| Project
3 - Enno Klußmann |
| |
|
| Date
of Birth: |
16
February 1964 |
| Nationality:
|
German |
| |
|
| EDUCATION: |
|
| 10/85
- 08/88 |
Study
of Genetics, University of London, Queen Mary College, England
degree: Bachelor of Science
|
| 10/88
- 04/92 |
Study
of Biology, Philipps-University Marburg, Germany
degree: Diploma
Zoology, microbiology, biochemistry, molecular genetics Title
of Diploma thesis: Isolation and characterization of monoclonal
antibodies against the mitochondrially encoded subunits of cytochrome
c oxidase
|
| 07/92
- 09/96 |
Ph.
D.: Department of Gastroenterology, Charité - University
Medicine, Free University and Humboldt University Berlin, Campus
Benjamin Franklin, Germany. Group of Prof. Dr. C. Hanski: Expression
of the colon carcinoma-associated antigen sialyl-Lewisx and gene
expression differences between normal and malignant colon mucosa |
| 06/05
|
Habilitation
in Pharmacology and Toxicology, Charité - University Medicine,
Free University and Humboldt University Berlin, Germany: A kinase
anchoring proteins and the small GTPase RhoA are involved in the
vasopressin-meditated translocation of aquaporin-2 into the plasma
membrane of renal principal cells |
PROFESSIONAL
EXPERIENCE:
|
|
| 10/96
- 12/96 |
Charité
- University Medicine, Free University and Humboldt University Berlin,
Campus Benjamin Franklin, Germany
Department of Gastroenterology, Group of Prof. Dr. C. Hanski: Identification
of gene expression differences between mucinous and non mucinous
colon carcinoma
|
| 01/97
- 07/97 |
Institute
of Pharmacology, Group of Prof. Dr. G. Schultz: Search for membrane-associated
steroid hormone receptors
|
| 08/97
- 10/01 |
Research
Institute for Molecular Pharmacology, Berlin and Charité
– University Medicine, Germany. Group of Prof. Dr. W. Rosenthal:
Molecular mechanisms controlling vasopressin-mediated water reabsorption |
| 11/01
- dato |
Group
leader: Research Institute for Molecular Pharmacology, Berlin,
and Institute of Pharmacology, Charité - University Medicine,
Free Uni-versity and Humboldt University Berlin, Campus Benjamin
Franklin, Germany. Head of Anchored Signalling Group: A kinase
anchoring proteins and small GTPases of the Rho family in exocytic
processes and cardiac myocyte contraction |
| |
|
| RESEARCH
INTERESTS: |
AQP2 shuttle vesicular transport
A-kinase anchoring proteins (AKAPs)
PKA anchoring disruption
|
|
TOP TEN PUBLICATIONS: |
|
| 1.
|
Klussmann,
E., Maric, K., Wiesner, B., Beyermann, M., and Rosenthal, W. Protein
kinase A anchoring proteins are required for vasopressin-mediated
translocation of aq-uaporin-2 into cell membranes of renal principal
cells. J. Biol. Chem. 274, 4934-4938, 1999.
|
| 2.
|
Klussmann,
E., Maric, K., and Rosenthal, W. The mechanisms of aquaporin control
in the renal collecting duct. Rev. Physiol. Biochem. Pharmacol.
141, 33-95, 2000. |
| 3.
|
Klussmann,
E., Tamma, G., Lorenz, D., Wiesner, B., Maric, K., Hofmann, F.,
Akto-ries, K., Valenti, G., and Rosenthal, W. An inhibitory role
of Rho in the vasopressin-mediated translocation of aquaporin-2
into cell membranes of renal principal cells. J. Biol. Chem. 276,
20451-20457, 2001. |
| 4. |
Klussmann,
E. and Rosenthal W. The role and identification of protein kinase
A an-choring proteins in vasopressin-mediated aquaporin-2 translocation.
Kidney Int. 60, 446-449, 2001. |
| 5.
|
Tamma,
G., Klussmann, E., Procino, G., Svelto, M., Rosenthal, W., and
Valenti, G. cAMP-induced AQP2 translocation is associated with
RhoA inhibition through RhoA phos-phorylation and interaction
with RhoGDI. J. Cell Sci., 116, 1519-1525, 2003. |
| 6.
|
Tamma,
G., Wiesner, B., Furkert, J., Oksche, A., Schaefer, M., Valenti,
G., Rosen-thal, W., and Klussmann, E. The prostaglandin E2 analogue
sulprostone antagonizes vaso-pressin-induced antidiuresis through
activation of Rho. J. Cell Sci., 116, 3285-3294, 2003. |
| 7.
|
Henn,
V., Edemir, B., Stefan, E., Wiesner, B., Lorenz, D., Theilig,
F., Schmitt, R., Vossebein, L., Tamma, G., Beyermann, M., Krause,
E., Herberg. F. W., Valenti, G., Bach-mann, S., Rosenthal, W.,
and Klussmann, E. Identification of a novel A-kinase anchoring
protein 18 isoform and evidence for its role in the vasopressin-induced
aquaporin-2 shuttle in renal principal cells. J. Biol. Chem. 279,
26654-26665, 2004. |
| 8. |
Tamma,
G, Klussmann, E., Oehlke, J., Krause, E., Rosenthal, W., Svelto,
M., and Valenti, G. Actin remodelling requires ERM function to
facilitate AQP2 apical targeting. J. Cell Science, 118, 3623-3630,
2005. |
| 9. |
Henn,
V., Stefan, E., Baillie, G. S., Houslay, M., D., Rosenthal, W.,
and Klussmann, E. Compartmentalised cAMP signalling regulates
vasopressin-mediated water reabsorption by controlling aquaporin-2,
Biochem. Soc. Trans. 33, 1316-1318, 2005. |
| 10. |
McSorley,
T., Henn,. V., Stefan, E., Baillie, G. S., Houslay, M. D., Rosenthal,
W., and Klussmann, E. Spatial organisation of AKAP18 and PDE4
isoforms in renal collecting duct principal cells. Eur. J. Cell
Biol., in press. |
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