Institute of Biochemistry CCM

Projects

• Adressierung von 26S Proteasomen
• Affinitätsmarkierung des aktiven Zentrums von Lipoxygenasen durch Azidofettsäuren
• Analysis of Proteasome-Subtypes
• Antigenverarbeitung
• Biochemische und funktionelle Analyse von Subtypen der multikatalytischen Proteinase in 20S und 26S Proteasomen.
• Cryo-electron microscopy of the protein targeting and translocation machinery
• Damping properties of granular materials
• DFG priority programme Selenoproteins, phase 3
• Eicosanoids and nitric oxide. Mediators of cardiovascular, cerebral and neoplastic diseases.
• Expression of alternative spliced alpha importin and characterisation of recombinant proteins
• Expression regulation of monoamine oxidases
• Expression regulation of Monoaminoxydase-A
• Function of proteasomes in CVB3 antigen presentation
• Functional Characterisation of the HERP Protein
• Horizontal sequencing for phylogenetic analyses: comparison of TIM and ribisomal sequences
• Impact of LOX-inhibitors on cellular oxidation of LDL
• Innov.-kolleg Biomolek.Erkennung TP 2.1
• Interfaces
• Investigation of the influence of cytokines and infection on proteasomal antigen processing
• Kinetic modelling of the intracellular protein degradation
• Kinetic Modelling of the 20S Proteasome
• Lipoxygenases and foam cell formation
• Lokale Randomisierung an der ß-Can-Struktur des Grünen Fluoreszierenden Proteins
• LOX Mutagenesis
• Mass spectrometric analysis of subproteomes
• Membrane binding of lipoxygenase
• Model studies on structure and recognition of biologically relevant molecules at atomic resolution
• Nuclear Targeting of 26S Proteasomes
• Optimized molecular libraries
• Optimized ß-sheet modul for effective expression of antibody Fab fragments in E.coli
• Opt.ß-Faltblattmodul
• Oxidative Modification of LDL as pathogenetic process in Atherogenesis.
• Particle simulation on parallel computers
• Proteasomale Antigenprozessierung
• Proteasomassemblierung
• Protein Cofactor Interactions
• Removal of nitric oxide in the vasculature by the catalytic activity of lipoxygenases
• ß-Can-Struktur
• Screening of peptide libraries for chitinase inhibitors and structural characterization of complexes
• Selenoproteins
• Siebtest nach isoform-spezifischen Lipoxygenaseinhibitoren
• Structural analysis of the anti-myc antibody 9E10 in complex with its epitope
• Structural characterization of the human transmembrane pyrophosphate channel ANK
• Structure and Function of membran bound receptors
• Studies on clathrin-mediated vesicular transport
• Studies on enzymatic mechanism of the eukaryotic signal peptidase
• System Dynamics and long term behaviour of railway ballast
• Untersuchungen zu den strukturellen Voraussetzungen für die Penetration des Sauerstoffs bei Lipoxygenasen
• Untersuchungen zur Rolle der seleno-organischen Verbindung ebselen bei der Atherogenese
• Untersuchungen zur Wirkung von LOX-Hemmstoffen auf die Atherogenese in murinen Ganztiermodellen
• Viscoelasticity
• 20S/26S Ubiquitin-Proteasomsy

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