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Hermann-Georg Holzhütter
Computational Systems Biochemistry Group
phone +49 30 450 528 166 |
charite.de
Research Interests
- Systems biology
- Virtual Liver
- HepatoSys
- Constrained optimization of flux-balance models
- Kinetic models of cellular processes
- Network reconstruction and validation
- Relating gene expression to cellular function
- Biometry of toxicological alternative methods
- Theory-based experimental design
Recent Publications
Berndt N, Hoffmann S, Benda J, Holzhütter HG. (2011) The influence of the chloride currents on action potential firing and volume regulation of excitable cells studied by a kinetic model. J Theor Biol., 276(1):42-49. [PubMed]
Herling A, König M, Bulik S, Holzhütter HG. (2011) Enzymatic Features of the Glucose Metabolism in Tumor Cells. FEBS J., doi: 10.1111/j.1742-4658.2011.08174.x. [PubMed]
Hoppe A, Hoffmann S, Gerasch A, Gille C, Holzhutter HG. (2011) FASIMU: flexible software for flux-balance computation series in large metabolic networks. BMC Bioinformatics., 12(1):28. [PubMed]
Hoppe A, Richter C, Holzhütter HG. (2011) Enzyme maintenance effort as criterion for the characterization of alternative pathways and length distribution of isofunctional enzymes. BioSystems., [in print]
Gille C, Bölling C, Hoppe A, Bulik S, Hoffmann S, Hübner K, Karlstädt A, Ganeshan R, König M, Rother K, Weidlich M, Behre J, Holzhütter HG. (2010) HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol Syst Biol., 6:411. [PubMed]
Huthmacher C, Hoppe A, Bulik S, Holzhutter HG. (2010) Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis. BMC Syst Biol., 4(1):120. [Epub ahead of print] [PubMed]
Rother K, Hoffmann S, Bulik S, Hoppe A, Gasteiger J, Holzhütter HG. (2010) IGERS: Inferring Gibbs energy changes of biochemical reactions from reaction similarities. Biophys J., 98(11):2478-86. [PubMed]
Sun G, Rosu DM, Zhang X, Hovestädt M, Pop S, Schade U, Aulich D, Gensch M, Ay B, Holzhütter HG, Zahn DRT, Esser N, Volkmer R, Rappich J and Hinrichs K (2010)
Synchrotron infrared spectroscopic ellipsometry (IRSE) for characterization of biofunctional surfaces.
physica status solidi (b), 247: 1925–1931.
[doi]
Bech-Otschir D, Helfrich A, Enenkel C, Consiglieri G, Seeger M, Holzhütter HG, Dahlmann B, Kloetzel PM. (2009) Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome. Nat Struct Mol Biol., 16(2):219-25. [PubMed]
Binder B, Goede A, Berndt N, Holzhütter HG. (2009) A conceptual mathematical model of the dynamic self-organisation of distinct cellular organelles. PLoS One, 4(12):e8295. [PubMed]
Bulik S, Grimbs S, Huthmacher C, Selbig J, Holzhütter HG. (2009) Kinetic hybrid models composed of mechanistic and simplified enzymatic rate laws: A promising method for speeding up the kinetic modelling of complex metabolic networks. FEBS Journal, 276:410-424 [PubMed]
Hoffmann S and Holzhütter HG. (2009) Uncovering metabolic objectives pursued by changes of enzyme levels. Ann N Y Acad Sci., 1158:57-70. [PubMed]
Lock JF, Taheri P, Bauer S, Holzhütter HG, Malinowski M, Neuhaus P, Stockmann M. (2009) Interpretation of Non-Invasive Breath Tests Using 13C-labeled Substrates - A Preliminary Report With superset13 C-Methacetin. Eur J Med Res., 14(12):547-50. [PubMed]