Institute of Clinical Physiology

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Publications:  Michael Fromm

2013

• Kirschner N*, Rosenthal R* (*shared first authorship), Furuse M, Moll I, Fromm M, Brandner JM (2013) Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes. J. Invest. Dermatol. ###: ###-### (IF 6.3) [27.11.12 Accepted]

• Krug SM, Amasheh M, Dittmann I, Christoffel I, Fromm M, Amasheh S (2013) Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells. Biomaterials 34(1): 275-282 (IF 7.4) [PubMed] [WebPage] [PDF]

2012

• Amasheh M, Luettig J, Amasheh S, Zeitz M, Fromm M, Schulzke JD (2012) Effects of quercetin on the colonic cell culture model HT-29/B6 and rat intestine in vitro. Ann. N.Y. Acad. Sci. 1258: 100-107 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper)

• Barmeyer C, Erko I, Fromm A, Bojarski C, Allers C, Moos V, Zeitz M, Fromm M, Schulzke JD (2012) Ion transport and barrier function are disturbed in microscopic colitis. Ann. N.Y. Acad. Sci. 1258: 143-148 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper)

• Hackel D, Krug SM, Sauer RS, Mousa SA, Böcker A, Pflücke D, Wrede EJ, Kistner K, Hoffmann T, Niedermirtl B, Sommer C, Bloch L, Huber O, Blasig IE, Amasheh S, Reeh PW, Fromm M, Brack A, Rittner HL (2012) Transient opening of the perineurial barrier for analgesic drug delivery. Proc. Natl. Acad. Sci. USA 109(29): E2018-E2027 (IF 9.7) [PubMed] [WebPage] [PDF] 

• Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012) Claudin-17 forms tight junction channels with distinct anion selectivity. Cell. Mol. Life Sci. 69(16): 2765-2778 (IF 6.6) [PubMed] [WebPage] [PDF] [Supplement]

• Kuntzsch D, Bergann T, Dames P, Fromm A, Fromm M, Davis RA, Melzig MF, Schulzke JD (2012) The plant-derived glucocorticoid receptor agonist endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKs. PLoS One 7(11): e49426 (print pages 1-14) (IF 4.1) [PubMed] [WebPage] [PDF]

• Markov AG, Kruglova NM, Fomina YA, Fromm M, Amasheh S (2012) Altered expression of tight junction proteins in mammary epithelium after discontinued suckling in mice. Pflügers Arch. 463(2): 391-398 (IF 4.5) [PubMed] [HTML] [PDF]

• Rittner HL, Amasheh S, Moshourab R, Hackel D, Yamdeu RS, Fromm M, Stein C, Brack A (2012) Modulation of tight junction proteins in the perineurium to facilitate peripheral opioid analgesia. Anesthesiology 116(6): 1323-1334 (IF 5.4) [PubMed] [Full text via Ovid]

• Rosenthal R*, Günzel D* (*shared first authorship), Finger C, Krug SM, Richter JF, Schulzke JD, Fromm M, Amasheh S (2012) The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. Biomaterials 33(9): 2791-2800 (IF 7.4) [PubMed] [HTML] [PDF] [Supplement]

• Schumann M, Günzel D, Buergel N, Richter JF, Troeger H, May C, Fromm A, Sorgenfrei D, Daum S, Bojarski C, Heyman M, Zeitz M, Fromm M, Schulzke JD (2012) Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in celiac disease. Gut 61(2): 220-228 (IF 10.1) [PubMed] [HTML] [PDF] [Supplements]

• Shalapour S, Deiser K, Kühl AA, Glauben R, Krug SM, Fischer A, Sercan Ö, Chappaz S, Bereswill S, Heimesaat MM, Loddenkemper C, Fromm M, Finke D, Hämmerling GJ, Arnold B, Siegmund B, Schüler T (2012) Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis. PLoS One (IF 4.1) 7(2): e31939 (print pages 1-11) [PubMed] [HTML] [PDF]

• Takahashi A*, Saito Y*, Kondoh M*°, Matsushita K, Krug SM, Suzuki H, Tsujino H, Li X, Aoyama H, Matsuhisa K, Uno T, Fromm M, Hamakubo T, Yagi K (2012) Creation and biochemical analysis of a broad-specific claudin binder. Biomaterials 33(12): 3464-3474 (IF 7.4) [PubMed] [HTML with supplements] [PDF] (*shared first authorship, °corresponding author)

• Veshnyakova A, Krug SM, Mueller SL, Piontek J, Protze J, Fromm M, Krause G (2012) Determinants contributing to claudin ion channel formation. Ann. N.Y. Acad. Sci. 1257: 45-53 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper)

  • Handbook article

• Günzel D, Fromm M (2012) Claudins and other tight junction proteins. Comprehensive Physiology (former Handbook of Physiology) 2(3): 1819-1852 [PubMed: soon] [WebPage] [PDF]

  • Reviews

• Hackel D, Brack A, Fromm M, Rittner H (2012) Modulation of tight junction proteins in the perineurium for regional pain control. Ann. N.Y. Acad. Sci. 1257: 199-206 (IF 3.2) [PubMed]  [PDF]

• Hering NA, Fromm M, Schulzke JD (2012) Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics. J. Physiol. 590(5): 1035-1044 (IF 4.7) [PubMed] [HTML] [PDF]

• Krug SM, Günzel D, Conrad MP, Lee IM, Amasheh S, Fromm M, Yu ASL (2012) Charge-selective claudin channels. Ann. N.Y. Acad. Sci. 1257: 20-28 (IF 3.2) [PubMed] [WebPage] [PDF]

• Rosenthal R, Heydt MS, Amasheh M, Stein C, Fromm M, Amasheh S (2012) Analysis of absorption enhancers in epithelial cell models. Ann. N.Y. Acad. Sci. 1258: 86-92 (IF 3.2) [PubMed] [WebPage] [PDF]

• Schulzke JD, Günzel D, John LJ, Fromm M (2012) Perspectives in tight junction research. Ann. N.Y. Acad. Sci. 1257: 1-19 (IF 3.2) [PubMed] [WebPage] [PDF] 

  • Editions

• Fromm M, Schulzke JD, Volume Editors (2012) Barriers and channels formed by tight junction proteins, parts I and II. Ann. N.Y. Acad. Sci. 1257: 1-206 [WebPage] and 1258: 1-191 [WebPage] (IF 3.2) 48 papers

2011

• Bergann T, Fromm A, Borden SA, Fromm M, Schulzke JD (2011) Glucocorticoid receptor is indispensable for physiological responses to aldosterone in colonic epithelial Na⁺ channel induction via the mineralocorticoid receptor in a human colonic cell line. Eur. J. Cell Biol.  90(5): 432-439 (IF 2.8) [PubMed] [HTML] [PDF]

• Bücker R, Krug SM, Rosenthal R, Günzel D, Fromm A, Zeitz M, Chakraborty T, Fromm M, Epple HJ, Schulzke JD (2011) Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells. J. Infect. Dis. 204 (8): 1283-1292 (IF 6.4) [PubMed] [HTML] [PDF]

• Hering NA*, Andres S* (*shared first authorship), Fromm A, van Tol EA, Amasheh M, Mankertz J, Fromm M, Schulzke JD (2011) Transforming growth factor b, a whey protein component, strengthens the intestinal barrier by upregulating claudin-4 in HT-29/B6 cells. J. Nutr. 141(5): 783-789 (IF 3.9) [PubMed] [HTML] [PDF]

• Hering NA, Richter JF, Krug SM, Günzel D, Fromm A, Bohn E, Rosenthal R, Bücker R, Fromm M, Troeger H, Schulzke JD (2011) Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers. Lab. Invest. 91(2): 310-324 (IF 3.6) [PubMed] [HTML] [PDF] [Supplement DOC]

• John LJ, Fromm M, Schulzke JD (2011) Epithelial barriers in intestinal inflammation. Antioxid. Redox Signal. 15(5): 1255-1270 (IF 8.5) (Review) [PubMed] [HTML] [PDF for printing] [PDF with links]

• Markov AG, Voronkova MA, Volgin GN, Yablonsky PK, Fromm M, Amasheh S (2011) Tight junction proteins contribute to barrier properties in human pleura. Resp. Physiol. Neurobiol. 175(3): 331-335 (IF 2.2) [PubMed] [HTML] [PDF]

• Nielsen HL, Nielsen H, Ejlertsen T, Engberg J, Günzel D, Zeitz M, Hering NA, Fromm M, Schulzke JD, Bücker R (2011) Oral and fecal Campylobacter concisus strains perturb barrier function by apoptosis induction in HT-29/B6 intestinal epithelial cells. Plos One 6(8): e23858 (print pages 1-8) (IF 4.4) [PubMed] [HTML] [PDF]

• Rosenthal R, Fromm M (2011) Endothelin antagonism as an active principle for glaucoma therapy. Br. J. Pharmacol. 162(4): 806-816 (IF 4.4) (Review) [PubMed] [HTML] [PDF] [Free Teaching Material; Figs as PowerPoint slides]

• Stumpff F, Georgi MI, Mundhenk L, Rabbani I, Fromm M, Martens H, Günzel D (2011) Sheep rumen and omasum primary cultures and source epithelia: Barrier function aligns with expression of tight junction proteins. J. Exp. Biol. 214: 2871-2882 (IF 3.0) [PubMed] [HTML] [PDF] [Supplement]

  • Review

• Amasheh S, Fromm M, Günzel D (2011) Claudins of intestine and nephron - a correlation of molecular tight junction structure and barrier function. Acta Physiol. 201(1): 133-140 (IF 3.1) [PubMed] [HTML] [PDF]

 

2010

• Amasheh M, Fromm A, Krug SM, Amasheh S, Andres S, Zeitz M, Fromm M, Schulzke JD (2010) TNFa-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, pAkt, and NFkB signaling. J. Cell Sci. 123(23): 4145-4155 (IF 6.3) [PubMed] [HTML] [PDF] [Supplements]

• Epple HJ, Allers K, Tröger H, Kühl A, Erben U, Fromm M, Zeitz M, Loddenkemper C*, Schulzke JD*, Schneider T* (*shared last authorship) (2010) Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect. Gastroenterology 139(4): 1289-1300 (IF 12.0) [PubMed] [HTML] [PDF] [Supplement PDF]

• Kirschner N, Houdek P, Fromm M, Moll I, Brandner JM (2010) Tight junctions form a barrier in human epidermis. Eur. J. Cell Biol. 89(11): 839-842 (IF 3.6) [PubMed] [HTML] [PDF]

• Markov AG*, Veshnyakova A* (*shared first authorship), Fromm M, Amasheh M, Amasheh S (2010) Segmental expression of claudin proteins correlates with tight junction barrier properties in rat intestine. J. Comp. Physiol. B 180(4): 591-598 (IF 2.4) [PubMed] [HTML] [PDF]

• Milatz S, Krug SM, Rosenthal R, Günzel D, Müller D, Schulzke JD, Amasheh S*, Fromm M* (*shared last authorship) (2010) Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim. Biophys. Acta Biomembr. 1798: 2048-2057 (IF 4.6) [PubMed] [HTML] [PDF]

• Preston P, Wartosh L, Günzel D, Fromm M, Kongsuphol P, Ousingsawat J, Kunzelmann K, Barhanin J, Warth R, Jentsch TJ (2010) Disruption of the K⁺-channel β-subunit KCNE3 reveals an important role in colonic and tracheal Cl^- transport. J. Biol. Chem. 285(10): 7165-7175 (IF 5.3) [PubMed] [PDF] [Supplement]

• Rosenthal R, Milatz S, Krug SM, Oelrich B, Schulzke JD, Amasheh S, Günzel D, Fromm M (2010) Claudin-2, a component of the tight junction, forms a paracellular water channel. J. Cell Sci. 123(11): 1913-1921 (IF 6.3) [PubMed] [HTML] [PDF] [Supplement]

• Schulzke JD*, Pfaffenbach S* (*shared first authorship), Fromm A, Epple HJ, Troeger H*, Fromm M* (*shared last authorship) (2010) PGI₂ sensory input into the ENS during distension-induced colonic chloride secretion in rat colon. Acta Physiol. 199(3): 305-316 (IF 3.2) [PubMed] [HTML] [PDF]

• Westphal JK, Dörfel MJ, Krug SM, Cording JD, Piontek J, Blasig IE, Tauber R, Fromm M, Huber O (2010) Tricellulin forms homomeric and heteromeric tight junctional complexes. Cell. Mol. Life Sci. 67(12): 2057-2068 (IF 7.0) [PubMed] [HTML] [Supplement] [PDF]

  • Review / book chapter

• Günzel D, Krug SM, Rosenthal R, Fromm M (2010) Biophysical methods to study tight junction permeability. Curr. Top. Membr. 65: 39-78 [Directory] [HTML] [PDF]

  • Textbook chapter

• Fromm M (2010) Chapter 3 "Transport in Membranen und Epithelien", In: Physiologie des Menschen mit Pathophysiologie. Schmidt RF, Lang F, Heckmann M (eds.), 31. edn., Springer Medizin, Heidelberg. ISBN 978-3-642-01650-9, p 36-48 and p 895-897, review booklet p 3-4 [Textbook of Physiology] [Publisher's ad]

2009

• Amasheh M, Grotjohann I, Amasheh S, Fromm A, Söderholm JD, Zeitz M, Fromm M, Schulzke JD (2009) Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: A novel model for studying the pathomechanisms of inflammatory bowel disease cytokines. Scand. J. Gastroent. 44: 1226-1235 [PubMed] [HTML] [PDF]

• Amasheh S, Dullat S, Fromm M, Schulzke JD, Buhr HJ, Kroesen AJ (2009) Inflamed pouch mucosa possesses altered tight junctions indicating recurrence of inflammatory bowel disease. Int. J. Colorectal Dis. 24(10): 1149-1156 [PubMed] [HTML] [PDF] 

• Amasheh S*, Milatz S* (*shared first authorship), Krug SM, Bergs M, Amasheh M, Schulzke JD, Fromm M (2009) Na⁺ absorption defends from paracellular back-leakage by claudin-8 upregulation. Biochem. Biophys. Res. Comm. 378(1): 45-50  [PubMed] [HTML] [PDF]

• Bergann T, Plöger S, Fromm A, Zeissig S, Borden SA, Fromm M, Schulzke JD (2009) A colonic mineralocorticoid receptor cell model expressing epithelial Na⁺ channels. Biochem. Biophys. Res. Comm. 381(2): 280-285 [PubMed] [HTML] [PDF]

• Bergann T, Zeissig S, Fromm A, Richter JF, Fromm M, Schulzke JD (2009) Glucocorticoid and tumor necrosis factor-alpha synergize to induce absorption by the epithelial sodium channel in the colon. Gastroenterology 136(3): 933-942 [PubMed] [HTML] [PDF]

• Bücker R*, Troeger H* (*shared first authorship), Kleer J, Fromm M, Schulzke JD (2009) Arcobacter butzleri induces barrier dysfunction in intestinal epithelial cells. J. Infect. Dis. 200(5): 756-764 [PubMed] [HTML] [PDF]

• De Santo NG, Fromm M, Russo F, Wiederholt M (2009) Klaus Hierholzer [1929-2007] and his impact on our understanding of the renal effects of steroid hormones. J. Nephrol.  22(S14): 159-178 [PubMed] [PDF]

• Günzel D, Amasheh S, Pfaffenbach S, Richter JF, Kausalya PJ, Hunziker W, Fromm M (2009) Claudin-16 affects transcellular Cl^- secretion in MDCK cells. J. Physiol. (Lond.) 587(15): 3777-3793 [PubMed] [HTML] [PDF] [Supplement]

• Günzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Müller D (2009) Claudin-10 exists in six alternatively spliced isoforms which exhibit distinct localization and function. J. Cell Sci. 122: 1507-1517 [PubMed] [HTML] [PDF]

• Krug SM, Amasheh S, Richter JF, Milatz S, Günzel D, Westphal JK, Huber O, Schulzke JD, Fromm M (2009) Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol. Biol. Cell 20: 3713-3724 [PubMed] [HTML] [PDF] [Supplement text] [Supplement video]

• Krug SM, Fromm M, Günzel D (2009) Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys. J. 97(8): 2202-2211 [PubMed] [HTML] [PDF] [Supplement]

• Mankertz J*, Amasheh M* (*shared first authorship), Krug SM, Fromm A, Amasheh S, Hillenbrand B, Tavalali S, Fromm M, Schulzke JD (2009) TNFalpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling. Cell Tiss. Res. 336(1): 67-77 [PubMed] [HTML] [PDF]

• Richter JF, Gitter AH, Günzel D, Weiss S, Mohamed W, Chakraborti T, Fromm M, Schulzke JD (2009) Listeriolysin O affects barrier function and induces chloride secretion in HT-29/B6 colon epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 296(6): G1350-G1359 [PubMed] [HTML] [PDF]

• Troeger H, Loddenkemper C, Schneider T, Schreier E, Epple HJ, Zeitz M, Fromm M, Schulzke JD (2009) Structural and functional changes of the duodenum in human norovirus infection. Gut 58: 1070-1077 [PubMed] [HTML] [PDF]

• Yu ASL, Cheng MH, Angelow S, Günzel D, Kanzawa SA, Schneeberger EE, Fromm M, Coalson RD (2009) Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site. J. Gen. Physiol. 133(1): 111-127 [PubMed] [HTML] [PDF]

• Ziera T, Irlbacher H, Fromm A, Latouche C, Krug SM, Fromm M, Jaisser F, Borden SA (2009) Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel. FASEB J. 23(11): 3936-3946 [PubMed] [HTML] [PDF]

  • Reviews

• Amasheh M, Andres S, Amasheh S, Fromm M, Schulzke JD (2009) Barrier effects of nutritional factors. Ann. N.Y. Acad. Sci. 1165: 267-273 [PubMed] [HTML] [PDF]

• Amasheh S, Milatz S, Krug SM, Markov AG, Günzel D, Amasheh M, Fromm M (2009) Tight junction proteins as channel formers and barrier builders: claudin-2, -5, and -8. Ann. N.Y. Acad. Sci. 1165: 211-219 [PubMed] [HTML] [PDF]

• Fromm M, Krug SM, Zeissig S, Richter JF, Rosenthal R, Schulzke JD, Günzel D (2009) High resolution analysis of barrier function. Ann. N.Y. Acad. Sci. 1165: 74-81 [PubMed] [HTML] [PDF]

• Schulzke JD, Fromm M (2009) Tight junctions: Molecular structure meets function. Ann. N.Y. Acad. Sci. 1165: 1-6 [PubMed] [HTML] [PDF]

• Schulzke JD*, Ploeger S* (*shared first authorship), Amasheh M, Fromm A, Zeissig S, Troeger H, Richter JF, Bojarski C, Schumann M, Fromm M (2009) Epithelial tight junctions in intestinal inflammation. Ann. N.Y. Acad. Sci. 1165: 294-300 [PubMed] [HTML] [PDF]

  • Textbook chapter

• Fromm M, Gaebel G (2009) chapter 13: "Niere" [Kidney], In: Physiologie der Haustiere. Engelhardt W von (ed), 3rd fully revised edn, Enke Verlag, Stuttgart, p 292-320 [Publishers ad] (Textbook of Veterinary Physiology)

  • Edition

• Fromm M, Schulzke JD, Volume Editors (2009) Molecular structure and function of the tight junction. Ann. N.Y. Acad. Sci. 1165, pp 1-346, 46 papers, ISBN 978-1-57331-749-8 [Contents and Full Papers] [Cover]

2008

• Amasheh M, Schlichter S, Amasheh S, Mankertz J, Zeitz M, Fromm M, Schulzke JD (2008) Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells. J. Nutr. 138(6):1067-1073 [PubMed] [HTML] [PDF]

• Epple HJ, Schneider T, Troeger H, Kunkel D, Allers K, Moos V, Amasheh M, Loddenkemper C, Fromm M, Zeitz M, Schulzke JD (2009, Epub 04.11.2008) Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut 58: 220-227  [PubMed] [HTML] [PDF]

• Kroesen AJ, Dullat S, Schulzke JD, Fromm M, Buhr HJ (2008) Permanently increased mucosal permeability in patients with backwashileitis after ileoanal pouch for ulcerative colitis. Scand. J. Gastroent. 43(6): 704-711 [PubMed] [HTML] [PDF]

• Schumann M, Richter JF, Wedell I, Moos V, Zimmermann-Kordmann M, Schneider T, Daum S, Zeitz M, Fromm M, Schulzke JD (2008) Mechanisms of epithelial translocation of the a2-gliadin-33mer in celiac sprue. Gut 57(6): 747-754 [PubMed] [HTML] [PDF]

• Will C, Fromm M, Müller D (2008) Claudin tight junction proteins: novel aspects in paracellular transport. Periton. Dialysis Int. 28(6): 577-584 [PubMed] [PDF]

• Zeissig S, Bergann T, Fromm A, Bojarski C, Heller F, Guenther U, Zeitz M, Fromm M, Schulzke JD (2008) Altered ENaC expression leads to impaired sodium absorption in the non-inflamed intestine in Crohn's disease. Gastroenterology 134(5): 1436-1447 [PubMed] [HTML] [PDF]

  • Textbook chapters

• Fromm M, Schulzke JD (2008) Diarrhea. In: Encyclopedia of molecular mechanisms of disease. Lang F (ed), Springer, Berlin Heidelberg, ISBN 978-3-540-67136-7 (Print) 978-3-540-29676-8 (Online), Part 4, p 528-530. [Online entry] [HTML]

• Schulzke JD, Fromm M (2008) Malabsorption. In: Encyclopedia of molecular mechanisms of disease. Lang F (ed), Springer, Berlin Heidelberg, ISBN 978-3-540-67136-7 (Print) 978-3-540-29676-8 (Online), Part 13, p 1250-1252. [Online entry] [HTML]

  • Book

• De Santo NG, Fromm M, Russo F, Wiederholt M (2008) Klaus Hierholzer in memoriam: Klaus Hierholzer and his impact on the renal effects of steroid hormones. Arte Tipografica, Napoli, ISBN 978-88-89776-97-1, pp 48.

2007

• Rosenthal R, Choritz L, Zorn R, Münzer G, Fromm M, Pfeiffer N, Thieme H (2007) Endothelin receptor B in trabecular meshwork. Exp. Eye Res. 85: 482-481 [PubMed] [HTML + links] [PDF]

• Troeger H*, Richter JF* (*shared first authorship), Beutin L, Günzel D, Dobrindt U, Epple HJ, Gitter AH, Zeitz M, Fromm M, Schulzke JD (2007) E. coli alpha-hemolysin induces focal leaks in colonic epithelium – a novel mechanism of bacterial translocation. Cell. Microbiol. 9(10): 2530-2540 [PubMed] [HTML] [PDF]

• Troeger H, Epple HJ, Schneider T, Wahnschaffe U, Ullrich R, Burchard GD, Jelinek T, Zeitz M, Fromm M, Schulzke JD (2007) Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum. Gut  56(3): 328-335 [PubMed] [HTML] [PDF]  Comment in: Gut 2007 56(3): 316-317

• Zeissig S, Fromm A, Mankertz J, Weiske J, Zeitz M, Fromm M, Schulzke JD (2007) Butyrate induces intestinal sodium absorption via Sp3-mediated transcriptional up-regulation of epithelial sodium channels. Gastroenterology 132(1): 236-248 [PubMed] [HTML] [PDF]

• Zeissig S, Bürgel N, Günzel D, Richter JF, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2007) Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56(1): 61-72 [PubMed] [HTML] [PDF]

  • Textbook chapters

• Fromm M (2007) {Numerous key words}, In: Pschyrembel, Klinisches Wörterbuch. Pschyrembel W (Hrsg.), 261. Auflage, deGruyter, Berlin. Book: ISBN 978-3-11-018534-8, CD-ROM: ISBN 978-3-11-019126-4, Book plus CD-ROM: ISBN 978-3-11-019127-1 [Medical dictionary] [Publisher's ad] [Online version]

• Fromm M (2007) Chapter 3: "Transport in Membranen und Epithelien", In: Physiologie des Menschen mit Pathophysiologie. Schmidt RF, Lang F (Hrsg.), 30. Auflage, Springer, Berlin Heidelberg NewYork. ISBN 978-3-540-32908-4, p 41-54 and 971-973 [Textbook of Physiology] [Publisher's ad]

2006

• Günzel D*, Florian P* (*shared first authorship), Richter JF, Troeger H, Schulzke JD, Fromm M, Gitter AH (2006) Restitution of single-cell defects in the mouse colon epithelium differs from that of cultured cells. Am. J. Physiol. - Reg. Integ. Comp. Physiol. 290: R1496-R1507 [PubMed] [HTML] [PDF] [Supplemental videos]

• Kausalya PJ*, Amasheh S* (*shared first authorship), Günzel D, Wurps H, Müller D, Fromm M, Hunziker W (2006) Disease-associated mutations affect intracellular traffic and paracellular Mg²⁺ transport function of claudin-16. J. Clin. Invest. 116(4): 878-891 [PubMed] [HTML] [PDF]

• Kroesen AJ, Leistenschneider P, Lehmann K, Ransco C, Dullat S, Blaut M, Schulzke JD, Fromm M, Buhr HJ (2006) Increased bacterial permeation in long-lasting ileoanal pouches. Inflamm. Bowel Dis. 12(8): 736-744 [PubMed] [HTML and PDF]

• Markov AG, Shadrin LV, Veshnyakova A, Amasheh S, Fromm M (2006) The tight junction proteins claudin-2 and -16 expression in mammary epithelium of mice. Russ. J. Physiol. (Ross. Fiziol. Zh. Im. I. M. Sechenova) 92(11): 1382-1386 [PubMed listing]

• Reiter B, Kraft R, Günzel D, Zeissig S, Schulzke JD, Fromm M, Harteneck C (2006) TRPV4-mediated regulation of epithelial permeability. FASEB J. 20: 1802-1812 [PubMed] [HTML] [PDF]

• Schulzke JD, Bojarski C, Zeissig S, Heller F, Gitter AH, Fromm M (2006) Disrupted barrier function through epithelial cell apoptosis. Ann. N.Y. Acad. Sci. 1072: 288-299 [PubMed] [PDF] [Publisher's ad]

• Thieme H, Schimmat C, Münzer G, Boxberger M, Fromm M, Pfeiffer N, Rosenthal R (2006) Endothelin-antagonism: effects of FP receptor agonists prostaglandin F2a and fluprostenol on trabecular meshwork contractility. Invest. Ophth. Vis. Sci. 47(3): 938-945 [PubMed] [HTML] [PDF]

• Zeissig S, Fromm A, Mankertz J, Zeitz M, Fromm M, Schulzke JD (2006) Restoration of ENaC expression by glucocorticoid receptor transfection in human HT-29/B6 colon cells. Biochem. Biophys. Res. Commun. 344(4): 1065-1070 [PubMed] [HTML] [PDF]

  • Textbook chapter

• Häussinger D, Fromm M, Tauber R (2006) Kapitel 3: "Proteinstoffwechsel", In: Klinische Pathophysiologie. Siegenthaler W, Blum HE, ed., 9^th edtn., Thieme Verlag, Stuttgart, p 108-128 [Textbook of pathophysiology] [Verlagsprospekt / publisher's ad]

2005

• Amasheh S, Schmidt T, Mahn M, Florian P, Mankertz J, Tavalali S, Gitter AH, Schulzke JD, Fromm M (2005) Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells. Cell Tissue Res. 321(1): 89-96 [PubMed] [HTML] [PDF]

• Bode H, Lenzner L, Kraemer OH, Bendfeldt K, Schulzke JD, Fromm M, Stoltenburg-Didinger G, Zeitz M, Ullrich R (2005) The HIV protease inhibitors saquinavir, ritonavir, and nelfinavir induce apoptosis and decrease barrier function in human intestinal epithelial cells. Antivir. Ther. 10(5): 645-655 [PubMed] [PDF]

• Choritz L, Rosenthal R, Fromm M, Foerster MH, Thieme H (2005) Pharmacological and functional characterization of endothelin receptors in bovine trabecular meshwork and ciliary muscle. Ophthalm. Res. 37(4): 179-187 [PubMed] [PDF]

• Heller F, Florian P, Bojarski C, Richter JF, Christ M, Hillenbrand B, Mankertz J, Gitter AH, Bürgel N, Fromm M, Zeitz M, Fuss I, Strober W, Schulzke JD (2005) Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis and cell restitution. Gastroenterology 129(2): 550-564 [PubMed] [HTML] [PDF]

• Schulzke JD, Gitter AH, Mankertz J, Spiegel S, Seidler U, Amasheh S, Saitou M, Tsukita S, Fromm M (2005) Epithelial transport and barrier function in occludin-deficient mice. Biochim. Biophys. Acta - Biomembranes 1669(1): 34-42 [PubMed] [HTML] [PDF]

• Tunggal JA*, Helfrich I* (*shared first authorship), Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T, Niessen CM (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 24: 1146-1156 [PubMed] [HTML] [PDF]

  • Textbook chapters

• Fromm M (2005) Kapitel 3: "Transport in Membranen und Epithelien", In: Physiologie des Menschen. Schmidt RF, Lang F, Thews G (Hrsg.), 29. Auflage, Springer, Berlin Heidelberg NewYork. ISBN 3-540-21882-3, p 39-55 [Textbook of physiology] [Publisher's ad]

• and in: Physiologie des Menschen, Die Bilder-CD-ROM 2.0, Schmidt RF, Lang F, Thews G (Hrsg.), Version 2.0, ISBN 3-540-21919-6 [Publisher's ad]

• Fromm M, Gaebel G (2005) Kapitel 13: "Niere", In: Physiologie der Haustiere. Engelhardt W von, Breves G (Hrsg.), 2. Auflage, Enke Verlag, Stuttgart, p 277-303 [Textbook of veterinary physiology] [Publisher's ad]

2004

• Amasheh S, Barmeyer C, Koch CS, Tavalali S, Mankertz J, Epple HJ, Gehring MM, Florian P, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2004) Cytokine-dependent transcriptional down-regulation of epithelial sodium channel (ENaC) in ulcerative colitis. Gastroenterology 126: 1711-1720 [PubMed] [HTML] [PDF]

• Barmeyer C*, Amasheh S* (*shared first authorship), Tavalali S, Mankertz J, Zeitz M, Fromm M, Schulzke JD (2004) IL-1beta and TNFalpha regulate sodium absorption in rat distal colon. Biochem. Biophys. Res. Comm. 317: 500-507 [PubMed] [HTML] [PDF]

• Barmeyer C, Harren M, Schmitz H, Heizel-Pleines U, Mankertz J, Seidler U, Horak I, Wiedenmann B, Fromm M, Schulzke JD (2004) Mechanisms of diarrhea in the interleukin-2 deficient mouse model of colonic inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 286: G244-G252 [PubMed] [HTML] [PDF]

• Bojarski C, Weiske J, Schöneberg T, Schröder W, Mankertz J, Schulzke JD, Florian P, Fromm M, Tauber R, Huber O (2004) The specific fate of tight junction proteins in apoptotic epithelial cells. J. Cell Sci. 117: 2097-2107 [PubMed] [HTML] [PDF]

• Epple HJ, Mankertz J, Ignatius R, Liesenfeld O, Fromm M, Zeitz M, Chakraborty T, Schulzke JD (2004) Aeromonas hydrophila beta-hemolysin induces active chloride secretion in colon epithelial cells (HT-29/B6). Infect. Immun. 72(8): 4848-4858 [PubMed] [HTML] [PDF]

• Lipka C, Mankertz J, Fromm M, Bühler H, Kühn W, Ragosch V, Hundertmark S (2004) Impairment of the antiproliferative effect of glucocorticosteroids by 11beta-hydroxysteroid dehydrogenase type 2 overexpression in MCF-7 breast cancer cells. Hormone Metab. Res. 36: 437-444 [PubMed] [HTML] [PDF]

• Mankertz J*, Hillenbrand B* (*shared first authorship), Tavalali S, Huber O, Fromm M, Schulzke JD (2004) Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. Biochem. Biophys. Res. Comm. 314(4): 1001-1007 [PubMed]  [HTML] [PDF]

• Zeissig S*, Bojarski C* (*shared first authorship), Bürgel N, Mankertz J, Zeitz M, Fromm M, Schulzke JD (2004) Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by TNFalpha antibody treatment. Gut  53: 1295-1302 [PubMed] [HTML] [PDF]

2003

• Barmeyer C, Horak I, Zeitz M, Fromm M, Schulzke JD (2003) The Interleukin-2-deficient mouse model. Pathobiology 70(3): 139-142 [PubMed] [Full text]

• Florian P, Amasheh S, Lessidrensky M, Todt I, Bloedow A, Ernst A, Fromm M, Gitter AH (2003) Claudins in the tight junctions of stria vascularis marginal cells. Biochem. Biophys. Res. Comm. 304: 5-10 [PubMed] [HTML] [PDF]

  • Textbook chapter

• Hierholzer K, Fromm M (2003) "Elementi di physiologia renale" In: Malattie dell' apparato urinario. De Santo NG, Camussi G, D'Armiento M (eds), Editoriale Bios, Cosenza, ISBN 88-7740-353-5, 1st ed, chapter 1, p 3-44 [chapter "Elements of renal physiology" in Italian textbook "Renal diseases"]

2002

• Amasheh S, Meiri N, Gitter AH, Schöneberg T, Mankertz J, Schulzke JD, Fromm M (2002) Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J. Cell Sci. 115(24): 4969-4976 [PubMed] [HTML] [PDF]

• Bürgel N, Bojarski C, Mankertz J, Zeitz M, Fromm M, Schulzke JD (2002) Mechanisms of diarrhea in collagenous colitis. Gastroenterology 123(2): 433-443 [PubMed] [HTML] [PDF]

• Florian P, Schöneberg T, Schulzke JD, Fromm M, Gitter AH (2002) Single-cell epithelial defects close rapidly by an actinomyosin purse string mechanism with functional tight junctions. J. Physiol. (Lond.) 545(2): 485-499  [PubMed] [HTML] [PDF] [Supplementary movies]

• Kroesen AJ, Stockmann M, Ransco C, Schulzke JD, Fromm M, Buhr HJ (2002) Impairment of epithelial transport but not of barrier function in idiopathic pouchitis after ulcerative colitis. Gut 50(6): 821-826 [PubMed] [HTML] [PDF]

• Mankertz J, Waller JS, Hillenbrand B, Tavalali S, Florian P, Schöneberg T, Fromm M, Schulzke JD (2002) Gene expression of the tight junction protein occludin includes differential splicing and alternative promoter usage. Biochem. Biophys. Res. Comm. 298: 657-666 [PubMed] [PDF]

• Schmitz H, Rokos K, Florian P, Gitter AH, Fromm M, Scholz P, Ullrich R, Zeitz M, Pauli G, Schulzke JD (2002) Supernatants of HIV-infected immune cells affect the barrier function of human HT-29/B6 intestinal epithelial cells. AIDS 16(7): 983-991  [PubMed] [HTML or PDF]

• Tebbe B, Mankertz J, Schwarz C, Amasheh S, Fromm M, Schultz-Ehrenburg U, Sánchez Ruderisch H, Schulzke JD, Orfanos CE (2002) Tight junction proteins: A novel class of integral membrane proteins. Expression in human epidermis and HaCaT keratinocytes. Arch. Dermatol. Res. 294: 14-18 [PubMed] [HTML] [PDF]

2001

• Bojarski C, Gitter AH, Bendfeldt K, Mankertz J, Schmitz H, Wagner S, Fromm M, Schulzke JD (2001) Permeability of HT-29/B6 colonic epithelium as a function of apoptosis. J. Physiol. (Lond.) 535(2): 541-552 [PubMed] [HTML] [PDF]

• Epple HJ, Fromm M, Riecken EO, Schulzke JD (2001) Antisecretory effect of loperamide in colon epithelial cells by inhibition of basolateral K⁺ conductance. Scand. J. Gastroent. 36: 731-737 [PubMed] [PDF]

• Gitter AH, Wullstein F, Fromm M, Schulzke JD (2001) Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging. Gastroenterology 121: 1320-1328 [PubMed] [HTML] [PDF]

• Hundertmark S, Bühler H, Fromm M, Kruner-Gareis B, Kruner M, Ragosch V, Kuhlmann K, Seckl JR (2001) Ontogeny of 11beta-hydroxysteroid dehydrogenase: activity in the placenta, kidney, colon of fetal rats and rabbits. Horm. Metab. Res. 33(2): 78-83 [PubMed] [HTML] [PDF]

  • Textbook chapter

• Häussinger D, Fromm M, Tauber R (2001) "Proteinstoffwechsel". In: Klinische Pathophysiologie. Siegenthaler W, ed., 8^th edtn., Thieme Verlag, Stuttgart, Kapitel 3, pp 105-125 [Textbook of pathophysiology]

  • Book chapter

• Schulzke JD, Fromm M (2001) Tight junctions in intestinal inflammation. In: Tight junctions, 2^nd edn., Anderson J, Cereijido M, eds., CRC Press, Boca Raton, ISBN 0-8493-2383-5, p 553-574 [Publisher's ad] [Retailer's ad]

2000

• Bojarski C, Epple HJ, Kirstein FW, Fromm M, Bisson S, Riecken EO, Schulzke JD (2000) Patients with dyspepsia benefit from eradication of Helicobacter pylori if other organic causes for dyspepsia were carefully ruled out. Z. Gastroenterol. 38(3): 211-219 [PubMed]

• Epple HJ, Amasheh S, Mankertz J, Goltz M, Schulzke JD, Fromm M (2000) Early aldosterone effect in distal colon by transcriptional regulation of ENaC subunits. Am. J. Physiol. 278(5): G718-G724 [PubMed] [HTML] [PDF]

• Gitter AH, Bendfeldt K, Schulzke JD, Fromm M (2000a) Trans-/paracellular, surface/crypt, and epithelial/subepithelial resistances of mammalian colonic epithelia. Pflügers Arch. 439(4): 477-482. [PubMed] [PDF] [Related articles]

• Gitter AH, Bendfeldt K, Schulzke JD, Fromm M (2000b) Leaks in the epithelial barrier caused by spontaneous and TNFa-induced single-cell apoptosis. FASEB J. 14(12): 1749-1753 [PubMed] [HTML] [PDF]

• Mankertz J, Tavalali S, Schmitz H, Mankertz A, Riecken EO, Fromm M, Schulzke JD (2000) Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J. Cell Sci. 113(Pt 11): 2085-2090 [PubMed] [PDF] [GenBank: Homo sapiens occludin gene, partial sequence]

• Saitou M, Furuse M, Sasaki H, Schulzke JD, Fromm M, Takano H, Noda T, Tsukita S (2000) Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol. Biol. Cell 11(12): 4131-4142 [PubMed] [HTML] [PDF]

  • Reviews

• Amasheh S, Epple HJ, Mankertz J, Detjen K, Goltz M, Schulzke JD, Fromm M (2000) Differential regulation of ENaC by aldosterone in rat early and late distal colon. Ann. N.Y. Acad. Sci. 915: 92-94. [PubMed reference] [Full text]

• Bode H, Schmidt W, Schulzke JD, Fromm M, Riecken EO, Ullrich R (2000) Effects of HIV protease inhibitors on barrier function in the human intestinal cell line HT-29/B6. Ann. N.Y. Acad. Sci. 915: 117-122. [PubMed reference] [Full text]

• Bojarski C, Bendfeldt K, Gitter AH, Mankertz J, Fromm M, Wagner S, Riecken EO, Schulzke JD (2000) Apoptosis and intestinal barrier function. Ann. N.Y. Acad. Sci. 915: 270-274. [PubMed summary] [Full text]

• Bühner S, Mayr B, Bode H, Schmitz H, Schulzke JD, Fromm M, Lochs H (2000) Effects of endotoxin on human large intestine. Ann. N.Y. Acad. Sci. 915: 264-266.  [PubMed reference] [Full text]

• Gitter AH, Bendfeldt K, Schmitz H, Schulzke JD, Bentzel CJ, Fromm M (2000) Epithelial barrier defects in HT-29/B6 colonic cell monolayers induced by tumor necrosis factor-alpha. Ann. N.Y. Acad. Sci. 915: 193-203. [PubMed summary] [Full text]

• Grotjohann I, Schmitz H, Fromm M, Schulzke JD (2000) Effect of TNF alpha and IFN gamma on epithelial barrier function in rat rectum in vitro. Ann. N.Y. Acad. Sci. 915: 282-286. [PubMed reference] [Full text]

• Harren M, Barmeyer C, Schmitz H, Fromm M, Horak I, Dignass A, John M, Wiedenmann B, Schulzke JD (2000) Enhanced expression of iNOS in inflamed colons of IL-2-deficient mice does not impair colonic epithelial barrier function. Ann. N.Y. Acad. Sci. 915: 204-213. [PubMed summary] [Full text]

• Kroesen AJ, Stockmann M, Schulzke JD, Fromm M, Buhr HJ (2000) Colectomy and ileal pouch. Transport and barrier in pouchitis. Ann. N.Y. Acad. Sci. 915: 287-292. [PubMed reference] [Full text]

• Schmitz H, Barmeyer C, Gitter AH, Wullstein F, Bentzel CJ, Fromm M, Riecken EO, Schulzke JD (2000) Epithelial barrier and transport function of the colon in ulcerative colitis. Ann. N.Y. Acad. Sci. 915: 312-326. [PubMed reference] [Full text]

• Stockmann M, Schmitz H, Fromm M, Schmidt W, Pauli G, Scholz P, Riecken EO, Schulzke JD (2000) Mechanisms of epithelial barrier impairment in HIV infection. Ann. N.Y. Acad. Sci. 915: 293-303. [PubMed summary] [Full text]

  • Textbook chapters

• Fromm M, Hierholzer K (2000) "Niere". In: Physiologie der Haustiere. W.v. Engelhardt, G. Breves (eds.), 1^st edition, Enke, Stuttgart, Kapitel 12, p 254-288. [Textbook of veterinary physiology]

• Fromm M, Hierholzer K (2000) "Epithelien". In: Physiologie des Menschen. Kapitel 34, R.F. Schmidt, G. Thews, F. Lang, eds., 28. Auflage, Springer, Berlin Heidelberg New York, pp 719-736 [Textbook of physiology]

• Lang F, Fromm M (2000) "Funktionen der Niere". In: Physiologie des Menschen. Kapitel 35, R.F. Schmidt, G. Thews, F. Lang, eds., 28. Auflage, Springer, Berlin Heidelberg New York, pp 737-776 [Textbook of physiology]

  • Edition

• Schulzke JD, Fromm M, Riecken EO, Binder H, Volume Editors (2000) Epithelial transport and barrier function: pathomechanisms in gastrointestinal disorders. Ann. N.Y. Acad. Sci. 915: 375 pp. [Contents & links]

1999

• Bode H, Schmidt W, Schulzke JD, Fromm M, Zippel T, Wahnschaffe U, Bendfeldt K, Riecken EO, Ullrich R (1999) The HIV protease inhibitors saquinavir, ritonavir, and nelfinavir, but not indinavir, impair the epithelial barrier in the human intestinal cell line HT-29/B6. AIDS 13(18): 2595-2597. [PubMed reference] [PDF] [Related articles]

• Grotjohann I, Schulzke JD, Fromm M (1999) Electrogenic Na⁺ transport in rat late distal colon by natural and synthetic glucocorticosteroids and their metabolites. Am. J. Physiol. 276: G491-G498. [PubMed] [HTML] [PDF]

• Schmitz H, Barmeyer C, Fromm M, Runkel N, Foss HD, Bentzel CJ, Riecken EO, Schulzke JD (1999) Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology 116: 301-309. [PubMed] [HTML] [PDF] [DCCV-Preis 1999 / award of the DCCV]

• Schmitz H, Fromm M, Bentzel CJ, Scholz P, Detjen K, Mankertz J, Bode H, Epple HJ, Riecken EO, Schulzke JD (1999) Tumor necrosis factor-alpha (TNFa) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J. Cell Sci. 112: 137-146. [PubMed] [PDF]

• Stockmann M, Gitter AH, Sorgenfrei D, Fromm M, Schulzke JD (1999) Low edge damage container insert that adjusts intestinal forceps biopsies into Ussing chamber systems. Pflügers Arch. 438: 107-112. [PubMed] [PDF]

1998

• Bendfeldt K, Gitter AH, Fromm M (1998) Trans- and paracellular conductivity of HT-29/B6 cells measured by high-resolution conductance scanning. Ann. N.Y. Acad. Sci. 859: 295-299. [PubMed reference] [HTML] [PDF]

• Bode H, Schmitz H, Fromm M, Scholz P, Riecken EO, Schulzke JD (1998) IL1b and TNFa, but not IFNa, IFNg, IL6 or IL8, are secretory mediators in human distal colon. Cytokine 10: 457-465. [PubMed] [PDF]

• Fey-Lamprecht F, Gross U, Groth TH, Albrecht W, Paul D, Fromm M, Gitter AH (1998) Functionality of MDCK kidney tubular cells on flat polymer membranes for biohybrid kidney. J. Mater. Sci. Mater. Med. 9: 711-715. [Abstract] [PDF]

• Gitter AH, Fromm M, Schulzke JD (1998) Impedance analysis for determination of epithelial and subepithelial resistance in intestinal tissues. J. Biochem. Biophys. Meth. 37: 35-46. [PubMed] [PDF]

• Grotjohann I, Gitter AH, Köckerling A, Bertog M, Schulzke JD, Fromm M (1998) Localization of cAMP- and aldosterone-induced K⁺ secretion in rat distal colon by conductance scanning. J. Physiol. (Lond.) 507: 561-570. [PubMed] [HTML] [PDF]

• Grotjohann I, Gitter AH, Hoppe B, Schulzke JD, Fromm M (1998) Ion transport in rat colon measured by medium-resolution conductance scanning. Ann. N.Y. Acad. Sci. 859: 300-303. [PubMed reference] [HTML] [PDF]

• Hotz HG, Foitzik T, Rohweder J, Schulzke JD, Fromm M, Runkel NSF, Buhr HJ (1998) Intestinal microcirculation and gut permeability in acute pancreatitits: early changes and therapeutic implications. J. Gastrointest. Surg. 2: 518-525. [PubMed] [PDF]

• Kirstein FW, Epple HJ, Bojarski C, Victor L, Fromm M, Riecken EO, Schulzke JD (1998) Dual versus triple therapy: comparison of 5 antibiotic regimens for eradication of Helicobacter pylori in a prospective, randomized study. Z. Gastroenterol. 36: 803-809. [PubMed] [PDF]

• Schulzke JD, Bentzel CJ, Schulzke I, Riecken EO, Fromm M (1998) Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatric Res. 43: 435-441. [PubMed] [HTML]

• Stockmann M, Fromm M, Riecken EO, Schulzke JD (1998) Non-malabsorptive mechanisms of diarrhea in HIV infection. Pathobiology 66: 165-169. [PubMed] [PDF]

• Stockmann M, Fromm M, Schmitz H, Schmidt W, Riecken EO, Schulzke JD (1998) Duodenal biopsies of HIV infected patients with diarrhea show epithelial barrier defects but no secretion. AIDS 12(1): 43-51. [PubMed] [HTML] [PDF]

• Stockmann M, Schmitz H, Fromm M, Schmidt W, Rokos K, Pauli G, Scholz P, Riecken EO, Schulzke JD (1998) The mechanism of diarrhea in HIV is based on an impaired epithelial barrier function that could be induced by a specific cytokine pattern. Ann. N.Y. Acad. Sci. 859: 267-270. [PubMed reference] [HTML] [PDF]

  • Reviews

• Gitter AH, Victor L, Bertog M, Foss HD, Schulzke JD, Fromm M (1998) Cartography of barrier defects in human colon by low-resolution conductance scanning. Ann. N.Y. Acad. Sci. 859: 285-928. [PubMed reference] [HTML] [PDF]

• Schulzke JD, Schmitz H, Fromm M, Bentzel CJ, Riecken EO (1998) Clinical models of intestinal adaptation. Ann. N.Y. Acad. Sci. 859: 127-138. [PubMed summary] [HTML] [PDF]

1997

• Epple HJ, Kirstein FW, Bojarski C, Frege J, Fromm M, Riecken EO, Schulzke JD (1997) ¹³C-urea breath test in Helicobacter pylori diagnosis and eradication: correlation to histology, origin of "false" results, and influence of food intake. Scand. J. Gastroent. 32: 308-314. [PubMed] [PDF]

• Epple HJ, Kreusel KM, Hanski C, Schulzke JD, Riecken EO, Fromm M (1997) Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol. Pflügers Arch. 433: 638-647. [PubMed] [PDF]

• Foitzik T, Stufler M, Hotz HG, Klinnert J, Wagner J, Warshaw AL, Schulzke JD, Fromm M, Buhr HJ (1997) Glutamine stabilizes intestinal permeability and reduces pancreatic infection in acute experimental pancreatitis. J. Gastrointest. Surg. 1: 40-47. [PubMed] [PDF]

• Gitter AH, Bertog M, Schulzke JD, Fromm M (1997) Measurement of paracellular epithelial conductivity by conductance scanning. Pflügers Arch. 434: 830-840. [PubMed] [PDF]

• Gitter AH, Schulzke JD, Sorgenfrei D, Fromm M (1997) Ussing chamber for high-frequency transmural impedance analysis of epithelial tissues. J. Biochem. Biophys. Meth. 35(2): 81-88. [PubMed] [HTML] [PDF]

  • Textbook chapters

• Fromm M, Hierholzer K (1995, 1997) "Epithelien". In: Physiologie des Menschen. Kapitel 34, R.F. Schmidt und G. Thews eds., 26. und 27. Auflage, Springer, Berlin Heidelberg New York, pp 719-736 [Textbook of physiology]

• Hierholzer K, Fromm M (1995, 1997) "Funktionen der Niere2. In: Physiologie des Menschen. Kapitel 35, R.F. Schmidt und G. Thews eds., 26. und 27. Auflage, Springer, Berlin Heidelberg New York, pp 737-776 [Textbook of physiology]

• Hierholzer K, Fromm M (1995, 1997) "Elektrolyt- und Wasserhaushalt". In: Physiologie des Menschen. Kapitel 36, R.F. Schmidt und G. Thews eds., 26. und 27. Auflage., Springer, Berlin Heidelberg NewYork, pp 778-791 [Textbook of physiology]

1995 - 1996

• Diener M, Bertog M, Fromm M, Scharrer E (1996) Segmental heterogeneity of swelling-induced Cl^- transport in rat small intestine. Pflügers Arch. 432: 293-300. [PubMed] [PDF]

• Schmitz H, Fromm M, Bode H, Scholz P, Riecken EO, Schulzke JD (1996) Tumor necrosis factor alpha induces Cl^- and K⁺ secretion in human distal colon driven by prostaglandin E₂. Am. J. Physiol. 271: G669-G674. [PubMed] [PDF]

• Epple HJ, Schulzke JD, Schmitz H, Fromm M (1995) Enzyme and mineralocorticoid receptor controlled electrogenic Na⁺ absorption in the human rectum, in vitro. Am. J. Physiol. 269: G42-G48. [PubMed] [PDF]

• Schulzke JD, Riecken EO, Fromm M (1995) Distension-induced electrogenic Cl^- secretion is mediated via VIP-ergic neurons in rat rectal colon. Am. J. Physiol. 268: G725-G731. [PubMed] [PDF]

• Schulzke JD, Schulzke I, Fromm M, Riecken EO (1995) Epithelial barrier and ion transport in celiac sprue: electrical measurements on intestinal aspiration biopsies. Gut 37: 777-782. [PubMed] [Gut abstract+citations] [PDF]

1994

• Gogarten W, Köckerling A, Fromm M, Riecken EO, Schulzke JD (1994) Effect of acute Yersinia Enterocolitica infection on intestinal barrier function in the mouse. Scand. J. Gastroent. 29: 814-819. [PubMed] [PDF]

• Hundertmark S, Ragosch V, Schein B, Bühler H, Lorenz U, Fromm M, Weitzel HK (1994) Gestational age dependence of 11b-hydroxysteroid dehydrogenase and its relationship to the enzymes of phosphatidylcholine synthesis in lung and liver of rat. Biochim. Biophys. Acta 1210: 348-354. [PubMed] [PDF]

• Noske W, Fromm M, Levarlet B, Kreusel KM, Hirsch M (1994) Tight junctions of the human corneal endothelium: morphological and electrophysiological features. Ger. J. Ophtalmol. 3: 253-257. [PubMed]

• Noske W, Levarlet B, Kreusel KM, Fromm M, Hirsch M (1994) Tight junctions and paracellular permeability in cultured bovine corneal endothelial cells. Graefes Arch. Clin. Exp. Ophthalmol. 232: 608-613. [PubMed] [PDF]

  • Review

• Fromm M, Schulzke JD (1994) Parazellulärer Nährstofftransport: Fakten und Irrtümer [Paracellular sugar transport: facts and doubts]. Z. Gastroent. 32: 30-34 (Review) [Summary]

  • Textbook chapters

• Fromm M, Hegel U, M. Wiederholt (1994) "Epithelien". In: Pathophysiologie des Menschen, Kapitel 5, K. Hierholzer und R.F. Schmidt eds., Chapman & Hall, Weinheim, pp 5.1-5.19. [Textbook of pathophysiology]

• Fromm M (1994) "Störungen der Verdauung und des epithelialen Transports". In: Pathophysiologie des Menschen, Kapitel 6.5, K. Hierholzer und R.F. Schmidt eds., Chapman & Hall, Weinheim, pp 6.28-6.38 [Textbook of pathophysiology]

• Hierholzer K, Fromm M, Ebel H (1994) "Elektrolyt- und Wasserhaushalt". In: Pathophysiologie des Menschen. Hierholzer K, Schmidt RF eds., Chapman & Hall, Weinheim, Kapitel 10, pp 10.1-10.16 [Textbook of pathophysiology]

1993

• Fromm M, Schulzke JD, Hegel U (1993) Control of electrogenic Na⁺ absorption in rat late distal colon by nanomolar aldosterone added in vitro. Am. J. Physiol. 264: E68-E73. [PubMed] [PDF]

• Hegel U, Fromm M, Kreusel KM, Wiederholt M (1993) Bovine and porcine large intestine as model epithelia in a student lab course. Am. J. Physiol. 265: S10-S19. [PubMed] [PDF] (1996 we switched to rabbit distal colon which we obtain from a rabbit slaughtery nearby Berlin)

• Hundertmark S, Ragosch V, Schein B, Bühler H, Fromm M, Lorenz U, Weitzel H (1993) 11-beta-hydroxysteroid dehydrogenase of rat lung: enzyme kinetic, oxidase-reductase ratio, electrolyte and trace element dependence. Enzyme Protein 47: 83-91. [PubMed] [PDF]

• Köckerling A, Sorgenfrei D, Fromm M (1993) Electrogenic Na⁺ absorption of rat distal colon is confined to surface epithelium. A voltage scanning study. Am. J. Physiol. 264: C1285-C1293. [PubMed] [PDF]

• Köckerling A, Fromm M (1993) Origin of cAMP dependent Cl^- secretion from both crypts and surface epithelia of rat intestine. Am. J. Physiol. 264: C1294-C1301. [PubMed] [PDF]

• Schulzke JD, Fromm M, Gogarten W, Gebhard H, Schröder P, Riecken EO (1993) Epithelial ion transport in the ileal J-pouch after proctocolectomy in the rat. Scand. J. Gastroent. 28: 533-539. [PubMed] [PDF]

1991 - 1992

• Schulzke JD, Fromm M, Bentzel CJ, Zeitz M, Menge H, Riecken EO (1992) Ion transport in the experimental short bowel syndrome of the rat: increased glucose-dependent Na-absorption is the main adaptive response. Gastroenterology 102: 497-504. [PubMed] [PDF]

• Kreusel KM, Fromm M, Schulzke JD, Hegel U (1991) Cl^- secretion in epithelial monolayers of mucus-forming human colon cells (HT-29/B6). Am. J. Physiol. 261: C574-C582. [PubMed] [PDF]

• Roslyn JJ, Abedin MZ, Saunders KD, Cates JA, Strichartz SD, Alperin M, Fromm M, Palant CE (1991) Uncoupled basal sodium absorption and chloride secretion in prairie dog gallbladder. Comp. Biochem. Physiol. A 100: 335-341. [PubMed] [PDF]

  • Book chapter

• Bentzel CJ, Palant CE, Fromm M (1992) Physiological and pathological factors affecting the tight junction. In: Tight junctions, chapter 11, M. Cereijido ed., CRC Press, Boca Raton, p 151-173 (Review / book chapter).