Institute of Medical Physics and Biophysics CCM

Projects

• Biophysical characterization of proteins in large scale
• Casein-kinase II as apotential light-dependent regulator of centrins in photoreceptor cells
• Characterization and Application of Infrared Radiation from BESSY II
• Cryo-EM studies on light-activated rhodopsin (SFB 449 TP 16)
• Crystal structure of centrin and centrin-G protein complex
• Derivates of Oligomycin A and its complexes with monovalent cations
• Functional characterization of centrins and their interactions with heterotrimeric G-protein
• Inactive conformation of rhodopsin
• Influence of cholesterol on the binding of PDE in disc membranes
• Interaction of active rhodopsin (SFB 449)
• Ligand Channeling: The Opsin/Retinal "Exit Site" Complex
• Light-induced interaction of two-dimensional rhodopsin crystals and the visual G protein transducin
• Opsin/all-trans-retinal complex a second binding site of retinal to the photoreceptor rhodopsin
• PDE-lipid-interaction in disc membranes
• Phospholipide - signaltransduction
• Protein-Cofaktor-Interactions in the Signaling State of Rhodopsin (SFB 498)
• Role of phospholipids in the visual signal transduction
• Signal structure of messenger RNA
• Signaling states of G-protein coupled receptors (SFB 366)
• Spektroscopic investigations of proteins in the THz range.
• Structure of the inactive conformationof arrestin
• Surface viscosity of the pure water surface
• Synthesis, biophysical and biochemical Characterization of new derivates of gossypol and lasalocid

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