| Project
7 - Thomas Jentsch |
| |
|
| Date
of Birth: |
24
April 1953 |
| Nationality:
|
German
|
| |
|
| EDUCATION: |
|
| 1972-1978 |
Study
of medicine at the Free University of Berlin (FUB) |
| 1974-1980 |
Study
of physics at the Free University of Berlin |
| 1982 |
Ph.D.
in physics (thesis on field ionization (surface physics), at the
Fritz-Haber-Institute (Max-Planck-Institute) Berlin; thesis adviser:
Prof. Block) |
| 1984 |
M.D.
(thesis on pHi-regulating processes, at the Institut für
Klinische Physiologie, FUB; thesis adviser: Prof. Wiederholt) |
| 1991 |
"Habilitation"
in Cell Biochemistry at the Medical School of Hamburg University |
PROFESSIONAL
EXPERIENCE:
|
|
| 1981-1985 |
Staff
scientist with Michael Wiederholt at the Institut für Klinische
Physiologie, FUB |
| 1986-1988 |
Postdoctoral
fellow with Harvey Lodish at the Whitehead Institute (MIT), Cambridge
MA |
| 1988-1993 |
Research
group leader at the Centre for Molecular Neurobiology Hamburg
(ZMNH), Hamburg University (roughly equivalent to assistant professor
in the US) |
| 1993 |
Full
professor (C4) of Molecular Neuropathology at the ZMNH, Hamburg
University; Director of the Institut für Molekulare Neuropathobiologie |
1995-1998
and
2001-2003 |
Director
of the Center for Molecular Neurobiology Hamburg (ZMNH) |
| since
1993 |
Director
of the Institute for Molecular Neuropathologie |
| RESEARCH
INTERESTS: |
|
| |
Ion transport processes, in particular CLC chloride channels and
transporters, KCNQ K channels and KCC K-Cl cotransporters; biophysics;
physiology; neurobiology; renal transport processes; KO and transgenic
mouse models; ion channel diseases, human genetics
|
| HONORS/AWARDS:
|
|
| 1992 |
Wilhelm-Vaillant-Preis
(for medical research) |
| 1995 |
Leibniz-Preis
of the DFG (highest German research award |
| 1998 |
Alfred
Hauptmann Preis (for research on epilepsy); Franz Volhard Preis
(for research in nephrology)
|
| 1999 |
Zülch-Preis
for research in neurology (awarded by the Max-Planck-Society) |
| 2000 |
Feldberg
Prize (awarded by Foundation for Anglo-German Science)
Familie Hansen Preis
Prix Louis-Jeantet de médecine
Elected Member of the Academia Europaea (European Academy of Sciences)
Elected Member of EMBO (European Molecular Biology Organization)
|
| 2001 |
Ernst
Jung-Preis für Medizin
Elected Member of the Berlin-Brandenburg Academy of Sciences and
Humanities
FEPS Lecture (Federation of European Physiological Societies)
|
| 2003 |
'Berliner
Professorship' (lecture) at Yale University
'Rainer Greger' lecture at the World Congress of Nephrology, Berlin
|
| 2004 |
'Gottschalk
Lecture', Experimental Biology, Washington DC
Adolf-Fick-Prize for Physiology/Biophysics
Elected member of the Deutsche Akademie der Naturforscher Leopoldina
Homer W. Smith Award of the American Society of Nephrology
|
| 2005 |
Elected
member of the Hamburg Academy of Sciences |
|
TOP PUBLICATIONS: |
|
| 1.
|
Lloyd
S.E., Pearce S.H.S., Fisher S.E., Steinmeyer K., Schwappach B.,
Scheinman S.S., Harding B., Bolino M., Devoto M., Goodyer P.,
Rigden S.P.A., Wrong O., Jentsch T.J., Craig I.W., Thakker R.V.
(1996). A common molecular basis for three inherited kidney stone
diseases. Nature 379: 445-449.
|
| 2.
|
Ludewig
U., Pusch M., Jentsch T.J. (1996). Two physically distinct pores
in the dimeric ClC-0 chloride channel. Nature 383: 340-343. |
| 3. |
Günther W., Lüchow A., Cluzeaud F., Vandewalle A., Jentsch
T.J. (1998). ClC-5, the chloride channel mutated in Dent's disease,
co-localizes with the proton pump in endocytotically active kidney
cells. Proc. Natl. Acad. Sci. U.S.A. 95: 8075-8080. |
| 4. |
Piwon
N., Günther W., Schwake M., Bösl M.R., Jentsch T.J.
(2000). ClC-5 Cl--channel disruption impairs endocytosis in a
mouse model for Dent’s disease. Nature 408: 369-373. |
| 5.
|
Kornak
U., Kasper D., Bösl M.R., Kaiser E., Schweizer M., Schulz
A., Friedrich W., Delling G., Jentsch T.J. (2001). Loss of the
ClC-7 chloride channel leads to osteopetrosis in mice and man.
Cell 104: 205-215. |
| 6.
|
Stobrawa
S.M., Breiderhoff T., Takamori, S., Engel D., Schweizer M., Zdebik
A.A., Bösl M.R., Ruether K., Jahn H., Draguhn A., Jahn R.,
Jentsch T.J. (2001). Disruption of ClC-3, a chloride channel expressed
on synaptic vesicles, leads to a loss of the hippocampus. Neuron
29: 185-196. |
| 7. |
Estévez
R., Boettger T., Stein V., Birkenhäger R., Otto E., Hildebrandt
F., Jentsch T.J. (2001). Barttin is a Cl- channel b-subunit crucial
for renal Cl- reabsorption and inner ear K+ secretion. Nature
414: 558-561. |
| 8. |
Schwake
M., Friedrich T., Jentsch T.J. (2001). An internalization signal
in ClC-5, an endosomal Cl--channel mutated in Dent’s disease.
J. Biol. Chem. 276, 12049-12054. |
| 9. |
Boettger
T., Hübner C.A., Maier H., Rust M., Beck F.X., Jentsch T.J.
(2002). Deafness and renal tubular acidosis in mice lacking the
K-Cl co-transporter KCC4. Nature 416: 874-878. |
| 10. |
Estévez
R., Schroeder B.C., Accardi A., Jentsch T.J., Pusch M. (2003).
Conservation of chloride channel structure revealed by an inhibitor
binding site in ClC-1. Neuron 38: 47-59. |
| 11.
|
Günther
W., Piwon N., Jentsch T.J. (2003). The ClC-5 chloride channel
knock-out mouse - an animal model for Dent's disease. Pflügers
Arch., 445, 456-462. |
| 12.
|
Kasper
D., Planells-Cases R., Fuhrmann J.C., Scheel O., Zeitz O., Ruether
K., Schmitt A., Poët M., Steinfeld R., Schweizer M., Kornak
U., Jentsch T.J. (2005). Loss of the chloride channel ClC-7 leads
to lysosomal storage disease and neurodegeneration. EMBO J. 24:
1079-1091. |
| 13. |
Scheel
O., Zdebik A.A., Lourdel S., Jentsch T.J. (2005). Voltage-dependent
electrogenic chloride-proton exchange by endosomal CLC proteins.
Nature, 436: 424-427. |
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