 Institute of Clinical Physiology |
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Institute of Clinical Physiology |
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PubMed list |
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2013
Reviews
Günzel D, Yu AS
(2013) Claudins and the modulation of tight junction permeability.
Physiol. Rev. 93: ###-### (IF 26.9)
[10.01.13 Proofs, by PM]
2012
Cording J, Berg J, Käding N, Bellmann C, Tscheik C, Westphal JK, Milatz S, Günzel D, Wolburg H, Piontek J, Huber O, Blasig IE (2012) Tight junctions: Claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate the claudin oligomerization. J. Cell Sci. ###: ###-### (IF 6.1) [PubMed] [WebPage] [PDF]
Kirschner N, Rosenthal R, Günzel D, Moll I, Brandner JM (2012) Tight junctions and differentiation – a chicken or the egg question? Exp. Dermatol. 21(3): 171-175
Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012) Claudin-17 forms tight junction channels with distinct anion selectivity. Cell. Mol. Life Sci. 69(16): 2765-2778
Rosenthal R*, Günzel D* (*shared first authorship), Finger C, Krug SM, Richter JF, Schulzke JD, Fromm M, Amasheh S (2012) The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. Biomaterials 33(9): 2791-2800 (IF 7.4) [PubMed] [HTML] [PDF] [Supplement]
Schumann M, Günzel D, Buergel N, Richter JF, Troeger H, May C, Fromm A, Sorgenfrei D, Daum S, Bojarski C, Heyman M, Zeitz M, Fromm M, Schulzke JD (2012) Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in celiac disease. Gut 61(2): 220-228 (IF 10.1) [PubMed] [HTML] [PDF] [Supplements]
Handbook article
Günzel D, Fromm M (2012) Claudins and other tight junction proteins. Comprehensive Physiology (former Handbook of Physiology) 2(3): 1819-1852 [PubMed: soon] [WebPage] [PDF]
Reviews
Günzel D, Zakrzewski S, Schmid T, Pangalos M, Wiedenhoeft J, Blasse C, Ozboda C, Krug SM (2012) From TER to trans- and paracellular resistance: Lessons from impedance spectroscopy. Ann. N.Y. Acad. Sci. 1257: 142-151 (IF 3.2) [PubMed] [WebPage] [PDF]
Krug SM, Günzel D, Conrad MP, Lee IM, Amasheh S, Fromm M, Yu ASL (2012) Charge-selective claudin channels. Ann. N.Y. Acad. Sci. 1257: 20-28
Schulzke JD, Günzel D, John LJ, Fromm M (2012) Perspectives in tight junction research. Ann. N.Y. Acad. Sci. 1257: 1-19
2011
Stumpff F, Georgi MI, Mundhenk L, Rabbani I, Fromm M, Martens H, Günzel D (2011) Sheep rumen and omasum primary cultures and source epithelia: Barrier function aligns with expression of tight junction proteins. J. Exp. Biol. 214: 2871-2882 (IF 3.0) [PubMed] [HTML] [PDF] [Supplement]
Nielsen HL, Nielsen H, Ejlertsen T, Engberg J, Günzel D, Zeitz M, Hering NA, Fromm M, Schulzke JD, Bücker R (2011) Oral and fecal Campylobacter concisus strains perturb barrier function by apoptosis induction in HT-29/B6 intestinal epithelial cells. Plos One 6(8): e23858 (print pages 1-8) (IF 4.1) [PubMed] [HTML] [PDF]
Bücker R, Krug SM, Rosenthal R, Günzel D, Fromm A, Zeitz M, Chakraborty T, Fromm M, Epple HJ, Schulzke JD (2011) Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells. J. Infect. Dis. 204 (8): 1283-1292 (IF 6.4) [PubMed] [HTML] [PDF]
Hering NA, Richter JF, Krug SM, Günzel D, Fromm A, Bohn E, Rosenthal R, Bücker R, Fromm M, Troeger H, Schulzke JD (2011) Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers. Lab. Invest. 91(2): 310-324 (IF 3.6) [PubMed] [HTML] [PDF] [Supplement DOC]
Stuiver M, Lainez S, Will C, Terryn S, Günzel D, Debaix H, Sommer K, Kopplin K, Thumfart J, Kampik NB, Querfeld U, Willnow TE, Nemec V, Wagner C, Hoenderop JG, Devuyst O, Knoers NVAM, Bindels RJ, Meij IC*, Müller D* (*shared last authorship) (2011) CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. Am. J. Hum. Genet. 88(3): 333-343
Schulzke JD*, Andres S*, Amasheh M* (*shared first authorship), Fromm A, Günzel D (2011) Anti-diarrheal mechanism of the traditional remedy Uzara via reduction of active chloride secretion. PLoS One 6(3): e18107 (print pages 1-9) (IF 4.1) [PubMed] [HTML] [PDF]
Review
Amasheh S, Fromm M, Günzel D (2011) Claudins of intestine and nephron - a correlation of molecular tight junction structure and barrier function. Acta Physiol. 201(1): 133-140 (IF 3.1) [PubMed] [HTML] [PDF]
2010
Milatz S, Krug SM, Rosenthal R, Günzel D, Müller D, Schulzke JD, Amasheh S*, Fromm M* (*shared last authorship) (2010) Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim. Biophys. Acta Biomembr. 1798: 2048-2057 [PubMed] [HTML] [PDF]]
Schmid T, Günzel D, Bogdan M (2010) Using an artificial neural network to determine electrical properties of epithelia. In: Diamantaras K, Duch W, Iliadis LS Eds., ICANN 2010, Part I, Lect. Notes Comput. Sci. 6352: 211-216 (DOI: 10.1007/978-3-642-15819-3_28) [WebPage] [PDF]
Rosenthal R, Milatz S, Krug SM,
Oelrich B, Schulzke JD, Amasheh S, Günzel D, Fromm M (2010) Claudin-2,
a component of the tight junction, forms a paracellular water channel.
J. Cell Sci. 123(11): 1913-1921 [PubMed]
[HTML] [PDF]
[Supplement]
Hillenbrand B, Günzel D, Richter JF, Höhne, Schreier E, Schulzke JD, Mankertz J (2010) Norovirus non-structural protein p20 leads to impaired restitution of epithelial defects by inhibition of actin cytoskeleton remodelling. Scand. J. Gastroent. 45(11): 1307-1319 [PubMed] [HTML] [PDF]
Will C, Breiderhoff T, Thumfart J, Stuiver M, Kopplin K, Sommer K, Günzel D, Querfeld U, Meij IC, Shan Q, Bleich M, Willnow TE, Müller D (2010) Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am. J. Physiol. Renal Physiol. 298: F1152-F1161 [PubMed] [HTML] [PDF]
Preston P, Wartosh L, Günzel D,
Fromm M, Kongsuphol P, Ousingsawat J, Kunzelmann K, Barhanin J, Warth R,
Jentsch TJ (2010) Disruption of the K+-channel
β-subunit KCNE3 reveals an important role in colonic and tracheal Cl-
transport. J. Biol. Chem. 285(10):
7165-7175 [PubMed] [PDF]
[Supplement] Review /
book chapter
Günzel D, Krug SM, Rosenthal R, Fromm M (2010) Biophysical methods to study tight junction permeability. Curr. Top. Membr. 65: 39-78 [Directory] [HTML] [PDF]
2009
Krug SM, Amasheh S, Richter JF, Milatz S, Günzel D, Westphal JK, Huber O, Schulzke JD, Fromm M (2009) Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol. Biol. Cell 20: 3713-3724 [PubMed] [HTML] [PDF] [Supplement text] [Supplement video]]
Krug SM, Fromm M, Günzel D (2009) Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys. J. 97(8): 2202-2211 [PubMed] [HTML] [PDF] [Supplement]
Günzel D, Amasheh S, Pfaffenbach S, Richter JF, Kausalya PJ, Hunziker W, Fromm M (2009b) Claudin-16 affects transcellular Cl- secretion in MDCK cells. J. Physiol. 587(15): 3777-3793 [PubMed] [HTML] [PDF] [Supplement]
Günzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Müller D (2009a) Claudin-10 exists in six alternatively spliced isoforms which exhibit distinct localization and function. J. Cell Sci. 122: 1507-1517 [PubMed] [HTML] [PDF]
Richter JF, Gitter AH, Günzel D, Weiss S, Mohamed W, Chakraborti T, Fromm M, Schulzke JD (2009) Listeriolysin O affects barrier function and induces chloride secretion in HT-29/B6 colon epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 296(6): G1350-G1359 [PubMed] [HTML] [PDF]
Yu ASL, Cheng MH, Angelow S, Günzel D, Kanzawa SA, Schneeberger EE, Fromm M, Coalson RD (2009) Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site. J. Gen. Physiol. 133(1): 111-127 [PubMed] [HTML] [PDF]
Reviews
Amasheh S, Milatz S, Krug SM, Markov AG, Günzel D, Amasheh M, Fromm M (2009) Tight junction proteins as channel formers and barrier builders: claudin-2, -5, and -8. Ann. N.Y. Acad. Sci. 1165: 211-219 [PubMed] [HTML] [PDF]
Fromm M, Krug SM, Zeissig S, Richter JF, Rosenthal R, Schulzke JD, Günzel D (2009) High resolution analysis of barrier function. Ann. N.Y. Acad. Sci. 1165: 74-81 [PubMed] [HTML] [PDF]
Günzel D, Haisch L, Pfaffenbach S, Krug SM, Milatz S, Amasheh S, Hunziker W, Müller D (2009) Claudin function in the thick ascending limb of Henle's loop. Ann. N.Y. Acad. Sci. 1165: 152-162 [PubMed] [HTML] [PDF]
Günzel D, Yu ASL (2009) Function and regulation of claudins in the thick ascending limb of Henle. Pflügers Arch. 458(1): 77-88 [PubMed] [HTML] [PDF]
2007 - 2008
Troeger H*, Richter JF* (*shared first authorship), Beutin L, Günzel D, Dobrindt U, Epple HJ, Gitter AH, Zeitz M, Fromm M, Schulzke JD (2007) E. coli alpha-hemolysin induces focal leaks in colonic epithelium – a novel mechanism of bacterial translocation. Cell. Microbiol. 9(10): 2530-2540 [PubMed] [HTML] [PDF]
Gabriel TE, Günzel D (2007) Quantification of Mg2+ extrusion and cytosolic Mg2+-buffering in Xenopus oocytes. Arch. Biochem. Biophys. 458(1): 3-15 [PubMed] [HTML] [PDF]
Zeissig S, Bürgel N, Günzel D, Richter JF, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2007) Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56(1): 61-72 [PubMed] [HTML] [PDF]
2006
Günzel D, Kucharski
LM, Kehres DG, Romero MF, Maguire ME (2006) The MgtC virulence factor of
Salmonella enterica serovar typhimurium activates Na+,K+-ATPase.
J. Bacteriol. 188(15): 5586-5594 [PubMed]
[HTML] [PDF]
Günzel D*, Florian P* (*shared first authorship), Richter JF, Troeger H, Schulzke JD, Fromm M, Gitter AH (2006) Restitution of single-cell defects in the mouse colon epithelium differs from that of cultured cells. Am. J. Physiol. - Reg. Integ. Comp. Physiol. 290: R1496-R1507 [PubMed] [HTML] [PDF] [Supplemental videos]
Reiter B, Kraft R, Günzel D, Zeissig S, Schulzke JD, Fromm M, Harteneck C (2006) TRPV4-mediated regulation of epithelial permeability. FASEB J. 20: 1802-1812 [PubMed] [HTML] [PDF]
Kausalya PJ*, Amasheh S* (*shared
first authorship), Günzel D, Wurps H, Müller D, Fromm M, Hunziker W
(2006) Disease-associated mutations affect intracellular traffic and
paracellular Mg2+ transport function of claudin-16.
J. Clin. Invest. 116(4): 878-891 [PubMed]
[HTML]
[PDF]
2005
Günzel D, Hintz K, Durry S, Schlue WR (2005) Mg2+-malate co-transport, a mechanism for Na+-independent Mg2+ transport in neurons of the leech Hirudo medicinalis. J. Neurophysiol. 94: 441-453 [PubMed] [HTML] [PDF]
Tunggal JA*, Helfrich I* (*shared
first authorship), Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R,
Krieg T, Niessen CM (2005) E-cadherin is essential for in vivo epidermal
barrier function by regulating tight junctions.
EMBO J. 24: 1146-1156 [PubMed]
[HTML] [PDF]
Günzel D, McGuigan JAS, Schlue WR (2005) Use of Mg2+ and Ca2+ macroelectrodes to measure binding in extracellular-like physiological solutions. Front. Biosci. 10: 905-918 [PubMed] [Full text] [Request text]
2001 - 2003
Müller A, Günzel D, Schlue WR (2003) Activation of AMPA/kainate receptors but not acetylcholine receptors causes Mg2+ influx into Retzius neurones of the leech Hirudo medicinalis. J. Gen. Physiol. 122: 727-739 [PubMed] [Full text, HTML] [PDF]
Günzel D, Schlue WR (2002) Determination of [Mg(2+)]i - an update on the use of Mg(2+)-selective electrodes. Biometals 15(3): 237-249 [PubMed] [Full text (produces an error at first attempt and sets a cookie, then click again)]
McGuigan JAS, Elder HY, Günzel D, Schlue W-R (2002) Magnesium homeostasis in heart: a critical reappraisal. J. Clin. Basic Cardiol. 5: 5-22
Mooren FC, Turi S, Günzel D, Schlue WR, Domschke W, Singh J, Lerch MM (2001) Calcium-magnesium interactions in pancreatic acinar cells. FASEB J. 15(3): 659-672 [PubMed] [Full text, HTML] [PDF]
Günzel D, Zimmermann F, Durry S, Schlue WR (2001) Apparent intracellular Mg2+ buffering in neurons of the leech Hirudo medicinalis. Biophys. J. 80(3): 1298-1310 [PubMed] [Full text, HTML] [Full text, PDF]
1999 - 2000
Günzel D, Galler S (2000) Intracellular pH of crab and crayfish muscle fibre types during GABA application and inhibitory nerve stimulation. J. Comp. Physiol. [B] 170(7): 523-529 [PubMed] [PDF]
Günzel D, Schlue WR (2000) Mechanisms of Mg2+ influx, efflux and intracellular 'muffling' in leech neurones and glial cells. Magnes. Res. 13(2): 123-138. [PubMed]
Günzel D, Müller A, Durry S, Schlue WR (1999) Multi-barrelled ion-sensitive microelectrodes and their application in micro-droplets and biological systems. Electrochim. Acta 44: 3785-3793 [PDF]
Lüthi D, Günzel D, McGuigan JA (1999) Mg-ATP binding: its modification by spermine, the relevance to cytosolic Mg2+ buffering, changes in the intracellular ionized Mg2+ concentration and the estimation of Mg2+ by 31P-NMR. Exp. Physiol. 84(2): 231-252. [PubMed reference] [HTML]
Hintz K, Günzel D, Schlue WR (1999) Na+-dependent regulation of the free Mg2+ concentration in neuropile glial cells and P neurones of the leech Hirudo medicinalis. Pflügers Arch. 437(3): 354-362 [PubMed] [PDF]
1991 - 1997
Günzel D, Durry S, Schlue WR (1997) Intracellular alkalinization causes Mg2+ release from intracellular binding sites in leech Retzius neurones. Pflügers Arch. 435(1): 65-73 [PubMed] [PDF]
Schlue W-R, Kilb W, Günzel D (1997) Ultramicroelectrodes for membrane research. Electrochim. Acta 42: 3197-3205 [PDF]
Günzel D, Schlue W-R (1997) Intracellular Mg2+ is regulated by 1 Na+/1 Mg2+ antiport in neurones of an invertebrate central nervous system. Electrochim. Acta 42: 3207-3215 [PDF]
Günzel D, Schlue WR (1996) Sodium-magnesium antiport in Retzius neurones of the leech Hirudo medicinalis. J. Physiol. 491(Pt 3): 595-608 [PubMed]
Günzel D, Rathmayer W (1994) Non-uniformity of sarcomere lengths can explain the 'catch-like' effect of arthropod muscle. J. Muscle Res. Cell Motil. 15(5): 535-546 [PubMed]
Günzel D, Galler S, Rathmayer W (1993) Fibre heterogeneity in the closer and opener muscles of crayfish walking legs. J. Exp. Biol. 175: 267-281 [PDF]
Günzel D, Galler S (1991) Intracellular free Mg2+ concentration in skeletal muscle fibres of frog and crayfish. Pflügers Arch. 417(5): 446-453 [PubMed]
