
Home Research VirtualLiver People Publications Software Positions Events Contact		Research Constrained optimization of flux-balance models Kinetic models of cellular processes Network reconstruction and validation Relating gene expression to cellular function Biometry of toxicological alternative methods Theory-based experimental design Future projects Finished & former projects Constrained Optimization of Flux-Balance Models Zonation of hepatocyte metabolism Prediction of metabolic flux changes (MFC) Integration of metabolism and signaling Flux-balance analysis of metabolic networks Top Kinetic Models of Cellular Processes Hepatocyte polarity - signaling. Metabolism and vesicular traffic Kinetic model of FLD development Integration of metabolism and signaling Integrative kinetic model of hepatocyte metabolism Development of an electric-metabolic osmotic (EMO) model for neuronal cells Neuronal excitations as a perturbation of the energetic and osmotic homeostasis: Implication for rubust network behaviour Liver function test - methacetin kinetics Membrane biogenesis modeling of a Toxoplasma gondii-infected human cell and deduction of underlying metabolic principles Top Network Reconstruction and Validation Liver knowledge base (LKB) Reconstruction of myocyte metabolism Top Relating Gene Expression to Cellular Function Analysis and interpretation of transcription profiles and visualization of gene expression levels in metabolic networks Top Biometry of Toxicological Alternative Methods Phototox Acusoft Top Theory-Based Experimental Design Analysis of degradation of support fixed peptides by the 20S proteasome Computer-based identification of fragments in proteasome digest (mass spectrometry) Top Future Projects Modeling the foam-cell formation Top Finished & Former Projects HepatoSys Verification of the stoichiometric model of the hepatocyte with flux-balance optimization Metabolic network reconstruction and modeling of human hepatocytes Knowledgebase and bioinformatic tool development for analysis of large metabolic networks Integrative kinetic model of hepatocyte metabolism Mathematical modeling of the vesicle transport Lipid transport in hepatocytes Exploitation of high-throughput data to increase the reliability of metabolic flux predictions Antigen presentation Development of methods for kinetic modeling of complex systems Influence of enzyme costs on fluxes in metabolic networks Minimal flux modes (MinModes) - fundamental flux modes with a unique functional interpretation Computational estimation of Gibbs free energy values of enzymatic reactions Functional relevance of protein-protein interactions in metabolic networks Modeling the lipoprotein metabolism Molecular dynamics of oxygen transport in lipoygenase Substrate binding studies with the 20S proteasome Top