GRK 1123:

Cellular Mechanisms of Learning and Memory Consolidation in the Hippocampal Formation

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This Research Training Group is funded by the German Research Council DFG

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©2006, FU Berlin
GRK 1123

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Benjamin Rost Address: Charité Universitätsmedizin Berlin Neuroscience Research Center AG Schmitz Charitéplatz 1 10117 Berlin Tel: +49-(30) 450-639063 Fax: +49-(30)-450 539943 mailto: benjamin.rost@charite.de

PhD-Project " Mechanisms of presynaptic inhibition on hippocampal neurons" Synopsis Neurotransmitter release from presynaptic terminals is under tight control of various metabotropic receptors. The common model for presynaptic inhibition is a G-protein dependent inhibition of voltage gated calcium channels. The aim of my PhD project is to investigate whether and to what extent other signaling pathways contribute to the inhibition of neurotransmitter release. I use whole cell patch clamp recordings in both acute hippocampal slice preparations as well neuronal cell cultures to study presynaptic inhibition by the metabotropic GABAB receptor on glutamatergic synapses. Supervisor Prof. Dr. Dietmar Schmitz MSc Degree (Diploma) "The role of TRPC6 in physiological and pathophysiological processes of the respiratory system" Philipps-University Marburg, Germany (supervisor: PD Dr. Alexander Dietrich)