15.01.2013

Kennziffer: DM.06.13

Bewerbungsfrist: 29.01.2013

1 PhD Student DM.06.13

for research on metabolism and action of novel thyroid hormones and their metabolites such as thyronamines and thyroacetic acids. Thyroid hormones are key regulators of energy metabolism, growth, and development, with major influence on maintenance of body weight. Impact of thyroid hormones and their novel metabolites on obesity and energy metabolism is of high current interest in molecular and cellular endocrinology. The project is also linked to the recently prolonged DFG Clinical Research Group KFO218-2 and the DFG graduate programme GK1208, both focussing on energy metabolism and body weight control in the well funded interdisciplinary Institute of Experimental Endocrinology at Charité, Berlin. References: (http://www.charite.de/exp-endo) Hoefig CS et al. Evidence for extrathyroidal formation of 3-Iodothyronamine in humans as provided by a novel monoclonal antibody-based chemiluminescent serum immunoassay. JCEM 2011; 96:1864; Piehl S et al. J. Thyronamines - Past, Present, and Future. Endocr Rev 2011;32:64-80; Brix K et al. Molecules important for thyroid hormone synthesis and action - known facts and future perspectives. Thyroid Res 2011; 4 Suppl 1:S9 Charité is a certified equal opportunity employer.

Stellenbeschreibung

Centrum - Einrichtung - Abteilung:

CC 4: Therapieforschung

Institute of Experimental Endocrinology, CC4

Dienstart:

Wissenschaftliche(r) Mitarbeiter/in

Aufgabengebiet:

The PhD student will work on the project “Effects of thyronamines and thyroacetic acid metabolites on energy metabolism – mitochondrial function, Ca2+-signalling, plasma membrane action.” This topic includes molecular, cellular, bioenergetic, signal transduction as well as analytical aspects mainly employing cell culture models and ex vivo analyses from rodent tissues.

Voraussetzungen:

  • Candidates are highly motivated PhD students with strong interest and experience in endocrine, metabolic, cellular or molecular research and analytics of thyroid hormones and their metabolites. Sound scientific knowledge, flexibility, and team orientation are of advantage.

Einstellungstermin:

ab sofort

Dauer der Beschäftigung:

for 3 years

Arbeitszeit:

65%

Vergütung:

TV-Charité, E13

Bewerbungsanschrift:

The positions are available as from now, but later starting dates are possible.

Please apply by submitting your cover letter, summary of research experience, CV, and names of 2 references, preferably by e-mail as a single pdf-file, to

Prof. Dr. Josef Köhrle: josef.koehrle@charite.de or his secretariate expendo@charite.de

Nachfragen / Kontakt:

Prof. Dr. Josef Köhrle: josef.koehrle@charite.de or his secretariate expendo(at)charite.de




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