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Hermann-Georg Holzhütter
Computational Systems Biochemistry Group
phone +49 30 450 528 166 |
charite.de
Research Interests
- Systems biology
- HepatoSys
- Constrained optimization of flux-balance models
- Kinetic models of cellular processes
- Network reconstruction and validation
- Relating gene expression to cellular function
- Biometry of toxicological alternative methods
- Theory-based experimental design
Recent Publications
Rother K, Hoffmann S, Bulik S, Hoppe A, Gasteiger J, Holzhütter HG. (2010) IGERS: Inferring Gibbs energy changes of biochemical reactions from reaction similarities. Biophys J., 98(11):2478-86. [PubMed]
Binder B, Goede A, Berndt N, Holzhütter HG. (2009) A conceptual mathematical model of the dynamic self-organisation of distinct cellular organelles. PLoS One, 4(12):e8295. [PubMed]
Bech-Otschir D, Helfrich A, Enenkel C, Consiglieri G, Seeger M, Holzhütter HG, Dahlmann B, Kloetzel PM. (2009) Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome. Nat Struct Mol Biol., 16(2):219-25. [PubMed]
Bulik S, Grimbs S, Huthmacher C, Selbig J, Holzhütter HG. (2009) Kinetic hybrid models composed of mechanistic and simplified enzymatic rate laws: A promising method for speeding up the kinetic modelling of complex metabolic networks. FEBS Journal, 276:410-424 [PubMed]
Hoffmann S and Holzhütter HG. (2009) Uncovering metabolic objectives pursued by changes of enzyme levels. Ann N Y Acad Sci., 1158:57-70. [PubMed]
Gille C, Hoppe A, Holzhütter HG. (2008) Web-Links as a Means to Document Annotated Sequence and 3D-Structure Alignments in Systems Biology. Genome Inform.; 20:277-84. [PubMed]
Hübner K, Schwager T, Winkler K, Reich JG, Holzhütter HG. (2008) Computational lipidology: predicting lipoprotein density profiles in human blood plasma. PLoS Comput Biol., 23;4(5):e1000079. [PubMed]
Huthmacher C, Gille C, Holzhütter HG. (2008) A computational analysis of protein interactions in metabolic networks reveals novel enzyme pairs potentially involved in metabolic channeling. J Theor Biol., 252(3):456-64. [PubMed]