Sabrina Hoffmann

Computational Systems Biochemistry Group

Charité - Universitätsmedizin Berlin
Seestr. 73
13347 Berlin
Germany

sabrina.hoffmannweb.de

Research Interests

  • Metabolic pathway analysis
  • Metabolic flux prediction based on optimization principles (i.e. flux balance analysis)
  • Systems biology
  • Robustness and modularity of biological systems

Education and Training

  • 1998 - 2000: Basic studies in biotechnology at the Technical University Braunschweig.
  • 2000 - 2003: Master studies in biotechnology at the Ecole Superieur de Biotechnologie Strasbourg (ESBS), France. Finished with Diploma
  • Jan. 2003 - Sept. 2003: Internship for diploma thesis at the research group of Jacky Snoep, Stellenbosch University, South Africa
  • 2003 - 2005: Postgraduate master studies in bioinformatics at TFH Berlin.
  • Sept. 2004 - June 2005: Master's thesis with the following title
    "Entwicklung von Werkzeugen und mathematischen Methoden für die modulare Rekonstruktion und Analyse von metabolischen Netzwerken"
  • Since Aug. 2005: PhD studies in the field of metabolic flux balance analysis.

Publications

Berndt N, Hoffmann S, Benda J, Holzhütter HG. (2011) The influence of the chloride currents on action potential firing and volume regulation of excitable cells studied by a kinetic model. J Theor Biol., 276(1):42-49. [PubMed]

Hoppe A, Hoffmann S, Gerasch A, Gille C, Holzhutter HG. (2011) FASIMU: flexible software for flux-balance computation series in large metabolic networks. BMC Bioinformatics., 12(1):28. [PubMed]

Gille C, Bölling C, Hoppe A, Bulik S, Hoffmann S, Hübner K, Karlstädt A, Ganeshan R, König M, Rother K, Weidlich M, Behre J, Holzhütter HG. (2010) HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol Syst Biol., 6:411. [PubMed]

Rother K, Hoffmann S, Bulik S, Hoppe A, Gasteiger J, Holzhütter HG. (2010) IGERS: Inferring Gibbs energy changes of biochemical reactions from reaction similarities. Biophys J., 98(11):2478-86. [PubMed]

Hoffmann S and Holzhütter HG. (2009) Uncovering metabolic objectives pursued by changes of enzyme levels. Ann N Y Acad Sci., 1158:57-70. [PubMed]

Gille C, Hoffmann S, Holzhütter HG. (2007) METANNOGEN: compiling features of biochemical reactions needed for the reconstruction of metabolic networks. BMC Syst Biol., 1:5. [PubMed]

Hoffmann S, Hoppe A and Holzhütter HG. (2007) Pruning genome-scale metabolic models to consistent ad functionem networks. Genome Informatics, 18(1), 308-19. [pdf]

Hoppe A, Hoffmann S, Holzhütter HG. (2007) Including metabolite concentrations into flux-balance analysis: Thermodynamic realizability as a constraint on flux distributions in metabolic networks BMC Syst. Biol., 1(1): 23. [pdf, journal, PubMed]

Hoffmann S, Hoppe A and Holzhütter HG. (2006) Composition of Metabolic Flux Distributions by Functionally Interpretable Minimal Flux Modes (MinModes) Genome Informatics, 17(1), 195-207. [pdf]

Gille C, Hoffmann S, Holzhütter HG. (2005) Combining Bioinformatics Resources for the Structural Modelling of Eukaryotic Metabolic Networks Genome Informatics, 16(1), 223-232. [pdf]