GRK 1123:

Cellular Mechanisms of Learning and Memory Consolidation in the Hippocampal Formation

| Home

---

| News

---

| Research

---

| Study Program

---

| Events

---

| Faculty

---

| Students

---

| Links

---

This Research Training Group is funded by the German Research Council DFG

---

©2006, FU Berlin
GRK 1123

---

Imprint & Disclaimer

---

Agnieszka Rybak Address: Institute of Cell Biology and Neurobiology Center for Anatomy Charité, Universitätsmedizin Berlin Phillipstr . 12 D-10115 Berlin Tel +49 (30) 450-528278 Fax +49 (30) 450-528902 mailto: agnieszkarybak@yahoo.com

Let-7 microRNA expression during mouse development

PhD-Project "Functional analysis of a mammalian lin-41 homolog during vertebrate nervous system development" Synopsis MicroRNAs (miRNAs), are a class of small (20-24 nt) noncoding RNAs that regulate gene expression by binding to complementary sequences in target mRNAs. Predicted miRNA genes in the mouse number in the thousands, with a particularly rich repertoire expressed in the CNS.During development,the combined actions of microRNAs and transcription factors are able to tune the expression of proteins on a global level in a manner that cannot be achieved by transcription factors alone. I focused my research on microRNAs expression as well as characterization the function of let-7 microRNA target gene mouse Lin-41 (mLin-41) during vertebrate nervous system development. Supervisor Prof. Dr. Robert Nitsch MSc Thesis "Construction and characterization Rhizobium leguminosarum bv. trifolii bacterial artificial chromosome library" (in Poland) Publications sent for submission Awards 2003/2004 scholarship awarded by the Ministry of Education and Sport (in Poland)