|
Project
8 - Harm Peters |
| |
|
| Date
of Birth: |
01
December 1960 |
| Nationality:
|
German |
| |
|
| EDUCATION: |
|
| 1980-1988 |
Medical
School; Free University of Berlin |
1997
|
Internal
Medicine Degree |
| 2000 |
Assistant
Professor status (Priv.-Doz.) |
| 2004 |
Nephrology
Degree |
| 2005 |
Professor
of Medicine status |
| |
|
| PROFESSIONAL
EXPERIENCE: |
|
| 1989-1992 |
Resident
physician, Department of Endocrinology, Free University Berlin |
| 1993-1995 |
Resident
physician, Department of Nephrology, Free University Berlin |
1995-1997
|
Research
Fellow, Fibrosis Research Laboratory, Salt Lake City, USA (Prof.
Wayne A. Border, Prof. Nancy A. Noble) |
| since
1997 |
Assistant
Medical Director, Department of Nephrology, Charité, Humboldt
University Berlin |
| 1997-2003 |
Group
leader “Fibrosis Research”, Charité, Campus
Mitte, Humboldt University Berlin |
| since
2003 |
Group
leader “Fibrosis Research”, Center for Cardiovascular
Research, Charité, Universitätsmedizin Berlin, Campus
Mitte |
| |
|
| RESEARCH
INTERESTS: |
- Proteinuria and renal progression
- TGF-ß as main mediator and target in renal fibrosis
- L-Arginine-Nitric Oxide-cGMP- pathway in renal disease
- Anti-fibrotic potential of soluble guanylate cyclase activation
and stimulation
- Sphingolipids in acute and chronic renal matrix expansion
- Non-renal cells as mediators of renal fibrosis
- Cardiovascular consequences of moderate renal insufficiency
- Mechanisms of renal cachexia
|
|
TOP TEN PUBLICATIONS: |
|
| 1.
|
H.
Peters, W.A. Border, N.A. Noble. Targeting transforming growth
factor-ß overexpression in renal disease: Maximizing the
antifibrotic action of angiotensin II blockade.
Kidney Int 54: 1570-1580 (1998).
|
| 2.
|
H.
Peters, W.A. Border, M. Rückert, S. Krämer, H.-H. Neumayer,
N.A. Noble. L-Arginine supplementation accelerates renal fibrosis
and shortens life span in experimental lupus nephritis.
Kidney Int 63:1382-92 (2003).
|
| 3.
|
H.
Peters, S. Martini, R. Woydt, M. Rückert, F. Shimizu, H.
Kawachi, L. Liefeldt, S. Krämer, H.-H. Neumayer. Moderate
alcohol intake has no impact on acute and chronic-progressive
anti-thy1 glomerulonephritis.
Am J Physiol: Renal Physiol 284:F1105-14 (2003).
|
| 4. |
H.
Peters, U. Daig, M. Rückert, F. Schäper, L. Liefeldt,
S. Krämer H.-H. Neumayer. NO mediates the antifibrotic action
of L-arginine supplementation in acute anti-thy1 glomerulonephritis.
Kidney Int 64: 509-518 (2003).
|
| 5.
|
H.
Peters, R. Eisenberg, U. Daig, J. Gaedeke, L. Liefeldt, S. Krämer,
H.-H. Neumayer. Platelet inhibition limits TGF-ß overexpression
and matrix expansion following induction of anti-thy1 glomerulonephritis.
Kidney In 65: 2238-48 (2004).
|
| 6.
|
H.
Peters, S. Martini, Y. Wang, F. Shimizu, H. Kawachi, S. Krämer,
H.-H. Neumayer. Selective lymphocyte inhibition by FTY720 slows
the progressive course of chronic anti-thy1 glomerulosclerosis.
Kidney Int 66: 1434-43 (2004).
|
| 7.
|
H. Peters, S. Martini, Y. Wang, F. Shimizu, H. Kawachi, S. Krämer,
H.-H. Neumayer. Selective lymphocyte inhibition by FTY720 slows
the progressive course of chronic anti-thy1 glomerulosclerosis.
Kidney Int 66: 1434-43 (2004).
|
| 8. |
H. Peters, Y. Wang, T. Loof, S. Martini, S. Kron, S. Krämer
and H.-H. Neumayer. Expression and activity of soluble guanylate
cyclase in injury and repair of anti-thy1 glomerulonephritis.
Kidney Int, 66: 2224-36 (2004).
|
| 9. |
S. Krämer, L. Loof, S. Martini, M. Rückert, Y. Wang,
F. Shimizu, T. Böhler, H. Kawachi, H.-H. Neumayer, H. Peters.
Mycophenolate mofetil slows progression in anti-thy1-induced chronic
renal fibrosis, but is not additive to a high dose of enalapril.
Am J Physiol: Renal Physiol, 289:F359-368 (2005). |
| 10.
|
J.
Gaedeke, H. Peters. Relaxin: Exploring the anti-fibrotic potential
of a pregnancy hormone.
Kidney Int 68: 405-406 (2005).
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