Projects

Visit our Webgalery of posters (in pdf Format) to check out projects (don't bother if you are connected with a slow modem!):

• Cell cycle dysregulation in stroke
• NO and cerebrovascular coupling
• Corticosterone attenuates apoptotic neuronal cell death
• DNA repair in cerebral ischemia
• Endogenous neuroprotection by erythropoietin
• Neuroprotection by gelsolin
• HIF1alpha mediated neuroprotective cascades
• Optical imaging of neurovascular coupling
• iNOS mediates preconditioning by volatile anesthetics
• Meningitis
• Migraine
• Mouse behavior
• Neurogenesis
• Quinonreductase and neuronal cell death
• Serial analysis of gene expression (SAGE)
• Stroke induced immunodepression (SIDS)
• Spreading ischemia
• Statins and cerebral blood flow in man
• Withdrawal of statins: consequences for brain protection
• Neuroprotection by Statins in vitro

or check out papers typical for the projects pursued in our department (pdf format):

Cerebral ischemia

• Overview on mechanisms of damage
• Influence of blood pressure on infarct size
• DNA Methylation and stroke
• Screening of gene expression in cerebral ischemia
• Statins and stroke I
• Statins and stroke II
• Statins and stroke III
• Cerebral ischemia and cell cycle regulation
• Cytoskeleton and cerebral ischemia
• Hypoxia/ischemia and the proteasome

Coupling of cerebral blood flow and metabolism

• Optical imaging of cortical activation
• Physical model for optical imaging
• Role of the bioradical NO in coupling
• Nitric oxide from perivascular nerves modulates cerebral arterial pH reactivity

Bone marrow derived cells in the brain

• Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo
• Targeting gene-modified hematopoietic cells to the central nervous system
• Pericytes and bone marrow derived cells

Meningitis

• Autocrine loop of TNF alpha in meninigitis
• AIP and neuronal apoptosis in meninigitis
• Pneumolysin and H2O2 mediate apoptosis in meningitis

Mechanisms of damage: apoptosis vs necrosis!

• Melatonin neuroprotection
• Estradiol neuroprotection

Mechanisms of migraine

• iNOS and migraine pathophysiology
• Intrinsic brain activity and migraine

Preconditioning against cerebral ischemia: Endogenous neuroprotection!

• Overview on preconditioning
• Preconditioning in vitro I
• Preconditioning in vitro II
• HIF/EPO and paracrine preconditioning
• Pharmacological preconditioning with DFX
• Preconditioning with volatile anesthetics
• Preconditioning: a clinical reality?

Subarachnoid hemorrhage: Mechanisms of delayed vasospasm

• Delayed vasospasm explained?
• Focal abnormalities after SAH in MR
• Endothelin and migrainous aura

for a more recent and comprehensive list of puplications, click here.