages:
Charité-based author(s): Burmester GR.
Authors:Zuraw B et al.
Title:Oral once-daily berotralstat for the prevention of hereditary angioedema attacks: a randomized, double-blind, placebo-controlled phase 3 trial.

Journal:J Allergy Clin Immunol. 2020 Oct 21:S0091-6749(20)31484-6. :Pages:
Charité-based author(s): Maurer M.
Authors:Koehler J et al.
Title:Telemonitoring in patients with chronic heart failure and moderate depressed symptoms: results of the Telemedical Interventional Monitoring in Heart Failure (TIM-HF) study.

Journal:Eur J Heart Fail. 2020 Oct 15. doi: 10.1002/ejhf.2025. :Pages:
Charité-based author(s): Koehler J, Stengel A, Hofmann T, Koehler K, Rose M, Deckwart O, Anker SD, Koehler F.
Authors:Ballhausen A et al.
Title:Phase I study of everolimus, letrozole, and trastuzumab in patients with hormone receptor-positive metastatic breast cancer or other solid tumors.

Journal:Clin Cancer Res. 2020 Oct 28:clincanres.2878.2020. :Pages:
Charité-based author(s): Ballhausen A.

September 2020

Authors:Ostendorf L et al.
Title:Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus.

Journal:N Engl J Med. 2020 Sep 17;383(12):1149-1155. :Pages:
Charité-based author(s): Ostendorf L, Burns M, Durek P, Heinz GA, Heinrich F, Garantziotis P, Enghard P, Richter U, Biesen R, Schneider U, Knebel F, Burmester G, Radbruch A, Mei HE, Mashreghi MF, Hiepe F, Alexander T.
Authors:Schweizer L et al.
Title:Molecular characterization of CNS paragangliomas identifies cauda equina paragangliomas as a distinct tumor entity.

Journal:Acta Neuropathol. 2020 Sep 14. doi: 10.1007/s00401-020-02218-7. :Pages:
Charité-based author(s): Schweizer L, Thierfelder F, Wessels L, Misch M, Kim HY, Jödicke R, Teichmann D, Kaul D, Kahn J, Bockmayr M, Vajkoczy P, Heppner FL, Capper D, Schöler A, Koch A.
Authors:Verner G et al.
Title:Maternal Psychological Resilience During Pregnancy and Newborn Telomere Length: A Prospective Study.

Journal:Am J Psychiatry. 2020 Sep 11:appiajp202019101003. :Pages:
Charité-based author(s): Verner G, Buss C, Entringer S.
Authors:Bogdanow B et al.
Title:Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis.

Journal:Nat Commun. 2020 Sep 24;11(1):4845. :Pages:
Charité-based author(s): Schmidt M, Weisbach H, Gruska I, Vetter B, Selbach M, Hagemeier C, Wiebusch L.
Authors:Amini L et al.
Title:CRISPR-Cas9-Edited Tacrolimus-Resistant Antiviral T Cells for Advanced Adoptive Immunotherapy in Transplant Recipients.

Journal:Mol Ther. 2020 Sep 8:S1525-0016(20)30468-8. :Pages:
Charité-based author(s): Amini L, Wagner DL, Rössler U, Zarrinrad G, Wagner LF, Vollmer T, Wendering DJ, Kornak U, Volk HD, Reinke P, Schmueck-Henneresse M.
Authors:Klotz-Noack K et al.
Title:SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells.

Journal:Cell Rep. 2020 Sep 22;32(12):108184. :Pages:
Charité-based author(s):Klotz-Noack K, Klinger B, Bublitz N, Uhlitz F, Riemer P, Lüthen M, Sell T, Kasack K, Gastl B, Ispasanie SSS, Simon T, Horst D, Blüthgen N, Schäfer R, Morkel M, Sers C.
Authors:Wang Y et al.
Title:Selenium deficiency is linearly associated with hypoglycemia in healthy adults.

Journal:Redox Biol. 2020 Sep 1;37:101709. :Pages:
Charité-based author(s): Rijntjes E, Schomburg L.
Authors:Knaak C et al.
Title:Treatment and Mortality of Hemophagocytic Lymphohistiocytosis in Adult Critically Ill Patients: A Systematic Review With Pooled Analysis.

Journal:Crit Care Med. 2020 Nov;48(11):e1137-e1146. :Pages:
Charité-based author(s) Knaak C, Schuster FS, Nyvlt P, Spies C, Keh D, Lachmann G.
Authors:Puthucheary ZA et al.
Title:Implications for post critical illness trial design: sub-phenotyping trajectories of functional recovery among sepsis survivors.

Journal:Crit Care. 2020 Sep 25;24(1):577. :Pages:
Charité-based author(s): Heintze C, Neumann K, Wollersheim T, Schmidt KFR.
Authors:Scholz J et al.
Title:Vitamin A controls the allergic response through T follicular helper cell as well as plasmablast differentiation.

Journal:Allergy. 2020 Sep 7. doi: 10.1111/all.14581. :Pages:
Charité-based author(s): Scholz J, Worm M, Heine G.

August 2020

Authors:Sadik A et al.
Title:IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.

Journal:Cell. 2020 Sep 3;182(5):1252-1270.e34. :Pages:
Charité-based author(s): Ishaque N, Trump S.
Authors:Schulte-Schrepping J et al.
Title:Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.

Journal:Cell. 2020 Aug 5:S0092-8674(20)30992-2. :Pages:
Charité-based author(s): Paclik D, Schlickeiser S, Brumhard S, Wendisch D, Conrad C, Kunkel D, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Meisel C, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Sawitzki B, Sander LE.
Authors:Grünwald V et al.
Title:Randomized Comparison of Pazopanib and Doxorubicin as First-Line Treatment in Patients With Metastatic Soft Tissue Sarcoma Age 60 Years or Older: Results of a German Intergroup Study.

Journal:J Clin Oncol. 2020 Aug 24:JCO2000714. :Pages:
Charité-based author(s): Kunitz A.
Authors:Kresoja KP et al.
Title:Transcatheter tricuspid valve repair in the setting of heart failure with preserved or reduced left ventricular ejection fraction.

Journal:Eur J Heart Fail. 2020 Aug 2. doi: 10.1002/ejhf.1975. :Pages:
Charité-based author(s): Lauten A, Alushi B, Stangl K, Landmesser U.
Authors:Correll CU et al.
Title:Effects of Olanzapine Combined With Samidorphan on Weight Gain in Schizophrenia: A 24-Week Phase 3 Study.

Journal:Am J Psychiatry. 2020 Aug 14:appiajp202019121279. :Pages:
Charité-based author(s): Correll CU.
Authors:Sattler A et al.
Title:SARS-CoV-2 specific T-cell responses and correlations with COVID-19 patient predisposition.

Journal:J Clin Invest. 2020 Aug 24:140965. :Pages:
Charité-based author(s): Sattler A, Angermair S, Stockmann H, Heim KM, Khadzhynov D, Treskatsch S, Halleck F, Kreis ME, Kotsch K.
Authors:Erfinanda L et al.
Title:Estrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation.

Journal:Eur Respir J. 2020 Aug 6:2000921. :Pages:
Charité-based author(s): Erfinanda L, Kohse F, Gallo K, Preissner R, Kuebler WM.
Authors:von Haehling S et al.
Title:Muscle wasting as an independent predictor of survival in patients with chronic heart failure.

Journal:J Cachexia Sarcopenia Muscle. 2020 Aug 6. doi: 10.1002/jcsm.12603. :Pages:
Charité-based author(s): Anker MS, Doehner W, Anker SD.
Authors:Daneshgar A et al.
Title:The human liver matrisome - Proteomic analysis of native and fibrotic human liver extracellular matrices for organ engineering approaches.

Journal:Biomaterials. 2020 Oct;257:120247. :Pages:
Charité-based author(s): Daneshgar A, Tang P, Arnold A, Pohl J, Moosburner S, Raschzok N, Bahra M, Pratschke J, Sauer IM, Hillebrandt KH.
Authors:Krenzien F et al.
Title:The ILLS Laparoscopic Liver Surgery Fellow Skills Curriculum.

Journal:Ann Surg. 2020 Aug 21. doi: 10.1097/SLA.0000000000004175. :Pages:
Charité-based author(s): Krenzien F, Schöning W, Brunnbauer P, Benzing C, Öllinger R, Biebl M, Bahra M, Raschzok N, Schmelzle M, Pratschke J.

July 2020

Authors:Burmester GR et al.
Title:Continuing versus tapering glucocorticoids after achievement of low disease activity or remission in rheumatoid arthritis (SEMIRA): a double-blind, multicentre, randomised controlled trial.

Journal:Lancet. 2020 Jul 25;396(10246):267-276. :Pages:
Charité-based author(s): Burmester GR, Buttgereit F.
Authors:Braun J et al.
Title:SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19.

Journal:Nature. 2020 Jul 29. doi: 10.1038/s41586-020-2598-9. :Pages:
Charité-based author(s): Braun J, Loyal L, Frentsch M, Wendisch D, Georg P, Kurth F, Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Drosten C, Corman VM, Sander LE, Thiel A.
Authors:Mühlemann B at al.
Title:Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age.

Journal:Science. 2020 Jul 24;369(6502):eaaw8977. :Pages:
Charité-based author(s): Mühlemann B, Drosten C, Jones TC.
Authors:Lang S et al.
Title:Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease.

Journal:Gastroenterology. 2020 Jul 8:S0016-5085(20)34923-4. :Pages:
Charité-based author(s): Demir M, Roderburg C, Tacke F.
Authors:Fan Y et al.
Title:TWIST1 Drives Smooth Muscle Cell Proliferation in Pulmonary Hypertension via Loss of GATA-6 and BMPR2.

Journal:Am J Respir Crit Care Med. 2020 Jul 21. doi: 10.1164/rccm.201909-1884OC. :Pages:
Charité-based author(s): Solymosi P, Kuebler WM.
Authors:Graeber SY et al.
Title:Comparison of Organoid Swelling and in vivo Biomarkers of CFTR Function to Determine Effects of Lumacaftor-ivacaftor in Patients with Cystic Fibrosis Homozygous for the F508del Mutation.

Journal:Am J Respir Crit Care Med. 2020 Jul 20. doi: 10.1164/rccm.202004-1200LE. :Pages:
Charité-based author(s): Graeber SY, Mall MA.
Authors:Papadopoulos IN et al.
Title:Dynamic conjugate F-SHARP microscopy.

Journal:Light Sci Appl. 2020 Jun 30;9:110. :Pages:
Charité-based author(s): Papadopoulos IN, Judkewitz B.
Authors:Endisch C et al.
Title:Hypoxic-Ischemic Encephalopathy Evaluated by Brain Autopsy and Neuroprognostication After Cardiac Arrest.

Journal:JAMA Neurol. 2020 Jul 20:e202340. :Pages:
Charité-based author(s): Endisch C, Kenda M, Streitberger KJ, Stenzel W, Storm C, Ploner CJ, Leithner C.
Authors:Schleich K et al.
Title:H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients.

Journal:Nat Commun. 2020 Jul 20;11(1):3651. :Pages:
Charité-based author(s): Schleich K, Kase J, Dörr JR, Bhattacharya A, Wailes EM, Fan DNY, Milanovic M, Lau A, Lenze D, Hummel M, Reimann M, Lee S, Schmitt CA.
Authors:Li N et al.
Title:A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder.

Journal:Nat Commun. 2020 Jul 3;11(1):3364. :Pages:
Charité-based author(s): Li N, Al-Fatly B, Kühn AA, Horn A.

June 2020

Authors:Kurth T et al.
Title:Association of Migraine With Aura and Other Risk Factors With Incident Cardiovascular Disease in Women.

Journal:JAMA. 2020 Jun 9;323(22):2281-2289. :Pages:
Charité-based author(s): Kurth T.
Authors:Chua RL et al.
Title:COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.

Journal:Nat Biotechnol. 2020 Jun 26. doi: 10.1038/s41587-020-0602-4. :Pages:
Charité-based author(s): Chua RL, Lukassen S, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Kazmierski J, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Lehmann I, Conrad C, Sander LE, Eils R.
Authors:Ercu M et al.
Title:Phosphodiesterase 3A and Arterial Hypertension.

Journal:Circulation. 2020 Jul 14;142(2):133-149. :Pages:
Charité-based author(s): Markó L, Schächterle C, Tsvetkov D, Cui Y, Bartolomaeus TUP, Hübner N, Illas RM, Anistan YM, Forslund SK, Kamer I, Müller DN, Gollasch M, Bähring S, Luft FC.
Authors:Jenning M et al.
Title:Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production.

Journal:Ann Rheum Dis. 2020 Jun 12:annrheumdis-2019-216919. :Pages:
Charité-based author(s): Jenning M, Marklein B, Häupl T, Burmester GR, Skriner K.
Authors:Francuzik W et al.
Title:Phenotype and risk factors of venom-induced anaphylaxis: a case-control study of the European Anaphylaxis Registry.

Journal:J Allergy Clin Immunol. 2020 Jun 22:S0091-6749(20)30838-1. :Pages:
Charité-based author(s): Francuzik W, Dölle-Bierke S, Worm M.
Authors:Roehmel JF et al.
Title:Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4⁺ T lymphocytes.

Journal:J Allergy Clin Immunol. 2020 Jun 8:S0091-6749(20)30811-3. :Pages:
Charité-based author(s): Roehmel JF, Rohrbach A, Mall MA.
Authors:Regen F et al.
Title:Clozapine modulates retinoid homeostasis in human brain and normalizes serum retinoic acid deficit in patients with schizophrenia.

Journal:Mol Psychiatry. 2020 Jun 2. doi: 10.1038/s41380-020-0791-8. :Pages:
Charité-based author(s): Regen F, Cosma NC, Otto LR, Clemens V, Saksone L, Gellrich J, Uesekes B, Ta TMT, Hahn E, Dettling M, Heuser I, Hellmann-Regen J.
Authors:Vardar G et al.
Title:Epilepsy-causing STX1B mutations translate altered protein functions into distinct phenotypes in mouse neurons.

Journal:Brain. 2020 Jun 23:awaa151. :Pages:
Charité-based author(s): Vardar G, Trimbuch T, Rosenmund C.
Authors:Eriksen BO et al.
Title:GFR in Healthy Aging: an Individual Participant Data Meta-Analysis of Iohexol Clearance in European Population-Based Cohorts.

Journal:J Am Soc Nephrol. 2020 Jul;31(7):1602-1615. :Pages:
Charité-based author(s): Ebert N, van der Giet M, Schaeffner E.
Authors:Schreiber A et al.
Title:Neutrophil Gelatinase-Associated Lipocalin Protects from ANCA-Induced GN by Inhibiting TH17 Immunity.

Journal:J Am Soc Nephrol. 2020 Jul;31(7):1569-1584. :Pages:
Charité-based author(s): Schreiber A, Rousselle A, Klocke J, Bachmann S, Popovic S, Bontscho J, Schmidt-Ott KM, Siffrin V, Jerke U, Ashraf MI, Kettritz R.

May 2020

Authors:Sawitzki B et al.
Title:Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.

Journal:Lancet. 2020 May 23;395(10237):1627-1639. :Pages:
Charité-based author(s): Sawitzki B, Reinke P, Streitz M, Juerchott K, Otto NM, Öllinger R, Schlickeiser S, Volk HD.
Authors:Schaupp L et al.
Title:Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells.

Journal:Cell. 2020 May 28;181(5):1080-1096.e19. :Pages:
Charité-based author(s): Schaupp L, Rogell L, Kofoed-Branzk M, Guendel F, Diefenbach A.
Authors:Solmi M et al.
Title:Safety of 80 antidepressants, antipsychotics, anti-attention-deficit/hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta-review of 78 adverse effects.

Journal:World Psychiatry. 2020 Jun;19(2):214-232. :Pages:
Charité-based author(s): Correll CU.
Authors:Piccininni M et al.
Title:Use of all cause mortality to quantify the consequences of covid-19 in Nembro, Lombardy: descriptive study.

Journal:BMJ. 2020 May 14;369:m1835. :Pages:
Charité-based author(s): Piccininni M, Rohmann JL, Kurth T.
Authors:Böhmer MM et al.
Title:Investigation of a COVID-19 outbreak in Germany resulting from a single travel-associated primary case: a case series.

Journal:Lancet Infect Dis. 2020 May 15:S1473-3099(20)30314-5. :Pages:
Charité-based author(s): Corman VM, Schneider J, Veith T, Mühlemann B, Wölfel R, Antwerpen M, Walter M, Protzer U, Drosten C.
Authors:Doehner W et al.
Title:Obesity and weight loss are inversely related to mortality and cardiovascular outcome in prediabetes and type 2 diabetes: data from the ORIGIN trial.

Journal:Eur Heart J. 2020 May 13:ehaa293. :Pages:
Charité-based author(s): Doehner W, Anker SD.
Authors:Lefere S et al.
Title:Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages.

Journal:J Hepatol. 2020 Apr 29:S0168-8278(20)30269-5. :Pages:
Charité-based author(s):Puengel T, Hundertmark J, Guillot A, Heymann F, Tacke F.
Authors:Kedor C et al.
Title:Canakinumab for Treatment of Adult-Onset Still's Disease to Achieve Reduction of Arthritic Manifestation (CONSIDER): phase II, randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial.

Journal:Ann Rheum Dis. 2020 May 13:annrheumdis-2020-217155. :Pages:
Charité-based author(s): Kedor C, Zernicke J, Feist E.
Authors:Rastogi S et al.
Title:PGE₂ deficiency predisposes to anaphylaxis by causing mast cell hyper-responsiveness.

Journal:J Allergy Clin Immunol. 2020 May 11:S0091-6749(20)30639-4. :Pages:
Charité-based author(s): Rastogi S, Willmes DM, Nassiri M, Babina M, Worm M.
Authors:Edelmann F et al.
Title:Rationale and Study Design of OUTSTEP-HF: A Randomized Controlled Study to Assess the Effect of Sacubitril/Valsartan and Enalapril on Physical Activity measured by Accelerometry in Patients with Heart Failure with Reduced Ejection Fraction.

Journal:Eur J Heart Fail. 2020 May 28. doi: 10.1002/ejhf.1919. :Pages:
Charité-based author(s): Edelmann F.

April 2020

Authors:Wölfel R et al.
Title:Virological assessment of hospitalized patients with COVID-2019.

Journal:Nature. 2020 Apr 1. doi: 10.1038/s41586-020-2196-x. :Pages:
Charité-based author(s): Corman VM, Müller MA, Niemeyer D, Jones TC, Bleicker T, Brünink S, Schneider J, Drosten C.
Authors:Kaminski MM et al.
Title:A CRISPR-based assay for the detection of opportunistic infections post-transplantation and for the monitoring of transplant rejection.

Journal:Nat Biomed Eng. 2020 Apr 13. doi: 10.1038/s41551-020-0546-5. :Pages:
Charité-based author(s): Kaminski MM, Greensmith R.
Authors:Berndt N et al.
Title:Functional consequences of metabolic zonation in murine livers: New insights for an old story.

Journal:Hepatology. 2020 Apr 14. doi: 10.1002/hep.31274. :Pages:
Charité-based author(s): Berndt N, Eckstein J, Holzhütter HG.
Authors:Butler J et al.
Title:Minimal clinically important difference in quality of life scores for patients with heart failure and reduced ejection fraction.

Journal:Eur J Heart Fail. 2020 Apr 2. doi: 10.1002/ejhf.1810. :Pages:
Charité-based author(s): Anker SD.
Authors:Haase N et al.
Title:RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.

Journal:J Clin Invest. 2020 Apr 27:99417. :Pages:
Charité-based author(s): Haase N, Golic M, Herse F, Kräker K, Müller DN, Dechend R.
Authors:Ambrozkiewicz MC et al.
Title:The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.

Journal:Mol Psychiatry. 2020 Apr 6. doi: 10.1038/s41380-020-0714-8. :Pages:
Charité-based author(s):Ambrozkiewicz MC, Schaub T, Smorodchenko A, Weber AI, Mueller S, Horan ST, Rosário M, Boehm-Sturm P, Tarabykin V.
Authors:Duerr J et al.
Title:Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.

Journal:Nat Commun. 2020 Apr 24;11(1):2012. :Pages:
Charité-based author(s): Duerr J, Leitz DHW, Ochs M, Mall MA.
Authors:Nitzan N et al.
Title:Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway.

Journal:Nat Commun. 2020 Apr 23;11(1):1947. :Pages:
Charité-based author(s): Nitzan N, Beed P, Oldani S, Tukker JJ, Schmitz D.
Authors:Basu Roy R et al.
Title:Performance of immune-based and microbiological tests in children with TB meningitis in Europe - a multi-center Paediatric Tuberculosis Network European Trials Group (ptbnet) study.

Journal:Eur Respir J. 2020 Apr 16:1902004. :Pages:
Charité-based author(s): Thee S, Krüger R.
Authors:Lukassen S et al.
Title:SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.

Journal:EMBO J. 2020 Apr 4:e105114. :Pages:
Charité-based author(s): Lukassen S, Chua RL, Trefzer T, Hennig BP, Conrad C, Eils R.

March 2020

Authors:Bockstahler M et al.
Title:Heart-Specific Immune Responses in an Animal Model of AutoimmuneRelated Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation.

Journal:Circulation. 2020 Mar 12. doi: 10.1161/CIRCULATIONAHA.119.043171. :Pages:
Charité-based author(s): Goetzke CC, Neumaier HL, Kespohl M, Landmesser U, Kratzer A, Beling A.
Authors:Flamar AL et al.
Title:Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity.

Journal:Immunity. 2020 Apr 14;52(4):606-619.e6. :Pages:
Charité-based author(s): Klose CSN, Stokic-Trtica V.
Authors:Hoffmann S et al.
Title:Complement deposition at the neuromuscular junction in seronegative myasthenia gravis.

Journal:Acta Neuropathol. 2020 Mar 10. doi: 10.1007/s00401-020-02147-5. :Pages:
Charité-based author(s): Hoffmann S, Harms L, Schuelke M, Rückert JC, Goebel HH, Stenzel W, Meisel A.
Authors:Grent-'t-Jong T et al.
Title:Association of Magnetoencephalographically Measured High-Frequency Oscillations in Visual Cortex With Circuit Dysfunctions in Local and Large-scale Networks During Emerging Psychosis.

Journal:JAMA Psychiatry. 2020 Mar 25:e200284. :Pages:
Charité-based author(s): Grent-'t-Jong T, Uhlhaas PJ.
Authors:Ullah I et al.
Title:Adult Tissue Extracellular Matrix Determines Tissue Specification of Human iPSC-Derived Embryonic Stage Mesodermal Precursor Cells.

Journal:Adv Sci (Weinh). 2020 Jan 21;7(5):1901198. :Pages:
Charité-based author(s): Ullah I, Busch JF, Rabien A, Ergün B, Stamm C, Hippenstiel S, Reinke P, Kurtz A.
Authors:Kramer F et al.
Title:Evaluation of high-sensitivity C-reactive protein and uric acid in vericiguat-treated patients with heart failure with reduced ejection fraction.

Journal:Eur J Heart Fail. 2020 Mar 25. doi: 10.1002/ejhf.1787. :Pages:
Charité-based author(s): Pieske B.
Authors:Anker MS et al.
Title:Increased resting heart rate and prognosis in treatment-naïve unselected cancer patients: results from a prospective observational study.

Journal:Eur J Heart Fail. 2020 Mar 23. doi: 10.1002/ejhf.1782. :Pages:
Charité-based author(s): Anker MS.
Authors:Kespohl M et al.
Title:Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming.

Journal:Sci Adv. 2020 Mar 11;6(11):eaay1109. :Pages:
Charité-based author(s): Kespohl M, Bredow C, Voß M, Paeschke A, Zickler M, Poller W, Eckstein J, Spranger J, Fähling M, Wirth EK, Berndt N, Beling A.
Authors:Hagner M et al.
Title:New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.

Journal:Eur Respir J. 2020 Mar 5:1902355. :Pages:
Charité-based author(s): Mall MA.
Authors:Banerjee P et al.
Title:SuperCYPsPred-a web server for the prediction of cytochrome activity.

Journal:Nucleic Acids Res. 2020 Mar 17:gkaa166. :Pages:
Charité-based author(s): Banerjee P, Dunkel M, Kemmler E, Preissner R.

February 2020

Authors:Maechler F et al.
Title:Contact isolation versus standard precautions to decrease acquisition of extended-spectrum β-lactamase-producing Enterobacterales in non-critical care wards: a cluster-randomised crossover trial.

Journal:Lancet Infect Dis. 2020 Feb 19:S1473-3099(19)30626-7. :Pages:
Charité-based author(s): Maechler F, Schwab F, Hansen S, Behnke M, Golembus J, Kola A, Gastmeier P.
Authors:Biederstädt et al.
Title:SUMO pathway inhibition targets an aggressive pancreatic cancer subtype.

Journal:Gut. 2020 Jan 30. doi: 10.1136/gutjnl-2018-317856. :Pages:
Charité-based author(s): Schick M, Wirth M, Schneider G, Keller U.
Authors:Pötsch MS et al.
Title:MT-102 prevents tissue wasting and improves survival in a rat model of severe cancer cachexia.

Journal:J Cachexia Sarcopenia Muscle. 2020 Feb 17. doi: 10.1002/jcsm.12537. :Pages:
Charité-based author(s): Ishida J, Palus S, Tschirner A, Döhner W, Anker SD, Springer J.
Authors:Eede P et al.
Title:Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice.

Journal:EMBO Rep. 2020 Mar 4;21(3). doi: 10.15252/embr.201948530. :Pages:
Charité-based author(s): Eede P, Obst J, Benke E, Yvon-Durocher G, Richard BC, Gimber N, Schmoranzer J, Prokop S, Heppner FL.
Authors:Weber D et al.
Title:Plasma carotenoids, tocopherols and retinol - Association with age in the Berlin Aging Study II.

Journal:Redox Biol. 2020 Feb 13;32:101461. :Pages:
Charité-based author(s): Demuth I, Steinhagen-Thiessen E, Norman K.
Authors:Booker SA et al.
Title:Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network.

Journal:Elife. 2020 Feb 19;9:e51156. :Pages:
Charité-based author(s): Booker SA, Vida I.
Authors:Tizian C et al.
Title:c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells.

Journal:Elife. 2020 Feb 10;9:e52549. :Pages:
Charité-based author(s): Tizian C, Hölsken O, Cosovanu C, Kofoed-Branzk M, Diefenbach A, Neumann C.
Authors:Hotter B et al.
Title:Inflammatory and stress markers predicting pneumonia, outcome, and etiology in patients with stroke: Biomarkers for predicting pneumonia, functional outcome, and death after stroke.

Journal:Neurol Neuroimmunol Neuroinflamm. 2020 Feb 25;7(3):e692. :Pages:
Charité-based author(s): Hotter B, Hoffmann S, Ulm L, Meisel C, Meisel A.
Authors:Weilnhammer V et al.
Title:Psychotic Experiences in Schizophrenia and Sensitivity to Sensory Evidence.

Journal:Schizophr Bull. 2020 Feb 24:sbaa003. :Pages:
Charité-based author(s): Weilnhammer V, Röd L, Eckert AL, Stuke H, Heinz A, Sterzer P.
Authors:Roßberg S et al.
Title:Orally applied bacterial lysate in infants at risk for atopy does not prevent atopic dermatitis, allergic rhinitis, asthma or allergic sensitization at school age: follow-up of a randomized trial.

Journal:Allergy. 2020 Feb 22. doi: 10.1111/all.14247. :Pages:
Charité-based author(s): Roßberg S, Keller T, Icke K, Keil T, Lau S.

January 2020

Authors:Gidon A et al.
Title:Dendritic action potentials and computation in human layer 2/3 cortical neurons.

Journal:Science. 2020 Jan 3;367(6473):83-87. :Pages:
Charité-based author(s): Fidzinski P, Bolduan F, Holtkamp M, Vida I, Larkum ME.
Authors:Correll CU et al.
Title:Metformin add-on vs. antipsychotic switch vs. continued antipsychotic treatment plus healthy lifestyle education in overweight or obese youth with severe mental illness: results from the IMPACT trial.

Journal:World Psychiatry. 2020 Feb;19(1):69-80. :Pages:
Charité-based author(s): Correll CU, Kapoor S.
Authors:Barz MJ et al.
Title:Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia.

Journal:Blood. 2020 Jan 22. doi: 10.1182/blood.2019002499. :Pages:
Charité-based author(s): Barz MJ, Hof J, Groeneveld-Krentz S, Astrahantseff K, von Stackelberg A.
Authors:Correll CU et al.
Title:Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial.

Journal:Blood. 2020 Jan 22. doi: 10.1182/blood.2019002499. :Pages:
Charité-based author(s): Correll CU.
Authors:Ratziu V et al.
Title:Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study.

Journal:Hepatology. 2020 Jan 13:10.1002/hep.31108. :Pages:
Charité-based author(s): Tacke F.
Authors:Schürmann D et al.
Title:Safety, pharmacokinetics, and antiretroviral activity of islatravir (ISL, MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor, following single-dose administration to treatment-naive adults infected with HIV-1: an open-label, phase 1b, consecutive-panel trial.

Journal:Lancet HIV. 2020;S2352-3018(19)30372-8. :Pages:
Charité-based author(s): Schürmann D, Keicher C, Huser A, Hofmann J.
Authors:Bartels F et al.
Title:Neuronal autoantibodies associated with cognitive impairment in melanoma patients.

Journal:Ann Oncol. 2019 May 1;30(5):823-829. :Pages:
Charité-based author(s): Bartels F, Stronisch T, Farmer K, Kiecker F, Finke C.
Authors:Stintzing S et al.
Title:Consensus molecular subgroups (CMS) of colorectal cancer (CRC) and first-line efficacy of FOLFIRI plus cetuximab or bevacizumab in the FIRE3 (AIO KRK-0306) trial.

Journal:Ann Oncol. 2019 Nov 1;30(11):1796-1803. :Pages:
Charité-based author(s): Stintzing S.
Authors:Petutschnigg J et al.
Title:Body fat phenotypes and treatment response to spironolactone in ambulatory patients with heart failure and preserved ejection fraction: a post-hoc analysis of the Aldo-DHF trial.

Journal:Eur J Heart Fail. 2020 Jan 7:10.1002/ejhf.1723. :Pages:
Charité-based author(s): Petutschnigg J, Trippel TD, Hashemi D, Pieske B, Edelmann F.
Authors:Scheffel J et al.
Title:Cold-induced urticarial autoinflammatory syndrome related to factor XII activation.

Journal:Nat Commun. 2020 Jan 10;11(1):179. :Pages:
Charité-based author(s): Scheffel J, Mahnke NA, Wu J, Bonnekoh H, Church MK, Maurer M, Krause K.

Publications 2019

December 2019

Authors:Stahn AC et al.
Title:Brain Changes in Response to Long Antarctic Expeditions.

Journal:N Engl J Med. 2019 Dec 5;381(23):2273-2275. :Pages:
Charité-based author(s): Stahn AC, Gunga HC.
Authors:Deodhar A et al.
Title:Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial.

Journal:Lancet. 2020 Jan 4;395(10217):53-64. :Pages:
Charité-based author(s): Poddubnyy D, Sieper J.
Authors:Koche RP et al.
Title:Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.

Journal:Nat Genet. 2019 Dec 16;10.1038/s41588-019-0547-z. :Pages:
Charité-based author(s): Helmsauer K, MacArthur IC, Chamorro R, Munoz-Perez N, Dorado Garcia H, Bei Y, Röefzaad C, Bardinet V, Szymansky A, Winkler A, Thole T, Timme N, Fuchs S, Klironomos F, Schmelz K, Künkele A, Hundsdörfer P, Deubzer H, Toedling J, Hertwig F, Eggert A, Schulte JH, Henssen AG.
Authors:Solmi M et al.
Title:Disparities in cancer screening in people with mental illness across the world versus the general population: prevalence and comparative meta-analysis including 4,717,839 people.

Journal:Lancet Psychiatry. 2020 Jan;7(1):52-63. :Pages:
Charité-based author(s): Correll CU.
Authors:Stintzing S et al.
Title:Consensus molecular subgroups (CMS) of colorectal cancer (CRC) and first-line efficacy of FOLFIRI plus cetuximab or bevacizumab in the FIRE3 (AIO KRK-0306) trial.

Journal:Ann Oncol. 2019 Nov 1;30(11):1796-1803. :Pages:
Charité-based author(s): Stintzing S.
Authors:Möckel M et al.
Title:Improve Management of acute heart failure with ProcAlCiTonin in EUrope: results of the randomized clinical trial IMPACT EU Biomarkers in Cardiology (BIC) 18.

Journal:Eur J Heart Fail. 2019 Dec 12. doi: 10.1002/ejhf.1667. :Pages:
Charité-based author(s): Möckel M, Slagman AC.
Authors:Pieske B et al.
Title:Baseline features of the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial.

Journal:Eur J Heart Fail. 2019 Dec;21(12):1596-1604. :Pages:
Charité-based author(s): Pieske B et al..
Authors:Marg A et al.
Title:Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.

Journal:Nat Commun. 2019 Dec 18;10(1):5776. :Pages:
Charité-based author(s): Marg A, Escobar H, Grunwald SA, Metzler E, Kieshauer J, Pasemann D, Schneider J, Schülke M, Spuler S.
Authors:Ziegler JF et al.
Title:Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.

Journal:Nat Commun. 2019 Dec 10;10(1):5629. :Pages:
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Journal:Am J Hum Genet. 2020 Jan 2;106(1):102-111. :Pages:
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November 2019

Authors:Middleton PG et al.
Title:Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele.

Journal:N Engl J Med. 2019 Nov 7;381(19):1809-1819. :Pages:
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Title:Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis (SELECT-AXIS 1): a multicentre, randomised, double-blind, placebo-controlled, phase 2/3 trial.

Journal:Lancet. 2019 Dec 7;394(10214):2108-2117. :Pages:
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Title:A support programme for secondary prevention in patients with transient ischaemic attack and minor stroke (INSPiRE-TMS): an open-label, randomised controlled trial.

Journal:Lancet Neurol. 2019 Nov 7. doi: 10.1016/S1474-4422(19)30369-2. :Pages:
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Title:DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput.

Journal:Nat Methods. 2019 Nov 25. doi: 10.1038/s41592-019-0638-x. :Pages:
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Title:Mapping microglia states in the human brain through the integration of high-dimensional techniques.

Journal:Nat Neurosci. 2019 Dec;22(12):2098-2110. :Pages:
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Title:Long-term effects of Na+ /Ca2+ exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction.

Journal:Eur J Heart Fail. 2019 Nov 24. doi: 10.1002/ejhf.1619. :Pages:
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Title:Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation.

Journal:Nat Commun. 2019 Nov 14;10(1):5155. :Pages:
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Title:Niche-mimicking interactions in peptide-functionalized 3D hydrogels amplify mesenchymal stromal cell paracrine effects.

Journal:Biomaterials. 2019 Nov 20:119639. :Pages:
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Title:Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington's disease.

Journal:Proc Natl Acad Sci U S A. 2019 Dec3;116(49):24840-24851. :Pages:
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Title:The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches.

Journal:Cell Rep. 2019 Nov 12;29(7):2028-2040.e8. :Pages:
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October 2019

Authors:Maurer M et al.
Title:Ligelizumab for Chronic Spontaneous Urticaria.

Journal:N Engl J Med. 2019 Oct 3;381(14):1321-1332. :Pages:
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Title:Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.

Journal:Cell. 2019 Oct 3;179(2):498-513.e22. :Pages:
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Title:Improving Stratification for Children With Late Bone Marrow B-Cell Acute Lymphoblastic Leukemia Relapses With Refined Response Classification and Integration of Genetics.

Journal:J Clin Oncol. 2019 Oct 23:JCO1901694. doi: 10.1200/JCO.19.01694. :Pages:
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Authors:Wu H et al.
Title:Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages.

Journal:EMBO Mol Med. 2019 Nov 7;11(11):e10698. :Pages:
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Title:Reduction of Postoperative Wound Infections by Antiseptica (RECIPE)?: A Randomized Controlled Trial.

Journal:Ann Surg. 2019 Oct 9. doi: 10.1097/SLA.0000000000003645. :Pages:
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Title:Network-Specific Synchronization of Electrical Slow-Wave Oscillations Regulates Sleep Drive in Drosophila.

Journal:Curr Biol. 2019 Nov 4;29(21):3611-3621.e3. :Pages:
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Title:CMKLR1-targeting peptide tracers for PET/MR imaging of breast cancer.

Journal:Theranostics. 2019 Sep 19;9(22):6719-6733. :Pages:
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Journal:JAMA Dermatol. 2019 Oct 16. doi: 10.1001/jamadermatol.2019.2941. :Pages:
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Title:Association of uric acid levels before start of conditioning with mortality after alloSCT: a prospective, non-interventional study of the EBMT Transplant Complication Working Party.

Journal:Haematologica. 2019 Oct 10. doi: 10.3324/haematol.2019.228668. :Pages:
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Title:Clonal hematopoiesis in patients with ANCA-associated vasculitis.

Journal:Haematologica. 2019 Oct 3. doi: 10.3324/haematol.2019.223305. :Pages:
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September 2019

Authors:Nave AH et al.
Title:Physical Fitness Training in Patients with Subacute Stroke (PHYS-STROKE): multicentre, randomised controlled, endpoint blinded trial.

Journal:BMJ. 2019 Sep 18;366:l5101. :Pages:
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Title:How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).

Journal:Eur Heart J. 2019 Oct 21;40(40):3297-3317. :Pages:
Charité-based author(s): Pieske B, Tschöpe C, Anker SD, Edelmann F, Morris DA, Pieske-Kraigher E.
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Title:Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

Journal:Acta Neuropathol. 2019 Sep 28. doi: 10.1007/s00401-019-02078-w. :Pages:
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Title:Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases.

Journal:Sci Transl Med. 2019 Sep 11;11(509). :Pages:
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Title:Immunosuppression in inflammatory cardiomyopathy and parvovirus B19 persistence.

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Title:R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon.

Journal:Nat Commun. 2019 Sep 25;10(1):4368. :Pages:
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Journal:Biol Psychiatry. 2019 Jul 26. doi: 10.1016/j.biopsych.2019.07.011. :Pages:
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Title:Mast cells are critical for controlling the bacterial burden and the healing of infected wounds.

Journal:Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20500-20504. :Pages:
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Title:Intrathecal IgM production is a strong risk factor for early conversion to multiple sclerosis.

Journal:Neurology. 2019 Oct 8;93(15):e1439-e1451. :Pages:
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Title:Tomoelastography distinguishes non-invasively between benign and malignant liver lesions.

Journal:Cancer Res. 2019 Sep 24. doi: 10.1158/0008-5472.CAN-19-2150. :Pages:
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August 2019

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Title:Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism.

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Title:Risk of Psychosis Among Refugees: A Systematic Review and Meta-analysis.

Journal:JAMA Psychiatry. 2019 Aug 14. doi: 10.1001/jamapsychiatry.2019.1937. :Pages:
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Title:Association With Hospitalization and All-Cause Discontinuation Among Patients With Schizophrenia on Clozapine vs Other Oral Second-Generation Antipsychotics: A Systematic Review and Meta-analysis of Cohort Studies.

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Title:Detection of KIT D816V mutation in patients with severe anaphylaxis and normal basal tryptase-first data from the Anaphylaxis Registry (NORA).

Journal:J Allergy Clin Immunol. 2019 Aug 12. doi: 10.1016/j.jaci.2019.07.037. :Pages:
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Title:Prevalence, 12-Month Prognosis, and Clinical Management Need of Depression in Coronary Heart Disease Patients: A Prospective Cohort Study.

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Title:Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators.

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Title:Deep brain stimulation induced normalization of the human functional connectome in Parkinson's disease.

Journal:Brain. 2019 Aug 14. doi: 10.1093/brain/awz239. :Pages:
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Title:Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor.

Journal:Brain. 2019 Aug 3. doi: 10.1093/brain/awz236. :Pages:
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Title:Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.

Journal:J Cachexia Sarcopenia Muscle. 2019 Aug 23. doi: 10.1002/jcsm.12491. :Pages:
Charité-based author(s): Hahn A, Kny M, Pablo-Tortola C, Schmidt S, Nowak M, Weber-Carstens S, Luft FC, Fielitz J.
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Title:Highly diversified shrew hepatitis B viruses corroborate ancient origins and divergent infection patterns of mammalian hepadnaviruses.

Journal:Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):17007-17012. :Pages:
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July 2019

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Title:Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture.

Journal:Nat Genet. 2019 Aug;51(8):1263-1271. :Pages:
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Title:The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis.

Journal:Nat Immunol. 2019 Aug;20(8):1012-1022. :Pages:
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Title:Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium.

Journal:Nat Commun. 2019 Jul 2;10(1):2919. :Pages:
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Title:Enzymatically-degradable alginate hydrogels promote cell spreading and in vivo tissue infiltration.

Journal:Biomaterials. 2019 Oct;217:119294. :Pages:
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Title:Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders.

Journal:Am J Hum Genet. 2019 Jul 19. doi: 10.1016/j.ajhg.2019.07.002 :Pages:
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Title:High-resolution diffusion-weighted imaging identifies ischemic lesions in a majority of transient ischemic attack patients.

Journal:Ann Neurol. 2019 Jul 12. doi: 10.1002/ana.25551. :Pages:
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Title:Immunologic Profiling of Mutational and Transcriptional Subgroups in Pediatric and Adult High-Grade Gliomas.

Journal:Cancer Immunol Res. 2019 Jul 2. doi: 10.1158/2326-6066.CIR-18-0939. :Pages:
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Title:US Time-Harmonic Elastography for the Early Detection of Glomerulonephritis.

Journal:Radiology. 2019 Jul 9:182574. :Pages:
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Authors:Schönenberger E et al.
Title:Kidney Injury after Intravenous versus Intra-arterial Contrast Agent in Patients Suspected of Having Coronary Artery Disease: A Randomized Trial.

Journal:Radiology. 2019 Jul 2:182220. :Pages:
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Title:IgA autoantibodies against native myelin basic protein in a patient with MS.

Journal:Neurol Neuroimmunol Neuroinflamm. 2019 May 1;6(4):e569. :Pages:
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June 2019

Authors:Haase R et al.
Title:Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data.

Journal:BMJ. 2019 Jun 12;365:l1945. :Pages:
Charité-based author(s): Haase R, Zimmermann E, Rief M, Röhle R, Schuetz GM, Schueler S, Coenen MH, Wieske V, Laule M, Dewey M.
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Title:R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.

Journal:Nat Cell Biol. 2019 Jul;21(7):812-823. :Pages:
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Title:Dipeptidyl Peptidase-4 Inhibitors and the Risk of Bullous Pemphigoid Among Patients With Type 2 Diabetes.

Journal:Diabetes Care. 2019 Jun 10. doi: 10.2337/dc19-0409. :Pages:
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Title:Rationale and design of the EMPERIAL-Preserved and EMPERIAL-Reduced trials of empagliflozin in patients with chronic heart failure.

Journal:Eur J Heart Fail. 2019 Jun 19. doi: 10.1002/ejhf.1486. :Pages:
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Title:Subthalamic neuromodulation improves short-term motor learning in Parkinson's disease.

Journal:Brain. 2019 Jun 6. doi: 10.1093/brain/awz152. :Pages:
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Title:VEGF - Supplemented extracellular matrix is sufficient to induce endothelial differentiation of human iPSC.

Journal:Biomaterials. 2019 Sep;216:119283. :Pages:
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Title:Outcome heterogeneity and bias in acute experimental spinal cord injury: A meta-analysis.

Journal:Neurology. 2019 Jul 2;93(1):e40-e51. :Pages:
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Title:PEDIA: prioritization of exome data by image analysis.

Journal:Genet Med. 2019 Jun 5. doi: 10.1038/s41436-019-0566-2. :Pages:
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Title:Abnormal involuntary movement scale in tardive dyskinesia: Minimal clinically important difference.

Journal:Mov Disord. 2019 Jun 24. doi: 10.1002/mds.27769. :Pages:
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Title:Image-guided Irreversible Electroporation of Localized Prostate Cancer: Functional and Oncologic Outcomes.

Journal:Radiology. 2019 Jul;292(1):250-257. :Pages:
Charité-based author(s): Collettini F, Enders J, Stephan C, Fischer T, Baur ADJ, Penzkofer T, Busch J, Hamm B, Gebauer B.

May 2019

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Title:Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial.

Journal:Lancet. 2019 Jun 1;393(10187):2201-2212. :Pages:
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Title:Long-term effectiveness of oral second-generation antipsychotics in patients with schizophrenia and related disorders: a systematic review and meta-analysis of direct head-to-head comparisons.

Journal:World Psychiatry. 2019 Jun;18(2):208-224. :Pages:
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Title:Early discharge and home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban: an international multicenter single-arm clinical trial.

Journal:Eur Heart J. 2019 May 23. doi: 10.1093/eurheartj/ehz367. :Pages:
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Title:Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany.

Journal:Eur Heart J. 2019 May 18. doi: 10.1093/eurheartj/ehz236. :Pages:
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Title:Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis.

Journal:Gut. 2019 May 10. doi: 10.1136/gutjnl-2019-318382. :Pages:
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Title:Collagen Fibrils Mechanically Contribute to Tissue Contraction in an In Vitro Wound Healing Scenario.

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Title:Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4(+) memory T cells.

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Title:Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis.

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Journal:Nucleic Acids Res. 2019 May 20. doi: 10.1093/nar/gkz327 :Pages:
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Title:MutationDistiller: user-driven identification of pathogenic DNA variants.

Journal:Nucleic Acids Res. 2019 May 20. doi: 10.1093/nar/gkz330. :Pages:
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April 2019

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Journal:Eur Heart J. 2019 Apr 19. doi: 10.1093/eurheartj/ehz117 :Pages:
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Journal:Am J Respir Crit Care Med. 2019 Apr 2. doi: 10.1164/rccm.201808-1597LE :Pages:
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Title:Muscle wasting and function after muscle activation and early protocol-based physiotherapy: an explorative trial.

Journal:J Cachexia Sarcopenia Muscle. 2019 Apr 23. doi: 10.1002/jcsm.12428 :Pages:
Charité-based author(s): Wollersheim T, Grunow JJ, Carbon NM, Haas K, Malleike J, Ramme SF, Schneider J, Spies CD, Märdian S, Mai K, Spuler S, Fielitz J, Weber-Carstens S.
Authors:Loibl S et al.
Title:Mutational Diversity and Therapy Response in Breast Cancer: A Sequencing Analysis in the Neoadjuvant GeparSepto Trial.

Journal:Clin Cancer Res. 2019 Apr 12. doi: 10.1158/1078-0432.CCR-18-3258 :Pages:
Charité-based author(s): Treue D, Budczies J, Schmitt WD, Jank P, Klauschen F, Möbs M, Sers C, Hummel M, Denkert C.
Authors:Piper SK et al.
Title:Exact replication: Foundation of science or game of chance?

Journal:PLoS Biol. 2019 Apr 9;17(4):e3000188 :Pages:
Charité-based author(s): Piper SK, Grittner U, Rex A, Riedel N, Fischer F, Nadon R, Siegerink B, Dirnagl U.
Authors:Lefaucheur C et al.
Title:Non-HLA agonistic anti-angiotensin II type 1 receptor antibodies induce a distinctive phenotype of antibody-mediated rejection in kidney transplant recipients.

Journal:Kidney Int. 2019 Mar 15. doi: 10.1016/j.kint.2019.01.030 :Pages:
Charité-based author(s): Philippe A, Dragun D.
Authors:Hofheinz et al.
Title:Confirmation of the prognostic value of pretherapeutic tumor SUR and MTV in patients with esophageal squamous cell carcinoma.

Journal:Eur J Nucl Med Mol Imaging. 2019 Apr 4. doi: 10.1007/s00259-019-04307-6 :Pages:
Charité-based author(s): Steffen IG, Zschaeck S.
Authors:Papadopoulou A et al.
Title:Damage of the lateral geniculate nucleus in MS: Assessing the missing node of the visual pathway.

Journal:Neurology. 2019 May 7;92(19):e2240-e2249 :Pages:
Charité-based author(s): Papadopoulou A, Brandt AU.

March 2019

Authors:Spillmann F et al.
Title:Mode-of-action of the PROPELLA concept in fulminant myocarditis.

Journal:Eur Heart J. 2019 Mar 19. doi: 10.1093/eurheartj/ehz124
Authors:Bartels F et al.
Title:Neuronal Autoantibodies Associated with Cognitive Impairment in Melanoma Patients.

Journal:Ann Oncol. 2019 Mar 6. doi: 10.1093/annonc/mdz083
Authors:Anker MS et al.
Title:Orphan disease status of cancer cachexia in the USA and in the European Union: a systematic re-view.

Journal:J Cachexia Sarcopenia Muscle. 2019 Feb;10(1):22-34
Authors:Ehlers L et al.
Title:2018 EULAR recommendations for a core data set to support observational research and clinical care in giant cell arteritis.

Journal:Ann Rheum Dis. 2019 Mar 21. doi: 10.1136/annrheumdis-2018-214755
Authors:Dörner T et al.
Title:Treatment of primary Sjögren's syndrome with ianalumab (VAY736) targeting B cells by BAFF re-ceptor blockade coupled with enhanced, antibody-dependent cellular cytotoxicity.

Journal:Ann Rheum Dis. 2019 Mar 2. doi: 10.1136/annrheumdis-2018-214720
Authors:Bobenko A et al.
Title:Exercise training in patients with a left ventricular assist device (Ex-VAD): rationale and design of a multicentre, prospective, assessor-blinded, randomized, controlled trial.

Journal:Eur J Heart Fail. 2019 Mar 28. doi: 10.1002/ejhf.1431
Authors:Wenke NK et al.
Title:N-Methyl-D-Aspartate Receptor Dysfunction by Unmutated Human Antibodies Against the NR1 Subunit.

Journal:Ann Neurol. 2019 Mar 6. doi: 10.1002/ana.25460
Authors:Bastian L et al.
Title:PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia.

Journal:Leukemia. 2019 Mar 6. doi: 10.1038/s41375-019-0430-z
Authors:Stefanski AL, Wiedemann A, Reiter K, Hiepe F, Lino AC, Dörner T.
Title:Enhanced PD-1 and diminished PD-L1 upregulation capacity mark post-activated lupus B cells.

Journal:Arthritis Rheumatol. 2019 Mar 27. doi: 10.1002/art.40897
Authors:Schulz A et al.
Title:Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage.

Journal:Elife. 2019 Mar 22;8

February 2019

Authors:Gronke K et al.
Title:Interleukin-22 protects intestinal stem cells against genotoxic stress.

Journal:Nature. 2019 Feb;566(7743):249-253
Authors:Douros A et al.
Title:Control of blood pressure and risk of mortality in a cohort of older adults: the Berlin Initiative Study.

Journal:Eur Heart J. 2019 Feb 25. doi: 10.1093/eurheartj/ehz071
Authors:Neumann C et al.
Title:c-Maf-dependent T(reg) cell control of intestinal T(H)17 cells and IgA establishes host-microbiota homeostasis.

Journal:Nat Immunol. 2019 Feb 18. doi: 10.1038/s41590-019-0316-2
Authors:Kraft K et al.
Title:Serial genomic inversions induce tissue-specific architectural stripes, gene misexpression and congenital malformations.

Journal:Nat Cell Biol. 2019 Mar;21(3):305-310
Authors:Marbach-Breitrück E et al.
Title:Tick-Tock Hedgehog-Mutual crosstalk with liver circadian clock promotes liver steatosis.

Journal:J Hepatol. 2019 Jan 31. doi: 10.1016/j.jhep.2019.01.022
Authors:Krupp F et al.
Title:Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor.

Journal:Mol Cell. 2019 Feb 12. doi: 10.1016/j.molcel.2019.01.016
Authors:Kulthanan K et al.
Title:Treatments of Cold Urticaria: A Systematic Review.

Journal:J Allergy Clin Immunol. 2019 Feb 15. doi: 10.1016/j.jaci.2019.02.005
Authors:Kreis P et al.
Title:ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.

Journal:Nat Commun. 2019 Jan 30;10(1):486
Authors:Lakin E, Church MK, Maurer M, Schmetzer O.
Title:On the Lipophilic Nature of Autoreactive IgE in Chronic Spontaneous Urticaria.

Journal:Theranostics. 2019 Jan 25;9(3):829-836
Authors:Kübler D et al.
Title:Widespread microglial activation in multiple system atrophy.

Journal:Mov Disord. 2019 Feb 6. doi: 10.1002/mds.27620

January 2019

Authors:Christen F et al.
Title:Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients.

Journal:Blood. 2019 Jan 4. doi: 10.1182/blood-2018-05-852822
Authors:Scherbakov N et al.
Title:Body weight changes and incidence of cachexia after stroke. J Cachexia Sarcopenia Muscle.

Journal:2019 Jan 24. doi: 10.1002/jcsm.12400
Authors:Starossom SC et al.
Title:Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.

Journal:Nat Commun. 2019 Jan 15;10(1):217
Authors:Hadar R et al.
Title:Prevention of schizophrenia deficits via non-invasive adolescent frontal cortex stimulation in rats.

Journal:Mol Psychiatry. 2019 Jan 28. doi: 10.1038/s41380-019-0356-x
Authors:Czuban M et al.
Title:Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections.

Journal:ACS Cent Sci. 2018 Dec 26;4(12):1624-1632
Authors:Anker SD et al.
Title:Cardiac contractility modulation improves long-term survival and hospitalizations in heart failure with reduced ejection fraction.

Journal:Eur J Heart Fail. 2019 Jan 16. doi: 10.1002/ejhf.1374
Authors:Houtman J, Freitag K, Gimber N, Schmoranzer J, Heppner FL, Jendrach M.
Title:Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3.

Journal:EMBO J. 2019 Feb 15;38(4)
Authors:Çakmak-Görür N et al.
Title:Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies.

Journal:Leukemia. 2019 Jan 3. doi: 10.1038/s41375-018-0330-7
Authors:Van Mieghem NM et al.
Title:Use of a Repositionable and Fully Retrievable Aortic Valve in Routine Clinical Practice: The RESPOND Study and RESPOND Extension Cohort.

Journal:JACC Cardiovasc Interv. 2019 Jan 14;12(1):38-49
Authors:Keilholz U et al
Title:Avelumab in patients with previously treated metastatic melanoma: phase 1b results from the JAVELIN Solid Tumor trial.

Journal:J Immunother Cancer. 2019 Jan 16;7(1):12

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Selected Publications by Charité authors

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Publications 2022

December 2022

Title:Efficacy of empagliflozin in heart failure with preserved versus mid-range ejection fraction: a pre-specified analysis of EMPEROR-Preserved.

Title:FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.

Title:Automated deep brain stimulation programming based on electrode location: a randomised, crossover trial using a data-driven algorithm.

Title:Ventilator-induced Lung Injury Is Modulated by the Circadian Clock.

Title:Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation.

Title:A critical period of translational control during brain development at codon resolution.

Title:Pathogen genomics study of an early medieval community in Germany reveals extensive co-infections.

Title:Primary radiation damage in bone evolves via collagen destruction by photoelectrons and secondary emission self-absorption.

Title:Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease.

Title:Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status.

November 2022

Title:Proteomic signatures for identification of impaired glucose tolerance.

Title:Rare and common genetic determinants of metabolic individuality and their effects on human health.

Title:Non-redundant functions of group 2 innate lymphoid cells.

Title:Associations of clonal haematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke.

Title:SuperNatural 3.0-a database of natural products and natural product-based derivatives.

Title:Weight change and clinical outcomes in heart failure with reduced ejection fraction: insights from EMPEROR-Reduced.

Title:DNA methylation-based classification of sinonasal tumors.

Title:Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer's disease.

Title:WiChR, a highly potassium-selective channelrhodopsin for low-light one- and two-photon inhibition of excitable cells.

Title:Anti-KIT antibody, barzolvolimab, reduces skin mast cells and disease activity in chronic inducible urticaria.

October 2022

Title:Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes.

Title:Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage.

Title:Clonal expansion and epigenetic inheritance of long-lasting NK cell memory.

Title:Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline rearranged genomes.

Title:H3.3K27M mutation is not a suitable target for immunotherapy in HLA-A2+ patients with diffuse midline glioma.

Title:Seizures, ataxia and parvalbumin-expressing interneurons respond to selenium supply in Selenop-deficient mice.

Title:Open tools for quantitative anonymization of tabular phenotype data: literature review.

Title:Effect of mobile stroke unit dispatch in all patients with acute stroke or TIA.

Title:Morphologic and Molecular Patterns of Polymyositis With Mitochondrial Pathology and Inclusion Body Myositis.

Title:Reduction in Multiple Cardiometabolic Risk Factors With Combined Olanzapine/Samidorphan Compared With Olanzapine: Post Hoc Analyses From a 24-Week Phase 3 Study.

September 2022

Title:Metabolomic profiles predict individual multidisease outcomes.

Title:Common human genetic variants of APOE impact murine COVID-19 mortality.

Title:The evolutionary dynamics of extrachromosomal DNA in human cancers.

Title:Effects of Empagliflozin in Women and Men With Heart Failure and Preserved Ejection Fraction.

Title:Molecular Markers of Response to Anti-PD1 Therapy in Advanced Hepatocellular Carcinoma.

Title:Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis.

Title:Heart failure outcomes according to heart rate and effects of empagliflozin in patients of the EMPEROR-Preserved trial.

Title:High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons.

Title:Protective alpha1-antitrypsin effects in autoimmune vasculitis are compromised by methionine oxidation.

Title:R-spondin-YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.

August 2022

Title:Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs.

Title:Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia.

Title:Early identification of axial psoriatic arthritis among patients with psoriasis: a prospective multicentre study.

Title:Efficacy and acceptability of psychosocial interventions in schizophrenia: systematic overview and quality appraisal of the meta-analytic evidence.

Title:ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.

Title:Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens.

Title:Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.

Title:Nonproductive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immune responses.

Title:Different classes of genomic inserts contribute to human antibody diversity.

Title:Deep Learning Detects Changes Indicative of Axial Spondyloarthritis at MRI of Sacroiliac Joints.

July 2022

Title:Increasing the throughput of sensitive proteomics by plexDIA.

Title:Structural mechanisms of GABAA receptor autoimmune encephalitis.

Title:Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial.

Title:Uric acid and sodium-glucose cotransporter-2 inhibition with empagliflozin in heart failure with reduced ejection fraction: the EMPEROR-reduced trial.

Title:Empagliflozin Improves Outcomes in Patients With Heart Failure and Preserved Ejection Fraction Irrespective of Age.

Title:Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function Mutation: A Phase 3B, Randomized, Placebo-Controlled Study.

Title:Dynamin is primed at endocytic sites for ultrafast endocytosis.

Title:Cardiac contractility modulation therapy improves health status in patients with heart failure with preserved ejection fraction: a pilot study (CCM-HFpEF).

Title:Biomarker-driven prognostic models in chronic heart failure with preserved ejection fraction: the EMPEROR-Preserved trial.

Title:Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.

Title:dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts.

June 2022

Title:Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.

Title:Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes.

Title:Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.

Title:Continuing, reducing, switching, or stopping antipsychotics in individuals with schizophrenia-spectrum disorders who are clinically stable: a systematic review and network meta-analysis.

Title:Treatment with tumour necrosis factor inhibitors is associated with a time-shifted retardation of radiographic spinal progression in patients with axial spondyloarthritis.

Title:Optimising both disease control and glucocorticoid dosing is essential for bone protection in patients with rheumatic disease.

Title:FABIAN-variant: predicting the effects of DNA variants on transcription factor binding.

Title:Stimulation of the EP₃ receptor causes lung edema by activation of TRPC6 in pulmonary endothelial cells.