GRK 1123:

Cellular Mechanisms of Learning and Memory Consolidation in the Hippocampal Formation

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This Research Training Group is funded by the German Research Council DFG

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©2006, FU Berlin
GRK 1123

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Jakob Gutzmann Address: Zentrum für Molekulare Neurobiologie Hamburg (ZMNH) Institute for Molecular and Cellular Cognition (IMCC) Falkenried 94 D-20251 Hamburg Tel +49 (40) 741055075 Fax +49 (40) 741055101 mailto: jakob.gutzmann@zmnh.uni-hamburg.de

PhD-Project "Identifying novel Arg3.1 interaction partners" Synopsis The immediate early gene Arg3.1 is highly and transiently expressed after neuronal activity and its mRNA is actively transported into dendrites and synapses of neurons with a recent history of activity. Experiments with Arg3.1 knockout mice demonstrate that Arg3.1 is crucial for the consolidation of long-term memories in a variety of behavioural paradigms (Plath et al., 2006). Although some interaction partners of the Arg3.1 protein have been described, these interactions fail to explain the full range of deficits observed in the Arg3.1 knockout mice on a molecular and mechanistic level. The aim of my PhD-project is to identify and to further characterize novel interaction partners of Arg3.1 by Tandem-Affinity-Purification and Yeast-Two-Hybrid analysis. Supervisor Prof. Dr. Dietmar Kuhl MSc Degree (Diploma) “Characterization of the activity regulated gene SorCS1” Freie Universität Berlin (supervisors: Prof. Dr. Dietmar Kuhl and PD Dr. Guido Hermey)