 Institute of Clinical Physiology |
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Institute of Clinical Physiology |
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Highlight papers |
Günzel
D, Yu AS (2013) Claudins and the modulation of tight junction permeability.
Physiol. Rev. ###: ###-###
(IF 26.9) [01.01.12
Proofs]
Rachow
S*, Zorn-Kruppa M* (*shared first authorship), Ohnemus U, Kirschner N,
Vidal-y-Sy S, von den Driesch P, Eberle J, Mildner M, Vettorazzi E, Rosenthal
R, Moll I, Brandner JM (2013) Occludin is involved in adhesion, apoptosis,
differentiation and Ca2+-homeostasis of human
keratinocytes: implications for tumorigenesis.
PLoS One #(#): e##### (IF 4.1)
[19.12.12 Accepted]
Kirschner
N*, Rosenthal R* (*shared first authorship), Furuse M, Moll I, Fromm M,
Brandner JM (2013) Contribution of tight junction proteins to ion,
macromolecule, and water barrier in keratinocytes.
J. Invest. Dermatol. ###: ###-###
(IF 6.3) [27.11.12
Accepted]
Kuntzsch
D, Bergann T, Dames P, Fromm A, Fromm M, Davis RA, Melzig MF, Schulzke JD
(2012) The plant-derived glucocorticoid receptor agonist endiandrin A acts as
co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and
MAPKs. PLoS One 7(11):
e49426 (print pages 1-14) (IF 4.1) [PubMed]
[WebPage]
[PDF]
Krug
SM, Amasheh M, Dittmann I, Christoffel I, Fromm M, Amasheh S (2013) Sodium
caprate as an enhancer of macromolecule permeation across tricellular tight
junctions of intestinal cells. Biomaterials
34(1): 275-282 (IF 7.4) [PubMed]
[WebPage]
[PDF]
Cording
J, Berg J, Käding N, Bellmann C, Tscheik C,
Westphal JK, Milatz S, Günzel D, Wolburg H, Piontek J, Huber O, Blasig
IE (2012) Tight junctions: Claudins regulate the interactions between
occludin, tricellulin and marvelD3, which, inversely, modulate the claudin
oligomerization. J. Cell Sci. ###:
###-### (IF 6.1)
[PubMed]
[WebPage]
[PDF]
Fromm M, Schulzke JD, Volume Editors (2012) Barriers and channels formed by tight junction proteins, parts I and II. Ann. N.Y. Acad. Sci. 1257: 1-206 [WebPage] and 1258: 1-191 [WebPage] (IF 3.2) (48 original and review papers)
Günzel D, Fromm M (2012) Claudins and other tight junction proteins. Comprehensive Physiology (former Handbook of Physiology) 2(3): 1819-1852 [PubMed: soon] [WebPage] [PDF]
Hackel D, Krug SM, Sauer RS, Mousa SA, Böcker A, Pflücke D, Wrede EJ, Kistner K, Hoffmann T, Niedermirtl B, Sommer C, Bloch L, Huber O, Blasig IE, Amasheh S, Reeh PW, Fromm M, Brack A, Rittner HL (2012) Transient opening of the perineurial barrier for analgesic drug delivery. Proc. Natl. Acad. Sci. USA 109(29): E2018-E2027 (IF 9.7) [PubMed] [WebPage] [PDF]
Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012) Claudin-17 forms tight junction channels with distinct anion selectivity. Cell. Mol. Life Sci. 69(16): 2765-2778 (IF 6.6) [PubMed] [WebPage] [PDF] [Supplement]
Rosenthal R*, Günzel D* (*shared first authorship), Finger C, Krug SM, Richter JF, Schulzke JD, Fromm M, Amasheh S (2012) The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. Biomaterials 33(9): 2791-2800 (IF 7.4) [PubMed] [HTML] [PDF] [Supplement]
Schumann M, Günzel D, Buergel N, Richter JF, Troeger H, May C, Fromm A, Sorgenfrei D, Daum S, Bojarski C, Heyman M, Zeitz M, Fromm M, Schulzke JD (2012) Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in celiac disease. Gut 61(2): 220-228 (IF 10.1) [PubMed] [HTML] [PDF] [Supplements]
Bücker R, Krug SM, Rosenthal R, Günzel D, Fromm A, Zeitz M, Chakraborty T, Fromm M, Epple HJ, Schulzke JD (2011) Aerolysin from Aeromonas hydrophila perturbs tight junction integrity and cell lesion repair in intestinal epithelial HT-29/B6 cells. J. Infect. Dis. 204 (8): 1283-1292 (IF 6.4) [PubMed] [HTML] [PDF]
Amasheh M, Fromm A, Krug SM, Amasheh S, Andres S, Zeitz M, Fromm M, Schulzke JD (2010) TNFa-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, pAkt, and NFkB signaling. J. Cell Sci. 123(23): 4145-4155 (IF 6.3) [PubMed] [HTML] [PDF] [Supplements]
Epple
HJ, Allers K, Tröger H, Kühl A, Erben U, Fromm M, Zeitz M, Loddenkemper C*,
Schulzke JD*, Schneider T* (*shared last authorship) (2010) Acute HIV
infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial
apoptosis, and a mucosal barrier defect.
Gastroenterology 139(4): 1289-1300 (IF
12.0) [PubMed]
[HTML]
[PDF]
[Supplement
PDF]
Rosenthal R, Milatz S, Krug SM,
Oelrich B, Schulzke JD, Amasheh S, Günzel D, Fromm M (2010) Claudin-2, a
component of the tight junction, forms a paracellular water channel.
J. Cell Sci. 123(11): 1913-1921
(IF 6.3) [PubMed]
[HTML] [PDF]
[Supplement]
Bergann T, Zeissig S, Fromm A, Richter JF, Fromm M, Schulzke JD (2009) Glucocorticoid and tumor necrosis factor-alpha synergize to induce absorption by the epithelial sodium channel in the colon. Gastroenterology 136(3): 933-942 (IF 12.9) [PubMed] [HTML] [PDF]
Bücker R*, Troeger H* (*shared first authorship), Kleer J, Fromm M, Schulzke JD (2009) Arcobacter butzleri induces barrier dysfunction in intestinal epithelial cells. J. Infect. Dis. 200(5): 756-764 (IF 5.9) [PubMed] [HTML] [PDF]
Epple HJ, Schneider T, Troeger H, Kunkel D, Allers K, Moos V, Amasheh M, Loddenkemper C, Fromm M, Zeitz M, Schulzke JD (2009) Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut 58: 220-227 (IF 9.4) [PubMed] [HTML] [PDF]
Günzel D, Amasheh S, Pfaffenbach S, Richter JF, Kausalya PJ, Hunziker W, Fromm M (2009) Claudin-16 affects transcellular Cl- secretion in MDCK cells. J. Physiol. (Lond.) 587(15): 3777-3793 (IF 4.8) [PubMed] [HTML] [PDF] [Supplement]
Günzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Müller D (2009) Claudin-10 exists in six alternatively spliced isoforms which exhibit distinct localization and function. J. Cell Sci. 122: 1507-1517 (IF 6.1) [PubMed] [HTML] [PDF]
Krug SM, Amasheh S, Richter JF, Milatz S, Günzel D, Westphal JK, Huber O, Schulzke JD, Fromm M (2009) Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol. Biol. Cell 20: 3713-3724 (IF 6.0) [PubMed] [HTML] [PDF] [Supplement text] [Supplement video]
Krug SM, Fromm M, Günzel D (2009) Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys. J. 97(8): 2202-2211 (IF 4.4) [PubMed] [HTML] [PDF] [Supplement]
Troeger H, Loddenkemper C,
Schneider T, Schreier E, Epple HJ, Zeitz M, Fromm M, Schulzke JD (2009)
Structural and functional changes of the duodenum in human norovirus
infection. Gut 58: 1070-1077
(IF 9.4) [PubMed]
[HTML] [PDF]
Yu ASL, Cheng MH, Angelow S, Günzel D, Kanzawa SA, Schneeberger EE, Fromm M, Coalson RD (2009) Molecular basis for cation selectivity in claudin-2-based paracellular pores: Identification of an electrostatic interaction site. J. Gen. Physiol. 133(1): 111-127 (IF 4.3) [PubMed] [HTML] [PDF]
Amasheh M, Schlichter S, Amasheh S, Mankertz J, Zeitz M, Fromm M, Schulzke JD (2008) Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells. J. Nutr. 138(6): 1067-1073 (IF 3.6) [PubMed] [HTML] [PDF]
Heller F, Fromm A, Gitter AH, Mankertz J, Schulzke JD (2008) Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function. Mucosal Immun. 1: S58-S61 (new journal, IF2010 6.8) [PubMed] [HTML] [PDF]
Schumann M, Richter JF, Wedell I,
Moos V, Zimmermann-Kordmann M, Schneider T, Daum S, Zeitz M, Fromm M, Schulzke
JD (2008) Mechanisms of epithelial translocation of the a2-gliadin-33mer
in celiac sprue.
Zeissig S, Bergann T, Fromm A, Bojarski C, Heller F, Guenther U, Zeitz M, Fromm M, Schulzke JD (2008) Altered ENaC expression leads to impaired sodium absorption in the non-inflamed intestine in Crohn's disease. Gastroenterology 134(5): 1436-1447 (IF 12.6) [PubMed] [HTML] [PDF]
Troeger H, Epple HJ, Schneider T,
Wahnschaffe U, Ullrich R, Burchard GD, Jelinek T, Zeitz M, Fromm M, Schulzke
JD (2007) Effect of chronic Giardia lamblia infection on epithelial
transport and barrier function in human duodenum.
Troeger H*, Richter JF* (*shared first authorship), Beutin L, Günzel D, Dobrindt U, Epple HJ, Gitter AH, Zeitz M, Fromm M, Schulzke JD (2007) E. coli alpha-hemolysin induces focal leaks in colonic epithelium – a novel mechanism of bacterial translocation. Cell. Microbiol. 9(10): 2530-2540 (IF 5.3) [PubMed] [HTML] [PDF]
Zeissig S, Bürgel N, Günzel D, Richter JF, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2007) Changes in expression and distribution of claudin-2, -5 and -8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 56(1): 61-72 (IF 10.0) [PubMed] [HTML] [PDF]
Zeissig S, Fromm A, Mankertz J, Weiske J, Zeitz M, Fromm M, Schulzke JD (2007) Butyrate induces intestinal sodium absorption via Sp3-mediated transcriptional up-regulation of epithelial sodium channels. Gastroenterology 132(1): 236-248 (IF 11.7) [PubMed] [HTML] [PDF]
Günzel D, Kucharski LM, Kehres DG,
Romero MF, Maguire ME (2006) The MgtC virulence factor of Salmonella enterica
serovar typhimurium activates Na+,K+-ATPase.
J. Bacteriol. 188(15): 5586-5594 [PubMed]
[HTML] [PDF]
Kausalya PJ*, Amasheh S* (*shared
first authorship, p 890), Günzel D, Wurps H, Müller D, Fromm M, Hunziker W
(2006) Disease-associated mutations affect intracellular traffic and
paracellular Mg2+ transport function of
claudin-16. J. Clin. Invest.
116(4): 878-891 (IF 15.8) [PubMed]
[HTML]
[PDF]
Reiter B, Kraft R, Günzel D, Zeissig S, Schulzke JD, Fromm M, Harteneck C (2006) TRPV4-mediated regulation of epithelial permeability. FASEB J. 20: 1802-1812 (IF 6.7) [PubMed] [HTML] [PDF]
Rosenthal R, Bakall B, Peachey N,
Wimmers S, Wadelius C, Marmorstein A, Strauss O (2006) Expression of
bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca2+
channels in retinal pigment epithelial cells.
FASEB J. 20(1): 178-180 (IF 6.7)
[PubMed]
Heller F, Florian P, Bojarski C,
Richter JF, Christ M, Hillenbrand B, Mankertz J, Gitter AH, Bürgel N, Fromm M,
Zeitz M, Fuss I, Strober W, Schulzke JD (2005) Interleukin-13 is the key
effector Th2 cytokine in ulcerative colitis that affects epithelial tight
junctions, apoptosis and cell restitution.
Gastroenterology 129(2): 550-564 (IF
12.4) [PubMed]
[HTML]
[PDF]
Schulzke JD, Gitter AH, Mankertz J, Spiegel S, Seidler U, Amasheh S, Saitou M, Tsukita S, Fromm M (2005) Epithelial transport and barrier function in occludin-deficient mice. Biochim. Biophys. Acta - Biomembranes 1669(1): 34-42 (IF 4.2) [PubMed] [HTML] [PDF]
Tunggal JA*, Helfrich I* (*shared
first authorship), Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T,
Niessen CM (2005) E-cadherin is essential for in vivo epidermal barrier
function by regulating tight junctions. EMBO J.
24: 1146-1156 (IF 10.1) [PubMed]
[HTML] [PDF]
Amasheh S, Barmeyer C, Koch CS, Tavalali S, Mankertz J, Epple HJ, Gehring MM, Florian P, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2004) Cytokine-dependent transcriptional down-regulation of epithelial sodium channel (ENaC) in ulcerative colitis. Gastroenterology 126: 1711-1720 (IF 13.0) [PubMed] [HTML] [PDF]
Bojarski C, Weiske J, Schöneberg T, Schröder W, Mankertz J, Schulzke JD, Florian P, Fromm M, Tauber R, Huber O (2004) The specific fate of tight junction proteins in apoptotic epithelial cells. J. Cell Sci. 117: 2097-2107 (IF 6.9) [PubMed] [HTML] [PDF]
Epple HJ, Mankertz J, Ignatius R, Liesenfeld O, Fromm M, Zeitz M, Chakraborty T, Schulzke JD (2004) Aeromonas hydrophila beta-hemolysin induces active chloride secretion in colon epithelial cells (HT-29/B6). Infect. Immun. 72(8): 4848-4858 (IF 4.0) [PubMed] [HTML] [PDF]
Zeissig S*, Bojarski C* (*shared first authorship), Bürgel N, Mankertz J, Zeitz M, Fromm M, Schulzke JD (2004) Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by TNFalpha antibody treatment. Gut 53: 1295-1302 (IF 6.6) [PubMed] [HTML] [PDF]
Amasheh S, Meiri N, Gitter AH, Schöneberg T, Mankertz J, Schulzke JD, Fromm M (2002) Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J. Cell Sci. 115(24): 4969-4976 (IF 7.0) [PubMed] [HTML] [PDF]
Bürgel N, Bojarski C, Mankertz J, Zeitz M, Fromm M, Schulzke JD (2002) Mechanisms of diarrhea in collagenous colitis. Gastroenterology 123(2): 433-443 (IF 13.4) [PubMed] [HTML] [PDF]
Florian P, Schöneberg T, Schulzke
JD, Fromm M, Gitter AH (2002) Single-cell epithelial defects close rapidly by
an actinomyosin purse string mechanism with functional tight junctions.
J. Physiol. (Lond.) 545(2): 485-499
(IF 4.7) [PubMed]
[HTML] [PDF]
[Supplementary
movies]
Kroesen AJ, Stockmann M, Ransco C, Schulzke JD, Fromm M, Buhr HJ (2002) Impairment of epithelial transport but not of barrier function in idiopathic pouchitis after ulcerative colitis. Gut 50(6): 821-826 (IF 6.3) [PubMed] [Full text]
Schmitz H, Rokos K, Florian P, Gitter AH, Fromm M, Scholz P, Ullrich R, Zeitz M, Pauli G, Schulzke JD (2002) Supernatants of HIV-infected immune cells affect the barrier function of human HT-29/B6 intestinal epithelial cells. AIDS 16(7): 983-991 (IF 6.0) [PubMed] [HTML or PDF]
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