Toxicological data from in vitro tests or animal/human trials is not directly comparable due to heterogeneity of the biological test systems. It is necessary to relate those data by mathematical (prediction-) models to each other. Our main foci of attention are the development of prediction models for estimating eye irritation by chemical agents using cell- and tissue-based in vitro methods and the development of biometrical procedures (including software applications) for scoring phototoxity of chemical agents.
Researchers
Prof. Hermann-Georg Holzhütter
Dr. Björn Peters
Own Publications
Peters B and Holzhütter HG. (2002) In vitro phototoxicity testing: Development and validation of a new concentration response analysis software and biostatistical analyes relates to the use of various prediction models. ATLA, 30, 415-432. [PubMed]