Virtual Liver is a major national initiative funded by the German Federal Ministry for Education and Research (BMBF) following HepatoSys. The project was launched in 2010 with the objective to explore the physiology and functionality of the liver at different scales (cellular, intercellular, lobular and organ level) with the integration of these scales into a "virtual liver".
Work Packages (WPs)
| WP A1 | Cellular metabolism |
| WP A2 | Integration of signaling pathways in hepato-cellular responses (cellular signaling) |
| WP A3 | Cross-linking signaling and metabolism/hepatocyte polarization (cross-linking) |
| WP B | Communication of hepatocytes and non-parenchymal liver cells (cell-cell-communication) |
| WP C | Liver lobule |
| WP D | Whole organ |
| WP E | Integrated model |
| WP F | Data management |
| WP G | Clinical translation |
The Computational Systems Biochemistry Group within the Virtual Liver Network
- Prof. Holzhütter
- Workpackage Vice Coordinator of WP A1
- Workpackage Coordinator of WPs A3 and E
- Project Coordinator of the subprojects A1.1, A3.1, E1 and F2
- Principal Investigator in subprojects A1.1, A1.2, A1.3, A3.1, A3.2, A3.3, A3.5, B2.2, C3, E1, E4, F2
- Dr. Iwona Wallach
- local project manager of WPs A3, D, E
- Dr. Bernd Binder
- participates in subprojects A3.3, A3.5
- Dr. Christian Bölling
- participates in subprojects A3.1, F2
- Dr. Andreas Hoppe
- participates in subprojects A1.1, A1.2, A1.3, A3.1, A3.2, B2.2, C3
- Nikolaus Berndt
- participates in subprojects A1.1, A1.2, A1.3
- Sascha Bulik
- participates in subprojects A1.1, A1.2, A1.3, A3.1, A3.2, C3, E1, E4
- Matthias König
- participates in subprojects A1.1, A3.1, C3, F2
- Virtual Liver F1 Pal
- Michael Weidlich
- participates in subproject F2
Our Projects
- Zonation of Hepatocyte Metabolism
- main contributor: Andreas Hoppe
- other contributors: Matthias König, (Sascha Bulik)
- connected to WP subprojects A1.1, A1.2, A1.3, B2.2, C3
- Prediction of Metabolic Flux Changes (MFC)
- main contributor: Andreas Hoppe
- other contributors: (Christian Bölling)
- connected to WP subprojects A1.1, A1.3, A3.1, B2.2, C3
- Kinetic Model of FLD Development
- main contributor: Sascha Bulik
- other contributors: Matthias König, Nikolaus Berndt
- connected to WP subprojects A1.1, A1.2, A1.3
- Integration of Metabolism and Signaling
- main contributor: Hergo Holzhütter
- other contributors: Sascha Bulik, (Christian Bölling)
- connected to WP subprojects A3.1, E1, E4
- Hepatocyte Polarity - Signaling. Metabolism and Vesicular Traffic
- main contributor: Bernd Binder
- connected to WP subprojects A3.3, A3.5
- Liver Knowledge Base (LKB)
- main contributor: Christian Bölling
- other contributors: Michael Weidlich
- connected to WP subproject F2