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A. Referierte Originalarbeiten
1995
- Shakibaei M, Förster C, Merker H J, Stahlmann R (1995) Effects of ofloxacin
on integrin expression on epiphyseal mouse chondrocytes in vitro. Toxic in vitro
9:107-116
- Stahlmann R, Neubert R (1995) Value of non-human primate data (Intl. Workshop
on Environmental Immunotoxicology and Human Health) Hum Exp Toxicol 14:146-147
- Förster C, Shakibaei M, Schilcher H, Stahlmann R (1995) Expression of ß1-integrins
on epiphyseal chondrocytes is reduced by ofloxacin. Drugs 49 (Suppl 2): 279-282
- Shakibaei M, Förster C, Merker H-J, Stahlmann R (1995) Ofloxacin alters
expression of integrins on chondrocytes from mouse fetuses in vitro. Drugs 49 (Suppl
2): 293-295
- Stahlmann R, Förster C, Shakibaei M, Vormann J, Günther T, Merker
H-J (1995) Magnesium deficiency induces joint cartilage lesions in juvenile rats
which are identical to quinolone-induced arthropathy. Antimicrob Agents Chemother
39: 2013-2018
- Schulz TG, Stahlmann R, Edwards RJ, Debris K, Davies DS, Neubert D (1995) Enoxacin
is an inducer of CYP1A2 in rat liver. Biochem Pharmacol 50: 1517-1520
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1996
- Förster C, Kociok K, Shakibaei M, Merker H-J, Vormann J, Günther T,
Stahlmann R (1996) Integrins on joint cartilage chondrocytes and alterations by ofloxacin
or magnesium deficiency in immature rats. Arch Toxicol 70: 261-270
- Förster C, Kociok K, Shakibaei M, Merker H-J, Stahlmann R (1996) Quinolone-induced
cartilage lesions are not reversible in rats. Arch Toxicol 70: 474-481
- Shakibaei M, Kociok K, Förster C, Vormann J, Günther T, Stahlmann
R, Merker H-J (1996) Comparative evaluation of ultrastructural changes in articular
cartilage of ofloxacin-treated and magnesium-deficient immature rats. Toxicol Pathol
24: 580-587
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1997
- Günther T, Rücker M, Förster C, Vormann J, Stahlmann R (1997)
In vitro evidence for a Donnan distribution of Mg2+ and Ca2+ by chondroitin sulfate
in cartilage. Arch Toxicol 71: 471-475
- Vormann J, Förster C, Zippel U, Lozo E, Günther T, Merker HJ, Stahlmann
R (1997) Effects of magnesium deficiency on magnesium and calcium content in bone
and cartilage in developing rats in correlation to chondrotoxicity. Calc Tiss Intl
61: 230-238
- Förster C, Schwabe R, Lozo E, Zippel U,Vormann J, Günther T, Merker
HJ, Stahlmann R (1997) Quinolone-induced arthropathy: Exposure of magnesium-deficient
aged rats or immature rats, mineral concentrations in target tissues and pharmacokinetics.
Arch Toxicol 72: 26 -32
- Burkhardt JE, Förster C, Lozo E, Hill MA, Stahlmann R (1997) Immunohistochemistry
of articular cartilage from immature Beagle dogs dosed with difloxacin. Toxicol Pathol
25: 475-480
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1998
- Stahlmann R, Zippel U, Förster C, Schwabe R, Shakibaei M, Merker HJ, Borner
K (1998) Chondrotoxicity and toxicokinetics of sparfloxacin in juvenile rats. Antimicrob
Agents Chemother 42: 1470-1475
- Förster C, Rücker M, Shakibaei M, Baumann-Wilschke I, Vormann J, Stahlmann
R (1998) Effects of fluoroquinolones and magnesium deficiency in murine limb bud
cultures. Arch Toxicol 72: 411-419
- Stahlmann R, Lode H (1998) Safety of quinolones. The Lancet (Letter) 352/9136:
1313
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1999
- Stahlmann R, Schwabe R, Pfister K, Lozo E, Shakibaei M, Vormann J (1999) Supplementation
with magnesium and tocopherol diminishes quinolone-induced chondrotoxicity in immature
rats. Drugs 58 (Suppl 2): 393-394
- Stahlmann R, Kühner S, Shakibaei M, Schwabe R, van Sickle D (1999) Chondrotoxicity
of ciprofloxacin in immature Beagle dogs. Drugs 58 (Suppl 2): 388-389
- Schwabe R, Lozo E, Baumann-Wilschke I, Stahlmann R (1999) Chondrotoxicity and
target tissue kinetics of ofloxacin in immature rats after multiple doses. Drugs
58 (Suppl 2): 385-387
- Stahlmann R, Lode H (1999) Toxicity of quinolones. Drugs 58 (Suppl 2): 37-42
- Shakibaei M, Pfister K, Schwabe R, Stahlmann R (1999) Effects of ofloxacin on
the ultrastructure of Achilles tendon in rats. Drugs 58 (Suppl 2): 390-392
- Riecke K, Stahlmann R, Palavinskas R, Alexi-Meskishvili V, Mathar W (1999) Polychlorinated
dibenzodioxins and polychlorinated dibenzofurans in juvenile human thymus. Organohalogen
Compounds 44: 233-236
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2000
- Stahlmann R, Kühner S, Shakibaei M, Schwabe R, Flores J, Evander SA, van
Sickle DC (2000) Chondrotoxicity of ciprofloxacin in immature Beagle dogs: immunohistochemistry,
electron microscopy and drug plasma concentrations. Arch Toxicol 73: 564-572
- Stahlmann R, Kühner S, Shakibaei M, Flores J, Vormann J, van Sickle DC
(2000) Effects of magnesium deficiency on joint cartilage in immature Beagle dogs:
immunohistochemistry, electron microscopy and mineral concentrations. Arch Toxicol
73: 573-580
- Shakibaei M, Pfister K, Schwabe R, Vormann J, Stahlmann R (2000) Ultrastructure
of Achilles tendons of rats treated with ofloxacin and fed a normal or magnesium-deficient
diet. Antimicrob Agents Chemother 44/2: 261-266
- Riecke K, Schulz TG, Shakibaei M, Krause B, Chahoud I, Stahlmann R (2000) Developmental
toxicity of the HIV-protease inhibitor indinavir in rats. Teratology 62: 291-300
- Riecke K, Nogueira AC, Alexi-Meskishvili V, Stahlmann R (2000) Cross reactivity
of antibodies on thymic epithelial cells from humans and marmosets by flow-cytometry.
J Med Primatol 29: 343-349
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2001
- Thiel R, Metzner S, Gericke C, Rahm U, Stahlmann R (2001) Effects of fluoroquinolones
on the locomotor activity in rats. Arch Toxicol 75: 36-41
- Shakibaei M, Stahlmann R (2001) Ultrastructure of Achilles tendon from rats
after treatment with fleroxacin. Arch Toxicol 75: 97-102
- Shakibaei M, de Souza P, van Sickle D, Stahlmann R (2001) Biochemical changes
in Achilles tendon from juvenile dogs after treatment with ciprofloxacin or feeding
a magnesium-deficient diet. Arch Toxicol 75: 369-374
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2002
- Shakibaei M, Baumann-Wilschke I, Rücker M, Stahlmann R (2002) Ultrastructural
characterization of murine limb buds after in vitro exposure to grepafloxacin and
other fluoroquinolones. Arch Toxicol 75: 725-733.
PMID: 11876506
- Lozo E, Riecke K, Schwabe R, Vormann J, Stahlmann R (2002) Synergistic effect
of ofloxacin and magnesium deficiency on joint cartilage in immature rats. Antimicrob
Agents Chemother 46: 1755-1759.
PMID: 12019086
- Riecke K, Grimm D, Shakibaei M, Kossmehl P, Schulze-Tanzil G, Paul M, Stahlmann
R (2002) Low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin increase transforming growth
factor ß and cause myocardial fibrosis in marmosets (Callithrix jacchus). Arch Toxicol
76: 360-366.
PMID: 12107654
- Riecke K, Grimm D, Shakibaei M, Kossmehl P, Schulze-Tanzil G, Paul M, Stahlmann
R (2002) 2,3,7,8-Tetrachloro-dibenzo-p-dioxin induces myocardial fibrosis in marmosets
(Callithrix jacchus). Organohalogen Compounds 55: 351-354.
- Kappel EM, Shakibaei M, Bello A, Stahlmann R (2002) Effects of the des-F(6)-quinolone
garenoxacin (BMS-284756), in comparison to those of ciprofloxacin and ofloxacin,
on joint cartilage in immature rats. Antimicrob Agents Chemother 46: 3320-3322.
PMID: 12234871
- Stahlmann R, Lode H (2002) Fluoroquinolones in the elderly: Safety considerations.
Drugs and Aging, in press
- Pechere JC, Cenedese C, Muller O, Perez-Gorricho B, Ripoll M, Rossi A, Stahl
JP, Stahlmann R, Tramarin A.
Attitudinal classification of patients receiving antibiotic treatment for mild respiratory
tract infections. Int J Antimicrob Agents. 2002 Dec;20(6):399-406.
PMID: 12458132
- Stahlmann R. Clinical toxicological aspects of fluoroquinolones. Toxicol Lett.
2002 Feb 28;127(1-3):269-77.
PMID: 12052667
- Platzek T, Stahlmann R, Wegener M, Lang C (2002) Allergene in kosmetischen Mitteln,
Waschmitteln und Textilien. Mitt Lebensm Hyg 93: 591-616.
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2003
- Stahlmann R (2002) Children as a special population at risk - quinolones as
an example for xenobiotics exhibiting skeletal toxicity. Arch Toxicol. 2003 Jan;77(1):7-11.
PMID: 12491034
- Schwenk M, Gundert-Remy U, Heinemeyer G, Olejniczak K, Stahlmann R, Kaufmann
W, Bolt HM, Greim H, Von Keutz E, Gelbke HP. Children as a sensitive subgroup and
their role in regulatory toxicology: DGPT workshop report.
Arch Toxicol. 2003 Jan;77(1):2-6.
PMID: 12491033
- Stahlmann R, Lode H (2003) Fluoroquinolones in the elderly: Safety considerations.
Drugs and Aging 20: 289-302.
PMID: 12641485
- Riecke K, Schmidt A, Stahlmann R (2003) Effects of 2,3,7,8-TCDD and PCB 126
on human thymic epithelial cells in vitro. Arch Toxicol 77: 358-364.
PMID: 12799776
- Müller O, Stahlmann R (2003) Patientenerwartungen und Compliance bei der
antibiotischen Therapie von Infektionen der oberen Atemwege. Chemother J 12: 13-20.
- Shakibaei M, Stahlmann R (2003) Ultrastructural Changes Induced by the Des-F(6)-Quinolone
Garenoxacin (BMS-284756) and Two Fluoroquinolones in Achilles Tendon from Immature
Rats. Arch Toxicol 77: 521-526.
PMID: 12811465
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2004
- Kastner M, Rahm U, Baumann-Wilschke I, Bello A, Stahlmann R (2004) Concentrations
of the Des-F(6)-quinolone garenoxacin in plasma and joint cartilage of immature rats.
Arch Toxicol 78: 61-67.
PMID:14661070
- Ball P, Stahlmann R, Kubin R, Choudhri S, Owens R. (2004) Safety profile of
oral and intravenous moxifloxacin: cumulative data from clinical trials and postmarketing
studies. Clin Ther. 2004 Jul;26(7):940-50.
PMID:
15336463 [PubMed - in process]
- Ulbrich B, Stahlmann R. (2004) Developmental toxicity of polychlorinated biphenyls
(PCBs): a systematic review of experimental data. Arch Toxicol. 2004 May;78(5):252-68.
Epub 2004 Apr 02. Review.
PMID:
15064922 [PubMed - in process] - REVIEW | ELECTRONIC MATERIAL
- Stahlmann R, Sendzik J. (2004) [Adverse effects of anti-infectives. Undesirable
effects and interactions of ketolides and oxazolidonones] Pharm Unserer Zeit. 2004;33(1):48-54.
Review. German. No abstract available.
PMID:
14968713 [PubMed - indexed for MEDLINE]
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2005
- Oberemm A, Meckert C, Brandenburger L, Herzig A, Lindner Y, Kalenberg K, Krause
E, Ittrich C, Kopp-Schneider A, Stahlmann R, Richter-Reichhelm HB, Gundert-Remy U.
Differential signatures of protein expression in marmoset liver and thymus induced
by single-dose TCDD treatment. Toxicology. 2005 Jan 5;206(1):33-48.
PMID:
15590107 [PubMed - in process]
- Sendzik J, Stahlmann R (2005) Arzneimittel gegen Kopflausbefall, Toxikologie
und Wirksamkeit. MMP 28:167
- Sendzik J, Shakibaei M, Schäfer-Korting M, Stahlmann R (2005) Fluoroquinolones
cause changes in extracellular matrix, signalling proteins, metalloproteinases and
caspase-3 in cultured human tendon cells. Toxicology. 2005 May 9; [Epub ahead of
print]
PMID:
15890441 [PubMed - as supplied by publisher]
- Kilic B, Kruse M, Stahlmann R. The in-vitro effects of quinupristin/dalfopristin,
erythromycin and levofloxacin at low concentrations on the expression of different
cell adhesion molecules on the surface of endothelial cells (Eahy926). Toxicology.
2006 Jan 20;218(1):30-8. Epub 2005 Nov 16.
PMID:
16297520 [PubMed - indexed for MEDLINE]
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2006
- Stahlmann R, Wegner M, Riecke K, Kruse M, Platzek T. Sensitising potential of
four textile dyes and some of their metabolites in a modified local lymph node assay.
Toxicology. 2006 Feb 15;219(1-3):113-23.
PMID:
16388883 [PubMed - in process]
- Nottebrock C, Riecke K, Kruse M, Shakibaei M, Stahlmann R. Effects of 2,3,7,8-tetrachloro-dibenzo-p-dioxin
on the extracellular matrix of the thymus in juvenile marmosets (Callithrix jacchus).
Toxicology. 2006 Sep 21;226(2-3):197-207. Epub 2006 Jul 14.
PMID:
16920245 [PubMed - in process]
- Kruse M, Kilic B, Flick B, Stahlmann R. Effect of
quinupristin/dalfopristin on 3T3 and Eahy926 cells in vitro in
comparison to other antimicrobial agents with the potential to induce
infusion phlebitis. Arch Toxicol. 2006 Nov 22; [Epub ahead of print]
PMID: 17119926 [PubMed - as supplied by publisher]
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2007
- Pfister K, Mazur D, Vormann J, Stahlmann R. Diminished
Ciprofloxacin-Induced Chondrotoxicity by Supplementation of Magnesium
and Vitamin E in Immature Rats. Antimicrob Agents Chemother. 2007 Jan
8; [Epub ahead of print]
PMID: 17210779 [PubMed - as supplied by publisher]
- Schreiner M, Peiser M, Briechle D, Stahlmann R, Zuberbier T, Wanner R.
A loose-fit coculture of activated keratinocytes and dendritic cell-related cells for prediction of sensitizing potential.
Allergy. 2007 Dec;62(12):1419-28.
PMID: 17983376 [PubMed - in process]
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2008
- Mazur D, Stahlmann R.
[Drug-induced adverse pulmonary reactions]
Dtsch Med Wochenschr. 2008 Jan;133(3):81-6. German. No abstract available.
PMID: 18186010 [PubMed - in process]
- Lode HM, Schmidt-Ionas M, Stahlmann R.
Gemifloxacin for community-acquired pneumonia.
Expert Opin Investig Drugs. 2008 May;17(5):779-86.
PMID: 18447602 [PubMed - in process]
- Schreiner M, Peiser M, Briechle D, Stahlmann R, Zuberbier T, Wanner R.
A new dendritic cell type suitable as sentinel of contact allergens. Toxicology. 2008 May 4. [Epub ahead of print]
PMID: 18547706 [PubMed - as supplied by publisher]
- Sendzik J, Lode H, Stahlmann R.
Quinolone-induced arthropathy: an update focusing on new mechanistic and clinical data. Int J Antimicrob Agents. 2008 Oct 1. [Epub ahead of print]
PMID: 18835137 [PubMed - as supplied by publisher]
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2009
- Ahuja V, Schreiber C, Platzek T, Stahlmann R.
Investigation of the sensitising and cross-sensitising potential of textile dyes and beta-lactam antibiotics using a biphasic mice local lymph node assay. Arch Toxicol. 2009 Feb 11. [Epub ahead of print]
PMID: 19212757 [PubMed - as supplied by publisher]
- Ahuja V, Wanner R, Platzek T, Stahlmann R.
Appraisal of the sensitising potential of orally and dermally administered Mercaptobenzothiazol by a biphasic protocol of the local lymph node assay. Arch Toxicol. 2009 Apr 19. [Epub ahead of print]
PMID: 19381614 [PubMed - as supplied by publisher]
- Millrose M, Kruse M, Flick B, Stahlmann R.
Effects of macrolides on proinflammatory epitops on endothelial cells in vitro. Arch Toxicol. 2009 May;83(5):469-76. Epub 2008 Dec 4. [Epub ahead of print]
PMID: 19052724 [PubMed - as supplied by publisher]
- Ahuja V, Eisenblätter M, Ignatius R, Stahlmann R.
Ammonium perfluorooctanoate substantially alters phenotype and cytokine secretion of human monocyte-derived dendritic cells in vitro. Immunopharmacol Immunotoxicol. 2009;31(4):641-6.
PMID: 19874235 [PubMed - in process]
- Breitschaft A, Stahlmann R.
[Nephrogenic systemic fibrosis]. Med Monatsschr Pharm. 2009 Oct;32(10):377-82. Review. German.
PMID: 19886227 [PubMed - indexed for MEDLINE]
- Bode K, Kunz A, Baumann-Wilschke I, Shakibaei M, Stahlmann R.
Effects of moxifloxacin and clinafloxacin on murine limb buds cultured in regular and in magnesium-deficient medium. Arch Toxicol. 2009 Dec 1. [Epub ahead of print]
PMID: 19949773 [PubMed - as supplied by publisher]
- Sendzik J, Shakibaei M, Schäfer-Korting M, Lode H, Stahlmann R.
Synergistic effects of dexamethasone and quinolones on human-derived tendon cells. Int J Antimicrob Agents. 2009 Dec 22. [Epub ahead of print]
PMID: 20034766 [PubMed - as supplied by publisher]
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2010
- Eckardt K, Stahlmann R.
Use of two validated in vitro tests to assess the embryotoxic potential of mycophenolic acid. Arch Toxicol. 2010 Jan;84(1):37-43. Epub 2009 Oct 25.
PMID: 19856175 [PubMed - in process]
- Wanner R, Sonnenburg A, Quatchadze M, Schreiner M, Peiser M, Zuberbier T, Stahlmann R.
Classification of sensitizing and irritative potential in a combined in-vitro assay. Toxicol Appl Pharmacol. 2010 Mar 8. [Epub ahead of print]
PMID: 20219181 [PubMed - as supplied by publisher]
- Stahlmann R, Lode H.
Safety considerations of fluoroquinolones in the elderly: an update. Drugs Aging. 2010 Mar 1;27(3):193-209. doi: 10.2165/11531490-000000000-00000.
PMID: 20210367 [PubMed - in process]
- Bode K, Kunz A, Baumann-Wilschke I, Shakibaei M, Stahlmann R. Effects of moxifloxacin and clinafloxacin on murine limb buds cultured in regular and in magnesium-deficient medium. Arch Toxicol. 2010 Mar;84(3):221-6. Epub 2009 Dec 1. PubMed
PMID: 19949773.
- Ahuja V, Platzek T, Fink H, Sonnenburg A, Stahlmann R. Study of the sensitising potential of various textile dyes using a biphasic murine local lymph node assay. Arch Toxicol. 2010 Sep;84(9):709-18. Epub 2010 Jun 29.
PubMed PMID: 20585758.
- Sendzik J, Shakibaei M, Schäfer-Korting M, Lode H, Stahlmann R. Synergistic effects of dexamethasone and quinolones on human-derived tendon cells. Int J Antimicrob Agents. 2010 Apr;35(4):366-74. Epub 2010 Jan 19.
PubMed PMID: 20034766.
- Breitschaft A, Stahlmann R. [Nephrogenic systemic fibrosis]. Med Monatsschr Pharm. 2009 Oct;32(10):377-82. Review. German.
PubMed PMID: 19886227.
- Mielke H, Anger LT, Schug M, Hengstler JG, Stahlmann R, Gundert-Remy U. A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing. Arch Toxicol. 2010 Nov 3. [Epub ahead of print]
PubMed PMID: 21046363.
- Ahuja V, Quatchadze M, Ahuja V, Stelter D, Albrecht A, Stahlmann R. Evaluation of biotechnology-derived novel proteins for the risk of food-allergic potential: advances in the development of animal models and future challenges. Arch Toxicol. 2010 Dec;84(12):909-17. Epub 2010 Sep 15. Review.
PubMed PMID: 20842347.
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2011
- Ju Q, Fimmel S, Hinz N, Stahlmann R, Xia L, Zouboulis CC. 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro. Exp Dermatol. 2011 Apr;20(4):320-5. doi: 10.1111/j.1600-0625.2010.01204.x.
PubMed PMID: 21410761.
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