Matthias König

Computational Systems Biochemistry Group
Charite´ - Universitätsmedizin Berlin
Charite´ Crossover (CCO), Raum 04 321, Virchowweg 6, 10117 Berlin, Germany
phone +49 30 450528-197
matthias.koenigcharite.de

Research Interests

  • Multi-scale modeling of liver metabolism
  • Kinetic modeling of biological systems
  • Liver central metabolism (focus on glucose & fatty acid metabolism)
  • Software Development for metabolic network analysis, data management and visualization (SBML)
  • Constraint-based methods (FBA) in metabolic networks

ResearchGate Profile
Google Scholar Profile

Publications

2014Ricken T., Werner D., Holzhütter HG., König M., Dahmen U., Dirsch O.
Modeling function-perfusion behavior in liver lobules including tissue, blood, glucose, lactate and glycogen by use of a coupled two-scale PDE-ODE approach.
Biomech Model Mechanobiol. 2014 Sep 19. [Epub ahead of print] [doi, PubMed]
2014König M. and Holzhütter HG.
Homeostasis of blood glucose - Computer simulations of central liver functions.
systembiologie.de 2014; 8:p.53-57 [PDF (de), PDF (en)]
2013König M., Holzhütter HG., Berndt N.
Metabolic Gradients as Key Regulators in Zonation of Tumor Energy Metabolism: A Tissue-scale Model Based Study.
Biotechnol J. 2013 Apr 16. [Epub ahead of print] [doi, PubMed]
2012König M. and Holzhütter HG.
Kinetic Modeling of Human Hepatic Glucose Metabolism in T2DM Predicts Higher Risk of Hypoglycemic Events in Rigorous Insulin Therapy
J Biol Chem. 2012 [DOI 10.1074/jbc.M112.382069]
2012König M., Dräger A. and Holzhütter HG.
CySBML: a Cytoscape plugin for SBML
Bioinformatics. 2012 Jul 5. [PubMed]
CySBML Homepage
2012König M., Bulik S. and Holzhütter HG.
Quantifying the Contribution of the Liver to the Homeostasis of Plasma Glucose: A Detailed Kinetic Model of Hepatic Glucose Metabolism Integrated with the Hormonal Control by Insulin, Glucagon and Epinephrine
PLoS Comput Biol. 2012 Jun;8(6):e1002577. Epub 2012 Jun 21. [PubMed]
2011Herling A, König M, Bulik S, Holzhütter HG.
Enzymatic Features of the Glucose Metabolism in Tumor Cells.
FEBS J. 2011 Jul;278(14):2436-59. [doi, PubMed]
2010König M. and Holzhütter HG.
FluxViz - Cytoscape Plug-in for Vizualisation of Flux Distributions in Networks
Genome Informatics 2010, Vol.24, p.96-103 [PubMed]
CyFluxViz Homepage
2010

Gille C, Bölling C, Hoppe A, Bulik S, Hoffmann S, Hübner K, Karlstädt A, Ganeshan R, König M, Rother K, Weidlich M, Behre J, Holzhütter HG.
HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology.
Mol Syst Biol., 6:411. [PubMed]

Software Development

CySBML : A Cytoscape plugin for SBML
CyFluxViz : A Cytoscape Plugin for Visualization of Flux Distributions
CySabioRK : Cytoscape plugin for loading reaction kinetics networks