Computational Systems Biochemistry Group

HepatoSys - A network for Germany

HepatoSys was launched in 2004 with the objective of studying the intracellular processes in hepatocytes and eventually in the entire liver. It was the first major research initiative in the field of systems biology to be brought into being by the German Federal Ministry of Education and Research (BMBF) and Project Management Jülich (PTJ).

Four different Networks are dedicated to the regeneration and differentiation of liver cells, the processes involved in endocytosis (EndoSys), detoxification and iron metabolism. The Networks are supported by two Platforms, Cell Biology and Modeling, which develop fundamental tools and make them available for use in the research association’s work.

Platform Modeling

Speaker: Prof. Hermann-Georg Holzhütter (Charité – Universitätsmedizin Berlin)
Vice speaker: Dr. Steffen Klamt (Max-Planck-Institute for Dynamics of Complex Technical Systems, Magdeburg)
Coordinator: Dr. Iwona Wallach (Charité – Universitätsmedizin Berlin)
Subprojects
Central Data Management

Mathematical modeling of complex biological processes is a fundamental element of systems biology research. The purpose is to represent networked reaction pathways comprising metabolism, signal transmission or gene regulation in the computer. This enables the dynamic correlations between life processes to be simulated. The models allow predictions about the behaviour of complex biological systems and help to plan experiments more specifically.

The task of the Platform Modeling, which has partners in

Berlin (Charité - Universitätsmedizin Berlin, Prof. HG. Holzhütter),
Heidelberg (EML-Research and Ruprecht-Karls-Universität, Prof. U. Kummer),
Jena (Friedrich-Schiller-Universität, Prof. S. Schuster and Hans Knöll Institut, Dr. R. Guthke),
Magdeburg (Max-Planck-Institute for Dynamics of Complex Technical Systems, Prof. ED. Gilles, Dr. S. Klamt),

is to develop these valuable tools and make them available to the HepatoSys research network. Over and above the systems biology of the liver, the models and software tools can also be used for investigations in other areas and consequently are of interest to cooperation partners in academia and industry.

Currently, the Platform Modeling consists of 12 subprojects, one of them being the Central Data Management for the HepatoSys Network located at the MPI Magdeburg.

The following figure shows the overview of the research areas of the Platfomr partners:

		HepatoSys - Platform Modeling
Sysbio Group HepatoSys Subprojects Data Management Meetings Contact		HepatoSys - A network for Germany HepatoSys was launched in 2004 with the objective of studying the intracellular processes in hepatocytes and eventually in the entire liver. It was the first major research initiative in the field of systems biology to be brought into being by the German Federal Ministry of Education and Research (BMBF) and Project Management Jülich (PTJ). Four different Networks are dedicated to the regeneration and differentiation of liver cells, the processes involved in endocytosis (EndoSys), detoxification and iron metabolism. The Networks are supported by two Platforms, Cell Biology and Modeling, which develop fundamental tools and make them available for use in the research association’s work. Platform Modeling Speaker: Prof. Hermann-Georg Holzhütter (Charité – Universitätsmedizin Berlin) Vice speaker: Dr. Steffen Klamt (Max-Planck-Institute for Dynamics of Complex Technical Systems, Magdeburg) Coordinator: Dr. Iwona Wallach (Charité – Universitätsmedizin Berlin) Subprojects Central Data Management Mathematical modeling of complex biological processes is a fundamental element of systems biology research. The purpose is to represent networked reaction pathways comprising metabolism, signal transmission or gene regulation in the computer. This enables the dynamic correlations between life processes to be simulated. The models allow predictions about the behaviour of complex biological systems and help to plan experiments more specifically. The task of the Platform Modeling, which has partners in Berlin (Charité - Universitätsmedizin Berlin, Prof. HG. Holzhütter), Heidelberg (EML-Research and Ruprecht-Karls-Universität, Prof. U. Kummer), Jena (Friedrich-Schiller-Universität, Prof. S. Schuster and Hans Knöll Institut, Dr. R. Guthke), Magdeburg (Max-Planck-Institute for Dynamics of Complex Technical Systems, Prof. ED. Gilles, Dr. S. Klamt), is to develop these valuable tools and make them available to the HepatoSys research network. Over and above the systems biology of the liver, the models and software tools can also be used for investigations in other areas and consequently are of interest to cooperation partners in academia and industry. Currently, the Platform Modeling consists of 12 subprojects, one of them being the Central Data Management for the HepatoSys Network located at the MPI Magdeburg. The following figure shows the overview of the research areas of the Platfomr partners: