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Freie Universität Berlin Charité University Medicine Berlin Humboldt University Berlin Max-Delbrück-Center for Molecular Medicine, Berlin-Buch |
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Freie Universität Berlin Charité University Medicine Berlin Humboldt University Berlin Max-Delbrück-Center for Molecular Medicine, Berlin-Buch |
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GRK 1123: |
Cellular Mechanisms of Learning and Memory Consolidation |
This Research Training Group is funded by the German Research Council DFG
| Anna Soriguera i Farrés Address: Charité Universitätsmedizin Berlin (CCM) Institute for Cell Biology and Neurobiology Molecular Neurobiology Research Group Philippstr. 12 D-10115 Berlin Tel +49 (30) 450-528031 |
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| PhD-Project "Analysis of the PRG-1 signaling cascade" Synopsis
Plasticity-related gene-1 (PRG-1) is the first member of the plasticity-related gene family (PRG-1-4) to have been identified. PRG-1 is brain specific, has six transmembrane domains and intercellularly located N- and C-terminus. Interestingly, it has been established that an up regulation occurs during regeneration after brain lesion. Overexpression of PRG-1 also protects against neurite retraction induced by LPA by means of an as yet unknown mechanism. To establish which pathway PRG-1 regulates, we performed studies to find out with which proteins is PRG-1 interacting. One of the putative interaction partners identified was the Ras-specific exchange factor 2 protein (Ras GRF-2). Ras GRF-2 belongs to a family of calcium/calmodulin-regulated guanine nucleotide exchange factors, it is widely expressed and predominantly present in the CNS, where is expressed in many neuronal cell types but not in glial cells, and activates Ras proteins. My project consists not only of studying the interaction between PRG-1 and Ras GRF-2 but also of analysing the functional consequences of this protein-protein interaction regarding axonal growth, dendritic branching and synaptogenesis.
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