| Project
2 - Sebastian Bachmann |
| |
|
| Date
of Birth: |
15
June 1950 |
| Nationality:
|
German |
| |
|
| EDUCATION: |
|
| 1970-1978 |
Biology at
the University of Kiel (1970-1972), and University of Salzburg (1972-1978) |
| 1979 |
Doctorate:
Biology (24.1.1979)
Dissertation:
„Die Feinstruktur des Axialkomplexes beim Seeigel (Sphaerechinus
granularis)“
|
PROFESSIONAL
EXPERIENCE:
|
|
| 1/1979-5/1980 |
Postdoctoral
fellow at the Department of Zoology, University of Salzburg |
| 1.6.1980 |
Assistant master
at the Department of Anatomy and Zoology, University of Heidelberg,
Head: Prof. Dr. W. Kriz |
| 1987 |
Postdoctoral
research stay at the Necker Children Hospital, Paris, Department
of Nephrology, INSERM; Head: Dr. Lise Bankir |
| From automn
1987-1995 |
Habilitation
(Ph.D. thesis) in the Department of Anatomy in Heidelberg, Head:
Prof. Dr. W. Kriz, as an assistant professor; activities in student’s
education and research |
| 1.8.1995 |
Professor
(tenure) C3 for Anatomy and Cell Biology at the Department of
Anatomy of the Humboldt University, Charité, Berlin, Germany |
| 6.1998 |
Full
professor and chairman of Anatomy and Cell Biology at the Department
of Anatomy of the Humboldt University, Charité, Berlin,
Germany |
| RESEARCH
INTERESTS: |
Kidney-oriented research in Anatomy and Cell Biology.
Main subjects: animal experiments, animal models, hypertension,
mediators, juxtaglomerular apparatus, tubular transport
|
|
TOP TEN PUBLICATIONS: |
|
| 1.
|
Theilig
F, Câmpean V, Paliege A, Breyer M, Briggs JP, Schnermann
J, Bachmann S: Epithelial COX-2 expression is not regulated by
NO: Colocalization studies in rat and mouse renal cortex. Hypertension
39: 848-853, 2002 |
| 2.
|
Schmitt
R, Ellison DH, Klussmann E, Bachmann S: Renal expression of sodium
transporters and aquaporin-2 in hypothyroid rats. Am J Physiol
284: F1097-F1104, 2003 |
| 3.
|
Câmpean
V, Theilig F, Paliege A, Breyer M, Bachmann S: Key enzymes for
renal prostaglandin synthesis: site-specific expression in rodent
kidney (rat, mouse). Am J Physiol 285: F19-F32, 2003 |
| 4. |
Bachmann
S, Schlichting U, Geist B, Mutig K, Petsch T, Bacic D, Wagner
CA, Kaissling B, Biber J, Murer H, Willnow T: Kidney-specific
inactivation of the megalin gene impairs trafficking of renal
inorganic sodium phosphate-cotransporter (NaPi-IIa). J Am Soc
Nephrol 15(4):892-900, 2004 |
| 5.
|
Henn
V, Edemir B, Stefan E, Wiesner B, Lorenz D, Theilig F, Schmitt
R, Vossebein L, Tamma G, Beyermann M, Krause E, Herberg FW, Valenti
G, Bachmann S, Rosenthal W, Klussmann E: Identification of a novel
A-kinase anchoring protein 18 isoform and evidence for its role
in the vasopressin-induced aquaporin-2 shuttle in renal principal
cells. J Biol Chem 279(25):26654-26665, 2004 |
| 6.
|
Paliege
A, Mizel D, Medina C, Pasumarthy A, Huang YG, Bachmann S, Briggs
JP, Schnermann JB, Yang T: Inhibition of nNOS expression in the
macula densa by COX-2 derived prostaglandin E2. Am J Physiol 287:F152-F159,
2004 |
| 7.
|
Jürgensen
JS, Rosenberger C, Wiesener MS, Warnecke C, Hörstrup JH,
Gräfe M, Philipp S, Griethe W, Maxwell PH, Frei U, MD; Bachmann
S, Willenbrock R, Eckardt KU: Persistent induction of HIF-1alpha
and -2alpha in cardiomyocytes and stromal cellsof ischemic myocardium.
FASEB J 18(12): 1415-1417, 2004
|
| 8. |
Rosenberger
C, Heyman SN, Rosen S, Shina A, Goldfarb M, Griethe W, Frei U,
Reinke P. Bachmann S, Eckardt KU: Upregulation of HIF in experimental
acute renal failure – evidence for a protective transcriptional
response to hypoxia. Kidney Int 67: 531-542, 2005
|
| 9. |
Bachmann
S, Mutig K, Bates J, Welker P, Gross V, Luft FC, Alenina N, Bader
M, Thiele BJ, Prasadan K, Raffi HS, Kumar S: Renal effects of
Tamm Horsfall protein (uromodulin) deficiency in mice. Am J Physiol
288(3): F559-F567, 2005 |
| 10.
|
Paliege
A, Parsumathy A, Mizel D, Yang T, Schnermann J, Bachmann S: Effect
of apocynin treatment on renal expression of COX-2, NOS1, and
renin in Wistar-Kyoto and spontaneously hypertensive rats. Am
J Physiol 290: 2006 , in press
|
top
|