Topic and Background of the Priority Programme
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Coordination of the DFG priority programme "Selenoproteins"
Prof. Dr. Josef Köhrle, Berlin
Priority Programme 1087 - Projects of 3. Funding Period 2004-2006
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Humane Thioredoxinreduktasen: Selenoproteine als Zielmoleküle potenzieller Chemotherapien
Prof. Dr. Katja Becker-Brandenburg, Gießen -
Charakterisierung von Mäusen ohne funktionelles Gen für mitochondriale Thioredoxinreduktase (TR2): gewebespezifische Deletion des Gens
Dr. Markus Brielmeier, München -
Regulation der gewebsspezifischen Expression individueller Glutathionperoxidasen
Prof. Dr. Regina Brigelius-Flohé, Bergholz-Rehbrücke -
Charakterisierung von Mäusen ohne funktionelles Gen für Phospholipid-Hydroperoxid- Glutathionperoxidase: gewebespezifische Inaktivierung des Gens
Prof. Dr. Georg Bornkamm, München & Dr. Markus Conrad, München -
Die Rolle der Phospholipidhydroperoxid-Glutathionperoxidase (PHGPx) in der Spermienreifung
Prof. Dr. Leopold Flohé, Braunschweig -
Genetik der Selenoproteinsynthese bei Drosophila melanogaster
Prof. Dr. Herbert Jäckle, Göttingen - Dr. Gerd Vorbrüggen, Göttingen -
The impact of Selenium and selenoproteins on stem cell based bone regeneration and regulation of calcium metabolism
Prof. Dr. Franz Jakob, Würzburg -
Selenoproteins of the thyroid gland Studies on the glutathione peroxidase isoenzymes GPx-3 and GPx-6 and on the effects of Se deficiency on susceptibility to thyroid disease
Prof. Dr. Josef Köhrle, Berlin und PD Dr. Cornelia Schmutzler, Berlin -
Expressionsregulation der Phospholipid-Hydroperoxid Gluthathion-Peroxidase Isoformen. Transkriptionale und posttranskriptionale Prozesse
Prof. Dr. Hartmut Kühn, Berlin -
Identifizierung von neuen Selenoproteinen im Säugetierorganismus und Aufklärung ihres Stoffwechsels und ihrer Funktion
Dr. Anton Kyriakopoulos, Berlin -
Molekulare Mechanismen des Selenocystein-Einbaus bei der Proteinsynthese
Prof. Marina Rodnina, Witten-Herdecke -
Analyse der Expressionsregulation von Selenoproteinen in Neuronen und Gliazellen
Dr. Savaskan/Dr. Bräuer, Berlin -
Physiologische Effekte eines veränderten Selentransports und veränderter Selenverteilung in Geweben in Selenoprotein P Knockout Mäusen - Untersuchungen zum Einfluss des Geschlechts
Dr. Schomburg & Dr. Schweizer, Berlin -
Untersuchungen zur antioxidativen Funktion von Selenoprotein P in Endothelzellen und Astrozyten
Prof. Dr. Helmut Sies, Düsseldorf -
Kristallstrukturuntersuchungen zur Selenproteinbiosynthese
Dr. Markus Wahl, Göttingen -
Reaktivitäts- und Modelling-Studien des Selens in Se-Proteinen und Referenzverbindungen - Untersuchung und Design selenselektiver Marker und Ligandenn
Prof. Dr. Ludger A. Wessjohann & Dr. Brandt, Halle -
Koordinierung Selenoprotein-Schwerpunktprogramm
Prof. Josef Köhrle, Berlin
New functions of selenoproteins in gram-positive, anaerobic bacteria Combining bioinformatics and biological experiments to characterize SECIS-elements for Eubacterium acidaminophilum Human thioredoxin reductases: selenoproteins as potential drug targets Identification and characterization of new selenoproteins in the mammalian organism Generation and characterization of mice lacking functional phospholipid
hydroperoxide glutathione peroxidase (PHGPx): tissue specific gene targeting Generation and characterization of mice lacking functional mitochondrial thioredoxin reductase (TRxR2): tissue-specific gene targeting Tissue-specific regulation of the expression on individual glutathione peroxidases Role of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in sperm maturation Genetics of selenoprotein synthesis in Drosophila melanogaster Expression, regulation and function of selenoproteins in bone: mesenchymal stem cells and differentiated cells of the osteogenic lineage of differentiation Selenoproteins of the thyroid - studies on the expression and function of the ER-resident Sep15 and on the role of
secreted selenoproteins for thyrocyte function and thyroglobulin polymerization Expression regulation of phospholipid hydroperoxide glutathione peroxidase isoforms and structural investigations on these enzymes Cellular localization and differential regulation of Selenoprotein W and phospholipid hydroperoxide glutathione
peroxidase in the brain of normal and selenium deficient rats Biological function on Selenoprotein P: role in blood plasma Mechanism of selenophosphate synthesis in gram positive anaerobic bacteria - thiols as natural selenium donors Crystal structure analyses of selenoprotein biosynthesis
Reactivity and modelling studies of selenium in Se-Proteins and reference compounds: examination and design of selenium-selective tags and ligands [reactivity of selenopeptoids] New functions of selenoproteins in gram-positive, anaerobic bacteria Human thioredoxin reductase: Selenoproteins as potential drug targets Identification and characterization of new selenoproteins in the mammalian organism Selenoprotein biosynthesis in Archaea Tissue-specific regulation of the expression on individual glutathione peroxidases Algorithmic determination of whether a protein's cysteine residue can be replaced by selenocysteine by silent/similiar pointwise mutagenesis in DNA/RNA.
Intended application to phase determination in X-ray crystallography and NMR spectroscopy. Role of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in sperm maturation Crystal structure analyses of selenoprotein biosynthesis Genetics of selenoprotein synthesis in Drosophila melanogaster Expression of selenoproteins in cells of the monocyte/macrophage differentiation pathway - Implications for the immune system Cellular location, differential regulation and function of selenoproteins in the human thyroid The functional interplay between 15-lipoxygenase and phospholipid hydroperoxide glutathione peroxidase and its regulation by cytokines Functional and structural characterization of the Se-Mo active site in CO dehydrogenase Cellular localization and differential regulation of Selenoprotein W in the rat CNS Biological function of Selenoprotein P: binding characteristics and cellular localization Mechanism of UGA decoding as selenocystein in gram-positive anaerobic bacteria Modulation of apoptotic cell death by selenium supplementation
Priority Programme 1087 - Projects of 2. Funding Period 2002-2004
Participants of the 2nd Colloquium of the DFG-Priority Programme Selenoproteins (July 7th - 8th, 2003 in Berlin)
Prof. Dr. Jan Remmer Andreesen, Halle
Prof. Dr. Rolf Backofen, Jena - Dr. Brigitte Söhling, Halle
Prof. Dr. Katja Becker-Brandenburg, Gießen
Prof. Dr. Dietrich Behne, Berlin
Prof. Dr. Georg Bornkamm, München - Dr. Markus Conrad, München
Dr. Markus Brielmeier, München
Prof. Dr. Regina Brigelius-Flohé, Bergholz-Rehbrücke
Prof. Dr. Leopold Flohé, Braunschweig
Prof. Dr. Herbert Jäckle, Göttingen - Dr. Gerd Vorbrüggen, Göttingen
Prof. Dr. Franz Jakob, Würzburg
Prof. Dr. Josef Köhrle, Berlin - PD Dr. Cornelia Schmutzler, Berlin
Prof. Dr. Hartmut Kühn, Berlin
Prof. Dr. Robert Nitsch, Berlin - Dr. Olaf Ninnemann, Berlin
Prof. Dr. Helmut Sies, Düsseldorf
Dr. Brigitte Söhling, Halle
Dr. Markus Wahl, München - Prof. Dr. Robert Huber, Martinsried
Prof. Dr. Ludger A. Wessjohann, Halle (Saale)
Priority Programme 1087 - Projects of 1. Funding Period 2000-2002
Teilnehmer des Rundtischgesprächs zur Einrichtung des SPP Selenoproteine
Prof. Dr. Jan Remmer Andreesen, Halle
Prof. Dr. Katja Becker-Brandenburg, Giessen
Prof. Dr. Dietrich Behne, Berlin
Prof. Dr. August Böck, München
Prof. Dr. Regina Brigelius-Flohé, Bergholz-Rehbrücke
Prof. Dr. R. Backofen, Jena - Prof. Dr. August Böck, München
Prof. Dr. Leopold Flohé, Braunschweig
Prof. Dr. Robert Huber, Martinsried
Prof. Dr. Herbert Jäckle, Göttingen - Dr. Gerd Vorbrüggen, Göttingen
Prof. Dr. Franz Jakob, Würzburg
Prof. Dr. Josef Köhrle, Würzburg
Prof. Dr. Hartmut Kühn, Berlin
Prof. Dr. Ortwin Meyer, Bayreuth
Prof. Dr. Robert Nitsch, Berlin
Prof. Dr. Helmut Sies, Düsseldorf
Dr. Brigitte Söhling, Halle
Prof. Dr. rer. nat. Albrecht Wendel, Konstanz
