Doctoral graduates

Name	Project	Study	Supervision	mail
PhD graduates of the FOR 721/2 (01/2010-12/2012)
Christian Bellmann	TP5	biology	Blasig
Marcel P. Conrad	TP1	biology	Fromm
Lena J. John	TP2	biology	Schulzke
Jonas Protze	TP6		Krause
PhD graduates of the FOR 721/1 (11/2006 - 12/2009)
Dr. Max J. Dörfel         (PhD 21.06.10)	TP3	biochemistry	Huber
Dr. Nina A. Hering        (PhD 14.12.10)	TP2	biology	Schulzke
Kathrin Kopplin     (submitted 08.11.12)	TP4	biology	Müller
Dr. Susanne M. Krug    (PhD 30.11.09)	TP1	biochemistry	Fromm
Dr. Svenja Ploeger       (PhD 17.06.11)	TP2	biology	Schulzke
Dr. Julie K. Westphal    (PhD 12.02.10)	TP3	biology	Huber
Dr. Constanze Will             (PhD 18.02.11)	TP4	biochemistry	Müller
Dr. Anna Veshnyakova   (PhD since 02.09)	TP6	biology	Krause

PhD graduates of the FOR 721/2

2012, PhD graduates of the FOR 721/2

• Cording J, Berg J, Käding N, Bellmann C, Tscheik C, Westphal JK, Milatz S, Günzel D, Wolburg H, Piontek J, Huber O, Blasig IE (2012) Tight junctions: Claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate the claudin oligomerization. J. Cell Sci. ###: ###-### (IF 6.1) [PubMed] [WebPage] [PDF] TP5+TP7+TP6+TP3

• Krug SM, Günzel D, Conrad MP, Lee IM, Amasheh S, Fromm M, Yu ASL (2012) Charge-selective claudin channels. Ann. N.Y. Acad. Sci. 1257: 20-28 (IF 3.2) [PubMed] [WebPage] [PDF] (Review) TP1+TP7

• Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012) Claudin-17 forms tight junction channels with distinct anion selectivity. Cell. Mol. Life Sci. 69(16): 2765-2778 (IF 6.6) [PubMed] [WebPage] [PDF] [Supplement] TP1+TP7+TP2

• Veshnyakova A, Krug SM, Mueller SL, Piontek J, Protze J, Fromm M, Krause G (2012) Determinants contributing to claudin ion channel formation. Ann. N.Y. Acad. Sci. 1257: 45-53 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper) TP6+TP1

• Schulzke JD, Günzel D, John LJ, Fromm M (2012) Perspectives in tight junction research. Ann. N.Y. Acad. Sci. 1257: 1-19 (IF 3.2) [PubMed] [WebPage] [PDF] (Superinducing Review) TP2+TP7+TP1

2011, PhD graduates of the FOR 721/2

• Blasig IE, Bellmann C, Cording J, del Vecchio G, Zwanziger D, Huber O, Haseloff RF (2011) Occludin protein family: oxidative stress and reducing conditions. Antioxid. Redox Signal. 15(5): 1195-1219 (IF 8.2) [PubMed] [HTML] [PDF for printing] [PDF with links] (Review)

• John LJ, Fromm M, Schulzke JD (2011) Epithelial barriers in intestinal inflammation. Antioxid. Redox Signal. 15(5): 1255-1270 (IF 8.2) [PubMed] [HTML] [PDF for printing] [PDF with links] (Review)

2010, PhD graduates of the FOR 721/2

• Heyne K, Conrad MP, Dohmen D, Huwer J, Assmann G, Roemer K (2010) Differential basal levels of MDM-2 transcription induced by p53-P72 and p53-R72. Cell Cycle [Accepted 31.08.10]

• Heyne K, Willnecker V, Schneider J, Conrad M, Raulf N, Schüle R, Roemer K (2010) NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle. Nucl. Acids Res. 38(10): 3159-3171 [PubMed] [HTML] [PDF] (no FOR topic)

• Veshnyakova A, Protze J, Rossa J, Blasig IE, Krause G, Piontek J (2010) On the interaction of clostridium perfringens enterotoxin with claudins. Toxins 2(6): 1336-1356 (review) [Abstract] [PDF]

PhD graduates of the FOR 721/1

Doctoral theses

• Ploeger S (2011) [The short-chain fatty acid, butyrate, stabilizes the intestinal epithelial barrier function by HNF-4alpha-dependent down-regulation of claudin-2 expression].
  Dr. rer. nat., Freie Universität Berlin. 17.06.11: Magna cum laude

  • Subsequent publications

• Will C (2011) [Generation and characterization of claudin-16- and claudin-10-deficient mice].
  Dr. rer. nat., Humboldt-Universität zu Berlin. 18.02.11: Magna cum laude

  • Subsequent publications

• Hering NA (2010) [The epithelial barrier as a target structure for pathogenic and probiotic bacteria: effector mechanisms of Y. enterocolitica and E. coli Nissle].
  Dr. rer. nat., Freie Universität Berlin. 14.12.10: Magna cum laude

  • Subsequent publications

• Doerfel MJ (2010) [Effect of posttranslational modifications on the function of the tight junction protein occludin].
  Dr. rer. nat., Freie Universität Berlin. 21.06.10: Magna cum laude

  • Subsequent publications

• Westphal JK (2010) [Structure, function, and regulation of the tight junction protein tricellulin].
  Dr. rer. nat., Freie Universität Berlin. 12.02.10: Magna cum laude

  • Subsequent publications

• Krug SM (2009) [Tricellulin and its function within the tricellular tight junction of epithelial cells].
  Dr. rer. nat., Freie Universität Berlin. 30.11.09: Summa cum laude

  • Subsequent publications

2012, PhD graduates of the FOR 721/1

• Breiderhoff T, Himmerkus N, Stuiver M, Mutig K, Will C, Meij IC, Bachmann S, Bleich M, Willnow TE, Müller D (2012) Deletion of Cldn10 in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis. Proc. Natl. Acad. Sci. USA 109(35): 14241-14246 (IF 9.7) [PubMed] [WebPage] [PDF w. Supplements]

• Cording J, Berg J, Käding N, Bellmann C, Tscheik C, Westphal JK, Milatz S, Günzel D, Wolburg H, Piontek J, Huber O, Blasig IE (2012) Tight junctions: Claudins regulate the interactions between occludin, tricellulin, and marvelD3, which, inversely, modulate the claudin oligomerization. J. Cell Sci. ###: ###-### (IF 6.1) [PubMed] [WebPage] [PDF]

• Hackel D, Krug SM, Sauer RS, Mousa SA, Böcker A, Pflücke D, Wrede EJ, Kistner K, Hoffmann T, Niedermirtl B, Sommer C, Bloch L, Huber O, Blasig IE, Amasheh S, Reeh PW, Fromm M, Brack A, Rittner HL (2012) Transient opening of the perineurial barrier for analgesic drug delivery. Proc. Natl. Acad. Sci. USA 109(29): E2018-E2027 (IF 9.7) [PubMed] [WebPage] [PDF]

• Krug SM, Amasheh M, Dittmann I, Christoffel I, Fromm M, Amasheh S (2012) Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells. Biomaterials ###: ###-### (IF 7.4) [PubMed] [WebPage] [PDF]

• Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012) Claudin-17 forms tight junction channels with distinct anion selectivity. Cell. Mol. Life Sci. 69(16): 2765-2778 (IF 6.6) [PubMed] [WebPage] [PDF] [Supplement]

• Krug SM, Günzel D, Conrad MP, Lee IM, Amasheh S, Fromm M, Yu ASL (2012) Charge-selective claudin channels. Ann. N.Y. Acad. Sci. 1257: 20-28 (IF 3.2) [PubMed] [WebPage] [PDF] (Review)

• Günzel D, Zakrzewski S, Schmid T, Pangalos M, Wiedenhoeft J, Blasse C, Ozboda C, Krug SM (2012) From TER to trans- and paracellular resistance: Lessons from impedance spectroscopy. Ann. N.Y. Acad. Sci. 1257: 142-151 (IF 3.2) [PubMed] [WebPage] [PDF] (Review)

• Rosenthal R*, Günzel D* (*shared first authorship), Finger C, Krug SM, Richter JF, Schulzke JD, Fromm M, Amasheh S (2012) The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. Biomaterials 33(9): 2791-2800 (IF 7.4) [PubMed] [WebPage] [PDF] [Supplement]

• Shalapour S, Deiser K, Kühl AA, Glauben R, Krug SM, Fischer A, Sercan Ö, Chappaz S, Bereswill S, Heimesaat MM, Loddenkemper C, Fromm M, Finke D, Hämmerling GJ, Arnold B, Siegmund B, Schüler T (2012) Interleukin-7 links T lymphocyte and intestinal epithelial cell homeostasis. PLoS One 7(2): e31939 (print pages 1-11) (IF 4.1) [PubMed] [WebPage] [PDF]

• Takahashi A*, Saito Y*, Kondoh M*°, Matsushita K, Krug SM, Suzuki H, Tsujino H, Li X, Aoyama H, Matsuhisa K, Uno T, Fromm M, Hamakubo T, Yagi K (2012) Creation and biochemical analysis of a broad-specific claudin binder. Biomaterials 33(12): 3464-3474 (IF 7.4) [PubMed] [WebPage] [PDF] (*shared first authorship, °corresponding author)

• Veshnyakova A, Krug SM, Mueller SL, Piontek J, Protze J, Fromm M, Krause G (2012) Determinants contributing to claudin ion channel formation. Ann. N.Y. Acad. Sci. 1257: 45-53 (IF 3.2) [PubMed] [WebPage] [PDF] (Original paper)   

2011, PhD graduates of the FOR 721/1

• Stuiver M, Lainez S, Will C, Terryn S, Günzel D, Debaix H, Sommer K, Kopplin K, Thumfart J, Kampik NB, Querfeld U, Willnow TE, Nemec V, Wagner C, Hoenderop JG, Devuyst O, Knoers NVAM, Bindels RJ, Meij IC*, Müller D* (*shared last authorship) (2011) CNNM2, encoding a basolateral protein required for renal Mg²⁺ handling, is mutated in dominant hypomagnesemia. Am. J. Hum. Genet. 88(3): 333-343 [PubMed] [HTML] [PDF] (IF 12.3)

2010, PhD graduates of the FOR 721/1

• Westphal JK, Dörfel MJ, Krug SM, Cording JD, Piontek J, Blasig IE, Tauber R, Fromm M, Huber O (2010) Tricellulin forms homomeric and heteromeric tight junctional complexes. Cell. Mol. Life Sci. 67(12): 2057-2068 [PubMed] [HTML] [Supplement] [PDF]

• Will C, Breiderhoff T, Thumfart J, Stuiver M, Kopplin K, Sommer K, Günzel D, Querfeld U, Meij IC, Shan Q, Bleich M, Willnow TE, Müller D (2010) Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca²⁺ and Mg²⁺ wasting. Am. J. Physiol. Renal Physiol. 298: F1152-F1161 [PubMed] [HTML] [PDF]

2009, PhD graduates of the FOR 721/1

• Amasheh S*, Milatz S* (*shared first authorship), Krug SM, Bergs M, Amasheh M, Schulzke JD, Fromm M (2009) Na⁺ absorption defends from paracellular back-leakage by claudin-8 upregulation. Biochem. Biophys. Res. Comm. 378(1): 45-50 [PubMed] [HTML] [PDF]

• Amasheh S, Milatz S, Krug SM, Markov AG, Günzel D, Amasheh M, Fromm M (2009) Tight junction proteins as channel formers and barrier builders: claudin-2, -5, and -8. Ann. N.Y. Acad. Sci. 1165: 211-219 [PubMed] [HTML] [PDF]

• Dechmann DK, John L, Noventa T, Voigt CC (2009) Polymorphic microsatellites for the lesser bulldog bat (Noctilio albiventris) cross-amplify with close and distant relatives. Conserv. Genet. Resour. 1(1): 167-170 [Abstract] [HTML] [PDF] (no FOR topic)

• Doerfel MJ, Westphal JK, Huber O (2009) Differential phosphorylation of occludin and tricellulin by CK2 and CK1. Ann. N.Y. Acad. Sci. 1165: 69-73 [PubMed] [HTML] [PDF]

• Fromm M, Krug SM, Zeissig S, Richter JF, Rosenthal R, Schulzke JD, Günzel D (2009) High resolution analysis of barrier function. Ann. N.Y. Acad. Sci. 1165: 74-81 [PubMed] [HTML] [PDF]

• Günzel D, Haisch L, Pfaffenbach S, Krug SM, Milatz S, Amasheh S, Hunziker W, Müller D (2009) Claudin function in the thick ascending limb of Henle's loop. Ann. N.Y. Acad. Sci. 1165: 152-162 [PubMed] [HTML] [PDF]

• Günzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Müller D (2009) Claudin-10 exists in six alternatively spliced isoforms which exhibit distinct localization and function. J. Cell Sci. 122: 1507-1517 [PubMed] [HTML] [PDF]

• Hering NA, Schulzke JD (2009) Therapeutic options to modulate barrier defects in inflammatory bowel disease. Dig. Dis. 27(4): 450-454 [PubMed] [PDF] (Review)

• Krug SM, Amasheh S, Richter JF, Milatz S, Günzel D, Westphal JK, Huber O, Schulzke JD, Fromm M (2009) Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol. Biol. Cell 20: 3713-3724 [PubMed] [HTML] [PDF] [Supplement text] [Supplement video]

• Krug SM, Fromm M, Günzel D (2009) Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys. J. 97(8): 2202-2211 [PubMed] [HTML] [PDF] [Supplement]

• Mankertz J*, Amasheh M* (*shared first authorship), Krug SM, Fromm A, Amasheh S, Hillenbrand B, Tavalali S, Fromm M, Schulzke JD (2009) TNFalpha up-regulates claudin-2 expression in epithelial HT-29/B6 cells via phosphatidylinositol-3-kinase signaling. Cell Tiss. Res. 336(1): 67-77 [PubMed] [HTML] [PDF]

• Bergann T, Ploeger S, Fromm A, Zeissig S, Borden SA, Fromm M, Schulzke JD (2009) A colonic mineralocorticoid receptor cell model expressing epithelial Na⁺ channels. Biochem. Biophys. Res. Comm. 381(2): 280-285 [PubMed] [HTML] [PDF] (no FOR topic)

• Schulzke JD*, Ploeger S* (*shared first authorship), Zeissig S, Amasheh M, Fromm A, Troeger H, Richter JF, Bojarski C, Schumann M, Fromm M (2009) Tight junctions in intestinal inflammation. Ann. N.Y. Acad. Sci. 1165: 294-300 [PubMed] [HTML] [PDF]

• Ziera T, Irlbacher H, Fromm A, Latouche C, Krug SM, Fromm M, Jaisser F, Borden SA (2009) Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel. FASEB J. 23(11): 3936-3946 [PubMed] [HTML] [PDF] (no FOR topic)

2008, PhD graduates of the FOR 721/1

• Doerfel MJ, Huber O (2008) CSNK1A1 (casein kinase 1, alpha 1). Atlas Genet. Cyotgenet. Oncol. Haematol. URL: http://AtlasGeneticsOncology.org/Genes/CSNK1A1ID40168ch5q32.html (no FOR topic)

• Will C, Fromm M, Müller D (2008) Claudin tight junction proteins: novel aspects in paracellular transport. Periton. Dialysis Int. 28(6): 577-584 [PubMed] [PDF] (Review)

2007, PhD graduates of the FOR 721/1

• Markov AG, Veshnyakova A, Krug SM, Milatz S (2007) Expression of tight junction proteins in the epithelium of small intestine of the rat. Russ. J. Physiol. (Ross. Fiziol. Zh. Im. I. M. Sechenova) 93(9): 1043-1054 [PubMed]