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Freie Universität Berlin Charité University Medicine Berlin Humboldt University Berlin Max-Delbrück-Center for Molecular Medicine, Berlin-Buch |
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Freie Universität Berlin Charité University Medicine Berlin Humboldt University Berlin Max-Delbrück-Center for Molecular Medicine, Berlin-Buch |
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GRK 1123: |
Cellular Mechanisms of Learning and Memory Consolidation |
This Research Training Group is funded by the German Research Council DFG
| Agustin Liotta Address: Charité Universitätsmedizin Berlin (CCM) Institut für Neurophysiologie AG Heinemann Tucholskystr. 2 D-10117 Berlin |
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| MD-Project "" Synopsis
My work explores the cellular mechanisms underlying in vitro sharp wave-ripple complexes (SPW-Rs) generated by repeated high frequency stimulation (HFS) in the hippocampal formation of adult rat. In vivo, this activity is believed to play an important role in memory consolidation in several species including humans. In vitro SPW-Rs are characterised by complex network interactions between inhibitory and excitatory systems and are also strongly influenced by neuromodulators. More precisely, I’m studying the effects of reduced inhibition on SPW-Rs due to pharmacological manipulation of the GABA-A system. Another important focus of my research is on the study of norepinephrine mediated effects on SPW-Rs. The techniques used are extra-cellular field potential recordings, simultaneous extra and intracellular recordings (sharp microelectrodes), extra-cellular [K+]o and [Ca++]o recordings using ion sensitive electrodes and [Ca++]i imaging.
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