| Project
1 - Thomas Willnow |
| |
|
| Date
of Birth: |
11
January 1961 |
| Nationality:
|
German |
| |
|
| EDUCATION: |
|
| 1988 |
Diploma
in Biology, University of Munich |
| 1992 |
Ph.D.
in Biochemistry (with honors), University of Munich |
| |
|
PROFESSIONAL
EXPERIENCE:
|
|
| 1985 |
Undergraduate
research fellow, Biochemistry Research Center, Boehringer Mannheim
GmbH, Penzberg |
| 1986 |
Undergraduate
research fellow, Institute for Biochemistry, University of Munich |
| 1987-1988 |
Undergraduate
research fellow, Biochemistry
Research Center, Boehringer Mannheim GmbH, Penzberg
|
| 1988-1991 |
Graduate
research fellow, Institute for Biochemistry,
University of Munich |
| 1992-1996 |
Postdoctoral
Fellow, UT Southwestern Medical Center, Dallas |
| 1996-2001 |
Head
of a Junior Research Group, Max-Delbrueck-Center for Molecular Medicine,
Berlin
Lecturer in Molecular Cell Biology and Biochemistry, Humboldt-University
of Berlin
Visiting scientist, Free University of Berlin, University Clinic
B. Franklin, Department of Clinical Pharmacology and Toxicology |
| 2005 |
Head
of Molecular Cardiovascular Research, Max-Delbrueck-Center for
Molecular Medicine,
BerlinCoordinator of the Cardiovascular Research Program, Max-Delbrueck-Center
for Molecular Medicine, Berlin
Speaker of the Cardiovascular and Metabolic Disease Research Program
of the Helmholtz Association of National Research Institutions
Full Professor of Molecular Cardiovascular Research, Charité,
Medical University of Berlin
CSO of ReceptIcon ApS, Aarhus/Berlin
|
| |
|
|
TOP PUBLICATIONS: |
|
| 1.
|
Andersen,
O.A., Reiche, R., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke,
J., von Arnim, C.A. F., Breiderhoff, T., Jansen, P., Wu, X., Bales,
K.R., Cappai, R., Masters, C.L., Gliemann, J., Mufson, E.J., Hyman,
B.T., Paul, S.M., Nykjær, N. and T. E. Willnow. (2005) SorLA/LR11,
a neuronal sorting receptor that regulates processing of the amyloid
precursor protein. Proc. Natl. Acad. Sci. USA 102: 13461-13466 |
| 2.
|
Hammes,
A., Andreassen, T. K., Spoelgen, R., Raila, J., Huebner, N., Schulz,
H., Metzger, J., Schweigert, F. J., Luppa, P. B., Nykjaerr, A.
and T. E. Willnow. (2005) Impaired development of the reproductive
organs in mice lacking megalin, an endocytic receptor for steroid
hormones. Cell 122: 751-762 |
| 3.
|
Spoelgen,
R., Hammes, A., Anzenberger, U., Zechner, D., Jerchow, B., Andersen,
O.M. and T.E. Willnow. (2005) LRP2/megalin is required for patterning
of the ventral telencephalon. Development 132: 405-414 |
| 4. |
Nykjaer,
A., Lee, R., Teng, T.T., Nielsen, M.S., Jansen, P., Madsen, P.,
Jacobsen, C., Kliemannel, M., Willnow, T.E., Hempstead, B. and
C.M. Petersen. (2004) A novel neurotrophin receptor essential
for proNGF induced neuronal cell death. Nature 427:843-848 |
| 5.
|
Leheste,
J., Melsen, F., Wellner, M., Jansen, P., Schlichting, U., Renner-Müller,
I., Andreassen, T.T., Wolf, E., Bachmann, S., Nykjaer A. and T.
E. Willnow. (2003). Hypocalcemia and osteopathy in mice with kidney-specific
megalin gene defect. FASEB J. 17: 247-249 |
| 6.
|
Nykjaer,
A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C.,Herz, J.,
Melsen, F., Christensen, E.I. and T.E. Willnow. (1999). An endocytic
pathway essential for renal uptake and activation of the steroid
25-(OH) vitamin D3. Cell 96: 507-515 |
| 7.
|
Willnow,
T.E., Hilpert, J., Armstrong, S.A., Rohlmann, A., Hammer, R.E.,
Burns, D.K. and J. Herz. (1996). Defective forebrain development
in mice lacking gp330/ megalin. Proc. Natl. Acad. Sci. USA 93:
8460-8464 |
| 8. |
Willnow,
T.E., Rohlmann, A., Horton, J., Otani, H., Braun, J.R., Hammer,
R.E. and J. Herz. (1996). RAP, a specialized chaperone, prevents
ligand-induced ER-retention and degradation of LDL receptor-related
receptors. EMBO J. 15: 2632-2639 |
| 9. |
Willnow,
T.E., Armstrong, S.A., Hammer, R.E. and J. Herz. (1995). Functional
expression of low density lipoprotein (LDL) receptor-related protein
(LRP) is controlled by receptor-associated protein (RAP) in vivo.
Proc. Natl. Acad. Sci. USA 92: 4537-4541 |
| 10.
|
Willnow,
T.E., Sheng, J., Ishibashi, S. and J. Herz. (1994). Inhibition
of hepatic chylomicron remnant uptake by adenoviral gene transfer
of a receptor antagonist. Science 264: 1472-1474 |
|