Previous publications of Prof. Holzhütter

2001 & 2000

1999 & before

Holzhütter HG, Frommel C and Kloetzel PM. (1999)
A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20 S proteasome. J. Mol. Biol., 286(4), 1251-65. [PubMed]

Kuon W, Lauster R, Holzhütter HG, Braun J, Sieper J. (1999)
Screening of the whole chlamydia trachomatis genome for peptides presented by HLA-B27. Arthritis & Rheumatism 42(9)Suppl., S375 (abstract).

Schmidtke G, Holzhütter HG, Bogyo M, Kairies N, Groll M, de Giuli R, Emch S and Groettrup M. (1999)
How an inhibitor of the HIV-I protease modulates proteasome activity. J. Biol. Chem., 274(50), 35734-35740. [PubMed]

Walther M, Holzhütter HG, Kuban RJ, Wiesner R, Rathmann J, Kühn H. (1999)
The Inhibition of Mammalian 15-Lipoxygenases by the Anti-Inflammatory Drug Ebselen: Dual-Type Mechanism Involving Covalent Linkage and Alteration of the Iron Ligand Sphere. Mol Pharmacol., 56(1):196-203. [PubMed]

Zaiss DM, Standera S, Holzhütter H, Kloetzel PM and Sijts AJ. (1999)
The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes. FEBS Lett., 457(3), 333-338. [PubMed]

Fentem JH, Archer GE, Balls M, Botham PA, Curren RD, Earl LK, Esdaile DJ, Holzhütter HG, Liebsch M. (1998)
The ECVAM international validation study on in vitro tests for skin corrosivity. 2. Results and evaluation by the management team. Toxicol In Vitro., 12(4):483-524. [PubMed]

Ivanov I, Schwarz K, Holzhütter HG, Myagkova G, Kühn H. (1998)
Omega-oxidation impairs oxidizability of polyenoic fatty acids by 15-LOX: consequences for substrate orientation of the active site. Biochem. J., 336( Pt 2):345-52. [PubMed]

Spielmann H, Balls M, Dupuis J, Pape WJW, DeSilva O, Holzhütter HG et al. (1998)
A Study on UV-Filter Chemicals from annex VII of European Union Directive 76/768/EEC in the in vitro 3T3 NRU phototoxicity test. ATLA, 26:679-708.

Spielmann H, Balls M, Dupuis J, Pape WJ, Pechovitch G, de Silva O, Holzhütter HG, Clothier R, Desolle P, Gerberick F, Liebsch M, Lovell WW, Maurer T, Pfannenbecker U, Potthast JM, Csato M, Sladowski D, Steiling W, Brantom P. (1998)
The International EU/COLIOPA in vitro phototoxicity validation study: results of phase II (Blind Trial). Part 1: The 3T3 NRU phototoxicity. Toxicol In Vitro., 12(3):305-27. [PubMed]

Archer G, Balls M, Bruner LH, Curren RD, Fentem JH, Holzhütter HG et al. (1997)
The validation of toxicological prediction models. ATLA, 25: 505-516.

Feder P, Carr G, Holzhütter HG, Lovell D, Springer J. (1997) Statistical planning and analysis considerations in the evaluation of in vitro alternatives to whole animal use for eye irritation testing. Food Chem. Tox., 35(1):167-74. [PubMed]

Holzhütter HG. (1997)
A general measure of in vitro phototoxicity derived from pairs of dose-response curves and its use for predicting the in vivo phototoxicity of chemicals. ATLA, 25: 445-462.

Holzhütter HG, Wiesner R, Rathmann J, Stösser R, Kühn H. (1997)
A kinetic model for the interaction of nitric oxide with a mammalian lipoxygenase. Eur J Biochem., 245(3):608-16. [PubMed]

Schwendel A, Grune T, Holzhütter HG, Siems WG. (1997)
Models for the regulation of purine metabolism in rat hepatocytes: evaluation of tracer experiments. Am. J. Physiol., 273(1 Pt 1):G239-46. [PubMed]

Spielmann H, Balls M, Pechovitch G, Dupuis J, deSilva O, Pape W, Holzhütter HG (1997)
A validaton study of in vitro photoirritation test in a joint EU/COLIPA project: preliminary report. In: Proc. of the World Congress on Animal Alternatives Welfare and Ethics (L.F.M. von Zutphen and M. Balls, eds.) pp 1135-1143.

Spielmann H, Liebsch M, Döring B, Moldenhauer F, Holzhütter HG et al. (1997)
Possibilities to check in vitro/in vivo correlations when validating in vitro methods in toxicology. In: Correlations between in vitro and in vivo investigation in inhalation toxicology. ILSI Monographs, ILSI Press Washington, DC (Eds. Mohr, U. et al.) pp. 94-111

Spielmann H, Liebsch M, Moldenhauer F, Holzhütter HG, Bagley DM, Lipman JM, Pape WJ, Miltenburger H, de Silva O, Hofer H, Steiling W. (1997)
IRAG working group 2. CAM-based assays. Interagency Regulatory Alternatives Group. Food Chem Toxicol., 35(1):39-66. [PubMed]

Holzhütter HG, Archer G, Dami N, Lovell DP, Saltelli A, Sjönstrom M. (1996)
Recommendations for the application of biostatistical methods during the development and validation of alternative toxicological methods. ATLA, 24: 511-530.

Holzhütter HG, Spielmann H. (1996)
The use of prediction models in validation studies: What should they predict? ATLA, 24: 881-884.

Spielmann H, Liebsch M, Kalweit S, Moldenhauer F, Wirnsberger T, Holzhütter HG et al. (1996)
Results of a validation study in Germany on two in vitro alternatives to the draize eye irritation test, the HET-CAM test and the 3T3 NRU cytotoxicity test. ATLA, 24: 741-858.

Wiesner R, Rathmann J, Holzhütter HG, Stößer R, Mäder K, Nolting H, Kühn H. (1996)
Nitric oxide oxidises a ferrous mammalian lipoxygenase to a pre-activated ferric species. FEBS Lett., 389: 229-232 [PubMed]

Schuster R and Holzhütter HG. (1995)
Use of Mathematical Models for Predicting the Metabolic Effect of Evolution of Large-Scale Enzyme Activity Alteration: Application to Enzyme Deficiencies of Red Blood Cells. Eur. J. Biochem., 229, 403-418. [PubMed]

Holzhütter HG, Schwendel A, Grune T, Quedenau J, Siems W. (1993)
Estimation of steady-state flux rates in metabolic systems by computer simulations of radioactive tracer experiments. Comput Appl Biosci., 9(5), 573-580. [PubMed]

Bartel T and Holzhütter HG. (1990)
Mathematical modelling of the purine metabolism of the rat liver Biochim. Biophys. Acta, 1035, 331-339. [PubMed]

Hausdorf G, Krüger K, Küttner G, Holzhütter HG, Frömmel C and Höhne WE (1987)
Oxydation of a methionine residue in subtilisin-type proteinases by the hydrogenperoxide-borate system - an active site directed reaction. Biochem. Biophys. Acta, 952: 20 - 26. [PubMed]

Frömmel C and Holzhütter HG. (1985)
An estimate on the effect of point mutation and natural selection on the rate of amino acid replacement in proteins. J. Mol. Evol., 21: 233 - 257. [PubMed]

Holzhütter HG, Henke W, Dubiel W and Gerber G. (1985)
A mathematical model to study the short-term regulation of mitochondrial energy transduction. Biochim. Biophys. Acta, 810, 252-268. [PubMed]

Küttner GAS, Holzhütter HG and Frömmel C. (1985)
The use of progress curves for the estimation of inactivation rate constants of enzymes. Biomed. Biochim. Acta, 44: 1025 - 1034. [PubMed]


Home Research VirtualLiver People Publications Software Positions Events Contact		Previous publications of Prof. Holzhütter 2001 & 2000 1999 & before Holzhütter HG, Frommel C and Kloetzel PM. (1999) A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20 S proteasome. J. Mol. Biol., 286(4), 1251-65. [PubMed] Kuon W, Lauster R, Holzhütter HG, Braun J, Sieper J. (1999) Screening of the whole chlamydia trachomatis genome for peptides presented by HLA-B27. Arthritis & Rheumatism 42(9)Suppl., S375 (abstract). Schmidtke G, Holzhütter HG, Bogyo M, Kairies N, Groll M, de Giuli R, Emch S and Groettrup M. (1999) How an inhibitor of the HIV-I protease modulates proteasome activity. J. Biol. Chem., 274(50), 35734-35740. [PubMed] Walther M, Holzhütter HG, Kuban RJ, Wiesner R, Rathmann J, Kühn H. (1999) The Inhibition of Mammalian 15-Lipoxygenases by the Anti-Inflammatory Drug Ebselen: Dual-Type Mechanism Involving Covalent Linkage and Alteration of the Iron Ligand Sphere. Mol Pharmacol., 56(1):196-203. [PubMed] Zaiss DM, Standera S, Holzhütter H, Kloetzel PM and Sijts AJ. (1999) The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes. FEBS Lett., 457(3), 333-338. [PubMed] Fentem JH, Archer GE, Balls M, Botham PA, Curren RD, Earl LK, Esdaile DJ, Holzhütter HG, Liebsch M. (1998) The ECVAM international validation study on in vitro tests for skin corrosivity. 2. Results and evaluation by the management team. Toxicol In Vitro., 12(4):483-524. [PubMed] Ivanov I, Schwarz K, Holzhütter HG, Myagkova G, Kühn H. (1998) Omega-oxidation impairs oxidizability of polyenoic fatty acids by 15-LOX: consequences for substrate orientation of the active site. Biochem. J., 336( Pt 2):345-52. [PubMed] Spielmann H, Balls M, Dupuis J, Pape WJW, DeSilva O, Holzhütter HG et al. (1998) A Study on UV-Filter Chemicals from annex VII of European Union Directive 76/768/EEC in the in vitro 3T3 NRU phototoxicity test. ATLA, 26:679-708. Spielmann H, Balls M, Dupuis J, Pape WJ, Pechovitch G, de Silva O, Holzhütter HG, Clothier R, Desolle P, Gerberick F, Liebsch M, Lovell WW, Maurer T, Pfannenbecker U, Potthast JM, Csato M, Sladowski D, Steiling W, Brantom P. (1998) The International EU/COLIOPA in vitro phototoxicity validation study: results of phase II (Blind Trial). Part 1: The 3T3 NRU phototoxicity. Toxicol In Vitro., 12(3):305-27. [PubMed] Archer G, Balls M, Bruner LH, Curren RD, Fentem JH, Holzhütter HG et al. (1997) The validation of toxicological prediction models. ATLA, 25: 505-516. Feder P, Carr G, Holzhütter HG, Lovell D, Springer J. (1997) Statistical planning and analysis considerations in the evaluation of in vitro alternatives to whole animal use for eye irritation testing. Food Chem. Tox., 35(1):167-74. [PubMed] Holzhütter HG. (1997) A general measure of in vitro phototoxicity derived from pairs of dose-response curves and its use for predicting the in vivo phototoxicity of chemicals. ATLA, 25: 445-462. Holzhütter HG, Wiesner R, Rathmann J, Stösser R, Kühn H. (1997) A kinetic model for the interaction of nitric oxide with a mammalian lipoxygenase. Eur J Biochem., 245(3):608-16. [PubMed] Schwendel A, Grune T, Holzhütter HG, Siems WG. (1997) Models for the regulation of purine metabolism in rat hepatocytes: evaluation of tracer experiments. Am. J. Physiol., 273(1 Pt 1):G239-46. [PubMed] Spielmann H, Balls M, Pechovitch G, Dupuis J, deSilva O, Pape W, Holzhütter HG (1997) A validaton study of in vitro photoirritation test in a joint EU/COLIPA project: preliminary report. In: Proc. of the World Congress on Animal Alternatives Welfare and Ethics (L.F.M. von Zutphen and M. Balls, eds.) pp 1135-1143. Spielmann H, Liebsch M, Döring B, Moldenhauer F, Holzhütter HG et al. (1997) Possibilities to check in vitro/in vivo correlations when validating in vitro methods in toxicology. In: Correlations between in vitro and in vivo investigation in inhalation toxicology. ILSI Monographs, ILSI Press Washington, DC (Eds. Mohr, U. et al.) pp. 94-111 Spielmann H, Liebsch M, Moldenhauer F, Holzhütter HG, Bagley DM, Lipman JM, Pape WJ, Miltenburger H, de Silva O, Hofer H, Steiling W. (1997) IRAG working group 2. CAM-based assays. Interagency Regulatory Alternatives Group. Food Chem Toxicol., 35(1):39-66. [PubMed] Holzhütter HG, Archer G, Dami N, Lovell DP, Saltelli A, Sjönstrom M. (1996) Recommendations for the application of biostatistical methods during the development and validation of alternative toxicological methods. ATLA, 24: 511-530. Holzhütter HG, Spielmann H. (1996) The use of prediction models in validation studies: What should they predict? ATLA, 24: 881-884. Spielmann H, Liebsch M, Kalweit S, Moldenhauer F, Wirnsberger T, Holzhütter HG et al. (1996) Results of a validation study in Germany on two in vitro alternatives to the draize eye irritation test, the HET-CAM test and the 3T3 NRU cytotoxicity test. ATLA, 24: 741-858. Wiesner R, Rathmann J, Holzhütter HG, Stößer R, Mäder K, Nolting H, Kühn H. (1996) Nitric oxide oxidises a ferrous mammalian lipoxygenase to a pre-activated ferric species. FEBS Lett., 389: 229-232 [PubMed] Schuster R and Holzhütter HG. (1995) Use of Mathematical Models for Predicting the Metabolic Effect of Evolution of Large-Scale Enzyme Activity Alteration: Application to Enzyme Deficiencies of Red Blood Cells. Eur. J. Biochem., 229, 403-418. [PubMed] Holzhütter HG, Schwendel A, Grune T, Quedenau J, Siems W. (1993) Estimation of steady-state flux rates in metabolic systems by computer simulations of radioactive tracer experiments. Comput Appl Biosci., 9(5), 573-580. [PubMed] Bartel T and Holzhütter HG. (1990) Mathematical modelling of the purine metabolism of the rat liver Biochim. Biophys. Acta, 1035, 331-339. [PubMed] Hausdorf G, Krüger K, Küttner G, Holzhütter HG, Frömmel C and Höhne WE (1987) Oxydation of a methionine residue in subtilisin-type proteinases by the hydrogenperoxide-borate system - an active site directed reaction. Biochem. Biophys. Acta, 952: 20 - 26. [PubMed] Frömmel C and Holzhütter HG. (1985) An estimate on the effect of point mutation and natural selection on the rate of amino acid replacement in proteins. J. Mol. Evol., 21: 233 - 257. [PubMed] Holzhütter HG, Henke W, Dubiel W and Gerber G. (1985) A mathematical model to study the short-term regulation of mitochondrial energy transduction. Biochim. Biophys. Acta, 810, 252-268. [PubMed] Küttner GAS, Holzhütter HG and Frömmel C. (1985) The use of progress curves for the estimation of inactivation rate constants of enzymes. Biomed. Biochim. Acta, 44: 1025 - 1034. [PubMed]