| Project
3 - Walter Rosenthal |
| |
|
| Date
of Birth: |
11
October 1954 |
| Nationality:
|
German |
| |
|
| EDUCATION: |
|
| 1974 - 1980 |
Medical
student, University of Gießen; Royal Free Hospital, London |
| 1977
- 1982 |
Thesis,
Rudolf-Buchheim-Institut, University of Gießen |
| 1983-1990 |
Research
on G-proteins: Universities of Heidelberg and Berlin; Baylor College
of Medicine, Houston; 1990 habilitation |
| |
|
PROFESSIONAL
EXPERIENCE:
|
|
| 1991-1993 |
Heisenberg
fellow, visiting professor, Baylor College of Medicine, Houston |
| 1993-1996 |
C4-professorship,
chair, Rudolf-Buchheim-Institut, University of Gießen |
| 1987-1988 |
Recipient
of a “Habilitandenstipendium” from the “Deutsche
Forschungsgemeinschaft” (Competitive German Grant), Max-Planck-Institut
für Entwicklungsbiologie, Tübingen |
| 1988-1993 |
Research
group leader at the Zentrum für Molekulare Neurobiologie,
Universitätskrankenhaus Eppendorf, Hamburg |
|
since 1996 |
Director
of the FMP |
| 1998-2003 |
SC4-professorship,
Institut für Pharmakologie (Dahlem), Free University of Berlin |
| since
2003 |
C4-professorship,
chair, Institut für Pharmakologie, Charité (Dahlem)
|
| since
2005 |
Spokesman,
Life Science Section of the Leibniz Association |
| since
2005 |
Spokesman,
Board of Directors, Forschungsverbund Berlin e.V. (8 Leibniz institutes,
1100 employees) |
| HONORS/AWARDS |
|
| 1980 |
Scholarship
of the German Academic Exchange Service (DAAD) |
| 1983 |
Scholarship
of the Boehringer Ingelheim Fonds |
| 1991-1993 |
Heisenberg
scholarship of the German Research Foundation (DFG) |
| RESEARCH
INTERESTS: |
Major research areas:
Intracellular protein trafficking, scaffolding proteins, G-protein-coupled
receptors, cAMP/PKA-triggered pathways, aquaporins, molecular
defects underlying human disease, pharmacological interference
Highlights:
Regulation of ion channels by G-proteins; assignment of functions
to subtypes of G-Protein subunits; molecular cloning of the human
V2 (ADH) receptor; first description of disease-causing mutations
in a G protein-coupled hormone receptor; transport and processing
of G-protein-coupled receptors; molecular basis of cAMP-triggered
exocytosis (aquaporin 2 shuttle); disruptors of protein-protein
interactions |
| COOPERATIVE
RESEARCH ACTIVITIES: |
Board member, principal investigator: SFB 366 “Cellular
Signal Recognition and Transduction”
Board member, principal investigator: SFB 449 “Structure
and Function of Membrane Proteins”
Member DFG Research Group 341 “Mechanisms and Pathomechanisms
of Vascular Regulation”
Member Graduate School “Signal recognition and translation”
(GRK 276)
Principal investigator, EU QLK3-CT-2002-02149 “Anchored
cAMP signalling”
|
|
TOP PUBLICATIONS: |
|
| 1.
|
Kaufmann
JE, Oksche A, Wollheim CB, Günther G, Rosenthal W, Vischer
UM (2000) Vasopressin-induced von Willebrand factor secretion
from endothelial cells involves V2 receptors and cAMP. J Clin
Invest 106: 107-116 |
| 2.
|
Marr
N, Bichet DG, Lonergan M, Arthus MF, Jeck N, Seyberth H, Rosenthal
W, van Os CH, Oksche A, Deen PMT (2002) Heteroligomerisation of
an aquaporin-2 mutant with wild-type aquaporin and their misrouting
to late endosomes/lysosomes explains dominant nephrogenic diabetes
insipidus. Hum Mol Genet 11: 779-789 |
| 3.
|
Lorenz
D, Krylov A, Hahm D, Hagen V, Rosenthal W, Pohl P, Maric K (2003)
Cyclic AMP is sufficient for triggering the exocytic recruitment
of aquaporin-2 in renal epithelial cells. EMBO Report 4: 88-93
|
| 4. |
Henn
V, Edemir B, Stefan E, Wiesner B, Lorenz D, Theilig F, Schmitt
R, Vossebein L, Tamma G, Beyermann M, Krause E, Herberg FW, Valenti
G, Bachmann S, Rosenthal W, Klussmann E (2004) Identification
of a novel A-kinase anchoring protein 18 isoform and evidence
for its role in the vasopressin-induced aquaporin-2 shuttle in
renal principal cells. J Biol Chem 279: 26654-26665 |
| 5.
|
Hermosilla
R, Oueslati M, Donalies U, Schönenberger E, Krause E, Oksche
A, Rosenthal W, Schülein R (2004) Disease-causing V2 vasopressin
receptors are retained in different compartments of the early
secretory pathway. Traffic 5: 993-1005 |
| 6.
|
Giebing
G, Tölle M, Jürgensen J, Eichhorst J, Furkert J, Beyermann
M, Neuschäfer-Rube F, Rosenthal W, Zidek W, van der Giet
M, Oksche A (2005) Arrestin-independent internalization and recycling
of the urotensin receptor contribute to long-lasting urotensin
II-mediated vasoconstriction. Circ Res 97: 707-715 |
top
|