Dept. of Gastroenterology, Infectiology and Rheumatology

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> FU Berlin / HU Berlin  > Charité     CBF   > Departments    CC13    > Inst. Clin. Physiology     > Research associates      > Hans-Jörg Epple       > Publications

Cooperation partner of the Inst. of Clinical Physiology
Publications:  Hans-Jörg Epple

2012

• Epple HJ, Zeitz M (2012) Intestinal mucosal barrier function in HIV infection. Ann. N.Y. Acad. Sci. 1258: 19-24 (IF 3.2) [PubMed] [WebPage] [PDF] (Review)

2011

• Bücker R, Krug SM, Rosenthal R, Günzel D, Fromm A, Zeitz M, Chakraborty T, Fromm M, Epple HJ, Schulzke JD (2011) Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells. J. Infect. Dis. 204 (8): 1283-1292 (IF 6.4) [PubMed] [HTML] [PDF]

• Epple HJ, Zeitz M (2011) Enteritis infectiosa. Internist 52: 1038-1046 [PubMed] [HTML] [PDF] (Review)

• Kunkel J, Loddenkemper C, Grozdanovic Z, Schulze K, Schmittel A, Epple HJ, Daum S, Zeitz M (2011) Interstitial lung disease under erlotinib plus gemcitabine for pancreatic carcinoma: a therapeutic dilemma. Pancreas 40(1): 170-171 (IF 2.4) (Case report) [PubMed] [HTML]

2010

• Epple HJ, Allers K, Tröger H, Kühl A, Erben U, Fromm M, Zeitz M, Loddenkemper C*, Schulzke JD*, Schneider T* (*shared last authorship) (2010) Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect. Gastroenterology 139(4): 1289-1300 (IF 12.0) [PubMed] [HTML] [PDF] [Supplement PDF]

• Allers K, Loddenkemper C, Hofmann J, Unbehaun A, Kunkel D, Moos V, Kaup FJ, Stahl-Hennig C, Epple HJ, Schneider T (2010) Gut mucosal FOXP3+ regulatory CD4+ T cells and non-regulatory CD4+ T cells are differentially affected by SIV infection in rhesus macaques. J. Virol. 84(7): 3259-3269 (IF 5.2) [PubMed] [HTML] [PDF]  

• Schulzke JD*, Pfaffenbach S* (*shared first authorship), Fromm A, Epple HJ, Troeger H*, Fromm M* (*shared last authorship) (2010) PGI₂ sensory input into the ENS during distension-induced colonic chloride secretion in rat colon. Acta Physiol. 199(3): 305-316 (IF 3.2) [PubMed] [HTML] [PDF]

2009

• Epple HJ (2009) Therapy- and non-therapy-dependent infectious complications in inflammatory bowel disease. Dig. Dis. 27: 555–559 [PubMed] [PDF] (Review)

• Epple HJ, Schneider T, Troeger H, Kunkel D, Allers K, Moos V, Amasheh M, Loddenkemper C, Fromm M, Zeitz M, Schulzke JD (2009, Epub 04.11.2008) Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut 58: 220-227  [PubMed] [HTML] [PDF]

• Troeger H, Loddenkemper C, Schneider T, Schreier E, Epple HJ, Zeitz M, Fromm M, Schulzke JD (2009) Structural and functional changes of the duodenum in human norovirus infection. Gut 58: 1070-1077 [PubMed] [HTML] [PDF]

• Schmiedel D, Epple HJ, Loddenkemper C, Ignatius R, Wagner J, Hammer B, Petrich A, Stein H, Göbel UB, Schneider T, Moter A (2009) Rapid and accurate Diagnosis of Human Intestinal Spirochaetosis by Fluorescence in situ Hybridization. J. Clin. Microbiol. 47: 1393-1401 [PubMed] [HTML] [PDF]

2008

• Aebischer T*, Bumann D*, Epple HJ*, Metzger W*, Schneider T* (*shared first authorship), Cherepnev G, Walduck AK, Kunkel D, Moos V, Loddenkemper C, Jiadze I, Panasyuk M, Stolte M, Graham DY, Zeitz M, Meyer TF (2008) Correlation of T cell response and bacterial clearance in human volunteers challenged with H. pylori revealed by randomized controlled vaccination with Ty21a-based Salmonella vaccines. Gut 56: 328-235 [PubMed] [HTML] [PDF]

• Günther U, Epple HJ, Heller F, Loddenkemper C, Grünbaum M, Schneider T, Zeitz M, Bojarski C (2008) In vivo diagnosis of intestinal spirochaetosis by confocal endomicroscopy. Gut 57(9): 1331-1333 (Comment on Gut 55(4): 591-592) [PubMed] [HTML] [PDF]

• Schulbin H, Bode H, Stocker H, Schmidt W, Zippel T, Loddenkemper C, Engelmann E, Epple HJ, Arastéh K, Zeitz M, Ullrich R (2008) Cytokine expression in the colonic mucosa of HIV-infected individuals before and during nine months of antiretroviral therapy. Antimicrob. Agents Chemother. 52: 3377-3384 [PubMed] [HTML] [PDF]

2006 - 2007

• Troeger H*, Richter JF* (*shared first authorship), Beutin L, Günzel D, Dobrindt U, Epple HJ, Gitter AH, Zeitz M, Fromm M, Schulzke JD (2007) E. coli alpha-hemolysin induces focal leaks in colonic epithelium – a novel mechanism of bacterial translocation. Cell. Microbiol. 9(10): 2530-2540 [PubMed] [HTML] [PDF]

• Troeger H, Epple HJ, Schneider T, Wahnschaffe U, Ullrich R, Burchard GD, Jelinek T, Zeitz M, Fromm M, Schulzke JD (2007) Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum. Gut  56(3): 328-335 [PubMed] [HTML] [PDF]  Comment in: Gut 2007 56(3): 316-317

• Epple HJ*, Loddenkemper C*, Kunkel D* (*shared first authorship), Troeger H, Maul J, Moos V, Berg E, Ullrich R, Schulzke JD, Stein H, Duchmann R, Zeitz M, Schneider T (2006) Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood 108: 3072-3078  [PubMed] [HTML] [PDF]

2001 - 2004

• Amasheh S, Barmeyer C, Koch CS, Tavalali S, Mankertz J, Epple HJ, Gehring MM, Florian P, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2004) Cytokine-dependent transcriptional down-regulation of epithelial sodium channel (ENaC) in ulcerative colitis. Gastroenterology 126: 1711-1720 [PubMed] [HTML] [PDF]

• Epple HJ, Mankertz J, Ignatius R, Liesenfeld O, Fromm M, Zeitz M, Chakraborty T, Schulzke JD (2004) Aeromonas hydrophila beta-hemolysin induces active chloride secretion in colon epithelial cells (HT-29/B6). Infect. Immun. 72(8): 4848-4858 [PubMed] [HTML] [PDF]

• Epple HJ, Harms G, Notter M, Husack R, Zeitz M, Schneider T (2003) HIV-positiver Patient mit Panzytopenie und massiver Splenomegalie. Internist 44: 1031-1036 [PubMed] (Case report)

• Epple HJ, Schmidt W, Zeitz M (2002) Gastrointestinale Manifestationen der HIV-Infektion. Med. Klin. 97:12-21 [PubMed] (Review)

• Epple HJ, Fromm M, Riecken EO, Schulzke JD (2001) Antisecretory effect of loperamide in colon epithelial cells by inhibition of basolateral K⁺ conductance. Scand. J. Gastroent. 36: 731-737 [PubMed] [PDF]

1997 - 2000

• Bojarski C, Epple HJ, Kirstein FW, Fromm M, Bisson S, Riecken EO, Schulzke JD (2000) Patients with dyspepsia benefit from eradication of Helicobacter pylori if other organic causes for dyspepsia were carefully ruled out. Z. Gastroenterol. 38(3): 211-219 [PubMed]

• Amasheh S, Epple HJ, Mankertz J, Detjen K, Goltz M, Schulzke JD, Fromm M (2000) Differential regulation of ENaC by aldosterone in rat early and late distal colon. Ann. N.Y. Acad. Sci. 915: 92-94 [PubMed reference] [Full text]

• Epple HJ, Amasheh S, Mankertz J, Goltz M, Schulzke JD, Fromm M (2000) Early aldosterone effect in distal colon by transcriptional regulation of ENaC subunits. Am. J. Physiol. 278(5): G718-G724 [PubMed] [HTML] [PDF]

• Schmitz H, Fromm M, Bentzel CJ, Scholz P, Detjen K, Mankertz J, Bode H, Epple HJ, Riecken EO, Schulzke JD (1999) Tumor necrosis factor-alpha (TNFa) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J. Cell Sci. 112: 137-146 [PubMed] [PDF]

• Kirstein FW, Epple HJ, Bojarski C, Victor L, Fromm M, Riecken EO, Schulzke JD (1998) Dual versus triple therapy: comparison of 5 antibiotic regimens for eradication of Helicobacter pylori in a prospective, randomized study. Z. Gastroenterol. 36: 803-809 [PubMed]

• Epple HJ, Kirstein FW, Bojarski C, Frege J, Fromm M, Riecken EO, Schulzke JD (1997) ¹³C-urea breath test in Helicobacter pylori diagnosis and eradication: correlation to histology, origin of "false" results, and influence of food intake. Scand. J. Gastroent. 32: 308-314 [PubMed]

• Epple HJ, Kreusel KM, Hanski C, Schulzke JD, Riecken EO, Fromm M (1997) Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol. Pflügers Arch. 433: 638-647. [PubMed] [PDF]

1993 - 1996

• Schmidt W, Schneider T, Heise W, Weinke T, Epple HJ, Stöffler-Meilicke M, Liesenfeld O, Ignatius R, Zeitz M, Riecken EO, Ullrich R (1996) Stool viruses, coinfections, and diarrhea in HIV-infected patients. Berlin Diarrhea/Wasting Syndrome Study Group. J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. 13: 33-38 [PubMed]

• Epple HJ, Schulzke JD, Schmitz H, Fromm M (1995) Enzyme and mineralocorticoid receptor controlled electrogenic Na⁺ absorption in the human rectum, in vitro. Am. J. Physiol. 269: G42-G48. [PubMed] [PDF]

• Epple HJ, Schulzke JD, Riecken EO, Fromm M (1994) Effektormechanismen intestinaler Sekretion in HT-29/B6-Zellen: Beeinflussung durch Loperamid. Z. Gastroent. 32: 75-79

• Epple HJ, Schulzke JD, Fromm M (1993) Mechanismus der mineralocorticoiden Wirkung von Lakritze. Z. Gastroent. 31: 70-72

Textbook chapters

• Epple HJ, Schneider T, Zeitz M (2009). Akute infektiöse Enteritiden. In: Therapie-Handbuch, 5. Auflage. W. Domschke, M. Berger, W. Hohenberger, T. Meinertz, K. Possinger. Elsevier GmbH, Urban & Fischer Verlag, München. F6.1-F6.11

• Epple HJ, Schneider T, Zeitz M (2008). Kapitel 4.8: Infektionskrankheiten des Ösophagus. In: Gastroenterologie. J.F. Riemann, W. Fischbach, P.R. Galle, J. Mössner (Hrsg.), Thieme Verlag, Stuttgart, Seiten 449-456.

• Epple HJ, Schneider T, Zeitz M (2008). Kapitel 7.9: Gastrointestinale Manifestationen der HIV-Infektion. In: Gastroenterologie. J.F. Riemann, W. Fischbach, P.R. Galle, J. Mössner (Hrsg.), Thieme Verlag, Stuttgart, Seiten 1084-1109.

• Epple HJ, Schneider T (2005) Kapitel 138: Shigellose. In: Harrisons Innere Medizin, Deutsche Ausgabe, 16. Auflage. Manfred Dietel, Norbert Suttorp, Martin Zeitz (Hrsg.). ABW Wissenschaftsverlag, Berlin,