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Dr. Katrin Hübner
Modeling of Biological Processes Group
phone +49 6221 5451-276 |
Research Interests
- Systems biology: Modeling and simulation of metabolic systems
- Virtual Lipidology: Modeling the lipoprotein metabolism and computation of lipoprotein density profiles
- Modeling the foam-cell formation
- Stoichiometric network of the hepatocyte
- Integration of genetic variation into metabolic modeling
- Information modeling and knowledge representation
- Petri net theory
- Science communication and management
Education and Training
- 1996 - 2000: Studies in Biochemistry at Freie Universität Berlin
- Diploma thesis in the Bioinformatics group (Prof. Jens-Georg Reich) at Max-Delbrück-Center for Molecular Medicine
- 2000 - 2002: Scientific consultant for an IT-Company
- 2002: Postgraduate studies in Bioinformatics at the "Akademie für Weiterbildung an den Universitäten Heidelberg und Mannheim e.V."
- PhD studies in the Bioinformatics group (Prof. Jens-Georg Reich) at Max-Delbrück-Center for Molecular Medicine, associated to the Graduate Program 'Dynamics and Evolution of Cellular and Macromolecular Processes'
- Sept. 2004 - Dec 2007: PhD student in the Systems Biology group at the Institute of Biochemistry, Charité and member of the German Systems Biology Research Initiative HepatoSys funded by the BMBF
Publications
Gille C, Bölling C, Hoppe A, Bulik S, Hoffmann S, Hübner K, Karlstädt A, Ganeshan R, König M, Rother K, Weidlich M, Behre J, Holzhütter HG. (2010) HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol Syst Biol., 6:411. [PubMed]
Hübner K, Schwager T, Winkler K, Reich JG, Holzhütter HG. (2008) Computational lipidology: predicting lipoprotein density profiles in human blood plasma. PLoS Comput Biol., 23;4(5):e1000079. [PubMed]
Talks
Hübner K (2006). Lipoprotein profiles - What is behind common density classes? 36. Jahrestagung des Arbeitskreises "Klinischer Lipidstoffwechsel", Nov 30 - Dec 2, Maikammer, GermanyHübner K (2006). In silico analysis and prediction of higher resolution lipoprotein density profiles. Invited talk at department of clinical chemistry, University of Freiburg, Oct 17, Freiburg, Germany
Hafez K (Hübner), Schwager T, Reich JG, Holzhütter HG (2005). Kinetic modeling of the lipoprotein metabolism. Platform Meeting "Modeling&Bioinformatics" of the BMBF HepatoSys Research Initiative, January 27-28, Berlin, Germany
Poster
Hübner K, Schwager T, Reich JG, Holzhütter HG (2006). Computational approaches towards prediction of lipoprotein composition. XIV International Symposium on Atherosclerosis, June 18-22, Rome, ItalyHafez K (Hübner), Reich JG (2004). Modeling Approaches in Lipid Metabolism. 4th International Workshop on Bioinformatics and Systems Biology}, June 1-3, Kyoto, Japan
Scholarships
- Fellowship of the Klaus Tschira Foundation gGmbH for the postgraduate studies in Bioinformatics
bioquant.uni-heidelberg.de