| Project
4 - Kai Martin Schmidt-Ott |
| |
|
| Date
of Birth: |
3
April 1972 |
| Nationality:
|
German |
| |
|
| EDUCATION: |
|
| 1992-2000 |
Medical
School, Free University of Berlin, Germany |
| 1996-2002 |
Doctoral
Thesis: “Endothelin-dependent morphological transformation
of astrocytes under hypoxia” (Honors: Summa cum laude)
Department of Clinical Pharmacology and Toxicology, Free University
of Berlin, Germany
Principal Investigator Prof. Martin Paul |
PROFESSIONAL
EXPERIENCE:
|
|
| 2003-2005 |
Emmy
Noether Fellow, Department of Nephrology, College of Physicians
and Surgeons, Columbia University, New York, NY (Principal Investigator
Prof. Jonathan Barasch) |
| 2005-2007 |
Research
Associate, Department of Nephrology, College of Physicians and Surgeons,
Columbia University, New York, NY (Principal Investigator Prof.
Jonathan Barasch)
|
| Since
06/2007 |
Emmy
Noether Junior Group Leader, Max-Delbrück Center for Molecular
Medicine, Berlin, Germany |
| From
2009 |
Junior
Professor of Molecular Medicine, Charité Berlin, Medical
Faculty of Humboldt University, Berlin, Germany |
| |
|
| RESEARCH
INTERESTS: |
Developmental
biology, cell biology, nephrology
|
|
SELECTED
PUBLICATIONS: |
|
| 1.
|
Schmidt-Ott
KM. Nephrologists Sans Frontieres: The art and science of branching.
Kidney Int. 2006; 69(11):1921-3. |
| 2.
|
Schmidt-Ott
KM, Chen X, Paragas N, Levinson RS, Mendelsohn CL, Barasch J.
c-kit Delineates a Distinct Domain of Progenitors in the Developing
Kidney. Dev Biol. 2006; 299(1):238-49. |
| 3.
|
Sanna-Cherchi S, Caridi G, Weng PL, Dagnino M, Seri M, Konka A,
Somenzi D, Carrea A, Izzi C, Casu D, Allegri L, Schmidt-Ott KM,
Barasch J, Scolari F, Ravazzolo R, Ghiggeri GM, Gharavi AG. Localization
of a Gene for Nonsyndromic Renal Hypodysplasia to Chromosome 1p32-33.
Am J Hum Genet. 2007;80(3):539-49. |
| 4. |
Schmidt-Ott
KM, Mori K, Li JY, Kalandadze A, Devarajan P, Barasch J. Dual
action of neutrophil gelatinase-associated lipocalin (NGAL). J
Am Soc Nephrol. 2007; 18(2):407-13. |
| 5.
|
Schmidt-Ott
KM, Masckauchan TN, Chen X, Hirsh BJ, Sarkar A, Yang J, Paragas
N, Wallace VA, Dufort D, Pavlidis P, Jagla B, Kitajewski J, Barasch
J. ß-catenin/TCF/Lef controls a differentiation-associated
transcriptional program in renal epithelial progenitors. Development.
2007;134(17):3177-90. |
| 6.
|
Metsuyanim
S, Pode-Shakked N, Schmidt-Ott KM, Keshet G, Rechavi G, Blumental
D, Dekel B. Accumulation of Malignant Renal Stem Cells is Associated
with Epigenetic Changes in Normal Renal Progenitor Genes. Stem
Cells 2008, 26:1808-17. |
| 7.
|
Schmidt-Ott
KM. Unraveling the Role of Connective Tissue Growth Factor in
Diabetic Nephropathy. Kidney Int. 2008;73(4):375-6. |
| 8. |
Schmidt-Ott
KM, Barasch J. WNT/ß-catenin signaling in nephron progenitors
and their epithelial progeny. Kidney Int. 2008;74(8):1004-8. |
| 9. |
Li
JY, Paragas N, Ned RM, Qiu A, Viltard M, Leete T, Drexler IR,
Chen X, Sanna-Cherchi S, Mohammed F, Williams D, Lin CS, Schmidt-Ott
KM, Andrews NC, Barasch J. Scara5 is a ferritin receptor mediating
non-transferrin iron delivery. Dev Cell. 2009;16(1):35-46. |
| 10.
|
Marlier A, Schmidt-Ott KM, Gallagher AR, Barasch J, Karihaloo
A. Vegf as an epithelial cell morphogen modulates branching morphogenesis
of embryonic kidney by directly acting on the ureteric bud. Mech
Dev. 2009. In press. |
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