 Institute of Clinical Physiology |
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Institute of Clinical Physiology |
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PubMed
list |
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2012
Rosenthal R*, Günzel D* (*shared first authorship), Finger C, Krug SM, Richter
JF, Schulzke JD, Fromm M, Amasheh S (2012) The effect of chitosan on transcellular and
paracellular mechanisms in the intestinal epithelial barrier. Biomaterials
33(9): 2791-2800 (IF 7.9) [PubMed
Abstract] [Full
text HTML] [Full
text PDF] [Supplement]
Günzel D, Fromm M (2012) Claudins and other tight junction proteins. Comprehensive Physiology (Review, former Handbook of Physiology) [21.11.11 Accepted]
Kirschner N, Rosenthal R, Günzel D, Moll I, Brandner JM (2012) Tight junctions and differentiation – a chicken or the egg question? Exp. Dermatol. ###: ###-### (IF 4.2) [05.12.11 Accepted]
2011
Stumpff F, Georgi MI, Mundhenk L, Rabbani I, Fromm M, Martens H, Günzel D (2011) Sheep rumen and omasum primary cultures and source epithelia: Barrier function aligns with expression of tight junction proteins. J. Exp. Biol. 214: 2871-2882 [PubMed Abstract] [Full text HTML] [Full text PDF] [Supplement]
Nielsen HL, Nielsen H, Ejlertsen T, Engberg J, Günzel D, Zeitz M, Hering NA, Fromm M, Schulzke JD, Bücker R (2011) Oral and fecal Campylobacter concisus strains perturb barrier function by apoptosis induction in HT-29/B6 intestinal epithelial cells. Plos One 6(8): e23858 (print pages 1-8) [PubMed Abstract] [Full text HTML] [Full text PDF]
Schumann M, Günzel D, Buergel N, Richter JF, Troeger H, May C, Fromm A, Sorgenfrei D, Daum S, Bojarski C, Heyman M, Zeitz M, Fromm M, Schulzke JD (2011) Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in celiac disease. Gut ###: ###-###
Amasheh S, Fromm M, Günzel D (2011) Claudins of intestine and nephron - a correlation of molecular tight junction structure and barrier function. Acta Physiol. 201(1): 133-140 [PubMed Abstract] [Full text HTML] [Full text PDF] (Review)
Bücker R, Krug SM, Rosenthal R, Günzel D, Fromm A, Zeitz M, Chakraborty T, Fromm M, Epple HJ, Schulzke JD (2011) Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells. J. Infect. Dis. 204 (8): 1283-1292 [PubMed Abstract] [Full text HTML] [Full text PDF]
Hering NA, Richter JF, Krug SM, Günzel D, Fromm A, Bohn E, Rosenthal R, Bücker R, Fromm M, Troeger H, Schulzke JD (2011) Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers. Lab. Invest. 91(2): 310-324 [PubMed Abstract] [Full text HTML] [Full text PDF] [Supplement DOC]
Stuiver M, Lainez S, Will C, Terryn S, Günzel D,
Debaix H, Sommer K, Kopplin K, Thumfart J, Kampik NB, Querfeld U, Willnow TE, Nemec V, Wagner C,
Hoenderop JG, Devuyst O, Knoers NVAM, Bindels RJ, Meij IC*, Müller D*
(*shared last authorship) (2011) CNNM2, encoding a basolateral protein required for renal
Mg2+ handling, is mutated in dominant hypomagnesemia. Am.
J. Hum. Genet. 88(3): 333-343 [PubMed
Abstract] [Full
text HTML] [Full
text PDF] (IF 12.3)
Schulzke JD*, Andres S*, Amasheh M* (*shared first authorship), Fromm A, Günzel D (2011) Anti-diarrheal mechanism of the traditional remedy Uzara via reduction of active chloride secretion. PLoS One
2010
Milatz S, Krug SM, Rosenthal R, Günzel D, Müller D, Schulzke JD, Amasheh S*, Fromm M* (*shared last authorship) (2010) Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim. Biophys. Acta Biomembr. 1798: 2048-2057 [PubMed Abstract] [Full text HTML] [Full text PDF]]
Schmid T, Günzel D, Bogdan M (2010) Using an artificial neural network to determine electrical properties of epithelia. In: Diamantaras K, Duch W, Iliadis LS Eds., ICANN 2010, Part I, Lect. Notes Comput. Sci. 6352: 211-216 (DOI: 10.1007/978-3-642-15819-3_28) [Abstract] [Full text PDF]
Rosenthal R, Milatz S, Krug SM, Oelrich B, Schulzke
JD, Amasheh S, Günzel D, Fromm M (2010) Claudin-2, a component of the tight junction,
forms a paracellular water channel. J. Cell Sci.
123(11): 1913-1921 [PubMed Abstract] [Full
text HTML] [Full text PDF
>>> if "Full text PDF" refuses: we have got 50
free PDF reprints] [Supplement]
Hillenbrand B, Günzel D, Richter JF, Höhne, Schreier E, Schulzke JD, Mankertz J (2010) Norovirus non-structural protein p20 leads to impaired restitution of epithelial defects by inhibition of actin cytoskeleton remodelling. Scand. J. Gastroent. 45(11): 1307-1319 [PubMed Abstract] [Full text HTML] [Full text PDF]
Günzel D, Krug SM, Rosenthal R, Fromm M (2010) Biophysical methods to study tight junction permeability. Curr. Top. Membr. 65: 39-78 [Directory] [Full text HTML] [Full text PDF] (review / book chapter)
Will C, Breiderhoff T, Thumfart J, Stuiver M, Kopplin K, Sommer K, Günzel D, Querfeld U, Meij IC, Shan Q, Bleich M, Willnow TE, Müller D (2010) Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am. J. Physiol. Renal Physiol. 298: F1152-F1161 [PubMed Abstract] [Full text HTML] [Full text PDF]
Preston P, Wartosh L, Günzel D, Fromm M, Kongsuphol P, Ousingsawat J, Kunzelmann K, Barhanin J, Warth R, Jentsch TJ (2010) Disruption of the K+-channel β-subunit KCNE3 reveals an important role in colonic and tracheal Cl- transport. J. Biol. Chem. 285(10): 7165-7175 [PubMed Abstract] [Full text PDF] [Supplement]
2009
Krug SM, Amasheh S, Richter JF, Milatz S, Günzel D, Westphal JK, Huber O, Schulzke JD, Fromm M (2009) Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol. Biol. Cell 20: 3713-3724 [PubMed abstract] [Full text HTML] [Full text PDF] [Supplement text] [Supplement video]]
Krug SM, Fromm M, Günzel D (2009) Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys. J. 97(8): 2202-2211 [PubMed abstract] [Full text HTML] [Full text PDF] [Supplement]
Günzel D, Amasheh S, Pfaffenbach S, Richter JF, Kausalya PJ, Hunziker W, Fromm M (2009b) Claudin-16 affects transcellular Cl- secretion in MDCK cells. J. Physiol. 587(15): 3777-3793 [PubMed abstract] [Full text HTML] [Full text PDF] [Supplement]
Günzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Müller D (2009a) Claudin-10 exists in six alternatively spliced isoforms which exhibit distinct localization and function. J. Cell Sci. 122: 1507-1517 [PubMed abstract] [Full text HTML] [Full text PDF]
Richter JF, Gitter AH, Günzel D, Weiss S, Mohamed W, Chakraborti T, Fromm M, Schulzke JD (2009) Listeriolysin O affects barrier function and induces chloride secretion in HT-29/B6 colon epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 296(6): G1350-G1359 [PubMed abstract] [Full text HTML] [Full text PDF]
Yu ASL, Cheng MH, Angelow S, Günzel D, Kanzawa SA, Schneeberger EE, Fromm M, Coalson RD (2009) Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site. J. Gen. Physiol. 133(1): 111-127 [PubMed abstract] [Full text HTML] [Full text PDF]
Amasheh S, Milatz S, Krug SM, Markov AG, Günzel D, Amasheh M, Fromm M (2009) Tight junction proteins as channel formers and barrier builders: claudin-2, -5, and -8. Ann. N.Y. Acad. Sci. 1165: 211-219 [PubMed abstract] [Full text HTML] [Full text PDF]
Günzel D, Haisch L, Pfaffenbach S, Krug SM, Milatz S, Amasheh S, Hunziker W, Müller D (2009) Claudin function in the thick ascending limb of Henle's loop. Ann. N.Y. Acad. Sci. 1165: 152-162 [PubMed abstract] [Full text HTML] [Full text PDF]
Fromm M, Krug SM, Zeissig S, Richter JF, Rosenthal R, Schulzke JD, Günzel D (2009) High resolution analysis of barrier function. Ann. N.Y. Acad. Sci. 1165: 74-81 [PubMed abstract] [Full text HTML] [Full text PDF]
2007 - 2008
Günzel D, Yu ASL (2009, Epub 16.09.2008) Function and regulation of claudins in the thick ascending limb of Henle. Pflügers Arch. 458(1): 77-88 [PubMed abstract] [Full text HTML] [Full text PDF]
Troeger H*, Richter JF* (*shared first authorship), Beutin L, Günzel D, Dobrindt U, Epple HJ, Gitter AH, Zeitz M, Fromm M, Schulzke JD (2007) E. coli alpha-hemolysin induces focal leaks in colonic epithelium – a novel mechanism of bacterial translocation. Cell. Microbiol. 9(10): 2530-2540 [PubMed abstract] [Full text HTML] [Full text PDF]
Gabriel TE, Günzel D (2007) Quantification of Mg2+ extrusion and cytosolic Mg2+-buffering in Xenopus oocytes. Arch. Biochem. Biophys. 458(1): 3-15 [PubMed abstract] [Full text HTML] [Full text PDF]
Zeissig S, Bürgel N, Günzel D, Richter JF, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2007) Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56(1): 61-72 [PubMed abstract] [Full text HTML] [Full text PDF]
2006
Günzel D, Kucharski LM, Kehres DG,
Romero MF, Maguire ME (2006) The MgtC virulence factor of Salmonella enterica serovar
typhimurium activates Na+,K+-ATPase.
J. Bacteriol. 188(15): 5586-5594 [PubMed
abstract] [Full text HTML] [Full
text PDF] 
Günzel D*, Florian P* (*shared first authorship), Richter JF, Troeger H, Schulzke JD, Fromm M, Gitter AH (2006) Restitution of single-cell defects in the mouse colon epithelium differs from that of cultured cells. Am. J. Physiol. - Reg. Integ. Comp. Physiol. 290: R1496-R1507 [PubMed abstract] [Full text HTML] [Full text PDF] [Supplemental videos]
Reiter B, Kraft R, Günzel D, Zeissig S, Schulzke JD, Fromm M, Harteneck C (2006) TRPV4-mediated regulation of epithelial permeability. FASEB J. 20: 1802-1812 [PubMed abstract] [Full text HTML] [Full text PDF]
Kausalya PJ*, Amasheh S* (*shared first authorship), Günzel
D, Wurps H, Müller D, Fromm M, Hunziker W (2006) Disease-associated mutations affect
intracellular traffic and paracellular Mg2+ transport function of
claudin-16. J. Clin. Invest. 116(4): 878-891 [PubMed
abstract] [Full
text HTML] [Full
text PDF]
2005
Günzel D, Hintz K, Durry S, Schlue WR (2005) Mg2+-malate co-transport, a mechanism for Na+-independent Mg2+ transport in neurons of the leech Hirudo medicinalis. J. Neurophysiol. 94: 441-453 [PubMed abstract] [Full text HTML] [Full text PDF]
Tunggal JA*, Helfrich I* (*shared first authorship),
Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T, Niessen CM (2005) E-cadherin
is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO
J. 24: 1146-1156 [PubMed
abstract] [Full
text HTML] [Full
text PDF]
Günzel D, McGuigan JAS, Schlue WR (2005) Use of Mg2+ and Ca2+ macroelectrodes to measure binding in extracellular-like physiological solutions. Front. Biosci. 10: 905-918 [PubMed abstract] [Full text] [Request text]
2001 - 2003
Müller A, Günzel D, Schlue WR (2003) Activation of AMPA/kainate receptors but not acetylcholine receptors causes Mg2+ influx into Retzius neurones of the leech Hirudo medicinalis. J. Gen. Physiol. 122: 727-739 [PubMed abstract] [Full text, HTML] [Full text PDF]
Günzel D, Schlue WR (2002) Determination of [Mg(2+)]i - an update on the use of Mg(2+)-selective electrodes. Biometals 15(3): 237-249 [PubMed abstract] [Full text (produces an error at first attempt and sets a cookie, then click again)]
McGuigan JAS, Elder HY, Günzel D, Schlue W-R (2002) Magnesium homeostasis in heart: a critical reappraisal. J. Clin. Basic Cardiol. 5: 5-22
Mooren FC, Turi S, Günzel D, Schlue WR, Domschke W, Singh J, Lerch MM (2001) Calcium-magnesium interactions in pancreatic acinar cells. FASEB J. 15(3): 659-672 [PubMed abstract] [Full text, HTML] [Full text PDF]
Günzel D, Zimmermann F, Durry S, Schlue WR (2001) Apparent intracellular Mg2+ buffering in neurons of the leech Hirudo medicinalis. Biophys. J. 80(3): 1298-1310 [PubMed abstract] [Full text, HTML] [Full text, PDF]
1999 - 2000
Günzel D, Galler S (2000) Intracellular pH of crab and crayfish muscle fibre types during GABA application and inhibitory nerve stimulation. J. Comp. Physiol. [B] 170(7): 523-529 [PubMed abstract] [Full text PDF]
Günzel D, Schlue WR (2000) Mechanisms of Mg2+ influx, efflux and intracellular 'muffling' in leech neurones and glial cells. Magnes. Res. 13(2): 123-138. [PubMed abstract]
Günzel D, Müller A, Durry S, Schlue WR (1999) Multi-barrelled ion-sensitive microelectrodes and their application in micro-droplets and biological systems. Electrochim. Acta 44: 3785-3793 [Full text PDF]
Lüthi D, Günzel D, McGuigan JA (1999) Mg-ATP binding: its modification by spermine, the relevance to cytosolic Mg2+ buffering, changes in the intracellular ionized Mg2+ concentration and the estimation of Mg2+ by 31P-NMR. Exp. Physiol. 84(2): 231-252. [PubMed reference] [Full text HTML]
Hintz K, Günzel D, Schlue WR (1999) Na+-dependent regulation of the free Mg2+ concentration in neuropile glial cells and P neurones of the leech Hirudo medicinalis. Pflügers Arch. 437(3): 354-362 [PubMed abstract] [Full text PDF]
1991 - 1997
Günzel D, Durry S, Schlue WR (1997) Intracellular alkalinization causes Mg2+ release from intracellular binding sites in leech Retzius neurones. Pflügers Arch. 435(1): 65-73 [PubMed abstract] [Full text PDF]
Schlue W-R, Kilb W, Günzel D (1997) Ultramicroelectrodes for membrane research. Electrochim. Acta 42: 3197-3205 [Full text PDF]
Günzel D, Schlue W-R (1997) Intracellular Mg2+ is regulated by 1 Na+/1 Mg2+ antiport in neurones of an invertebrate central nervous system. Electrochim. Acta 42: 3207-3215 [Full text PDF]
Günzel D, Schlue WR (1996) Sodium-magnesium antiport in Retzius neurones of the leech Hirudo medicinalis. J. Physiol. 491(Pt 3): 595-608 [PubMed abstract]
Günzel D, Rathmayer W (1994) Non-uniformity of sarcomere lengths can explain the 'catch-like' effect of arthropod muscle. J. Muscle Res. Cell Motil. 15(5): 535-546 [PubMed abstract]
Günzel D, Galler S, Rathmayer W (1993) Fibre heterogeneity in the closer and opener muscles of crayfish walking legs. J. Exp. Biol. 175: 267-281 [Full text PDF]
Günzel D, Galler S (1991) Intracellular free Mg2+ concentration in skeletal muscle fibres of frog and crayfish. Pflügers Arch. 417(5): 446-453 [PubMed abstract]
