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Dr. Christoph Gille
Work Group Proteolytic Systems
phone +49 30 450528-315 |
charite.de
Research Interests
- The computer program MetAnnoGen facilitates the reconstruction of metabolic networks. It is an information system to collect and manage data from different databases and scientific literature in order to generate a metabolic network of biochemical reactions that can be subjected to further computational analyses.
- Transient protein-protein interactions of enzymes in the context of metabolic networks.
- Comprehensive E-learning platform on Bioinformatics. The online course provides insight into standard methods of Bioinformatics. The E-learning resource has been successfully used for students of Molecular Medicine, Bioinformatics, Biophysics, Biochemistry and Biology.
- Distribution of intron-exon boundaries in genes of proteins with transmembrane helices.
- Systems Biology: Metabolic Networks
- Other Bioinformatics online resources:
- Discussion of expression data in the context of metabolic networks
Education and Training
- May 1989 - Jul 1993: Study of Medicine at Humboldt University, Berlin.
- Sep 1992 - Aug 1993: 4th year at Medical School of Bristol, England
- Oct 1995 - Jan 1997: PhD studies at Humboldt University, Berlin, sponsored by Studienstiftung des Deutschen Volkes
- Feb 1996 - Aug 1996: House Officer in medicine in Douglas - Isle of Man Hospital
- Feb 1997 - May 1997: House Officer in the general surgical practice Dr. Hoffman, Berlin Prenzlauer Berg Berlin.
- Senior House Officer in the gastroenterological as well as the endocrinological departments of the Charité
- since Apr 1998: Scientific work at the Institute for Biochemistry, Charité
Selected Publications
Hoppe A, Hoffmann S, Gerasch A, Gille C, Holzhutter HG. (2011) FASIMU: flexible software for flux-balance computation series in large metabolic networks. BMC Bioinformatics., 12(1):28. [PubMed]
Gille C, Bölling C, Hoppe A, Bulik S, Hoffmann S, Hübner K, Karlstädt A, Ganeshan R, König M, Rother K, Weidlich M, Behre J, Holzhütter HG. (2010) HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol Syst Biol., 6:411. [PubMed]
Bauer RA, Bourne PE, Formella A, Frömmel C, Gille C, Goede A, Guerler A, Hoppe A, Knapp EW, Pöschel T, Wittig B, Ziegler V, Preissner R. (2008) Superimpose: a 3D structural superposition server. Nucleic Acids Res., 36(Web Server issue):W47-54. [PubMed]
Gille C, Hoppe A, Holzhütter HG. (2008) Web-Links as a Means to Document Annotated Sequence and 3D-Structure Alignments in Systems Biology. Genome Inform.; 20:277-84. [PubMed]
Huthmacher C, Gille C, Holzhütter HG. (2008) A computational analysis of protein interactions in metabolic networks reveals novel enzyme pairs potentially involved in metabolic channeling. J Theor Biol., 252(3):456-64. [PubMed]
Menküc BS, Gille C, Holzhütter HG. (2008) Computer aided optimization of carbon atom labeling for tracer experiments. Genome Inform., 20:270-6. [PubMed]
Gille C, Hoffmann S, Holzhütter HG. (2007) METANNOGEN: compiling features of biochemical reactions needed for the reconstruction of metabolic networks. BMC Syst Biol., 1:5. [PubMed]
Huthmacher C, Gille C, Holzhütter HG. (2007) Computational analysis of protein-protein interactions in metabolic networks of Escherichia coli and yeast. Genome Inform., 18:162-72. [PubMed]
Booms P, Ney A, Barthel F, Moroy G, Counsell D, Gille C, Guo G, Pregla R, Mundlos S, Alix AJ, Robinson PN. (2006) A fibrillin-1-fragment containing the elastin-binding-protein GxxPG consensus sequence upregulates matrix metalloproteinase-1: biochemical and computational analysis. J Mol Cell Cardiol., 40(2):234-46. [PubMed]
Gille C. (2006) Structural interpretation of mutations and SNPs using STRAP-NT. Protein Science., 15:208-10 [PubMed]
Gille C, Robinson PN. (2006) HotSwap for bioinformatics: a STRAP tutorial. BMC Bioinformatics., 7:64. [PubMed, http://www.charite.de/bioinf/strap/]
Mordmüller B, Fendel R, Kreidenweiss A, Gille C, Hurwitz R, Metzger WG, Kun JF, Lamkemeyer T, Nordheim A, Kremsner PG. (2006) Plasmodia express two threonine-peptidase complexes during asexual development. Mol Biochem Parasitol., 148(1):79-85. [PubMed]
Gille C, Hoffmann S, Holzhutter HG. (2005) Combining bioinformatics resources for the structural modelling of eukaryotic metabolic networks. Genome Inform., 16, 223-32. [PubMed]
Awards
- 1986 Special price of the Akademie der Wissenschaften for "Digitale Filterung von Zeitreihen" (Heinrich-Hertz-Contest)
- Robert-Koch-Preis der Charité for the PhD thesis