GRK 1123:

Cellular Mechanisms of Learning and Memory Consolidation in the Hippocampal Formation

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This Research Training Group is funded by the German Research Council DFG

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©2006, FU Berlin
GRK 1123

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Arndt Pechstein Address: Freie Universitaet Berlin Institute for Chemistry and Biochemistry Takustrasse 6 D-14195 Berlin Tel +49 (30) 838-56931 Fax +49 (30) 838-56908 mailto: arndtp@chemie.fu-berlin.de

PhD-Project "Activity-dependent regulation of pre- and postsynaptic membrane transport events" Synopsis Selective modifications in synaptic efficacy assure that animals continually adapt their behavior in response to changes in their environment. Long-term potentiation (LTP) serves as a cellular model of synaptic plasticity. Within the scope of my PhD project the dependency of clathrin-mediated endocytosis on such plasticity phenomena are to be investigated. At the synapse phosphatidyl inositol (4,5)-bisphosphate (PIP2) is implicated in the assembly of the clathrin/ AP2 machinery. I intend to elucidate the regulation of enzymatic activity of the phosphatase synaptojanin 1 - the main PIP2-degrading enzyme- and therefore the regulation of PIP2 metabolism upon stimulation. At the post-synapse the dynamic redistribution of AMPA-type glutamate receptors (AMPARs) is an important mechanism for long-lasting synaptic modifications. To understand how the internalization of AMPAR subunits via clathrin-mediated endocytosis is regulated is the second aim within this PhD project. Supervisor Prof. Dr. Volker Haucke MSc Degree "Investigation of the interaction between the PPIase FKBP38 and the anti-apoptotic protein Bcl-2" Max-Planck Research Unit "Enzymology of Protein Folding" (supervisor: Gunter Fischer)