Institute of Clinical Physiology

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Publications:  Olaf Strauss
Experimental Ophthalmology, Dept. of  Ophthalmology, University Regensburg

2008

• Wimmers S, Coeppicus L, Rosenthal R, Strauss O (2008) Expression profile of voltage-dependent Ca²⁺ channel subunits in the human retinal pigment epithelium. Graefes Arch. Clin. Exp. Ophthalmol. 246(5): 685-692 [PubMed] [HTML] [PDF]

2007

• Rosenthal R, Heimann H, Agostini H, Martin G, Hansen LL, Strauss O (2007) Ca²⁺ channels in retinal pigment epithelial cells regulate VEGF secretion rates in health and disease. Mol. Vision 13: 443-456 [PubMed] [HTML] [PDF]

2006

• Wollmann G, Lenzner S, Berger W, Rosenthal R, Karl MO, Strauss O (2006) Voltage-dependent ion channels in the mouse RPE: Comparison with Norrie disease mice. Vision Res. 46(5): 688-698 [PubMed] [HTML] [PDF]

• Rosenthal R, Bakall B, Peachey N, Wimmers S, Wadelius C, Marmorstein A, Strauss O (2006) Expression of bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca²⁺ channels in retinal pigment epithelial cells. FASEB J.  20(1): 178-180 [PubMed] [HTML] [PDF]

2005

• Rosenthal R, Malek G, Salomon N, Peill-Meininghaus M, Coeppicus L, Wohlleben H, Wimmers S, Bowes Rickman C, Strauss O (2005) The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells. Biochem. Biophys. Res. Commun. 337(1): 241-247 [PubMed] [HTML] [PDF]

• Strauss O, Rosenthal R (2005) Funktion des Bestrophins. Ophthalmologe 102(2): 122-126 [PubMed] [HTML] [PDF]

• Thieme H, Steinhausen K, Ottlecz A, Lambrou GN, Strauss O, Wiederholt M, Rosenthal R (2005) Effects of unoprostone and endothelin-1 on L-type channel currents in human trabecular meshwork cells. Ophthalm. Res. 37(6): 293-300 [PubMed] [PDF]

2004

• Strauss O (2004) Morbus Best. Ophthalmologe 102(2): 109-110 [PubMed reference] [PDF]

• Rosenthal R, Wohlleben H, Malek G, Schlichting L, Thieme H, Bowes Rickman C, Strauss O (2004) Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration. Biochem. Biophys. Res. Comm. 323: 1203-1208 [PubMed] [HTML] [PDF]

2002 - 2003

• Fidzinski P, Knoll A, Rosenthal R, Schrey A, Vescovi A, Koert U, Wiederholt M, Strauss O (2003) Electrophysiological response of cultured trabecular meshwork cells to synthetic ion channels. Chem. Biol. 10(1): 35-43 [PubMed] [Full text].

• Rosenthal R, Strauss O (2003) Investigations of RPE cells of choriodal neovascular membranes from patients with age-related macula degeneration. Adv. Exp. Med. Biol. 533: 107-113 [PubMed reference]

• Rosenthal R, Strauss O (2002) Ca²⁺ channels in the RPE. Adv. Exp. Med. Biol. 514: 225-235 [PubMed reference]

• Strauss O, Rosenthal R, Dey D, Beninde J, Wollmann G, Thieme H, Wiederholt M (2002) Effects of protein kinase C on delayed rectifier K(+) channel regulation by tyrosine kinase in rat retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 43(5): 1645-1654 [PubMed] [PDF]

• Mergler S, Strauss O (2002) Stimulation of L-type Ca²⁺channels by increase of intracellular InsP3 in rat retinal pigment epithelial cells. Exp. Eye. Res. 74(1): 29-40 [PubMed] [PDF]

2001

• Thieme H, Hildebrand J, Choritz L, Strauss O, Wiederholt M (2001) Muscarinic receptors of the M2 subtype in human and bovine trabecular meshwork. Graefe's Arch. Clin. Exp. Ophthalmol. 239: 310-315 [PubMed] [PDF]

• Rosenthal R, Thieme H, Strauss O (2001) Fibroblast growth factor receptor 2 (FGFR2) in brain neurons and retinal pigment epithelial cells act via stimulation of neuroendocrine L-type channels (Ca(v)1.3). FASEB J. 15(6): 970-977 [PubMed] [Full text]

• Stumpff F, Boxberger M, Thieme H, Strauss O, Wiederholt M (2001) Flufenamic acid enhances current through maxi-K channels in the trabecular meshwork of the eye. Curr. Eye Res. 22(6): 427-437 [PubMed] [PDF]

2000

• Thieme H, Nuskovski M, Nass JU, Pleyer U, Strauss O, Wiederholt M (2000) Mediation of calcium-independent contraction in trabecular meshwork through protein kinase C and rho-A. Invest. Ophthalmol. Vis. Sci. 41(13): 4240-4246 [PubMed] [HTML]

• Strauss O, Buss F, Rosenthal R, Fischer D, Mergler S, Stumpff F, Thieme H (2000) Activation of neuroendocrine L-type channels (a1D subunits) in retinal pigment epithelial cells and brain neurons by pp60c-src. Biochem. Biophys. Res. Comm. 270(3): 806-810 [PubMed]

• Steinhausen K, Stumpff F, Strauss O, Thieme H, Wiederholt M (2000) Influence of muscarinic agonists and tyrosine kinase inhibitors on L-type Ca²⁺ channels in bovine and human trabecular meshwork cells. Exp. Eye Res. 70(3): 285-293 [PubMed] [PDF]

1999

• Valtink M, Engelmann K, Strauss O, Krüger R, Loliger C, Ventura AS, Richard G (1999) Physiological features of primary cultures and subcultures of human retinal pigment epithelial cells before and after cryopreservation for cell transplantation. Graefes Arch. Clin. Exp. Ophthalmol. 237(12): 1001-1006  [PubMed]

• Thieme H, Nass JU, Nuskovski M, Bechrakis NE, Stumpff F, Strauss O, Wiederholt M (1999) The effects of Protein Kinase C (PKC) on Trabecular Meshwork and Ciliary Muscle Contractility. Invest. Ophthalmol. Vis. Sci. 40(13): 3254-3261 [PubMed]

• Strauss O, Steinhausen K, Mergler S, Stumpff F, Wiederholt M (1999) Involvement of protein tyrosine kinase in the InsP3-induced activation of Ca²⁺-dependent Cl^- currents in cultured cells of the rat retinal pigment epithelium. J. Membr. Biol. 169: 141-153 [PubMed]

• Stumpff F, Que Y, Boxberger M, Strauss O, Wiederholt M (1999) Stimulation of maxi-K channels in trabecular meshwork by tyrosine kinase inhibitors. Invest. Ophthalmol. Vis. Sci. 40: 1404-1417 [PubMed]

1998

• Strauss O, Stumpff F, Mergler S, Wienrich M, Wiederholt M (1998) The Royal College of Surgeons rat: an animal model for inherited retinal degeneration with a still unknown genetic defect. Acta Anat. (Basel) 162: 101-111 [PubMed]

• Mergler S, Steinhausen K, Wiederholt M, Strauss O (1998) Altered regulation of L-type channels by protein kinase C and protein tyrosine kinases as a pathophysiologic effect in retinal degeneration. FASEB J. 12: 1125-1134 [PubMed]

• Strauss O, Steinhausen K, Wienrich M, Wiederholt M (1998) Activation of a Cl^--conductance by protein kinase-dependent phosphorylation in cultured rat retinal pigment epithelial cells. Exp. Eye Res. 66: 35-42 [PubMed]

• Wiederholt M, Groth J, Strauss O (1998) Role of protein tyrosine kinase on regulation of trabecular meshwork and ciliary muscle contractility. Invest. Ophthalmol. Vis. Sci. 39: 1012-1020 [PubMed]

1997

• Strauss O, Mergler S, Wiederholt M (1997) Regulation of L-type calcium channels by protein tyrosine kinase (PTK) and protein kinase C (PKC) in cultured rat and human retinal pigment epithelial cells. FASEB J. 11: 859-867 [PubMed]

• Stumpff F, Strauss O, Boxberger M, Wiederholt M (1997) Characterization of maxi-K-channels in trabecular meshwork and their regulation by cGMP. Invest. Ophthalmol. Vis. Sci. 38: 1883-1892 [PubMed]

1995 - 1996

• Strauss O, Wiederholt M, Wienrich M (1996) Activation of Cl^- currents in cultured rat retinal pigment epithelial cells by intracellular applications of inositol-1,4,5-triphosphate: differences between rats with retinal dystrophy (RCS) and normal rats. J. Membr. Biol. 151: 189-200 [PubMed]

• Noske W, Strauss O, Levarlet B, Wiederholt M, Hirsch M (1995) Incomplete belts of tight junctions in cultured non-pigmented human ciliary epithelial cells. J. Submicrosc. Cytol. Pathol. 27: 1-8 [PubMed]

1994

• Strauss O, Weiser T, Wienrich M (1994) Potassium currents in cultured cells of the rat retinal pigment epithelium. Comp. Biochem. Physiol. A 109: 975-983 [PubMed]

• Strauss O, Wienrich M (1994) Extracellular matrix proteins as substrate modulate the pattern of calcium channel expression in cultured rat retinal pigment epithelial cells. Pflügers Arch. 429: 137-139 [PubMed]

• Strauss O, Wienrich M (1994) Ca²⁺-conductances in cultured rat retinal pigment epithelial cells. J. Cell Physiol. 160: 89-96 [PubMed]

1991 - 1993

• Strauss O, Wienrich M (1993) Cultured retinal pigment epithelial cells from RCS rats express an increased calcium conductance compared with cells from non-dystrophic rats. Pflügers Arch. 425: 68-76  [PubMed]

• Strauss O, Richard G, Wienrich M (1993) Voltage-dependent potassium currents in cultured human retinal pigment epithelial cells. Biochem. Biophys. Res. Commun. 191: 775-781 [PubMed]

• Strauss O, Stahl F, Wiederholt M (1992) Elevation of cytosolic free calcium in cultured ciliary epithelial cells by histamine: effects of verapamil and staurosporine. J. Ocul. Pharmacol. 8: 359-366 [PubMed]

• Strauss O, Graszynski K (1992) Isolation of plasma membrane vesicles from the gill epithelium of the crayfish, Orconectes limosus Rafininesque, and properties of the Na⁺/H⁺-exchanger. Comp. Biochem. Physiol. A 102: 519-526.

• Strauss O, Wiederholt M (1991) Transepithelial resistance of ciliary epithelial cells in culture: Functional modification by protamine and extracellular calcium. Comp. Biochem. Physiol. A 100: 987-993 [PubMed]