Publications since the beginning of the Research Unit (January 2006)

Project 1

1. Anzenberger U, Dehmel B, Bit-Avragim N, Rohr S, Willnow TE, Abdelilah-Seyfried: Elucidation of Megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros. J Cell Sci 119: 2127-2137, 2006

2. Theilig F, Kriz W, Jerichow T, Schrade P, Hähnel B, Willnow T, Le Hir M, Bachmann S: Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulo-interstitial injury. J Am Soc Nephrol 18: 1824-1834, 2007

Project 2

1. Paliege A, Parsumathy A, Mizel D, Yang T, Schnermann J, Bachmann S: Effect of apocynin treatment on renal expression of COX-2, NOS1, and renin in Wistar-Kyoto and spontaneously hypertensive rats. Am J Physiol 290(3):R694-R700, 2006

2. Pfab T, Thöne-Reineke C, Theilig F, Lange I, Witt H, Maser-Gluth C, Bader M, Stasch JP, Ruiza P, Bachmann S, Yanagisawa M, Hocher B: Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure. J Am Soc Nephrol 17: 1082-1089, 2006

3. Castrop H, Oppermann M, Weiss Y, Huang Y, Mizel D, Lu H, Germain S, Schweda F, Theilig F, Bachmann S, Briggs J, Kurtz A, Schnermann J: Reporter gene recombination in juxtaglomerular granular and collecting duct cells by a human renin promoter-Cre recombinase transgene. Physiol Genomics 25(2):277-285, 2006

4. Amstislavsky S, Welker P, Frühauf JH, Maslova L, Ivanova L, Jensen B, Markel AL, Bachmann S. Renal and endocrine changes in rats with inherited stress-induced arterial hypertension (ISIAH). Histochem Cell Biol 125:651-659, 2006

5. Gersch M, Mutig K, Bachmann S, Kumar S, Ouyang X, Johnson R: Is salt-wasting the long awaited answer to the hyperuricaemia seen in uromodulin storage diseases? Nephrol Dial Transplant 21(7): 2028-2029, 2006

6. Theilig F, Debiec H, Nafz B, Ronco P, Nüsing R, Seyberth W, Pavenstädt H, Bouby N, Bachmann S: Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat). Am J Physiol 291: F987-F994, 2006

7. Oppermann M, Mizel D, Huang G, Li C, Deng C, Theilig F, Bachmann S, Briggs J, Schnermann J, Castrop H: Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na,K,2Cl co-transporter. J Am Soc Nephrol 17: 2143-2152, 2006

8. Welker P, Geist B, Frühauf JH, Salanova M, Groneberg DA, Krause E, Bachmann S: Role of lipid rafts in membrane delivery of renal epithelial Na+, K+-ATPase, thick ascending limb. Am J Physiol 292(3): R1328-R1337, 2007

9. Yang CL, Liu X, Paliege A, Zhu X, Bachmann S, Dawson DC, Ellison DH: WNK1 and WNK4 modulate CFTR activity. Biochem Biophys Res Commun 353(3): 535-540, 2007

10. Stefan E, Wiesner B, Baillie GS, Mollajew R, Henn V, Lorenz D, Furkert J, Santamaria K, Nedvetsky P, Hundsrucker C, Beyermann M, Krause E, Pohl P, Gall I, MacIntyre AN, Bachmann S, Houslay MD, Rosenthal W, Klussmann E: Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. J Am Soc Nephrol 18(1): 199-212, 2007

11. Quaschning T, Voss F, Relle K, Kalk P, Vignon-Zellweger N, Pfab T, Bauer C, Theilig F, Bachmann S, Kraemer-Guth A, Wanner C, Theuring F, Galle J, Hocher B: Lack of endothelial nitric oxide synthase promotes endothelin-induced hypertension: Lessons from Endothelin-1 transgenic/endothelial nitric oxide synthase knockout mice. J Am Soc Nephrol 18(3): 730-740, 2007

12. Theilig F, Kriz W, Jerichow T, Schrade P, Hähnel B, Willnow T, Le Hir M, Bachmann S: Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulo-interstitial injury. J Am Soc Nephrol 18: 1824-1834, 2007

13. Mutig K, Paliege A, Kahl T, Jöns T, Müller-Esterl W, Bachmann S. Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL. Am J Physiol 293(4):F1166-F1177, 2007

Project 3

1. Vossenkämper, A., Nedvetsky, P. I., Wiesner, B., Furkert, J., Rosenthal, W., Kluss-mann, E. Microtubules are needed for the perinuclear positioning of aquaporin-2 after its en-docytic retrieval in renal principal cells. Am. J. Physiol., Cell Physiol., 293(3):C1129-38. 2007.

2. Stefan, E., Wiesner, B., Baillie, G. S., Mollajew, R., Henn, V., Lorenz, D., Furkert, J., Santamaria, K., Nedvetsky, P., Hundsrucker, C., Beyermann, M., Krause, E., Pohl, P., Gall, I., MacIntyre, A. N., Bachmann, S., Houslay, M. D., Rosenthal, W., and Klussmann, E. Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. J. Am. Soc. Nephrol. 1, 199-212, 2007.

3. Nedvetsky, P. I., Stefan, E., Frische, S., Santamaria, K., Wiesner, B., Valenti, G., Hammer III, J. A., Nielsen, S., Goldenring, J. R., Rosenthal, W., Klussmann, E. A role of my-osin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic, 8, 110-23, 2007.

Project 4

1. Dekel B, Metsuyanim S, Schmidt-Ott KM, Fridman E, Jacob-Hirsch J, Simon A, Pinthus J, Mor Y, Barasch J, Amariglio N, Reisner Y, Kaminski N, Rechavi G: Multiple imprinted and stemness genes provide a link between normal and tumor progenitor cells of the developing human kidney. Cancer Res 66: 6040-6049, 2006

2. Schmidt-Ott KM: Nephrologists sans frontieres: the art and science of branching. Kidney Int 69: 1921-1923, 2006

3. Schmidt-Ott KM, Chen X, Paragas N, Levinson RS, Mendelsohn CL, Barasch J: c-kit delineates a distinct domain of progenitors in the developing kidney. Dev Biol 299: 238-249, 2006

4. Schmidt-Ott KM, Lan D, Hirsh BJ, Barasch J: Dissecting Stages of Mesenchymal-to-Epithelial Conversion during Kidney Development. Nephron Physiol 104: p56-p60, 2006

5. Schmidt-Ott KM, Mori K, Kalandadze A, Li JY, Paragas N, Nicholas T, Devarajan P, Barasch J: Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr Opin Nephrol Hypertens 15: 442-449, 2006

6. Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, Cohen DJ, Devarajan P, Barasch J: Dual action of neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 18: 407-413, 2007

7. Schmidt-Ott KM, Masckauchan TN, Chen X, Hirsh BJ, Sarkar A, Yang J, Paragas N, Wallace VA, Dufort D, Pavlidis P, Jagla B, Kitajewski J, Barasch J: beta-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors. Development 134: 3177-3190, 2007

8. Sanna-Cherchi S, Caridi G, Weng PL, Dagnino M, Seri M, Konka A, Somenzi D, Carrea A, Izzi C, Casu D, Allegri L, Schmidt-Ott KM, Barasch J, Scolari F, Ravazzolo R, Ghiggeri GM, Gharavi AG: Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33. Am J Hum Genet 80: 539-549, 2007

9. Schmidt-Ott KM: Unraveling the role of connective tissue growth factor in diabetic nephropathy. Kidney Int 73: 375-376, 2008

10. Metsuyanim S, Pode-Shakked N, Schmidt-Ott KM, Keshet G, Rechavi G, Blumental D, Dekel B: Accumulation of Malignant Renal Stem Cells is Associated with Epigenetic Changes in Normal Renal Progenitor Genes. Stem Cells 26(7):1808-1817, 2008

11. Schmidt-Ott KM, Barasch J: WNT/ß-catenin signaling in nephron progenitors and their epithelial progeny. Kidney Int 74(8):1004-1008, 2008

Project 5

1. Bachvarov D, Bachvarova M, Koumangaye R, Klein J, Pesquero JB, Neau E, Bader M, Schanstra JP, Bascands J-L. Renal gene expression profiling using kinin B1 and B2 receptor knockout mice reveals comparable modulation of functionally related genes. Biol Chem. 2006;387:15-22.

2. Burckle C, Danser AHJ, Müller DN, Garrelds IM, Gasc J-M, Plehm R, Peters J, Bader M, Nguyen G. Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension. 2006; 47:552-556

3. Campos LA, Plehm R, Cipolla-Neto J, Bader M, Baltatu O. Altered circadian rhythm reentrainment to light phase shifts in rats with low brain angiotensinogen. Am J Physiol 2006; 290: R1122-R1127

4. Campos LA, Iliescu R, Fontes M, Schlegel WP, Bader M, Baltatu OC. Enhanced isoproterenol-induced cardiac hypertrophy in transgenic rats with low brain angiotensinogen. Am J Physiol 2006, 291: H2371-H2376

5. Castro CH, Santos RA, Ferreira AJ, Bader M, Alenina N, Almeida AP. Effects of genetic deletion of angiotensin-(1-7) receptor Mas on cardiac function during ischemia/reperfusion in the isolated perfused mouse heart. Life Sci. 2006, 80: 264-268

6. Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, Willnow TE, Bader M, Martin U, Bauersachs J, Wollert KC, Dietz R, von Harsdorf R. Apoptosis Repressor With Caspase Recruitment Domain is required for cardioprotection in response to biomechanical and ischemic stress. Circulation 2006; 113:1203-1212.

7. Ferreira AJ, Pinheiro SVB, Castro CH, Silva GAB, Simoes e Silva AC, Almeida AP, Bader M, Rentzsch B, Reudelhuber TL, Santos RA. Renal functions in transgenic rats expressing an angiotensin-(1-7)-producing fusion protein. Regul Pept 2006, 137: 128-133

8. Koch M, Spillmann F, Dendorfer A, Westermann D, Altmann C, Sahabi M, Linthout SV, Bader M, Walther T, Schultheiss HP, Tschöpe C. Cardiac function and remodeling is attenuated in transgenic rats expressing the human kallikrein-1 gene after myocardial infarction. Eur J Pharmacol. 2006; 550 :143-148

9. Langenickel T, Buttgereit J, Pagel-Langenickel I, Lindner M, Beuerlein K, Al-Saadi N, Plehm R, Popova E, Tank J, Dietz R, Willenbrock R, Bader M. Cardiac hypertrophy in transgenic rats expressing a dominant negative mutant of the natriuretic peptide receptor B. Proc Natl Acad Sci USA. 2006; 103: 4735-4740

10. Santos RA, Castro CH, Gava E, Pinheiro SVB, Almeida AP, Paula DR, Cruz JS, Ramos AS, Rosa KT, Ingoyen MC, Bader M, Alenina N, Ferreira AJ. Impairment of in vitro and in vivo heart function in angiotensin-(1-7) receptor Mas knockout mice. Hypertension. 2006; 47: 996-1002

11. Si H, Heyken W-T, Wölfle SE, Tysiac M, Schubert R, Grgic I, Vil'ianovich L, Giebing G, Maier T, Gross V, Bader M, de Wit C, Hoyer J, Köhler R. Impaired EDHF mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+-channel. Circ Res. 2006, 99: 537-544.

12. Batenburg WW, Krop M, Garrelds IM, de Vries R, de Bruin RJA, Burckle C, Mueller DN, Bader M, Nguyen G, Danser AHJ. Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor. J Hypertens. 2007, 25: 2441-2453.

13. Botelho-Santos GA, Sampaio WO, Reudelhuber TL, Bader M, Campagnole-Santos MJ, Santos RA. Expression of an angiotensin-(1-7)-producing fusion protein in rats induced marked changes in regional vascular resistance. Am J Physiol. 2007, 292: H2485-H2490

14. Cayla C, Todiras M, Iliescu R, Gross V, Pilz B, Chai GX, Saul V, Merino VF, Pesquero JB, Baltatu O, Bader M. Mice deficient for both kinin receptors are normotensive and protected from endotoxin-induced hypotension. FASEB J. 2007, 21: 1689-1698.

15. Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A. A novel inflammatory pathway involved in leukocyte recruitment: Role for the kinin B1 receptor and the chemokine CXCL5. J Immunol. 2007;179:4849-4856.

16. Goncalves ACC, Leite R, Silva RAF, Pinheiro SVB, Sampaio WO, Reis AB, Reis FM, Thouyz RM, Webb R, Alenina N, Bader M, Santos RA. Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an essential role in erectile function. Am J Physiol. 2007, 293: H2588-H2596.

17. Ifuku M, Färber K, Okuno Y, Yamakawa Y, Miyamoto T, Nolte C, Merino VF, Kita S, Iwamoto T, Komuro I, Wang B, Cheung G, Ishikawa E, Ooboshi H, Bader M, Wada K, Kettenmann H, Noda M. Bradykinin-induced microglial migration mediated by B1-bradykinin receptors depends on Ca2+ influx via reverse-mode activity of the Na+/Ca2+ exchanger. J Neurosci. 2007, in press.

18. Jankowski V, Vanholder R, van der Giet M, Tölle M, Karadogan M, Giebing G, Gobom J, Furkert J, Oksche A, Krause E, Tepel M, Beyermann M, Bader M, Todiras M, Zidek W, Jankowski J. Mass-spectrometric identification of a novel angiotensin peptide in human plasma. Arterioscler Thromb Vasc Biol. 2007; 27: 297-302.

19. Lauton-Santos S, Guatimosim S, Castro CH, Oliveira FA, Almeida AP, Dias-Peixoto MF, Gomes MA, Pessoa P, Pesquero JL, Pesquero JB, Bader M, Cruz JS. Kinin B1 receptor participates in the control of cardiac function in mice. Life Sci. 2007, 81: 814-822.

20. Li HJ, Yin H, Yao YY, Shen B, Bader M, Chao L, Chao J. Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation. Cardiovasc Res. 2007, 73: 130-142

21. Morecroft I, Dempsie Y, Bader M, Walther DJ, Kotnik K, Loughlin L, Nilsen M, MacLean MR. Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. Hypertension. 2007, 49: 232-236

22. Santos EL, Reis RI, Silva RG, Shimuta SI, Pecher C, Bascands J-L, Schanstra JP, Oliveira L, Bader M, Paiva AC, Costa-Neto CM, Pesquero JB. Functional rescue of a defective angiotensin II AT1 receptor mutant by the Mas protooncogene. Regul Pept. 2007, 141: 159-167.

23. Santos EL, Souza KP, Cibrian-Uhalte E, Oliveira SM, Bader M, Costa-Neto CM, Oliveira L, Pesquero JB. Essential role of TM V and VI for binding the C-terminal sequences of Des-Arg-kinins. Int Immunopharmacol. 2007, in press.

24. Schulze-Topphoff U, Prat A, Bader M, Zipp F, Aktas O. Roles of the kallikrein/kinin system in the adaptive immune system. Int Immunopharmacol. 2007, in press.

25. Silva JA, Jr., Silva MR, Nascimento JW, Bader M, Pesquero JB. Protective actions of human tissue kallikrein gene in transgenic rat hearts. Int Immunopharmacol. 2007, in press.

26. Walther T, Tschöpe C, Sterner-Kock A, Westermann D, Heringer-Walther S, Riad A, Nikolic A, Wang Y, Ebermann L, Siems WE, Bader M, Shakibaei M, Schultheiss HP, Dörner A. Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease. Circulation. 2007; 115: 333-344.

27. Yin H, Chao J, Bader M, Chao L. Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Peptides 2007, 28: 1383-1389

Reviews

28. Burckle C, Bader M. Prorenin and its ancient receptor. Hypertension 2006; 48: 549-551

29. Nguyen G, Danser AHJ, Burckle C, Bader M, Mueller DN. (Pro)renin receptors: their functional properties. In: Re RN, DiPette DJ, Schiffrin EL, Sowers JR, editors. Molecular Mechanisms in Hypertension. London: Taylor & Francis, 2006, 69-74.

30. Panek AN, Bader M. Matrix reloaded – the Matrix Metalloproteinase paradox. Hypertension 2006; 47: 640-641.

31. Pesquero JB, Bader M. Genetically altered animal models in the kallikrein-kinin system. Biol Chem. 2006; 387:119-126.

32. Plehm R, Barbosa ME, Bader M. Animal models for hypertension / Blood pressure recording. Methods Mol Med 2006, 129: 115-126.

33. Bader M. KININ2007: Comeback for kinins. Int Immunopharmacol. 2007, in press.

34. Baltatu O, Bader M: Angiotensin. In Encyclopedia of Stress, edited by Fink G. 2nd ed. Oxford: Elsevier Ltd; 2007, in press.

35. Pagel-Langenickel I, Buttgereit J, Bader M, Langenickel T. Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy. J Mol Med. 2007; 85: 797-810.

36. Bader M. Renin-angiotensin-aldosterone system. In: Offermanns S, Rosenthal W, editors. Encyclopedia of Molecular Pharmacology. Heidelberg: Springer Verlag, 2008, in press.

37. Mori MAS, Bader M, Pesquero JB. Genetically altered animals in the study of the metabolic functions of peptide hormone systems. Curr Opin Nephrol Hypertens. 2008, in press.

 

Project 7

1. Lange P.F., Wartosch L., Jentsch T.J., Fuhrmann J.C. (2006). ClC-7 requires Ostm1 as a ß-subunit to support bone resorption and lysosomal function. Nature 440, 220-223.

2. Maritzen T., Rickheit G., Schmitt A., Jentsch T.J. (2006) Kidney-specific upregulation of vitamin D3 target genes in ClC-5 KO mice. Kidney Int. 70, 79-87.

Project 8

1. Castrop H, Oppermann M, Weiss Y, Huang Y, Mizel D, Lu H, Germain S, Schweda F, Theilig F, Bachmann S, Briggs J, Kurtz A, Schnermann J: Reporter gene recombination in juxtaglomerular granular and collecting duct cells by a human renin promoter-Cre recombinase transgene. Physiol Genomics 25(2):277-285, 2006

2. Theilig F, Debiec H, Nafz B, Ronco P, Nüsing R, Seyberth W, Pavenstädt H, Bouby N, Bachmann S: Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat). Am J Physiol 291: F987-F994, 2006

3. Oppermann M, Mizel D, Huang G, Li C, Deng C, Theilig F, Bachmann S, Briggs J, Schnermann J, Castrop H: Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na,K,2Cl co-transporter. J Am Soc Nephrol 17: 2143-2152, 2006

4. Merle U, Theilig F, Fein E, Gehrke S, Kallinowski B, Riedel HD, Bachmann S, Stremmel W, Kulaksiz H: Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes. Histochem Cell Biol 127(2): 221-226, 2007

5. Quaschning T, Voss F, Relle K, Kalk P, Vignon-Zellweger N, Pfab T, Bauer C, Theilig F, Bachmann S, Kraemer-Guth A, Wanner C, Theuring F, Galle J, Hocher B: Lack of endothelial nitric oxide synthase promotes endothelin-induced hypertension: Lessons from Endothelin-1 transgenic/endothelial nitric oxide synthase knockout mice. J Am Soc Nephrol 18(3): 730-740, 2007

6. Theilig F, Kriz W, Jerichow T, Schrade P, Hähnel B, Willnow T, Le Hir M, Bachmann S: Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulo-interstitial injury. J Am Soc Nephrol 18: 1824-1834, 2007

7. Y. Wang, S. Krämer, L. Loof, S. Martini, S. Kron, F. Shimizu, H. Kawachi, H.-H. Neumayer, H. Peters. Enhancing cGMP in experimental progressive renal fibrosis: soluble guanylate cyclase stimulation versus phosphodiesterase inhibition. Am J Physiol Renal Physiol, 290: F167-76 (2006).

8. J. Gaedeke, H. Peters. Pharmacological management of fibrotic renal disease. Expert Opin Pharmacother, 7:377-86 (2006).

9. J. Waiser, K. Dell, J. Kreutzkamp, T. Bohler, K. Budde, H. Peters, H.-H. Neumayer. FK506, transforming growth factor-beta1 and mesangial matrix synthesis: Parallels and differences compared with cyclosporine A. Cytokine, 21:59-65 (2006).

10. S. Martini, S. Krämer, T. Loof, Y. Wang-Rosenke, U. Daig, K. Budde, H.-H. Neumayer, H. Peters. The S1P modulator FTY720 limits matrix expansion in acute anti-thy1 mesangioproliferative glomerulonephritis. Am J Physiol Renal Physiol, 292:F1761-70 (2007).

11. S. Martini, H. Peters, T. Böhler, K. Budde. Current perspectives on FTY720. Expert Opin Investig Drugs 16:505-518 (2007).

12. H. Peters, T. Unger. Mast cells and the power of local RAS activation. Nephrol Dial Transplant. 22:40-2 (2007)

13. S. Martini, H. Peters. Medical treatment in retroperitoneal fibrosis: The difficulty to provide good evidence in rare diseases.
J Urol.178:143-4 (2007).

 

top