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Medical genomics

Next Generation Sequencing (NGS) is an innovative technology which enables researchers to sequence millions of DNA or RNA molecules simultaneously. This powerful tool is revolutionizing a myriad of research fields, including basic biological research and the study of disease-relevant processes.

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BIH Medical Genomics Core Facility

The Medical Genomics Core Facility is a joint core facility of Charité and the Berlin Institute of Health (BIH). The facility, which has sites at both Charité and the Max Delbrück Center for Molecular Medicine (MDC), aims to offer research groups a broad spectrum of next generation sequencing technology. Thanks to its proximity to the clinical environment, the Charité-based site’s focus lies within the fields of oncology and personalized medicine.

Services on offer include:

Clinical applications

Oncology / Pathology (blood, FFPE, fresh frozen)

  • Cancer diagnosis (exome, custom panels)
  • Tumor mutational burden test (exome, custom panels)
  • Liquid biopsy (Roche AVENIO, custom panels)

Diagnosis of rare diseases

  • Whole exome/Mendeliome sequencing
  • Targeted gene panel sequencing

Next Generation Sequencing (NGS) methods

  • Enrichment-based targeted sequencing
  • Amplicon-based targeted sequencing
  • Methylation-capture sequencing
  • General DNA library preparation (NEBNext, Nextera XT, KAPA Hyper)
  • NGS library preparation from fresh frozen and FFPE materials
  • 16S metagenomics
  • Transcriptome sequencing
  • (Low input) total RNA sequencing (ribosomal enrichment)
  • MicroRNA sequencing



  • Illumina MiSeq
  • Illumina NextSeq500
  • Illumina HiSeq4000


  • Agilent 2100 Bioanalyzer System
  • Agilent 4200 Bioanalyzer System
  • BMG Labtech FLUOstar Omega
  • Roche LightCycler 480 II
  • Thermo Fisher Countess II FL
  • Thermo Fisher NanoDrop One
  • Thermo Fisher Qubit 3.0


  • Agilent NGS Workstation (Option B) – Bravo
  • Beckman Coulter – Biomek i7
  • Brand Liquid Handling Station
  • Roche MagNA pure 24
  • Roche AVENIO Millisect System
  • Thermo KingFischer Fle

Specimen preparation

  • Sage Science PippinHT
  • Thermo Fisher Covaris ME220
  • 10x Genomics Chromium System


+49 30 450 643 527