Computational Systems Biochemistry Group

Metabolic networks handled in our department are frequently composed by many hundreds or even thousands of metabolites and reactions. The huge amount of information gathered and curated for every single entity of this network demands a highly organized infrastructure for storage and querying.

Therefore, we are restructuring our database backend and establishing a multi-tiered-architecture consisting of:

Presentation Layer (web-based user-interface)
Logic Layer (JAVA-modules for command processing, logical decision making, calculations and communication between the surrounding layers)
Data Layer (database backend)

A mayor focus is to integrate local and dispersed heterogeneous data and to derive new information automatically by exploitation of a set of semantic rules upon the ontological connections between entities.

Researcher

Michael Weidlich

This project is part of the HepatoSys Platform Modeling (SP 2.1 HepatoNet Stoichiometric model of hepatocyte metabolism).

Own Publications

Gille C, Bölling C, Hoppe A, Bulik S, Hoffmann S, Hübner K, Karlstädt A, Ganeshan R, König M, Rother K, Weidlich M, Behre J, Holzhütter HG. (2010) HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol Syst Biol., 6:411. [PubMed]

		Knowledgebase and Bioinformatic Tool Development for Analysis of Large Metabolic Networks
Home Research VirtualLiver People Publications Software Positions Events Contact		Metabolic networks handled in our department are frequently composed by many hundreds or even thousands of metabolites and reactions. The huge amount of information gathered and curated for every single entity of this network demands a highly organized infrastructure for storage and querying. Therefore, we are restructuring our database backend and establishing a multi-tiered-architecture consisting of: Presentation Layer (web-based user-interface) Logic Layer (JAVA-modules for command processing, logical decision making, calculations and communication between the surrounding layers) Data Layer (database backend) A mayor focus is to integrate local and dispersed heterogeneous data and to derive new information automatically by exploitation of a set of semantic rules upon the ontological connections between entities. Researcher Michael Weidlich This project is part of the HepatoSys Platform Modeling (SP 2.1 HepatoNet Stoichiometric model of hepatocyte metabolism). Own Publications Gille C, Bölling C, Hoppe A, Bulik S, Hoffmann S, Hübner K, Karlstädt A, Ganeshan R, König M, Rother K, Weidlich M, Behre J, Holzhütter HG. (2010) HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol Syst Biol., 6:411. [PubMed]