projects

1st Symposium of the
DFG-Research Unit FOR 667
Epithelial Mechanisms in Renal Volume Regulation

Egsdorf near Berlin
September 20th – 22th, 2007

Location
BIB (Bildung in Berlin)
Chausseestr. 47 - 15755 Egsdorf
Tel.: 033766/62851

Meeting Office
Pascale Schulte
Tel.: + 49 30 450 528 412
Fax: + 49 30 528 922
E-Mail: pascale.schulte@charite.de

Organization
Prof. Dr. Sebastian Bachmann
Charité – Universitätsmedizin Berlin
Institut für Vegetative Anatomie
Philippstr. 12
10115 Berlin
Tel.: + 49 30 450 528 001
Fax: + 49 30 450 528 922
E-Mail: sbachm@charite.de

Supported by :

Thursday, September 20, 2007

18: 00 Get together

19:00 Sebastian Bachmann, Dept. of Anatomy, Charité – Welcome

19:10 Armin Kurtz, Dept. of Physiology, Vice President of the University of Regensburg – News on the RAS and the juxtaglomerular apparatus

20:00 Dinner

Friday, September 21, 2007

7:30 Breakfast

8:30 Project 1, Thomas Willnow, MDC, Functional characterization of intracellular sorting receptors in transepithelial transport processes in the kidney

Thomas Willnow – Introduction into VPS0p domain receptors
Juliane Reiche – Role of sorLA in the kidney
Daniel Militz – Possible role of the sorLa receptor in the adrenal gland

9:30 Project 2, Sebastian Bachmann, Dept. of Anatomy, Charité,
Biology of the cation-chloride-cotransporter, thick ascending limb of Henle’s loop

Sebastian Bachmann – Renal concentrating mechanism, thick ascending limb and the biology of NKCC2
Alexander Paliege – Vasopressin-stimulated changes in outer medullary gene expression
Alexandra Böhlick/Pia Welker – Non-caveolar lipid raft association of NKCC2 and polar delivery by vasopression
Kerim Mutig – Tamm Horsfall protein associated with NKCC2 function

10:30 Coffee break

11:00 Project 3, Enno Klußmann, FMP,
Role of the cytoskeleton in vasopressin-induced aquaporin-2 shuttling in renal collecting duct principal cells

Enno Klußmann – Role of the motor protein myosin Vb in the trafficking of AQP2 in renal principal cells
Pavel Nedvetzky – Involvement of microtubuli in the recycling of AQP2

12:00 Project 4, Christian Harteneck, Dept. of Pharmacology, Charité,
Function of the osmo-regulated TRP- channels, TRPV4 and TRPM3, in renal volume homeostasis

Christian Harteneck – Volume-regulated TRP channels in the kidney
Isabelle Straub – Characterization of TRPM3-mediated currents

13.00 Lunch and outdoor activities

15:00 Project 5, Michael Bader, MDC,
Role of the tubular renin-angiotensin and the kallikrein kinin systems in kidney function and hypertensive nephropathy

Michael Bader – Overview on transgene-related advances in RAS and bradykinin biology
Gabin Sihn/Ping Xu – Functional analysis of angiotensins and bradykinin in the kidney

16.00 Project 6, Bernd Thiele,
Dept. of Physiology, Charité, Posttransscriptional control of the synthesis of ENaC

Bernd Thiele – Role of interactions between ENaC 3’UTRs and proteins expressed in ENaC producing cell line
Benno Nafz – Role of translational control for the regulation of Na transport and blood pressure regulation in the conscious rat

17:00 Coffee break

17:30 Project 7, Thomas Jentsch, FMP, Dissection of the role of ClC-5 in proximal tubular endocytosis and transport processes

Thomas Jentsch – A physiological role for the ubiquitination of ClC-5 in the proximal tubular endocytosis?
Lena Wartosch – Protein degradation in the proximal tubule: involvement of ClC-7

18:30 Project 8, Franziska Theilig,
Dept. of Anatomy, Cellular translocation of renal epithelial transporters under proteinuria

Franziska Theilig – Proteinuric renal damage and renal volume handling
Harm Peters – Epithelial transport function in Anti Thy1 nephritis
Christian Kastner – Altered transporter trafficking and surface expression under proteinuria: role of endocytosis
Marcus Pohl – Role of TRPM3A in endocytosis

19:30 Dinner

Saturday, September 22, 2007

8:00 Breakfast

9:00 Hartmut Schlüter, Core Facility, Protein Analytics, Charité, presents news on his MALDI-Unit and future possibilities

9:30 Michael Fromm, Dept. of Clinical Physiology, Charité , gives a report on the parallel DFG-Research Unit FOR 721 “Molecular structure and function of the tight Junction” and discusses possibilities of interactions

9:50 Dorothee Günzel, Dept. of Clinical Physiology, Charité, speaks about "Para- and transcellular effects of claudin-16"

10:00 Thomas Willnow refers on "Possibilities for funding FG667 related activities through the HGF"

10:30 Sebastian Bachmann highlights status, achievements, and aspects of existing and possible future collaborations among project groups

11:00 End of the symposium

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